HRP20211748T1 - Postupci i sastavi za sekreciju heterolognih polipeptida - Google Patents
Postupci i sastavi za sekreciju heterolognih polipeptida Download PDFInfo
- Publication number
- HRP20211748T1 HRP20211748T1 HRP20211748TT HRP20211748T HRP20211748T1 HR P20211748 T1 HRP20211748 T1 HR P20211748T1 HR P20211748T T HRP20211748T T HR P20211748TT HR P20211748 T HRP20211748 T HR P20211748T HR P20211748 T1 HRP20211748 T1 HR P20211748T1
- Authority
- HR
- Croatia
- Prior art keywords
- signal peptide
- antibody
- variant
- host cell
- polynucleotide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 25
- 238000000034 method Methods 0.000 title claims 12
- 230000028327 secretion Effects 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 42
- 102000040430 polynucleotide Human genes 0.000 claims 31
- 108091033319 polynucleotide Proteins 0.000 claims 31
- 239000002157 polynucleotide Substances 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 21
- 230000035772 mutation Effects 0.000 claims 13
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 claims 10
- 241000588724 Escherichia coli Species 0.000 claims 9
- 108010006519 Molecular Chaperones Proteins 0.000 claims 4
- 102000005431 Molecular Chaperones Human genes 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 4
- 101100084022 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) lapA gene Proteins 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 101150009573 phoA gene Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102200158393 rs5030732 Human genes 0.000 claims 4
- 102220558029 Glutathione hydrolase 5 proenzyme_L11I_mutation Human genes 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 101100178822 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) htrA1 gene Proteins 0.000 claims 3
- 101100277437 Rhizobium meliloti (strain 1021) degP1 gene Proteins 0.000 claims 3
- 101150018266 degP gene Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102220054627 rs45495192 Human genes 0.000 claims 2
- -1 tac Proteins 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 102220479740 Cell division cycle protein 123 homolog_S11I_mutation Human genes 0.000 claims 1
- 101150081864 Spr gene Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 102200048773 rs2224391 Human genes 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461953629P | 2014-03-14 | 2014-03-14 | |
| US201562107981P | 2015-01-26 | 2015-01-26 | |
| US201562108476P | 2015-01-27 | 2015-01-27 | |
| EP15716209.0A EP3116999B1 (en) | 2014-03-14 | 2015-03-16 | Methods and compositions for secretion of heterologous polypeptides |
| PCT/US2015/020783 WO2015139046A1 (en) | 2014-03-14 | 2015-03-16 | Methods and compositions for secretion of heterologous polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211748T1 true HRP20211748T1 (hr) | 2022-02-18 |
Family
ID=52829322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211748TT HRP20211748T1 (hr) | 2014-03-14 | 2015-03-16 | Postupci i sastavi za sekreciju heterolognih polipeptida |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10435694B2 (enExample) |
| EP (1) | EP3116999B1 (enExample) |
| JP (2) | JP6644717B2 (enExample) |
| KR (1) | KR102561695B1 (enExample) |
| CN (1) | CN106103730B (enExample) |
| AU (1) | AU2015229035B2 (enExample) |
| BR (1) | BR112016020822A2 (enExample) |
| CA (1) | CA2941687A1 (enExample) |
| ES (1) | ES2897765T3 (enExample) |
| HR (1) | HRP20211748T1 (enExample) |
| IL (1) | IL247632B (enExample) |
| MA (1) | MA39746A (enExample) |
| MX (2) | MX2016011637A (enExample) |
| PL (1) | PL3116999T3 (enExample) |
| RU (1) | RU2748026C2 (enExample) |
| SG (1) | SG11201607519VA (enExample) |
| SI (1) | SI3116999T1 (enExample) |
| WO (1) | WO2015139046A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015139046A1 (en) | 2014-03-14 | 2015-09-17 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US20190271022A1 (en) * | 2016-10-27 | 2019-09-05 | Medimmune, Llc | Signal Polypeptide For Improved Secretion Of Protein |
| CN106676122B (zh) * | 2017-01-24 | 2019-10-29 | 成都分子脉象生物科技有限公司 | 一种基于AraF信号肽的双功能DNA元件及其应用 |
| US20210163607A1 (en) | 2017-05-19 | 2021-06-03 | Nippon Zenyaku Kogyo Co., Ltd. | Method for suppressing regulatory t cell infiltration by ccr4 inhibition and method for treating canine neoplastic disease |
| GB201708277D0 (en) * | 2017-05-24 | 2017-07-05 | Ge Healthcare | A Recombinant protein |
| KR101946789B1 (ko) * | 2018-01-26 | 2019-02-12 | (주)휴온스 | 이황화결합 이성질화효소 신호 펩타이드를 포함하는 재조합 벡터 및 이의 용도 |
| KR20210105382A (ko) * | 2018-12-19 | 2021-08-26 | 베르사멥 아게 | 단백질을 코딩하는 rna |
| GB2590642B (en) * | 2019-12-20 | 2024-02-14 | Kymab Ltd | Improved lambda antibodies |
| US20240327849A1 (en) * | 2019-08-05 | 2024-10-03 | Wacker Chemie Ag | Bacterial strain for releasing a recombinant protein in a fermentation method |
| SE543945C2 (en) * | 2020-02-07 | 2021-10-05 | Cloneopt Ab | Synthetically evolved DNA constructs for regulating signal peptide performance as well as vectors and host cells thereof |
| EP4100534A4 (en) * | 2020-02-07 | 2024-06-05 | Xbrane Biopharma AB | Synthetically evolved dna constructs for regulating signal peptide performance as well as vectors, host cells and recombinant proteins thereof |
| SE544059C2 (en) * | 2020-02-07 | 2021-11-30 | Cloneopt Ab | Synthetically evolved dna constructs for regulating signal peptide performance as well as vectors and host cells thereof |
| AU2022349814A1 (en) * | 2021-09-24 | 2024-05-02 | Xbrane Biopharma Ab | Dna constructs and host cells for expressing recombinant protein |
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| CN106103730B (zh) | 2021-06-08 |
| CA2941687A1 (en) | 2015-09-17 |
| MA39746A (fr) | 2021-04-28 |
| MX2016011637A (es) | 2017-04-13 |
| PL3116999T3 (pl) | 2021-12-27 |
| SG11201607519VA (en) | 2016-10-28 |
| JP6644717B2 (ja) | 2020-02-12 |
| RU2016140244A3 (enExample) | 2019-05-22 |
| RU2748026C2 (ru) | 2021-05-19 |
| IL247632B (en) | 2021-02-28 |
| US20200181625A1 (en) | 2020-06-11 |
| EP3116999B1 (en) | 2021-09-15 |
| SI3116999T1 (sl) | 2021-12-31 |
| RU2016140244A (ru) | 2018-04-17 |
| AU2015229035A1 (en) | 2016-09-22 |
| US10435694B2 (en) | 2019-10-08 |
| BR112016020822A2 (pt) | 2017-10-03 |
| KR102561695B1 (ko) | 2023-07-28 |
| WO2015139046A1 (en) | 2015-09-17 |
| US20170029825A1 (en) | 2017-02-02 |
| JP2017510294A (ja) | 2017-04-13 |
| AU2015229035B2 (en) | 2021-08-05 |
| MX2021001460A (es) | 2021-04-28 |
| KR20160134758A (ko) | 2016-11-23 |
| US11390872B2 (en) | 2022-07-19 |
| EP3116999A1 (en) | 2017-01-18 |
| ES2897765T3 (es) | 2022-03-02 |
| CN106103730A (zh) | 2016-11-09 |
| IL247632A0 (en) | 2016-11-30 |
| JP2020078305A (ja) | 2020-05-28 |
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