DK2170309T3 - Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel - Google Patents

Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel Download PDF

Info

Publication number
DK2170309T3
DK2170309T3 DK08771748.4T DK08771748T DK2170309T3 DK 2170309 T3 DK2170309 T3 DK 2170309T3 DK 08771748 T DK08771748 T DK 08771748T DK 2170309 T3 DK2170309 T3 DK 2170309T3
Authority
DK
Denmark
Prior art keywords
trpa1
pain
compound
alkyl
substituted
Prior art date
Application number
DK08771748.4T
Other languages
Danish (da)
English (en)
Inventor
Manfred Weigele
Magdalene Moran
Jayhong Chong
Christopher Fanger
Camino Donato Del
Neil Hayward
Steven P Adams
Amy Ripka
Glenn R Larsen
Howard Ng
Original Assignee
Hydra Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hydra Biosciences Inc filed Critical Hydra Biosciences Inc
Application granted granted Critical
Publication of DK2170309T3 publication Critical patent/DK2170309T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK08771748.4T 2007-06-22 2008-06-23 Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel DK2170309T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94586607P 2007-06-22 2007-06-22
US94584007P 2007-06-22 2007-06-22
PCT/US2008/067901 WO2009002933A1 (en) 2007-06-22 2008-06-23 Methods and compositions for treating disorders

Publications (1)

Publication Number Publication Date
DK2170309T3 true DK2170309T3 (en) 2017-01-09

Family

ID=40186010

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08771748.4T DK2170309T3 (en) 2007-06-22 2008-06-23 Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel

Country Status (11)

Country Link
US (3) US8163761B2 (enExample)
EP (3) EP3184527B1 (enExample)
JP (5) JP2010530901A (enExample)
CN (4) CN103751194B (enExample)
AU (1) AU2008268463B2 (enExample)
CA (2) CA2691468C (enExample)
DK (1) DK2170309T3 (enExample)
ES (1) ES2609912T3 (enExample)
HR (1) HRP20200357T1 (enExample)
SI (1) SI3184527T1 (enExample)
WO (1) WO2009002933A1 (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767685B2 (en) * 2006-06-29 2010-08-03 King Pharmaceuticals Research And Development, Inc. Adenosine A2B receptor antagonists
US20120108614A1 (en) * 2008-05-14 2012-05-03 Chong Jayhong A Compounds and compositions for treating chemical warfare agent-induced injuries
WO2010039289A2 (en) 2008-05-14 2010-04-08 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2009140517A1 (en) * 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2010004390A1 (en) 2008-06-17 2010-01-14 Glenmark Pharmaceuticals, S.A. Quinazoline dione derivatives as trpa1 modulators
US8722896B2 (en) 2008-12-17 2014-05-13 The Regents Of The University Of California Prokineticin receptor antagonists and uses thereof
US8362025B2 (en) * 2008-12-22 2013-01-29 Hydra Biosciences, Inc. Compositions useful for treating disorders related to TRPA1
AU2010227225A1 (en) 2009-03-23 2011-09-15 Glenmark Pharmaceuticals, S.A. Furopyrimidinedione derivatives as TRPA1 modulators
ES2424340T3 (es) 2009-03-23 2013-10-01 Glenmark Pharmaceuticals S.A. Derivados de isotiazolo-pirimidindiona como moduladores de TRPA1
AU2010227245B2 (en) * 2009-03-23 2015-09-10 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
US8623880B2 (en) 2009-03-23 2014-01-07 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
CN102498107A (zh) * 2009-09-04 2012-06-13 诺瓦提斯公司 作为激酶抑制剂的杂芳基化合物
AU2011346763B2 (en) 2010-12-20 2016-01-07 Glenmark Pharmaceuticals S.A. 2-amino-4-arylthiazole compounds as TRPA1 antagonists
WO2012098281A2 (es) 2011-01-19 2012-07-26 Universidad Miguel Hernández De Elche Péptidos moduladores de receptores trp y sus usos
JP2014517031A (ja) 2011-06-13 2014-07-17 グレンマーク ファーマシューティカルズ， エセ．アー． Ｔｒｐａ１アンタゴニストを使用した呼吸器疾患の治療
WO2012176105A1 (en) 2011-06-22 2012-12-27 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
US20140107113A1 (en) 2011-06-22 2014-04-17 Glenmark Pharmaceuticals S.A. Pharmaceutical composition comprising a trpa1 antagonist and a beta-2 agonist
WO2013014597A1 (en) * 2011-07-25 2013-01-31 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a steroid
BR112014002960A2 (pt) * 2011-08-09 2017-02-21 Cubist Pharm Inc inibição de canal de íons potencial receptor transiente trpa1
US20140364445A1 (en) 2011-12-05 2014-12-11 Glenmark Pharmaceuticals S.A. Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
WO2013122979A1 (en) 2012-02-15 2013-08-22 Chirhoclin, Inc. Methods for treating pain associated with chronic pancreatitis
US9499533B2 (en) 2012-03-27 2016-11-22 Shionogi & Co., Ltd. Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity
US11406718B2 (en) 2012-05-29 2022-08-09 Chirhoclin, Inc. Methods of detecting pancreobiliary ductal leaks
US9221821B2 (en) 2012-06-05 2015-12-29 Forest Laboratories Holdings, Limited Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
HK1207643A1 (en) * 2012-06-08 2016-02-05 Glenmark Pharmaceuticals S.A. Amides of 2-amino-4-arylthiazole compounds and their salts
US20140163048A1 (en) * 2012-08-09 2014-06-12 Cubist Pharmaceuticals, Inc. Compositions with increased stability for inhibiting transient receptor potential ion channel trpa1
DK2928474T3 (en) 2012-12-07 2019-02-11 Chemocentryx Inc Diazollactamer
WO2014100735A2 (en) 2012-12-21 2014-06-26 Chemocentryx, Inc. Diazole amides
TW201441225A (zh) * 2013-01-18 2014-11-01 Cubist Pharm Inc 瞬時受體電位ａ１離子通道之抑制
US9394308B2 (en) 2013-01-18 2016-07-19 Merck Sharp & Dohme Corp. Inhibiting the transient receptor potential A1 ion channel
GB201309333D0 (en) * 2013-05-23 2013-07-10 Agency Science Tech & Res Purine diones as WNT pathway modulators
CN105492444B (zh) 2013-07-02 2018-09-07 百时美施贵宝公司 作为rock抑制剂的三环吡啶-甲酰胺衍生物
EP3016950B1 (en) 2013-07-02 2017-06-07 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
US9532988B2 (en) 2013-10-15 2017-01-03 Glenmark Pharmaceuticals S.A. Pharmaceutical composition comprising a TRPA1 antagonist and an analgesic agent
CN107739372A (zh) * 2013-11-03 2018-02-27 黑龙江福和华星制药集团股份有限公司 一种多索茶碱注射液
CN103788095A (zh) * 2014-01-20 2014-05-14 四川大学华西医院 2,4(1h,3h)-嘧啶二酮衍生物及其制备方法
WO2015134790A1 (en) * 2014-03-07 2015-09-11 Sanford-Burnham Medical Research Institute Small molecule fatty acid synthase inhibitors
TWI676626B (zh) * 2014-04-23 2019-11-11 美商美國禮來大藥廠 抑制瞬時受體電位ａ１離子通道
US20190175599A1 (en) 2014-09-16 2019-06-13 Glemark Pharmaceuticals S.A. Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
US10221177B2 (en) * 2014-09-19 2019-03-05 Hydra Biosciences, Inc. Inhibiting the transient receptor potential A1 ion channel
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
WO2017064068A1 (en) 2015-10-14 2017-04-20 Almirall, S.A. New trpa1 antagonists
RU2745195C2 (ru) 2016-04-07 2021-03-22 Кемосентрикс, Инк. Уменьшение массы опухоли путем введения ccr1 антагонистов в комбинации с pd-1 ингибиторами или pd-l1 ингибиторами
JP6788476B2 (ja) 2016-10-21 2020-11-25 株式会社ミツトヨ クロマティック共焦点センサ及び測定方法
US20190374552A1 (en) * 2016-11-02 2019-12-12 George Edward Hoag Multifunctional formulations and methods to control dermatitis and pruritus
CN110461838B (zh) * 2017-03-07 2022-05-06 豪夫迈·罗氏有限公司 噁二唑瞬时受体电位通道抑制剂
CN111655693B (zh) 2018-01-31 2023-03-28 伊莱利利公司 抑制瞬时型感受器电位a1离子通道
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
CN108997350B (zh) * 2018-07-03 2021-03-02 南昌立德生物技术有限公司 一种周期蛋白依赖性激酶8抑制剂
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7630439B2 (ja) 2019-03-11 2025-02-17 ノシオン セラピューティクス，インコーポレイテッド エステル置換イオンチャンネル遮断薬および使用方法
WO2020185928A1 (en) 2019-03-11 2020-09-17 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
KR20210143791A (ko) 2019-03-11 2021-11-29 녹시온 테라퓨틱스 인코포레이티드 하전된 이온 채널 차단제 및 사용 방법
CN110343759A (zh) * 2019-06-03 2019-10-18 张鹏 Trpv4的用途及其抑制剂的用途和药物筛选方法
CN110526878A (zh) * 2019-09-16 2019-12-03 成都睿智化学研究有限公司 一种2-(噁唑基)乙胺的制备方法
CN112691094B (zh) * 2019-10-22 2022-09-23 中国科学院分子细胞科学卓越创新中心 防治病毒的新型化合物及其应用
JP7513713B2 (ja) 2019-11-06 2024-07-09 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US10842798B1 (en) 2019-11-06 2020-11-24 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN119118953A (zh) 2020-03-11 2024-12-13 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US11744878B2 (en) 2020-08-19 2023-09-05 Chirhoclin, Inc. Methods for treatment of COVID-19 syndrome
AU2021350916A1 (en) * 2020-09-24 2023-06-08 Shanghai Yao Yuan Biotechnology Co., Ltd. Alpha protein kinase 1 inhibitors and methods of use
EP4079304A1 (en) * 2021-04-21 2022-10-26 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Compounds for use in the treatment of hyperproliferative disorders
CN115477626B (zh) * 2021-06-16 2024-08-02 上海璃道医药科技有限公司 N-取代苯基磺酰胺类化合物及其用途
CN114671875A (zh) * 2022-04-27 2022-06-28 成都施贝康生物医药科技有限公司 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途
US11951082B2 (en) 2022-08-22 2024-04-09 Ford Therapeutics, Llc Composition of chlorhexidine
CN117986195A (zh) * 2023-01-10 2024-05-07 四川大学 一种新型杂环化合物及其制备方法和用途
CN116655635B (zh) * 2023-05-19 2024-01-26 济南爱思医药科技有限公司 黑茶茶碱衍生物及在制备药物中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599337A (en) * 1977-08-09 1986-07-08 Eisai Co., Ltd. Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
DE3307395A1 (de) * 1982-03-02 1983-09-08 Eisai Co., Ltd., Tokyo Arzneimittel zur behandlung von schmerzen, fieber, gewebe- und/oder knochen- und gelenkentzuendungen mit einem gehalt an theobromin- oder theophyllinderivaten als aktivem bestandteil
HU190377B (en) * 1982-03-12 1986-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing theophyllinyl-alkyl-oxadiazoles
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
GB9524812D0 (en) 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
FR2761068B1 (fr) 1997-03-20 1999-04-23 Synthelabo Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique
US20030199693A1 (en) * 2000-07-28 2003-10-23 Ing-Jun Chen Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activies on PDE-5 phosphodiesterase
US7818808B1 (en) 2000-12-27 2010-10-19 Intel Corporation Processor mode for limiting the operation of guest software running on a virtual machine supported by a virtual machine monitor
GB0108770D0 (en) * 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
KR20040080939A (ko) * 2002-02-01 2004-09-20 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 8-헤테로아릴 크산틴 아데노신 에이투비 수용체 길항제
US20030203847A1 (en) * 2002-02-28 2003-10-30 Millennium Pharmaceuticals, Inc. Methods and compositions in treating pain and painful disorders using 9949, 14230, 760, 62553, 12216, 17719, 41897, 47174, 33408, 10002, 16209, 314, 636, 27410, 33260, 619, 15985, 69112, 2158, 224, 615, 44373, 95431, 22245, 2387, 16658, 55054, 16314, 1613, 1675, 9569 or 13424 molecules
GB0213869D0 (en) * 2002-06-17 2002-07-31 Arakis Ltd The treatment of pain
US20050209243A1 (en) 2002-09-27 2005-09-22 Ing-Jun Chen Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
US20070196866A1 (en) * 2004-03-13 2007-08-23 Irm Llc Modulators of ion channel trpa1
KR20060129411A (ko) * 2004-03-30 2006-12-15 패러다임 테라퓨틱스 리미티드 이온 채널
CA2549577A1 (en) 2004-09-09 2006-03-16 Avaya Technology Corp. Methods of and systems for network traffic security
US20070021992A1 (en) * 2005-07-19 2007-01-25 Srinivas Konakalla Method and system for generating a business intelligence system based on individual life cycles within a business process
WO2007054480A1 (en) * 2005-11-08 2007-05-18 N.V. Organon 2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor
CN101384261B (zh) * 2005-12-22 2011-12-07 海德拉生物科学公司 治疗疼痛的组合物
WO2007125405A2 (en) * 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
US20120108614A1 (en) 2008-05-14 2012-05-03 Chong Jayhong A Compounds and compositions for treating chemical warfare agent-induced injuries
WO2009140517A1 (en) 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries

Also Published As

Publication number Publication date
US8163761B2 (en) 2012-04-24
JP2019147808A (ja) 2019-09-05
HRP20200357T1 (hr) 2020-06-12
JP2010530901A (ja) 2010-09-16
AU2008268463B2 (en) 2015-03-05
CA2962043A1 (en) 2008-12-31
CN103751194B (zh) 2018-01-05
CN101801362A (zh) 2010-08-11
US20090143377A1 (en) 2009-06-04
JP2014141535A (ja) 2014-08-07
CN101801362B (zh) 2014-01-22
EP3184527A1 (en) 2017-06-28
JP5932883B2 (ja) 2016-06-08
SI3184527T1 (sl) 2020-03-31
US20130059869A1 (en) 2013-03-07
EP2170309A1 (en) 2010-04-07
ES2609912T3 (es) 2017-04-25
JP2015180700A (ja) 2015-10-15
EP2170309A4 (en) 2010-11-03
AU2008268463A1 (en) 2008-12-31
EP3184527B1 (en) 2020-01-29
CA2691468C (en) 2017-05-09
CA2691468A1 (en) 2008-12-31
US20180133170A1 (en) 2018-05-17
WO2009002933A1 (en) 2008-12-31
CN103751194A (zh) 2014-04-30
CN104825457B (zh) 2019-11-19
JP6258266B2 (ja) 2018-01-10
EP2170309B1 (en) 2016-10-26
EP3663295A1 (en) 2020-06-10
CN104825457A (zh) 2015-08-12
CN108042542A (zh) 2018-05-18
AU2008268463A2 (en) 2010-02-25
JP2017165790A (ja) 2017-09-21

Similar Documents

Publication Publication Date Title
DK2170309T3 (en) Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel
AU2016273866B2 (en) TRPA1 Inhibitors for Treating Pain
US8389546B2 (en) Compounds for modulating TRPV3 function
US20090018147A1 (en) Compounds for modulating TRPV3 function
WO2009158719A2 (en) Methods and compositions for treating disorders
AU2015202546B2 (en) Methods and Compositions for Treating Disorders
HK1240581B (en) 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel
HK1240581A1 (en) 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel
HK1142541A (en) 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel
HK1142541B (en) 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel
HK1122738B (en) Trpa1 inhibitors for treating pain