HK1198697A1 - 作為類香草素受體配體的被取代的、含有雜芳環吡唑的羧醯胺和脲衍生物 - Google Patents
作為類香草素受體配體的被取代的、含有雜芳環吡唑的羧醯胺和脲衍生物Info
- Publication number
- HK1198697A1 HK1198697A1 HK14112124.8A HK14112124A HK1198697A1 HK 1198697 A1 HK1198697 A1 HK 1198697A1 HK 14112124 A HK14112124 A HK 14112124A HK 1198697 A1 HK1198697 A1 HK 1198697A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrazole
- receptor ligands
- urea derivatives
- vanilloid receptor
- substituted heteroaromatic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11006114 | 2011-07-26 | ||
PCT/EP2012/003135 WO2013013815A1 (en) | 2011-07-26 | 2012-07-25 | Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1198697A1 true HK1198697A1 (zh) | 2015-05-29 |
Family
ID=46640622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14112124.8A HK1198697A1 (zh) | 2011-07-26 | 2014-12-02 | 作為類香草素受體配體的被取代的、含有雜芳環吡唑的羧醯胺和脲衍生物 |
Country Status (17)
Country | Link |
---|---|
US (1) | US20130029962A1 (zh) |
EP (1) | EP2736900A1 (zh) |
JP (1) | JP2014521616A (zh) |
KR (1) | KR20140049026A (zh) |
CN (1) | CN103842357A (zh) |
AR (1) | AR087301A1 (zh) |
BR (1) | BR112014001880A2 (zh) |
CA (1) | CA2842916A1 (zh) |
CL (1) | CL2013003816A1 (zh) |
CO (1) | CO6940410A2 (zh) |
EA (1) | EA201400161A1 (zh) |
EC (1) | ECSP14013164A (zh) |
HK (1) | HK1198697A1 (zh) |
MX (1) | MX2014000779A (zh) |
PE (1) | PE20140836A1 (zh) |
WO (1) | WO2013013815A1 (zh) |
ZA (1) | ZA201400085B (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5629331B2 (ja) | 2010-01-29 | 2014-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ナフチリジン及びsykキナーゼ阻害剤としてのその使用 |
AR087302A1 (es) * | 2011-07-26 | 2014-03-12 | Gruenenthal Gmbh | Derivados aza heterociclicos sustituidos |
CN103827090B (zh) | 2011-07-26 | 2016-04-20 | 勃林格殷格翰国际有限公司 | 取代的喹啉及其作为药物的用途 |
US9695350B2 (en) | 2013-05-31 | 2017-07-04 | Halliburton Energy Services, Inc. | Ampholyte polymeric compounds in subterranean applications |
CA2934327A1 (en) | 2013-12-19 | 2015-06-25 | Grunenthal Gmbh | Fluoromethyl-substituted pyrrole carboxamides as cav2.2 calcium channel blockers |
AU2014365744A1 (en) * | 2013-12-19 | 2016-05-26 | Grunenthal Gmbh | Fluoromethyl-substituted pyrrole carboxamides III |
EP3083613A1 (en) | 2013-12-19 | 2016-10-26 | Grünenthal GmbH | Fluoromethyl-substituted pyrrole carboxamides iv |
MX2016016399A (es) * | 2014-06-11 | 2017-04-06 | Bayer Cropscience Ag | Proceso para la preparacion de 3,5-bis(haloalquil)pirazoles por medio de la acilacion de cetiminas. |
EP3210969B1 (en) | 2014-10-24 | 2021-04-28 | ONO Pharmaceutical Co., Ltd. | Kcnq2-5 channel activator |
TW201625568A (zh) * | 2014-11-24 | 2016-07-16 | 歌林達有限公司 | 作爲類香草素受體之配位體ii之經取代以噁唑及噻唑爲主之甲醯胺及脲衍生物 |
CN104478911A (zh) * | 2014-12-19 | 2015-04-01 | 成都安斯利生物医药有限公司 | 一种制备3-三氟甲基吡咯硼酸的方法 |
WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
CN105523995A (zh) * | 2015-12-17 | 2016-04-27 | 浙江汇能生物股份有限公司 | 一种咯萘啶中间体2-甲氧基-5-氨基吡啶的制备方法 |
CN105753783B (zh) * | 2016-04-08 | 2017-12-15 | 李文淏 | 一种合成塞来昔布的方法 |
JP6197971B1 (ja) * | 2016-04-22 | 2017-09-20 | 小野薬品工業株式会社 | Kcnq2〜5チャネル関連疾患の予防および/または治療剤 |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
US20190367457A1 (en) | 2016-12-30 | 2019-12-05 | Mitobridge, Inc. | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (acmsd) inhibitors |
EP3570834B1 (en) | 2017-01-11 | 2021-12-22 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
MA49839B1 (fr) | 2017-08-07 | 2022-05-31 | Alkermes Inc | Inhibiteurs bicycliques de la histone déacétylase |
WO2022030589A1 (ja) * | 2020-08-05 | 2022-02-10 | 国立大学法人北海道大学 | 単座配位尿素化合物を含む配位子とそれを含むホウ素化触媒 |
EP4355733A1 (en) * | 2021-06-15 | 2024-04-24 | Grünenthal GmbH | Substituted pyrazole amides |
WO2024036243A2 (en) * | 2022-08-10 | 2024-02-15 | Vettore, LLC | Salts of heterocyclic inhibitors of monocarboxylate transporter 4 for the treatment of disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2660758A1 (en) * | 2006-08-24 | 2008-02-27 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
JP2010083763A (ja) * | 2008-09-29 | 2010-04-15 | Mitsui Chemicals Inc | ピラゾール誘導体およびその製造方法、ならびに殺菌剤 |
WO2010127855A1 (en) * | 2009-05-07 | 2010-11-11 | Grünenthal GmbH | Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands |
BRPI1011043B8 (pt) | 2009-05-07 | 2021-05-25 | Gruenenthal Gmbh | fenilureias e fenilamidas substituídas como ligantes de receptor de vaniloide, seus usos e seu processo de preparação, e composição farmacêutica |
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2012
- 2012-07-25 CN CN201280036860.XA patent/CN103842357A/zh active Pending
- 2012-07-25 MX MX2014000779A patent/MX2014000779A/es not_active Application Discontinuation
- 2012-07-25 KR KR1020147004940A patent/KR20140049026A/ko not_active Application Discontinuation
- 2012-07-25 WO PCT/EP2012/003135 patent/WO2013013815A1/en active Application Filing
- 2012-07-25 PE PE2014000105A patent/PE20140836A1/es not_active Application Discontinuation
- 2012-07-25 US US13/557,941 patent/US20130029962A1/en not_active Abandoned
- 2012-07-25 JP JP2014521984A patent/JP2014521616A/ja not_active Withdrawn
- 2012-07-25 CA CA2842916A patent/CA2842916A1/en not_active Abandoned
- 2012-07-25 EA EA201400161A patent/EA201400161A1/ru unknown
- 2012-07-25 EP EP12745622.6A patent/EP2736900A1/en not_active Withdrawn
- 2012-07-25 AR ARP120102684A patent/AR087301A1/es unknown
- 2012-07-25 BR BR112014001880A patent/BR112014001880A2/pt not_active IP Right Cessation
-
2013
- 2013-12-31 CL CL2013003816A patent/CL2013003816A1/es unknown
-
2014
- 2014-01-06 ZA ZA2014/00085A patent/ZA201400085B/en unknown
- 2014-01-10 CO CO14004193A patent/CO6940410A2/es unknown
- 2014-01-22 EC ECSP14013164 patent/ECSP14013164A/es unknown
- 2014-12-02 HK HK14112124.8A patent/HK1198697A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CO6940410A2 (es) | 2014-05-09 |
JP2014521616A (ja) | 2014-08-28 |
BR112014001880A2 (pt) | 2017-02-21 |
EP2736900A1 (en) | 2014-06-04 |
US20130029962A1 (en) | 2013-01-31 |
KR20140049026A (ko) | 2014-04-24 |
WO2013013815A1 (en) | 2013-01-31 |
MX2014000779A (es) | 2014-03-27 |
ECSP14013164A (es) | 2014-11-28 |
AR087301A1 (es) | 2014-03-12 |
CN103842357A (zh) | 2014-06-04 |
ZA201400085B (en) | 2015-07-29 |
WO2013013815A8 (en) | 2014-01-09 |
CL2013003816A1 (es) | 2014-06-20 |
CA2842916A1 (en) | 2013-01-31 |
EA201400161A1 (ru) | 2014-06-30 |
PE20140836A1 (es) | 2014-08-03 |
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