HRP20200357T1 - Spojevi 2,6-diokso,-2,3-dihidro-1h-purina, korisni u liječenju poremećaja povezanih s aktivnošću kanala trpa1 - Google Patents
Spojevi 2,6-diokso,-2,3-dihidro-1h-purina, korisni u liječenju poremećaja povezanih s aktivnošću kanala trpa1 Download PDFInfo
- Publication number
- HRP20200357T1 HRP20200357T1 HRP20200357TT HRP20200357T HRP20200357T1 HR P20200357 T1 HRP20200357 T1 HR P20200357T1 HR P20200357T T HRP20200357T T HR P20200357TT HR P20200357 T HRP20200357 T HR P20200357T HR P20200357 T1 HRP20200357 T1 HR P20200357T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- substituted
- carbocyclyl
- Prior art date
Links
- 102000012253 TRPA1 Cation Channel Human genes 0.000 title 1
- 108010036769 TRPA1 Cation Channel Proteins 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 206010068065 Burning mouth syndrome Diseases 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 229940100389 Sulfonylurea Drugs 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- -1 amino, amidyl Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 206010070237 Burning feet syndrome Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 101000764872 Homo sapiens Transient receptor potential cation channel subfamily A member 1 Proteins 0.000 claims 1
- 208000033830 Hot Flashes Diseases 0.000 claims 1
- 206010060800 Hot flush Diseases 0.000 claims 1
- 206010021639 Incontinence Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 102100026186 Transient receptor potential cation channel subfamily A member 1 Human genes 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 230000035617 depilation Effects 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 208000003265 stomatitis Diseases 0.000 claims 1
- 125000005864 sulfonamidyl group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/105—Persulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94586607P | 2007-06-22 | 2007-06-22 | |
| US94584007P | 2007-06-22 | 2007-06-22 | |
| EP16195618.0A EP3184527B1 (en) | 2007-06-22 | 2008-06-23 | 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200357T1 true HRP20200357T1 (hr) | 2020-06-12 |
Family
ID=40186010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200357TT HRP20200357T1 (hr) | 2007-06-22 | 2020-03-03 | Spojevi 2,6-diokso,-2,3-dihidro-1h-purina, korisni u liječenju poremećaja povezanih s aktivnošću kanala trpa1 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8163761B2 (enExample) |
| EP (3) | EP3663295A1 (enExample) |
| JP (5) | JP2010530901A (enExample) |
| CN (4) | CN101801362B (enExample) |
| AU (1) | AU2008268463B2 (enExample) |
| CA (2) | CA2691468C (enExample) |
| DK (1) | DK2170309T3 (enExample) |
| ES (1) | ES2609912T3 (enExample) |
| HR (1) | HRP20200357T1 (enExample) |
| SI (1) | SI3184527T1 (enExample) |
| WO (1) | WO2009002933A1 (enExample) |
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| US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
| WO2010039289A2 (en) | 2008-05-14 | 2010-04-08 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| WO2009140517A1 (en) | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| US20120108614A1 (en) * | 2008-05-14 | 2012-05-03 | Chong Jayhong A | Compounds and compositions for treating chemical warfare agent-induced injuries |
| WO2010004390A1 (en) | 2008-06-17 | 2010-01-14 | Glenmark Pharmaceuticals, S.A. | Quinazoline dione derivatives as trpa1 modulators |
| WO2010077976A2 (en) | 2008-12-17 | 2010-07-08 | The Regents Of The University Of California | Prokineticin receptor antagonists and uses thereof |
| US8362025B2 (en) * | 2008-12-22 | 2013-01-29 | Hydra Biosciences, Inc. | Compositions useful for treating disorders related to TRPA1 |
| US20120178766A1 (en) * | 2009-03-23 | 2012-07-12 | Sachin Sundarlal Chaudhari | Furopyrimidinedione derivatives as trpai modulators |
| UA108069C2 (uk) * | 2009-03-23 | 2015-03-25 | Гленмарк Фармасьютікалс, С.А. | Злиті піримідиндіонові похідні як модулятори trpa1 |
| US8623880B2 (en) | 2009-03-23 | 2014-01-07 | Glenmark Pharmaceuticals S.A. | Fused pyrimidine-dione derivatives as TRPA1 modulators |
| MX2011009821A (es) | 2009-03-23 | 2012-01-25 | Glenmark Pharmaceuticals Sa | Derivados de isotiazolo pirimidinadiona como moduladores del trpa1. |
| BR112012008147A2 (pt) * | 2009-09-04 | 2016-03-01 | Novartis Ag | compostos heteroarílicos como inibidores da quinase |
| AU2011346763B2 (en) | 2010-12-20 | 2016-01-07 | Glenmark Pharmaceuticals S.A. | 2-amino-4-arylthiazole compounds as TRPA1 antagonists |
| WO2012098281A2 (es) | 2011-01-19 | 2012-07-26 | Universidad Miguel Hernández De Elche | Péptidos moduladores de receptores trp y sus usos |
| WO2012172475A1 (en) | 2011-06-13 | 2012-12-20 | Glenmark Pharmaceuticals S.A. | Treatment of respiratory disorders using trpa1 antagonists |
| JP2014517062A (ja) | 2011-06-22 | 2014-07-17 | グレンマーク ファーマシューティカルズ， エセ．アー． | ＴＲＰＡ１アンタゴニスト及びβ２アゴニストを含む医薬組成物 |
| WO2012176105A1 (en) | 2011-06-22 | 2012-12-27 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist |
| CA2841417A1 (en) * | 2011-07-25 | 2013-01-31 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising a trpa1 antagonist and a steroid |
| EP2742048B1 (en) | 2011-08-09 | 2016-04-27 | Hydra Biosciences, Inc. | Inhibiting transient receptor potential ion channel trpa1 |
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| EP0087810B1 (en) * | 1982-03-02 | 1986-06-25 | Eisai Co., Ltd. | Antiphlogistic/antipyretic/analgesic pharmaceutical compositions containing theophylline derivatives as active ingredient |
| HU190377B (en) * | 1982-03-12 | 1986-08-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing theophyllinyl-alkyl-oxadiazoles |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| GB9524812D0 (en) | 1995-12-05 | 1996-02-07 | Leo Pharm Prod Ltd | Chemical compounds |
| FR2761068B1 (fr) * | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique |
| US20030199693A1 (en) * | 2000-07-28 | 2003-10-23 | Ing-Jun Chen | Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activies on PDE-5 phosphodiesterase |
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-
2008
- 2008-06-23 CN CN200880103802.8A patent/CN101801362B/zh not_active Expired - Fee Related
- 2008-06-23 CA CA2691468A patent/CA2691468C/en not_active Expired - Fee Related
- 2008-06-23 EP EP19211630.9A patent/EP3663295A1/en not_active Withdrawn
- 2008-06-23 AU AU2008268463A patent/AU2008268463B2/en not_active Ceased
- 2008-06-23 EP EP16195618.0A patent/EP3184527B1/en active Active
- 2008-06-23 US US12/144,354 patent/US8163761B2/en active Active
- 2008-06-23 CN CN201510111699.3A patent/CN104825457B/zh not_active Expired - Fee Related
- 2008-06-23 WO PCT/US2008/067901 patent/WO2009002933A1/en not_active Ceased
- 2008-06-23 CN CN201711272327.4A patent/CN108042542A/zh active Pending
- 2008-06-23 ES ES08771748.4T patent/ES2609912T3/es active Active
- 2008-06-23 CN CN201310718872.7A patent/CN103751194B/zh not_active Expired - Fee Related
- 2008-06-23 CA CA2962043A patent/CA2962043A1/en not_active Abandoned
- 2008-06-23 DK DK08771748.4T patent/DK2170309T3/en active
- 2008-06-23 SI SI200832113T patent/SI3184527T1/sl unknown
- 2008-06-23 JP JP2010513485A patent/JP2010530901A/ja not_active Withdrawn
- 2008-06-23 EP EP08771748.4A patent/EP2170309B1/en active Active
-
2012
- 2012-02-22 US US13/402,720 patent/US20130059869A1/en not_active Abandoned
-
2014
- 2014-05-14 JP JP2014100946A patent/JP5932883B2/ja not_active Expired - Fee Related
-
2015
- 2015-07-13 JP JP2015139797A patent/JP6258266B2/ja not_active Expired - Fee Related
-
2017
- 2017-06-30 US US15/639,776 patent/US20180133170A1/en not_active Abandoned
- 2017-07-04 JP JP2017131268A patent/JP2017165790A/ja not_active Withdrawn
-
2019
- 2019-04-12 JP JP2019076011A patent/JP2019147808A/ja not_active Withdrawn
-
2020
- 2020-03-03 HR HRP20200357TT patent/HRP20200357T1/hr unknown
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