CN101801362B - 用于治疗病症的方法和组合物 - Google Patents

用于治疗病症的方法和组合物 Download PDF

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Publication number
CN101801362B
CN101801362B CN200880103802.8A CN200880103802A CN101801362B CN 101801362 B CN101801362 B CN 101801362B CN 200880103802 A CN200880103802 A CN 200880103802A CN 101801362 B CN101801362 B CN 101801362B
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China
Prior art keywords
dimethyl
dioxo
acetamide
trpal
dihydro
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Expired - Fee Related
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CN200880103802.8A
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English (en)
Chinese (zh)
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CN101801362A (zh
Inventor
H·恩格
M·魏格勒
M·莫兰
J·郑
C·方格尔
G·R·拉尔森
D·德尔卡米诺
N·海沃德
S·P·亚当斯
A·里普卡
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Eli Lilly and Co
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Hydra Biosciences LLC
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Application filed by Hydra Biosciences LLC filed Critical Hydra Biosciences LLC
Priority to CN201310718872.7A priority Critical patent/CN103751194B/zh
Priority to CN201711272327.4A priority patent/CN108042542A/zh
Priority to CN201510111699.3A priority patent/CN104825457B/zh
Publication of CN101801362A publication Critical patent/CN101801362A/zh
Application granted granted Critical
Publication of CN101801362B publication Critical patent/CN101801362B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN200880103802.8A 2007-06-22 2008-06-23 用于治疗病症的方法和组合物 Expired - Fee Related CN101801362B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201310718872.7A CN103751194B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201711272327.4A CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201510111699.3A CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94584007P 2007-06-22 2007-06-22
US94586607P 2007-06-22 2007-06-22
US60/945,866 2007-06-22
US60/945,840 2007-06-22
PCT/US2008/067901 WO2009002933A1 (en) 2007-06-22 2008-06-23 Methods and compositions for treating disorders

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN201711272327.4A Division CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201510111699.3A Division CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201310718872.7A Division CN103751194B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

Publications (2)

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CN101801362A CN101801362A (zh) 2010-08-11
CN101801362B true CN101801362B (zh) 2014-01-22

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CN200880103802.8A Expired - Fee Related CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201310718872.7A Expired - Fee Related CN103751194B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201711272327.4A Pending CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201510111699.3A Expired - Fee Related CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

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CN201310718872.7A Expired - Fee Related CN103751194B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201711272327.4A Pending CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201510111699.3A Expired - Fee Related CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

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Country Link
US (3) US8163761B2 (enExample)
EP (3) EP2170309B1 (enExample)
JP (5) JP2010530901A (enExample)
CN (4) CN101801362B (enExample)
AU (1) AU2008268463B2 (enExample)
CA (2) CA2962043A1 (enExample)
DK (1) DK2170309T3 (enExample)
ES (1) ES2609912T3 (enExample)
HR (1) HRP20200357T1 (enExample)
SI (1) SI3184527T1 (enExample)
WO (1) WO2009002933A1 (enExample)

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