PE20140836A1 - Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide - Google Patents

Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide

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Publication number
PE20140836A1
PE20140836A1 PE2014000105A PE2014000105A PE20140836A1 PE 20140836 A1 PE20140836 A1 PE 20140836A1 PE 2014000105 A PE2014000105 A PE 2014000105A PE 2014000105 A PE2014000105 A PE 2014000105A PE 20140836 A1 PE20140836 A1 PE 20140836A1
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PE
Peru
Prior art keywords
carboxamide
vanilloid receptor
receptor ligands
urea derivatives
derivatives containing
Prior art date
Application number
PE2014000105A
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English (en)
Inventor
Robert Frank-Foltyn
Gregor Bahrenberg
Thomas Christoph
Bernhard Lesch
Jeewoo Lee
Original Assignee
Gruenenthal Chemie
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46640622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140836(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20140836A1 publication Critical patent/PE20140836A1/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CARBOXAMIDA Y UREA DE FORMULA (I) DONDE R1 ES H, C(=O)-OH, OH, NH2, ENTRE OTROS; R2 ES H, F, CN, CF3, ENTRE OTROS; R3 ES H O UN RESIDUO ALIFATICO(C1-C10); n ES DE 1 A 4; R3a ES H O UN RESIDUO ALIFATICO(C1-C4); R4a ES H, UN RESIDUO ALIFATICO(C1-C4), CICLOALIFATICO(C3-C6), ENTRE OTROS; Y ES O, S O N-CN; Z ES N O C-R4b, EN DONDE R4b ES H O UN RESIDUO ALIFATICO(C1-C4); T1 ES N O C-R5; U1 ES N O C-R6; V ES N O C-R7; U2 ES N O C-R8; T2 ES N O C-R9; R5, R6, R7, R8 Y R9 SON CADA UNO H, F, NO2, CN, CFH2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-((1-(3-CLOROFENIL)-3-(TRIFLUOROMETIL)-1H-PIRAZOL-5-IL)METIL)-2-(PIRIDIN-2-IL)ACETAMIDA; N-((3-TER-BUTIL-1-(3-CLOROFENIL)-1H-PIRAZOL-5-IL)METIL)-2-(PIRIDIN-2-IL)PROPANAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS DEL RECEPTOR VANILLOIDE SIENDO UTILES EN EL TRATAMIENTO DE DOLOR, ENFERMEDAD DE PARKINSON, SINDROME DEL INTESTINO IRRITABLE
PE2014000105A 2011-07-26 2012-07-25 Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide PE20140836A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11006114 2011-07-26

Publications (1)

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PE20140836A1 true PE20140836A1 (es) 2014-08-03

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ID=46640622

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PE2014000105A PE20140836A1 (es) 2011-07-26 2012-07-25 Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide

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US (1) US20130029962A1 (es)
EP (1) EP2736900A1 (es)
JP (1) JP2014521616A (es)
KR (1) KR20140049026A (es)
CN (1) CN103842357A (es)
AR (1) AR087301A1 (es)
BR (1) BR112014001880A2 (es)
CA (1) CA2842916A1 (es)
CL (1) CL2013003816A1 (es)
CO (1) CO6940410A2 (es)
EA (1) EA201400161A1 (es)
EC (1) ECSP14013164A (es)
HK (1) HK1198697A1 (es)
MX (1) MX2014000779A (es)
PE (1) PE20140836A1 (es)
WO (1) WO2013013815A1 (es)
ZA (1) ZA201400085B (es)

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