HK1198697A1 - Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands - Google Patents

Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

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Publication number
HK1198697A1
HK1198697A1 HK14112124.8A HK14112124A HK1198697A1 HK 1198697 A1 HK1198697 A1 HK 1198697A1 HK 14112124 A HK14112124 A HK 14112124A HK 1198697 A1 HK1198697 A1 HK 1198697A1
Authority
HK
Hong Kong
Prior art keywords
pyrazole
receptor ligands
urea derivatives
vanilloid receptor
substituted heteroaromatic
Prior art date
Application number
HK14112124.8A
Other languages
English (en)
Chinese (zh)
Inventor
Robert Frank-Foltyn
Gregor Bahrenberg
Thomas Christoph
Bernhard Lesch
Jeewoo Lee
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46640622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1198697(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of HK1198697A1 publication Critical patent/HK1198697A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
HK14112124.8A 2011-07-26 2014-12-02 Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands HK1198697A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11006114 2011-07-26
PCT/EP2012/003135 WO2013013815A1 (en) 2011-07-26 2012-07-25 Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

Publications (1)

Publication Number Publication Date
HK1198697A1 true HK1198697A1 (en) 2015-05-29

Family

ID=46640622

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14112124.8A HK1198697A1 (en) 2011-07-26 2014-12-02 Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

Country Status (17)

Country Link
US (1) US20130029962A1 (xx)
EP (1) EP2736900A1 (xx)
JP (1) JP2014521616A (xx)
KR (1) KR20140049026A (xx)
CN (1) CN103842357A (xx)
AR (1) AR087301A1 (xx)
BR (1) BR112014001880A2 (xx)
CA (1) CA2842916A1 (xx)
CL (1) CL2013003816A1 (xx)
CO (1) CO6940410A2 (xx)
EA (1) EA201400161A1 (xx)
EC (1) ECSP14013164A (xx)
HK (1) HK1198697A1 (xx)
MX (1) MX2014000779A (xx)
PE (1) PE20140836A1 (xx)
WO (1) WO2013013815A1 (xx)
ZA (1) ZA201400085B (xx)

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CN103827090B (zh) 2011-07-26 2016-04-20 勃林格殷格翰国际有限公司 取代的喹啉及其作为药物的用途
AU2012289255A1 (en) * 2011-07-26 2014-01-30 Grunenthal Gmbh Substituted heterocyclic aza derivatives
US9695350B2 (en) 2013-05-31 2017-07-04 Halliburton Energy Services, Inc. Ampholyte polymeric compounds in subterranean applications
WO2015090599A1 (en) 2013-12-19 2015-06-25 Grünenthal GmbH Fluoromethyl-substituted pyrrole carboxamides iv
CA2934327A1 (en) * 2013-12-19 2015-06-25 Grunenthal Gmbh Fluoromethyl-substituted pyrrole carboxamides as cav2.2 calcium channel blockers
MX2016007955A (es) * 2013-12-19 2016-09-09 Gruenenthal Gmbh Pirrol carboxamidas iii fluorometil-sustituidas.
WO2015189138A1 (en) * 2014-06-11 2015-12-17 Bayer Cropscience Ag Process for preparing 3,5-bis(haloalkyl)pyrazoles via acylation of ketimines
BR112017008178A2 (pt) * 2014-10-24 2017-12-19 Ono Pharmaceutical Co ativador do canal de kcnq2-5
CN107108593B (zh) * 2014-11-24 2020-03-24 美迪福伦Dbt有限公司 作为类香草素受体配体ii的基于取代的恶唑和噻唑的羧酰胺和脲衍生物
CN104478911A (zh) * 2014-12-19 2015-04-01 成都安斯利生物医药有限公司 一种制备3-三氟甲基吡咯硼酸的方法
ES2899906T3 (es) 2015-07-06 2022-03-15 Alkermes Inc Inhibidores bicíclicos de histona desacetilasa
EP3319968A1 (en) 2015-07-06 2018-05-16 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
CN105523995A (zh) * 2015-12-17 2016-04-27 浙江汇能生物股份有限公司 一种咯萘啶中间体2-甲氧基-5-氨基吡啶的制备方法
CN105753783B (zh) * 2016-04-08 2017-12-15 李文淏 一种合成塞来昔布的方法
JP6197971B1 (ja) * 2016-04-22 2017-09-20 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤
EP3241830A1 (de) 2016-05-04 2017-11-08 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
WO2018125983A1 (en) 2016-12-30 2018-07-05 Mitobridge, Inc. Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (acmsd) inhibitors
WO2018132533A1 (en) 2017-01-11 2018-07-19 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
CA3071861A1 (en) 2017-08-07 2019-02-14 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
WO2022030589A1 (ja) * 2020-08-05 2022-02-10 国立大学法人北海道大学 単座配位尿素化合物を含む配位子とそれを含むホウ素化触媒
WO2022263498A1 (en) * 2021-06-15 2022-12-22 Grünenthal GmbH Substituted pyrazole amides
WO2024036243A2 (en) * 2022-08-10 2024-02-15 Vettore, LLC Salts of heterocyclic inhibitors of monocarboxylate transporter 4 for the treatment of disease
PL442982A1 (pl) * 2022-11-29 2024-06-03 Uniwersytet Medyczny W Lublinie N-podstawione pochodne 1-(1-fenylo-3-arylo)-1H-pirazol-4-ylo)metanaminy, sposób ich wytwarzania i ich zastosowanie

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EP2057140B1 (en) * 2006-08-24 2012-08-08 AstraZeneca AB Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
JP2010083763A (ja) * 2008-09-29 2010-04-15 Mitsui Chemicals Inc ピラゾール誘導体およびその製造方法、ならびに殺菌剤
US8334315B2 (en) * 2009-05-07 2012-12-18 Gruenenthal Gmbh Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands
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WO2013013815A8 (en) 2014-01-09
CN103842357A (zh) 2014-06-04
MX2014000779A (es) 2014-03-27
BR112014001880A2 (pt) 2017-02-21
CL2013003816A1 (es) 2014-06-20
WO2013013815A1 (en) 2013-01-31
ZA201400085B (en) 2015-07-29
US20130029962A1 (en) 2013-01-31
JP2014521616A (ja) 2014-08-28
CO6940410A2 (es) 2014-05-09
ECSP14013164A (es) 2014-11-28
PE20140836A1 (es) 2014-08-03
EP2736900A1 (en) 2014-06-04
EA201400161A1 (ru) 2014-06-30
CA2842916A1 (en) 2013-01-31
AR087301A1 (es) 2014-03-12
KR20140049026A (ko) 2014-04-24

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