HRP20170295T1 - Oblik soli inhibitora ljudske histonske metiltransferaze ezh2 - Google Patents

Oblik soli inhibitora ljudske histonske metiltransferaze ezh2 Download PDF

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Publication number
HRP20170295T1
HRP20170295T1 HRP20170295TT HRP20170295T HRP20170295T1 HR P20170295 T1 HRP20170295 T1 HR P20170295T1 HR P20170295T T HRP20170295T T HR P20170295TT HR P20170295 T HRP20170295 T HR P20170295T HR P20170295 T1 HRP20170295 T1 HR P20170295T1
Authority
HR
Croatia
Prior art keywords
degrees
polymorph
theta
methyl
diffraction pattern
Prior art date
Application number
HRP20170295TT
Other languages
English (en)
Croatian (hr)
Inventor
Kevin Wayne Kuntz
Kuan-Chun Huang
Hyeong Wook Choi
Kristen SANDERS
Steven Mathieu
Arani CHANDA
Frank Fang
Original Assignee
Epizyme, Inc.
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme, Inc., Eisai R&D Management Co., Ltd. filed Critical Epizyme, Inc.
Publication of HRP20170295T1 publication Critical patent/HRP20170295T1/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HRP20170295TT 2012-04-13 2013-04-11 Oblik soli inhibitora ljudske histonske metiltransferaze ezh2 HRP20170295T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261624215P 2012-04-13 2012-04-13
EP13774979.2A EP2836491B1 (en) 2012-04-13 2013-04-11 Salt form of a human histone methyltransferase ezh2 inhibitor
PCT/US2013/036193 WO2013155317A1 (en) 2012-04-13 2013-04-11 Salt form of a human hi stone methyltransf erase ezh2 inhibitor

Publications (1)

Publication Number Publication Date
HRP20170295T1 true HRP20170295T1 (hr) 2017-04-21

Family

ID=49328166

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20170295TT HRP20170295T1 (hr) 2012-04-13 2013-04-11 Oblik soli inhibitora ljudske histonske metiltransferaze ezh2
HRP20191653TT HRP20191653T1 (hr) 2012-04-13 2019-09-13 N-((4,6-dimetil-2-okso-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2h-piran-4-il)amino)-4-metil-4' (morfolinometil)-[l,1'-bifenil]-3-karboksamid hidrobromid za uporabu u liječenju proliferativnih poremećaja stanica hematološkog sustava

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20191653TT HRP20191653T1 (hr) 2012-04-13 2019-09-13 N-((4,6-dimetil-2-okso-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2h-piran-4-il)amino)-4-metil-4' (morfolinometil)-[l,1'-bifenil]-3-karboksamid hidrobromid za uporabu u liječenju proliferativnih poremećaja stanica hematološkog sustava

Country Status (26)

Country Link
US (7) US9394283B2 (show.php)
EP (4) EP3628670B1 (show.php)
JP (3) JP6255382B2 (show.php)
KR (4) KR102744039B1 (show.php)
CN (2) CN104603130B (show.php)
AU (2) AU2013245878B2 (show.php)
BR (1) BR112014025508B1 (show.php)
CA (1) CA2870005C (show.php)
CY (2) CY1119383T1 (show.php)
DK (3) DK3184523T3 (show.php)
ES (3) ES2931316T3 (show.php)
HR (2) HRP20170295T1 (show.php)
HU (3) HUE060881T2 (show.php)
IL (4) IL282732B2 (show.php)
IN (1) IN2014DN09068A (show.php)
LT (2) LT3184523T (show.php)
MX (2) MX384641B (show.php)
NZ (1) NZ700761A (show.php)
PL (3) PL3184523T3 (show.php)
PT (3) PT3184523T (show.php)
RS (2) RS55690B1 (show.php)
RU (1) RU2658911C2 (show.php)
SG (3) SG10201608577RA (show.php)
SI (2) SI2836491T1 (show.php)
SM (2) SMT201900501T1 (show.php)
WO (1) WO2013155317A1 (show.php)

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Also Published As

Publication number Publication date
EP3184523A1 (en) 2017-06-28
IL282732B (en) 2022-12-01
EP3184523B1 (en) 2019-06-19
JP6255382B2 (ja) 2017-12-27
RS59392B1 (sr) 2019-11-29
US9394283B2 (en) 2016-07-19
EP4190777A1 (en) 2023-06-07
PT3184523T (pt) 2019-09-26
US20180243316A1 (en) 2018-08-30
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