HRP20210517T1 - Pripravci i postupci za protutijela usmjerena na epo - Google Patents

Pripravci i postupci za protutijela usmjerena na epo Download PDF

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Publication number
HRP20210517T1
HRP20210517T1 HRP20210517TT HRP20210517T HRP20210517T1 HR P20210517 T1 HRP20210517 T1 HR P20210517T1 HR P20210517T T HRP20210517T T HR P20210517TT HR P20210517 T HRP20210517 T HR P20210517T HR P20210517 T1 HRP20210517 T1 HR P20210517T1
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HR
Croatia
Prior art keywords
sequence
seq
nucleic acid
acid molecule
antigen
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HRP20210517TT
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English (en)
Inventor
Joy GHOSH
Mark Anthony RUTZ
Katrin Ulrike TISSOT-DAGUETTE
Igor Splawski
Michael Roguska
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Novartis Ag
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49881001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20210517(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HRP20210517T1 publication Critical patent/HRP20210517T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Claims (18)

1. Izolirano protutijelo ili njegov ulomak koji veže antigen koji veže ljudski eritropoetin (Epo), naznačeno time, da sadrži sekvence varijabilne domene teškog i lakog lanca Fab NVS1 predstavljene sa SEQ ID NO: 13 i 14, istim redom; od Fab NVS2 predstavljene sa SEQ ID NO: 33 i 34, istim redom; od Fab NVS3 predstavljene sa SEQ ID NO: 53 i 54, istim redom; ili od Fab NVS4 predstavljene sa SEQ ID NO: 73 i 74, istim redom.
2. Izolirano protutijelo ili njegov ulomak koji veže antigen prema patentnom zahtjevu 1, naznačeno time, da protutijelo ili njegov ulomak koji veže antigen sadrži sekvence varijabilne domene teškog i lakog lanca Fab NVS2 predstavljene sa SEQ ID NO: 33 i 34, istim redom.
3. Izolirano protutijelo ili njegov ulomak koji veže antigen prema patentnom zahtjevu 1, naznačeno time, da protutijelo ili njegov ulomak koji veže antigen sadrži sekvence teškog i lakog lanca SEQ ID NO: 15 i 16, istim redom; SEQ ID NO: 35 i 36, istim redom; SEQ ID NO: 55 i 56, istim redom; ili SEQ ID NO: 75 i 76, istim redom.
4. Izolirano protutijelo ili njegov ulomak koji veže antigen prema patentnom zahtjevu 3, naznačeno time, da protutijelo ili njegov ulomak koji veže antigen sadrži sekvence teškog i lakog lanca SEQ ID NO: 35 i 36, istim redom.
5. Izolirana molekula nukleinske kiseline, naznačena time, da sadrži nukleotidnu sekvencu koja kodira protutijelo ili ulomak koji kodira antigen prema bilo kojem od prethodnih patentnih zahtjeva.
6. Molekula nukleinske kiseline prema patentnom zahtjevu 5, naznačena time, da navedena molekula nukleinske kiseline sadrži sekvencu koja kodira varijabilnu domenu teškog lanca i navedena sekvenca je najmanje 95% identična u odnosu na sekvencu sa sekvencom odabranom od SEQ ID NO: 17, 37, 57 i 77.
7. Molekula nukleinske kiseline prema patentnom zahtjevu 5, naznačena time, da navedena molekula nukleinske kiseline sadrži sekvencu koja kodira varijabilnu domenu teškog lanca i navedena sekvenca je najmanje 95% identična u odnosu na sekvencu sa sekvencom SEQ ID NO: 37.
8. Molekula nukleinske kiseline prema patentnom zahtjevu 5, naznačena time, da navedena molekula nukleinske kiseline sadrži sekvencu koja kodira teški lanac i navedena sekvenca je najmanje 95% identična u odnosu sa sekvencu sa sekvencom SEQ ID NO: 39.
9. Molekula nukleinske kiseline prema patentnom zahtjevu 5, naznačena time, da navedena molekula nukleinske kiseline sadrži sekvencu koja kodira varijabilnu domenu lakog lanca i navedena sekvenca je najmanje 95% identična u odnosu na sekvencu sa sekvencom odabranom od SEQ ID NO: 18, 38, 58 i 78.
10. Molekula nukleinske kiseline prema patentnom zahtjevu 5, naznačena time, da navedena molekula nukleinske kiseline sadrži sekvencu koja kodira varijabilnu domenu lakog lanca i navedena sekvenca je najmanje 95% identična u odnosu na sekvencu sa sekvencom SEQ ID NO: 38.
11. Molekula nukleinske kiseline prema patentnom zahtjevu 5, naznačena time, da navedena molekula nukleinske kiseline sadrži sekvencu koja kodira laki lanac i navedena sekvenca je najmanje 95% identična u odnosu na sekvencu sa sekvencom SEQ ID NO: 40.
12. Vektor, naznačen time, da sadrži molekulu nukleinske kiseline prema bilo kojem od patentnih zahtjeva 5 do 11.
13. Izolirana stanica domaćina, naznačena time, da sadrži nukleinsku kiselinu prema bilo kojem od patentnih zahtjeva 5 do 11 ili vektor prema patentnom zahtjevu 12.
14. Pripravak, naznačen time, da sadrži protutijelo ili ulomak koji veže antigen prema bilo kojem od patentnih zahtjeva 1 do 4, i farmaceutski prihvatljivo sredstvo za razrjeđivanje ili nosač.
15. Pripravak koji sadrži protutijelo ili njegov ulomak koji veže antigen prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time, da je za uporabu u inhibiciji EPO-ovisne stanične proliferacije kod pojedinca.
16. Pripravak koji sadrži protutijelo ili njegov ulomak koji veže antigen prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time, da je za uporabu u liječenju vaskularne bolesti mrežnice kod pojedinca.
17. Pripravak za uporabu prema patentnom zahtjevu 16, naznačen time, da je vaskularna bolest mrežnice kod pojedinca povezana s bolešću ili stanjem odabranim od: dijabetičke retinopatije, dijabetičkog makularnog edema, proliferativne dijabetičke retinopatije, ne-proliferativne dijabetičke retinopatije, starosne makularne degeneracije, okluzije središnje mrežnične vene, multifokalnog horoiditisa, miopijske horoidalne neovaskularizacije i retinopatije nedonoščadi.
18. Pripravak koji sadrži protutijelo ili njegov ulomak koji veže antigen prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time, da je za uporabu u liječenju makularnog edema.
HRP20210517TT 2012-12-05 2021-03-30 Pripravci i postupci za protutijela usmjerena na epo HRP20210517T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261733566P 2012-12-05 2012-12-05
PCT/US2013/072915 WO2014089111A1 (en) 2012-12-05 2013-12-03 Compositions and methods for antibodies targeting epo
EP13812296.5A EP2928921B1 (en) 2012-12-05 2013-12-03 Compositions and methods for antibodies targeting epo

Publications (1)

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HRP20210517T1 true HRP20210517T1 (hr) 2021-05-14

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US (5) US9365646B2 (hr)
EP (2) EP2928921B1 (hr)
JP (5) JP6306605B2 (hr)
KR (2) KR102233664B1 (hr)
CN (2) CN104968678B (hr)
AP (1) AP2015008365A0 (hr)
AR (1) AR093803A1 (hr)
AU (4) AU2013355414B2 (hr)
CA (1) CA2893767C (hr)
CL (1) CL2015001472A1 (hr)
CY (1) CY1124028T1 (hr)
DK (1) DK2928921T3 (hr)
EA (1) EA033643B1 (hr)
ES (1) ES2864326T3 (hr)
HR (1) HRP20210517T1 (hr)
HU (1) HUE053669T2 (hr)
LT (1) LT2928921T (hr)
MX (1) MX368067B (hr)
PH (1) PH12015501243A1 (hr)
PL (1) PL2928921T3 (hr)
PT (1) PT2928921T (hr)
RS (1) RS61648B1 (hr)
SG (1) SG11201503567SA (hr)
SI (1) SI2928921T1 (hr)
TN (1) TN2015000124A1 (hr)
TW (1) TW201434858A (hr)
UY (1) UY35168A (hr)
WO (1) WO2014089111A1 (hr)
ZA (2) ZA201502291B (hr)

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