DK2170309T3 - Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel - Google Patents

Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel Download PDF

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Publication number
DK2170309T3
DK2170309T3 DK08771748.4T DK08771748T DK2170309T3 DK 2170309 T3 DK2170309 T3 DK 2170309T3 DK 08771748 T DK08771748 T DK 08771748T DK 2170309 T3 DK2170309 T3 DK 2170309T3
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DK
Denmark
Prior art keywords
trpa1
pain
compound
alkyl
substituted
Prior art date
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DK08771748.4T
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Danish (da)
English (en)
Inventor
Manfred Weigele
Magdalene Moran
Jayhong Chong
Christopher Fanger
Camino Donato Del
Neil Hayward
Steven P Adams
Amy Ripka
Glenn R Larsen
Howard Ng
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Hydra Biosciences Inc
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Publication of DK2170309T3 publication Critical patent/DK2170309T3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK08771748.4T 2007-06-22 2008-06-23 Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel DK2170309T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94586607P 2007-06-22 2007-06-22
US94584007P 2007-06-22 2007-06-22
PCT/US2008/067901 WO2009002933A1 (en) 2007-06-22 2008-06-23 Methods and compositions for treating disorders

Publications (1)

Publication Number Publication Date
DK2170309T3 true DK2170309T3 (en) 2017-01-09

Family

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Family Applications (1)

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DK08771748.4T DK2170309T3 (en) 2007-06-22 2008-06-23 Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel

Country Status (11)

Country Link
US (3) US8163761B2 (enExample)
EP (3) EP3663295A1 (enExample)
JP (5) JP2010530901A (enExample)
CN (4) CN101801362B (enExample)
AU (1) AU2008268463B2 (enExample)
CA (2) CA2691468C (enExample)
DK (1) DK2170309T3 (enExample)
ES (1) ES2609912T3 (enExample)
HR (1) HRP20200357T1 (enExample)
SI (1) SI3184527T1 (enExample)
WO (1) WO2009002933A1 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767685B2 (en) * 2006-06-29 2010-08-03 King Pharmaceuticals Research And Development, Inc. Adenosine A2B receptor antagonists
WO2009140519A1 (en) * 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2009140517A1 (en) 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
US8318728B2 (en) 2008-05-14 2012-11-27 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2010004390A1 (en) 2008-06-17 2010-01-14 Glenmark Pharmaceuticals, S.A. Quinazoline dione derivatives as trpa1 modulators
US8722896B2 (en) 2008-12-17 2014-05-13 The Regents Of The University Of California Prokineticin receptor antagonists and uses thereof
WO2010075353A1 (en) 2008-12-22 2010-07-01 Hydra Biosciences, Inc. Compositions useful for treating disorders related to trpa1
SG174398A1 (en) 2009-03-23 2011-10-28 Glenmark Pharmaceuticals Sa Furopyrimidinedione derivatives as trpa1 modulators
EA023857B1 (ru) * 2009-03-23 2016-07-29 Гленмарк Фармасеутикалс С.А. Сочлененные производные пиримидиндионов в качестве модуляторов trpa1
BRPI1009372A2 (pt) * 2009-03-23 2016-05-31 Glenmark Pharmaceuticals Sa compostos, composição farmacêutica e respectivos usos
US8623880B2 (en) 2009-03-23 2014-01-07 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
CA2771568A1 (en) * 2009-09-04 2011-03-10 Novartis Ag Heteroaryl compounds as kinase inhibitors
EP2655377B1 (en) 2010-12-20 2016-03-30 Glenmark Pharmaceuticals S.A. 2-amino-4-arylthiazole compounds as trpa1 antagonists
WO2012098281A2 (es) 2011-01-19 2012-07-26 Universidad Miguel Hernández De Elche Péptidos moduladores de receptores trp y sus usos
WO2012172475A1 (en) 2011-06-13 2012-12-20 Glenmark Pharmaceuticals S.A. Treatment of respiratory disorders using trpa1 antagonists
WO2012176143A1 (en) 2011-06-22 2012-12-27 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a beta-2 agonist
WO2012176105A1 (en) 2011-06-22 2012-12-27 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
WO2013014597A1 (en) 2011-07-25 2013-01-31 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a steroid
MX2014001551A (es) 2011-08-09 2014-09-15 Hydra Biosciences Inc Inhibicion de canal ionico del potencial receptor transitorio a1 (trpa1).
CA2857109A1 (en) 2011-12-05 2013-06-13 Glenmark Pharmaceuticals S.A. Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
WO2013122979A1 (en) 2012-02-15 2013-08-22 Chirhoclin, Inc. Methods for treating pain associated with chronic pancreatitis
US9499533B2 (en) 2012-03-27 2016-11-22 Shionogi & Co., Ltd. Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity
US11406718B2 (en) 2012-05-29 2022-08-09 Chirhoclin, Inc. Methods of detecting pancreobiliary ductal leaks
US9221821B2 (en) * 2012-06-05 2015-12-29 Forest Laboratories Holdings, Limited Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
KR20150015488A (ko) * 2012-06-08 2015-02-10 그렌마크 파머수티칼스 에스. 아. 2-아미노-4-아릴티아졸 화합물의 아미드 및 그의 염
US20140163048A1 (en) * 2012-08-09 2014-06-12 Cubist Pharmaceuticals, Inc. Compositions with increased stability for inhibiting transient receptor potential ion channel trpa1
AU2013355054B2 (en) 2012-12-07 2017-08-24 Chemocentryx, Inc. Diazole lactams
US9169248B2 (en) 2012-12-21 2015-10-27 Chemocentryx, Inc. Diazole amides
US9394308B2 (en) 2013-01-18 2016-07-19 Merck Sharp & Dohme Corp. Inhibiting the transient receptor potential A1 ion channel
EP2945947B1 (en) * 2013-01-18 2019-12-04 Merck Sharp & Dohme Corp. Inhibiting the transient receptor potential a1 ion channel
GB201309333D0 (en) 2013-05-23 2013-07-10 Agency Science Tech & Res Purine diones as WNT pathway modulators
ES2634628T3 (es) 2013-07-02 2017-09-28 Bristol-Myers Squibb Company Derivados tricíclicos de pirido-carboxamida como inhibidores ROCK
EP3016951B1 (en) 2013-07-02 2017-05-31 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
RU2016115093A (ru) 2013-10-15 2017-11-21 Гленмарк Фармасьютикалс С.А. Фармацевтическая композиция, содержащая антагонист trpa1 и анальгетический агент
CN107739372A (zh) * 2013-11-03 2018-02-27 黑龙江福和华星制药集团股份有限公司 一种多索茶碱注射液
CN103788095A (zh) * 2014-01-20 2014-05-14 四川大学华西医院 2,4(1h,3h)-嘧啶二酮衍生物及其制备方法
WO2015134790A1 (en) * 2014-03-07 2015-09-11 Sanford-Burnham Medical Research Institute Small molecule fatty acid synthase inhibitors
TWI676626B (zh) * 2014-04-23 2019-11-11 美商美國禮來大藥廠 抑制瞬時受體電位ａ１離子通道
WO2016042501A1 (en) 2014-09-16 2016-03-24 Glenmark Pharmaceuticals S.A. Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
DK3193880T3 (da) * 2014-09-19 2020-06-02 Lilly Co Eli Hæmning af den transiente receptor-potential-A1-ionkanal
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
WO2017064068A1 (en) 2015-10-14 2017-04-20 Almirall, S.A. New trpa1 antagonists
IL261998B2 (en) 2016-04-07 2023-03-01 Chemocentryx Inc Reducing your burden by giving ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
JP6788476B2 (ja) 2016-10-21 2020-11-25 株式会社ミツトヨ クロマティック共焦点センサ及び測定方法
US20190374552A1 (en) * 2016-11-02 2019-12-12 George Edward Hoag Multifunctional formulations and methods to control dermatitis and pruritus
JP7178357B2 (ja) * 2017-03-07 2022-11-25 エフ．ホフマン－ラ ロシュ アーゲー オキサジアゾール一過性受容器電位チャネル阻害剤
CA3088551C (en) 2018-01-31 2023-01-24 Eli Lilly And Company Inhibiting the transient receptor potential a1 ion channel
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
CN108997350B (zh) * 2018-07-03 2021-03-02 南昌立德生物技术有限公司 一种周期蛋白依赖性激酶8抑制剂
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
BR112021017809A2 (pt) 2019-03-11 2021-11-23 Nocion Therapeutics Inc Bloqueadores de canais iônicos substituídos por éster e métodos para uso
EP3937945A4 (en) 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
MA55307A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques chargés et procédés d'utilisation
CN110343759A (zh) * 2019-06-03 2019-10-18 张鹏 Trpv4的用途及其抑制剂的用途和药物筛选方法
CN110526878A (zh) * 2019-09-16 2019-12-03 成都睿智化学研究有限公司 一种2-(噁唑基)乙胺的制备方法
CN112691094B (zh) * 2019-10-22 2022-09-23 中国科学院分子细胞科学卓越创新中心 防治病毒的新型化合物及其应用
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2021091585A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7708777B2 (ja) 2020-03-11 2025-07-15 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US11744878B2 (en) 2020-08-19 2023-09-05 Chirhoclin, Inc. Methods for treatment of COVID-19 syndrome
US20240109853A1 (en) * 2020-09-24 2024-04-04 Shanghai Yao Yuan Biotechnology Co., Ltd. Alpha protein kinase 1 inhibitors and methods of use
PL4323368T3 (pl) * 2021-04-14 2025-06-23 Boehringer Ingelheim International Gmbh 3h,4h,5h,6h,7h-pirymido[4,5-b][1,4]oksazyno-4,6-dionowe pochodne jako inhibitory trpa1
EP4079304A1 (en) * 2021-04-21 2022-10-26 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Compounds for use in the treatment of hyperproliferative disorders
CN115477626B (zh) * 2021-06-16 2024-08-02 上海璃道医药科技有限公司 N-取代苯基磺酰胺类化合物及其用途
CN114671875A (zh) * 2022-04-27 2022-06-28 成都施贝康生物医药科技有限公司 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途
US11951082B2 (en) 2022-08-22 2024-04-09 Ford Therapeutics, Llc Composition of chlorhexidine
CN117986195A (zh) * 2023-01-10 2024-05-07 四川大学 一种新型杂环化合物及其制备方法和用途
CN116655635B (zh) * 2023-05-19 2024-01-26 济南爱思医药科技有限公司 黑茶茶碱衍生物及在制备药物中的应用
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599337A (en) * 1977-08-09 1986-07-08 Eisai Co., Ltd. Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
EP0087810B1 (en) * 1982-03-02 1986-06-25 Eisai Co., Ltd. Antiphlogistic/antipyretic/analgesic pharmaceutical compositions containing theophylline derivatives as active ingredient
HU190377B (en) * 1982-03-12 1986-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing theophyllinyl-alkyl-oxadiazoles
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
GB9524812D0 (en) 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
FR2761068B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique
US20030199693A1 (en) * 2000-07-28 2003-10-23 Ing-Jun Chen Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activies on PDE-5 phosphodiesterase
US7818808B1 (en) 2000-12-27 2010-10-19 Intel Corporation Processor mode for limiting the operation of guest software running on a virtual machine supported by a virtual machine monitor
GB0108770D0 (en) * 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
CA2443023A1 (en) * 2002-02-01 2003-08-07 King Pharmaceuticals Research And Development, Inc. 8-heteroaryl xanthine adenosine a2b receptor antagonists
AU2003213105A1 (en) * 2002-02-28 2003-09-16 Millennium Pharmaceuticals, Inc. Methods and compositions in treating pain using diacylglycerol kinase epsilon
GB0213869D0 (en) * 2002-06-17 2002-07-31 Arakis Ltd The treatment of pain
US20050209243A1 (en) * 2002-09-27 2005-09-22 Ing-Jun Chen Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
WO2005089206A2 (en) 2004-03-13 2005-09-29 Irm Llc Modulators of ion channel trpa1
KR20060129411A (ko) * 2004-03-30 2006-12-15 패러다임 테라퓨틱스 리미티드 이온 채널
CA2549577A1 (en) 2004-09-09 2006-03-16 Avaya Technology Corp. Methods of and systems for network traffic security
US20070021992A1 (en) * 2005-07-19 2007-01-25 Srinivas Konakalla Method and system for generating a business intelligence system based on individual life cycles within a business process
WO2007054480A1 (en) * 2005-11-08 2007-05-18 N.V. Organon 2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor
AU2006327181A1 (en) * 2005-12-22 2007-06-28 Hydra Biosciences, Inc. TRPA1 inhibitors for treating pain
CA2651072A1 (en) * 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
WO2009140519A1 (en) * 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2009140517A1 (en) 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries

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Publication number Publication date
AU2008268463A1 (en) 2008-12-31
EP3184527A1 (en) 2017-06-28
EP2170309A1 (en) 2010-04-07
JP2014141535A (ja) 2014-08-07
JP2017165790A (ja) 2017-09-21
JP6258266B2 (ja) 2018-01-10
US20180133170A1 (en) 2018-05-17
CA2691468C (en) 2017-05-09
CN103751194A (zh) 2014-04-30
CA2691468A1 (en) 2008-12-31
JP2015180700A (ja) 2015-10-15
HRP20200357T1 (hr) 2020-06-12
JP2010530901A (ja) 2010-09-16
US8163761B2 (en) 2012-04-24
JP5932883B2 (ja) 2016-06-08
JP2019147808A (ja) 2019-09-05
EP3184527B1 (en) 2020-01-29
SI3184527T1 (sl) 2020-03-31
CN108042542A (zh) 2018-05-18
US20130059869A1 (en) 2013-03-07
CN103751194B (zh) 2018-01-05
CN104825457B (zh) 2019-11-19
CN104825457A (zh) 2015-08-12
AU2008268463A2 (en) 2010-02-25
EP2170309B1 (en) 2016-10-26
AU2008268463B2 (en) 2015-03-05
CA2962043A1 (en) 2008-12-31
WO2009002933A1 (en) 2008-12-31
ES2609912T3 (es) 2017-04-25
EP3663295A1 (en) 2020-06-10
CN101801362A (zh) 2010-08-11
CN101801362B (zh) 2014-01-22
EP2170309A4 (en) 2010-11-03
US20090143377A1 (en) 2009-06-04

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