HRP20211748T1 - Postupci i sastavi za sekreciju heterolognih polipeptida - Google Patents
Postupci i sastavi za sekreciju heterolognih polipeptida Download PDFInfo
- Publication number
- HRP20211748T1 HRP20211748T1 HRP20211748TT HRP20211748T HRP20211748T1 HR P20211748 T1 HRP20211748 T1 HR P20211748T1 HR P20211748T T HRP20211748T T HR P20211748TT HR P20211748 T HRP20211748 T HR P20211748T HR P20211748 T1 HRP20211748 T1 HR P20211748T1
- Authority
- HR
- Croatia
- Prior art keywords
- signal peptide
- antibody
- variant
- host cell
- polynucleotide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 25
- 238000000034 method Methods 0.000 title claims 12
- 230000028327 secretion Effects 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 42
- 102000040430 polynucleotide Human genes 0.000 claims 31
- 108091033319 polynucleotide Proteins 0.000 claims 31
- 239000002157 polynucleotide Substances 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 21
- 230000035772 mutation Effects 0.000 claims 13
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 claims 10
- 241000588724 Escherichia coli Species 0.000 claims 9
- 108010006519 Molecular Chaperones Proteins 0.000 claims 4
- 102000005431 Molecular Chaperones Human genes 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 4
- 101100084022 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) lapA gene Proteins 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 101150009573 phoA gene Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102200158393 rs5030732 Human genes 0.000 claims 4
- 102220558029 Glutathione hydrolase 5 proenzyme_L11I_mutation Human genes 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 101100178822 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) htrA1 gene Proteins 0.000 claims 3
- 101100277437 Rhizobium meliloti (strain 1021) degP1 gene Proteins 0.000 claims 3
- 101150018266 degP gene Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102220054627 rs45495192 Human genes 0.000 claims 2
- -1 tac Proteins 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 102220479740 Cell division cycle protein 123 homolog_S11I_mutation Human genes 0.000 claims 1
- 101150081864 Spr gene Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 102200048773 rs2224391 Human genes 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461953629P | 2014-03-14 | 2014-03-14 | |
| US201562107981P | 2015-01-26 | 2015-01-26 | |
| US201562108476P | 2015-01-27 | 2015-01-27 | |
| EP15716209.0A EP3116999B1 (en) | 2014-03-14 | 2015-03-16 | Methods and compositions for secretion of heterologous polypeptides |
| PCT/US2015/020783 WO2015139046A1 (en) | 2014-03-14 | 2015-03-16 | Methods and compositions for secretion of heterologous polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211748T1 true HRP20211748T1 (hr) | 2022-02-18 |
Family
ID=52829322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211748TT HRP20211748T1 (hr) | 2014-03-14 | 2015-03-16 | Postupci i sastavi za sekreciju heterolognih polipeptida |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10435694B2 (enExample) |
| EP (1) | EP3116999B1 (enExample) |
| JP (2) | JP6644717B2 (enExample) |
| KR (1) | KR102561695B1 (enExample) |
| CN (1) | CN106103730B (enExample) |
| AU (1) | AU2015229035B2 (enExample) |
| BR (1) | BR112016020822A2 (enExample) |
| CA (1) | CA2941687A1 (enExample) |
| ES (1) | ES2897765T3 (enExample) |
| HR (1) | HRP20211748T1 (enExample) |
| IL (1) | IL247632B (enExample) |
| MA (1) | MA39746A (enExample) |
| MX (2) | MX2016011637A (enExample) |
| PL (1) | PL3116999T3 (enExample) |
| RU (1) | RU2748026C2 (enExample) |
| SG (1) | SG11201607519VA (enExample) |
| SI (1) | SI3116999T1 (enExample) |
| WO (1) | WO2015139046A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10435694B2 (en) | 2014-03-14 | 2019-10-08 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| EP3532618A4 (en) * | 2016-10-27 | 2020-05-20 | MedImmune, LLC | SIGNAL POLYPEPTIDES FOR IMPROVED PROTEIN SECRETION |
| CN106676122B (zh) * | 2017-01-24 | 2019-10-29 | 成都分子脉象生物科技有限公司 | 一种基于AraF信号肽的双功能DNA元件及其应用 |
| EP3626269A4 (en) | 2017-05-19 | 2021-03-03 | Shingo Maeda | METHOD FOR INFILTRATION OF REGULATORY T-CELLS USING CCR4 INHIBITION AND METHOD FOR TREATMENT OF NEOPLASTIC DISEASES IN DOGS |
| GB201708277D0 (en) * | 2017-05-24 | 2017-07-05 | Ge Healthcare | A Recombinant protein |
| KR101946789B1 (ko) * | 2018-01-26 | 2019-02-12 | (주)휴온스 | 이황화결합 이성질화효소 신호 펩타이드를 포함하는 재조합 벡터 및 이의 용도 |
| JP2022514863A (ja) * | 2018-12-19 | 2022-02-16 | ヴェルサメブ アーゲー | タンパク質をコードするｒｎａ |
| GB2590642B (en) * | 2019-12-20 | 2024-02-14 | Kymab Ltd | Improved lambda antibodies |
| ES3026707T3 (en) * | 2019-08-05 | 2025-06-12 | Wacker Chemie Ag | Bacterial strain for releasing a recombinant protein in a fermentation method |
| SE544059C2 (en) * | 2020-02-07 | 2021-11-30 | Cloneopt Ab | Synthetically evolved dna constructs for regulating signal peptide performance as well as vectors and host cells thereof |
| SE543945C2 (en) * | 2020-02-07 | 2021-10-05 | Cloneopt Ab | Synthetically evolved DNA constructs for regulating signal peptide performance as well as vectors and host cells thereof |
| EP4100534A4 (en) * | 2020-02-07 | 2024-06-05 | Xbrane Biopharma AB | Synthetically evolved dna constructs for regulating signal peptide performance as well as vectors, host cells and recombinant proteins thereof |
| KR20240099199A (ko) * | 2021-09-24 | 2024-06-28 | 엑스브레인 바이오파마 에이비 | 재조합 단백질을 발현시키기 위한 dna 구조체 및 숙주 세포 |
Family Cites Families (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3645090A (en) | 1969-06-19 | 1972-02-29 | Citizen Watch Co Ltd | Day-date quick-adjuster for calender timepiece |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4675187A (en) | 1983-05-16 | 1987-06-23 | Bristol-Myers Company | BBM-1675, a new antibiotic complex |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5264365A (en) | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
| US5508192A (en) | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| AU675916B2 (en) | 1991-06-14 | 1997-02-27 | Genentech Inc. | Method for making humanized antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ATE419355T1 (de) | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
| JPH08500017A (ja) | 1992-08-17 | 1996-01-09 | ジェネンテク，インコーポレイテッド | 二特異的免疫アドヘジン |
| WO1994011026A2 (en) | 1992-11-13 | 1994-05-26 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| JPH08511420A (ja) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | 抗 体 |
| DE4417598A1 (de) | 1994-05-19 | 1995-12-14 | Max Planck Gesellschaft | Verwendung des Tetracyclinpromotors zur stringent regulierten Produktion von rekombinanten Proteinen in prokaryontischen Zellen |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5639635A (en) | 1994-11-03 | 1997-06-17 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5747662A (en) | 1995-03-01 | 1998-05-05 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6242177B1 (en) | 1995-03-01 | 2001-06-05 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| WO1997038123A1 (en) | 1996-04-05 | 1997-10-16 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
| AU751659B2 (en) | 1997-05-02 | 2002-08-22 | Genentech Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| ES2244066T3 (es) | 1997-06-24 | 2005-12-01 | Genentech, Inc. | Procedimiento y composiciones de glicoproteinas galactosiladas. |
| CA2307166A1 (en) | 1997-10-31 | 1999-05-14 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
| WO1999029888A1 (en) | 1997-12-05 | 1999-06-17 | The Scripps Research Institute | Humanization of murine antibody |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| ES2292236T3 (es) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | Variantes de anticuerpos y sus fragmentos. |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP2364997A3 (en) | 1999-01-15 | 2012-07-04 | Genentech, Inc. | Polypeptide variants with altered effector function |
| ES2420835T3 (es) | 1999-04-09 | 2013-08-27 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de las moléculas inmunofuncionales |
| ES2329437T3 (es) | 1999-06-25 | 2009-11-26 | Genentech, Inc. | Anticuerpos anti-erbb2 humanizados y tratamiento con anticuerpos anti-erbb2. |
| AU7950400A (en) | 1999-10-19 | 2001-04-30 | Kyowa Hakko Kogyo Co. Ltd. | Process for producing polypeptide |
| IL149809A0 (en) | 1999-12-15 | 2002-11-10 | Genentech Inc | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
| EP2180054A1 (en) | 1999-12-24 | 2010-04-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| EP1242438B1 (en) | 1999-12-29 | 2006-11-08 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
| JP2003523207A (ja) | 2000-01-25 | 2003-08-05 | ジェネンテック・インコーポレーテッド | Ｌｉｖ−１関連タンパク質、それをコードするポリヌクレオチド、及び癌の治療へのその利用 |
| MXPA02010011A (es) | 2000-04-11 | 2003-04-25 | Genentech Inc | Anticuerpos multivalentes y usos para los mismos. |
| US20020022659A1 (en) * | 2000-07-19 | 2002-02-21 | Harris Gregory D. | Crystalline and salt forms of an HIV protease inhibitor |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| EP3263702A1 (en) | 2000-10-06 | 2018-01-03 | Kyowa Hakko Kirin Co., Ltd. | Cells producing antibody compositions |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7041870B2 (en) | 2000-11-30 | 2006-05-09 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| AU2002248184C1 (en) | 2000-12-12 | 2018-01-04 | Board Of Regents, The University Of Texas System | Molecules with extended half-lives, compositions and uses thereof |
| JP4309656B2 (ja) | 2000-12-14 | 2009-08-05 | ジェネンテック・インコーポレーテッド | 原核生物で生成させた抗体とその用途 |
| CZ304484B6 (cs) | 2000-12-14 | 2014-05-21 | Genentech, Inc. | Bakteriální hostitelské kmeny a způsob tvorby polypeptidu |
| US6979556B2 (en) | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
| KR20100018071A (ko) | 2001-08-03 | 2010-02-16 | 글리카트 바이오테크놀로지 아게 | 항체 의존적 세포 독성이 증가된 항체 글리코실화 변이체 |
| CA2454731C (en) * | 2001-08-27 | 2010-11-02 | Genentech, Inc. | A system for antibody expression and assembly |
| EP1908769A1 (en) | 2001-08-27 | 2008-04-09 | Genentech, Inc. | A system for antibody expression and assembly |
| MXPA04003798A (es) | 2001-10-25 | 2004-07-30 | Genentech Inc | Composiciones de glicoproteina. |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| CA2481920A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-containing medicament |
| CA2481658A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Method of enhancing of binding activity of antibody composition to fcy receptor iiia |
| JPWO2003085107A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | ゲノムが改変された細胞 |
| JPWO2003085118A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 抗体組成物の製造方法 |
| EP1502603A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | AN ANTIBODY COMPOSITION CONTAINING MEDICAMENT FOR PATIENTS WITH Fc gamma RIIIa POLYMORPHISM |
| EP1500698B1 (en) | 2002-04-09 | 2011-03-30 | Kyowa Hakko Kirin Co., Ltd. | Cell with depression or deletion of the activity of protein participating in gdp-fucose transport |
| EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| US7608429B2 (en) | 2002-10-31 | 2009-10-27 | Genentech, Inc. | Methods and compositions for increasing antibody production |
| PL212899B1 (pl) | 2002-12-16 | 2012-12-31 | Genentech Inc | Humanizowane przeciwcialo, kompozycja zawierajaca to przeciwcialo, wyrób fabryczny, przeciwcialo lub jego fragment do zastosowania w sposobie indukowania apoptozy, izolowany kwas nukleinowy, wektor ekspresji, komórka gospodarza, sposób wytwarzania przeciwciala lub jego fragmentu, plynny preparat i zastosowanie przeciwciala do wytwarzania leku |
| AU2004205631A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| CA2542046A1 (en) | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Fused protein composition |
| CA2542125A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing antibody composition by using rna inhibiting the function of .alpha.1,6-fucosyltransferase |
| KR100570422B1 (ko) * | 2003-10-16 | 2006-04-11 | 한미약품 주식회사 | 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법 |
| RS54450B1 (sr) | 2003-11-05 | 2016-06-30 | Roche Glycart Ag | Molekuli koji se vezuju za antigen sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom |
| DK1725249T3 (en) | 2003-11-06 | 2014-03-17 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugating to ligands. |
| WO2005053742A1 (ja) | 2003-12-04 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | 抗体組成物を含有する医薬 |
| BRPI0417107A (pt) * | 2003-12-19 | 2007-02-06 | Genentech Inc | fragmento de anticorpo, métodos de preparação do fragmento de anticorpo, ácido nucléico isolado, composições, célula hospedeira e métodos de fabricação e de geração de fragmento de anticorpo |
| MXPA06011199A (es) | 2004-03-31 | 2007-04-16 | Genentech Inc | Anticuerpos anti-tgf-beta humanizados. |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| AU2005294131A1 (en) | 2004-10-05 | 2006-04-20 | Wyeth | Methods and compositions for improving recombinant protein production |
| CA2599988A1 (en) | 2005-03-25 | 2006-10-05 | Genentech, Inc. | Methods and compositions for modulating hyperstabilized c-met |
| JP5042218B2 (ja) | 2005-07-08 | 2012-10-03 | ユニバーシティ・オブ・チューリッヒ | 融合ポリペプチドの翻訳と同時のトランスロケーションを使用するファージディスプレイ |
| CN100475965C (zh) | 2005-07-22 | 2009-04-08 | 上海高科联合生物技术研发有限公司 | 一种大肠杆菌高效外分泌表达溶葡萄球菌酶的方法 |
| US8679490B2 (en) | 2005-11-07 | 2014-03-25 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
| WO2007064919A2 (en) | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| JP2009536527A (ja) | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | 最適化されたスキャフォールドを備えた結合ポリペプチド |
| JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー／エス | 二重特異性抗体の生産 |
| DK2059533T3 (da) | 2006-08-30 | 2013-02-25 | Genentech Inc | Multispecifikke antistoffer |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| US8722584B2 (en) | 2007-01-12 | 2014-05-13 | Cornell University | Genetic selection for protein folding and solubility in the bacterial periplasm |
| KR101491867B1 (ko) * | 2007-01-31 | 2015-02-10 | 피페넥스 인크. | 증가된 발현을 위한 박테리아 리더 서열 |
| CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
| WO2009021548A1 (en) | 2007-08-10 | 2009-02-19 | Wacker Chemie Ag | Expression of full length igg and secretion into the culture medium of prokaryotic cells |
| AU2009204501B2 (en) | 2008-01-07 | 2015-02-12 | Amgen Inc. | Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects |
| SG188802A1 (en) | 2008-03-06 | 2013-04-30 | Genentech Inc | Combination therapy with c-met and egfr antagonists |
| JP2012508017A (ja) * | 2008-11-07 | 2012-04-05 | ファブラス エルエルシー | 抗ｄｌｌ４抗体及びその使用 |
| EP2358909B1 (en) * | 2008-11-17 | 2015-09-02 | Cornell University | A system useful for reporting protein-protein interactions in the bacterial periplasm |
| GB0917647D0 (en) | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| KR101968766B1 (ko) | 2009-11-05 | 2019-04-12 | 제넨테크, 인크. | 이종 폴리펩티드의 분비를 위한 방법 및 조성물 |
| WO2012031027A1 (en) | 2010-08-31 | 2012-03-08 | Genentech, Inc. | Biomarkers and methods of treatment |
| US20130004481A1 (en) | 2011-01-12 | 2013-01-03 | Boehringer Ingelheim International Gmbh | Anticancer therapy |
| JP2014522843A (ja) | 2011-06-30 | 2014-09-08 | ジェネンテック， インコーポレイテッド | 抗ｃ−ｍｅｔ抗体製剤 |
| RU2014114617A (ru) | 2011-09-19 | 2015-10-27 | Дженентек, Инк. | Комбинированные виды лечения, содержащие антагонисты с-мет и антагонисты b-raf |
| EP2782932A1 (en) | 2011-11-21 | 2014-10-01 | F.Hoffmann-La Roche Ag | Purification of anti-c-met antibodies |
| US10435694B2 (en) | 2014-03-14 | 2019-10-08 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
-
2015
- 2015-03-16 US US15/125,548 patent/US10435694B2/en active Active
- 2015-03-16 SI SI201531745T patent/SI3116999T1/sl unknown
- 2015-03-16 KR KR1020167028574A patent/KR102561695B1/ko active Active
- 2015-03-16 JP JP2016575644A patent/JP6644717B2/ja active Active
- 2015-03-16 MA MA039746A patent/MA39746A/fr unknown
- 2015-03-16 AU AU2015229035A patent/AU2015229035B2/en not_active Ceased
- 2015-03-16 RU RU2016140244A patent/RU2748026C2/ru active
- 2015-03-16 BR BR112016020822A patent/BR112016020822A2/pt not_active Application Discontinuation
- 2015-03-16 ES ES15716209T patent/ES2897765T3/es active Active
- 2015-03-16 PL PL15716209T patent/PL3116999T3/pl unknown
- 2015-03-16 SG SG11201607519VA patent/SG11201607519VA/en unknown
- 2015-03-16 WO PCT/US2015/020783 patent/WO2015139046A1/en not_active Ceased
- 2015-03-16 CN CN201580013658.9A patent/CN106103730B/zh active Active
- 2015-03-16 EP EP15716209.0A patent/EP3116999B1/en active Active
- 2015-03-16 MX MX2016011637A patent/MX2016011637A/es unknown
- 2015-03-16 CA CA2941687A patent/CA2941687A1/en active Pending
- 2015-03-16 HR HRP20211748TT patent/HRP20211748T1/hr unknown
-
2016
- 2016-09-05 IL IL247632A patent/IL247632B/en active IP Right Grant
- 2016-09-08 MX MX2021001460A patent/MX2021001460A/es unknown
-
2019
- 2019-08-22 US US16/548,599 patent/US11390872B2/en active Active
-
2020
- 2020-01-08 JP JP2020001218A patent/JP2020078305A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MA39746A (fr) | 2021-04-28 |
| RU2016140244A (ru) | 2018-04-17 |
| MX2021001460A (es) | 2021-04-28 |
| BR112016020822A2 (pt) | 2017-10-03 |
| US11390872B2 (en) | 2022-07-19 |
| CN106103730A (zh) | 2016-11-09 |
| IL247632A0 (en) | 2016-11-30 |
| RU2016140244A3 (enExample) | 2019-05-22 |
| EP3116999B1 (en) | 2021-09-15 |
| AU2015229035A1 (en) | 2016-09-22 |
| PL3116999T3 (pl) | 2021-12-27 |
| JP2020078305A (ja) | 2020-05-28 |
| US10435694B2 (en) | 2019-10-08 |
| IL247632B (en) | 2021-02-28 |
| SG11201607519VA (en) | 2016-10-28 |
| KR20160134758A (ko) | 2016-11-23 |
| AU2015229035B2 (en) | 2021-08-05 |
| US20200181625A1 (en) | 2020-06-11 |
| CN106103730B (zh) | 2021-06-08 |
| JP6644717B2 (ja) | 2020-02-12 |
| SI3116999T1 (sl) | 2021-12-31 |
| ES2897765T3 (es) | 2022-03-02 |
| US20170029825A1 (en) | 2017-02-02 |
| WO2015139046A1 (en) | 2015-09-17 |
| RU2748026C2 (ru) | 2021-05-19 |
| CA2941687A1 (en) | 2015-09-17 |
| MX2016011637A (es) | 2017-04-13 |
| JP2017510294A (ja) | 2017-04-13 |
| EP3116999A1 (en) | 2017-01-18 |
| KR102561695B1 (ko) | 2023-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20211748T1 (hr) | Postupci i sastavi za sekreciju heterolognih polipeptida | |
| JP2017510294A5 (enExample) | ||
| HRP20171136T1 (hr) | Postupci i sastav za sekreciju heterolognih polipeptida | |
| AU2018211081B2 (en) | Chimeric antigen receptors against Axl or Ror2 and methods of use thereof | |
| Song et al. | Improving protein production on the level of regulation of both expression and secretion pathways in Bacillus subtilis | |
| JP2020182473A (ja) | 核酸構築物 | |
| ES2609787T3 (es) | Expresión de anticuerpos monoclonales en Tetrahymena | |
| ES2921137T3 (es) | Producción de proteínas regulada por fuente de carbono en una célula huésped recombinante | |
| PH12020551039A1 (en) | Non-viral dna vectors and uses thereof for antibody and fusion protein production | |
| CN117886949A (zh) | 结合触发的转录开关及其使用方法 | |
| ES2871818T3 (es) | Métodos de selección celular y modificación del metabolismo celular | |
| JP2013535213A5 (enExample) | ||
| JP2016517691A5 (enExample) | ||
| EP3227436A1 (en) | Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof | |
| FI3527070T3 (fi) | Humanisoituja kevytketjuhiiriä | |
| JP2016518833A5 (enExample) | ||
| JP2016526909A5 (enExample) | ||
| ES2540753T3 (es) | Vectores de expresión que comprenden secuencias quiméricas de promotor y amplificador de citomegalovirus | |
| HRP20150659T1 (hr) | Domaä†inski soj bakterija koji sadrži mutirani spr gen te ima smanjenu tsp aktivnost | |
| WO2012009704A3 (en) | Novel peptides and uses thereof | |
| MX376466B (es) | Vectores de expresion para una secrecion de proteina mejorada. | |
| MX2021013976A (es) | Secuencias de direccionamiento para plataforma de visualizacion de endosporas basada en paenibacillus. | |
| WO2020102642A8 (en) | Endospore display platforms, products and methods | |
| CN110022907A (zh) | 非细胞毒性的修饰细胞及其用途 | |
| AU2013211001A1 (en) | Tools and methods for expression of membrane proteins |