HRP20240304T1 - Soli valbenazin dihidroklorida i njihovi polimorfi - Google Patents
Soli valbenazin dihidroklorida i njihovi polimorfi Download PDFInfo
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- HRP20240304T1 HRP20240304T1 HRP20240304TT HRP20240304T HRP20240304T1 HR P20240304 T1 HRP20240304 T1 HR P20240304T1 HR P20240304T T HRP20240304T T HR P20240304TT HR P20240304 T HRP20240304 T HR P20240304T HR P20240304 T1 HRP20240304 T1 HR P20240304T1
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- Prior art keywords
- crystalline form
- amorphous form
- temperature
- amorphous
- form according
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- PMSGGBFTMLDQAW-TZYFFPFWSA-N [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate dihydrochloride Chemical class Cl.Cl.COc1cc2CCN3C[C@@H](CC(C)C)[C@@H](C[C@@H]3c2cc1OC)OC(=O)[C@@H](N)C(C)C PMSGGBFTMLDQAW-TZYFFPFWSA-N 0.000 title 1
- 238000000034 method Methods 0.000 claims 9
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 6
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 6
- 238000001816 cooling Methods 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000000839 emulsion Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 3
- 206010008748 Chorea Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims 2
- 208000000323 Tourette Syndrome Diseases 0.000 claims 2
- 208000016620 Tourette disease Diseases 0.000 claims 2
- RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 claims 2
- 238000000113 differential scanning calorimetry Methods 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000001757 thermogravimetry curve Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 1
- 206010058504 Ballismus Diseases 0.000 claims 1
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- 208000014094 Dystonic disease Diseases 0.000 claims 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims 1
- 208000012601 choreatic disease Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010118 dystonia Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical group 0.000 claims 1
- GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 claims 1
- FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 claims 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 1
- 229940011051 isopropyl acetate Drugs 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 150000002828 nitro derivatives Chemical class 0.000 claims 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002411 thermogravimetry Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (26)
1. Kristalni oblik, naznačen time, da je od spoja Formule II:
[image]
2. Kristalni oblik prema patentnom zahtjevu 1, naznačen time, da posjeduje uzorak rendgenske difrakcije na prahu koji sadrži maksimume na 7,2, 9,2, i 18,0 stupnjeva dva-theta ± 0,2 theta.
3. Kristalni oblik prema patentnom zahtjevu 2, naznačen time, da posjeduje termogram diferencijalne pretražne kalorimetrije koji sadrži endotermičku pojavu s početnom temperaturom od 240°C i s maksimumom na 250°C.
4. Kristalni oblik prema patentnom zahtjevu 2 ili 3, naznačen time, da pokazuje povećanje mase od 14% kada se podvrgava povećanju relativne vlažnosti od 0% do 90% relativne vlage.
5. Kristalni oblik prema patentnom zahtjevu 1, naznačen time, da posjeduje uzorak rendgenske difrakcije na prahu koji sadrži maksimume na 4,8, 13,3, i 24,9 stupnjeva dva-theta ± 0,2 theta.
6. Kristalni oblik prema patentnom zahtjevu 5, naznačen time, da posjeduje termogram diferencijalne pretražne kalorimetrije koji sadrži endotermičku pojavu s početnom temperaturom od 80°C i s maksimumom na 106°C.
7. Kristalni oblik prema patentnom zahtjevu 5 ili 6, naznačen time, da posjeduje shemu toplinske gravimetrijske analize koja sadrži gubitak mase od 10% kada se zagrijava od 25°C do 140°C.
8. Kristalni oblik prema bilo kojem od patentnih zahtjeva 5 do 7, naznačen time, da pokazuje smanjenje mase od 12% kada se podvrgava smanjenju relativne vlažnosti od 75% do 0% relativne vlage.
9. Amorfni oblik, naznačen time, da je od spoja Formule II:
[image]
10. Farmaceutski pripravak, naznačen time, da sadrži kristalni oblik prema bilo kojem od patentnih zahtjeva 1 do 8, ili amorfni oblik prema patentnom zahtjevu 9, i farmaceutski prihvatljiv nosač.
11. Farmaceutski pripravak prema patentnom zahtjevu 10, naznačen time, da se pripravak formulira za oralnu primjenu.
12. Farmaceutski pripravak prema patentnom zahtjevu 10 ili 11, naznačen time, da se pripravak formulira kao jednostruki oblik za doziranje.
13. Kristalni oblik prema bilo kojem od patentnih zahtjeva 1 do 8, ili amorfni oblik prema patentnom zahtjevu 9, naznačen time, da je za uporabu u postupku za liječenje, prevenciju, ili poboljšavanje jednog ili više simptoma hiperkinetskog poremećaja.
14. Kristalni oblik ili amorfni oblik za uporabu prema patentnom zahtjevu 13, naznačen time, da hiperkinetski poremećaj je Huntingtonova bolest, tardivna diskinezija, Touretteov sindrom, distonija, hemibalizam, koreja, senilna koreja, ili tikovi.
15. Kristalni oblik ili amorfni oblik za uporabu prema patentnom zahtjevu 13, naznačen time, da hiperkinetski poremećaj je Huntingtonova bolest.
16. Kristalni oblik ili amorfni oblik za uporabu prema patentnom zahtjevu 13, naznačen time, da hiperkinetski poremećaj je tardivna diskinezija.
17. Kristalni oblik ili amorfni oblik za uporabu prema patentnom zahtjevu 13, naznačen time, da hiperkinetski poremećaj je Touretteov sindrom.
18. Kristalni oblik ili amorfni oblik za uporabu prema patentnom zahtjevu 13, naznačen time, da hiperkinetski poremećaj su tikovi.
19. Postupak za proizvodnju kristalnog oblika prema bilo kojem od patentnih zahtjeva 1 do 8, ili amorfnog oblika prema patentnom zahtjevu 9, naznačen time, da obuhvaća sljedeće faze:
(a) pripravljanje emulzije od spoja Formule II u otapalu na prvoj temperaturi; i
(b) generiranje kristalnog oblika ili amorfnog oblika putem hlađenja otopine na drugu temperaturu.
20. Postupak za proizvodnju kristalnog oblika prema bilo kojem od patentnih zahtjeva 1 do 8, ili amorfnog oblika prema patentnom zahtjevu 9, naznačen time, da obuhvaća sljedeće faze:
(a) pripravljanje otopine spoja Formule II u otapalu na prvoj temperaturi;
(b) formiranje emulzije putem hlađenja otopine na drugu temperaturu; i
(c) generiranje kristalnog oblika ili amorfnog oblika pomoću obrade emulzije s jednim ili više ciklusa zagrijavanja i hlađenja.
21. Postupak prema patentnom zahtjevu 20, naznačen time, da se ciklus zagrijavanja i hlađenja izvodi u temperaturnom rasponu od -50 do 120°C.
22. Postupak prema patentnom zahtjevu 20 ili 21, naznačen time, da prva temperatura iznosi od 20 do 200°C.
23. Postupak prema bilo kojem od patentnih zahtjeva 20 do 22, naznačen time, da druga temperatura iznosi od -100 do 100°C.
24. Postupak prema bilo kojem od patentnih zahtjeva 20 do 23, naznačen time, da nadalje obuhvaća fazu izoliranja kristalnog oblika ili amorfnog oblika.
25. Postupak prema bilo kojem od patentnih zahtjeva 20 do 24, naznačen time, da se otapalo bira od ugljikovodika, kloriranog ugljikovodika, alkohola, etera, ketona, estera, karbonata, amida, nitrila, nitro spoja, heterocikla, vode, i njihovih mješavina.
26. Postupak prema bilo kojem od patentnih zahtjeva 20 do 25, naznačen time, da se otapalo bira od acetonitrila, 1,2-dikloroetana, DMF, 1,4-dioksana, metanola, 2-metoksietanola, MIBK, toluena, heptana, kumena, acetona, 1-butanola, MTBE, etanola, etil acetata, etil formata, izobutil acetata, izopropil acetata, metil acetata, nitrometana, 1-propanola, IPA, MEK, THF, vode, i njihovih mješavina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562249074P | 2015-10-30 | 2015-10-30 | |
EP21153302.1A EP3875459B1 (en) | 2015-10-30 | 2016-10-28 | Valbenazine dihydrochloride salts and polymorphs thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20240304T1 true HRP20240304T1 (hr) | 2024-05-10 |
Family
ID=57281297
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20240304TT HRP20240304T1 (hr) | 2015-10-30 | 2016-10-28 | Soli valbenazin dihidroklorida i njihovi polimorfi |
HRP20210469TT HRP20210469T1 (hr) | 2015-10-30 | 2021-03-22 | Valbenazin ditosilat i njegovi polimorfi |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20210469TT HRP20210469T1 (hr) | 2015-10-30 | 2021-03-22 | Valbenazin ditosilat i njegovi polimorfi |
Country Status (31)
Country | Link |
---|---|
US (4) | US10065952B2 (hr) |
EP (3) | EP4344742A2 (hr) |
JP (2) | JP7109360B2 (hr) |
KR (1) | KR20180075591A (hr) |
CN (3) | CN108473489B (hr) |
AU (1) | AU2016343633B2 (hr) |
BR (1) | BR112018008460A2 (hr) |
CA (1) | CA3002074A1 (hr) |
CL (1) | CL2018001089A1 (hr) |
CO (1) | CO2018004589A2 (hr) |
CY (1) | CY1124002T1 (hr) |
DK (2) | DK3875459T3 (hr) |
EA (1) | EA201890852A1 (hr) |
ES (1) | ES2857085T3 (hr) |
FI (1) | FI3875459T3 (hr) |
HR (2) | HRP20240304T1 (hr) |
HU (1) | HUE053872T2 (hr) |
IL (2) | IL284874B2 (hr) |
LT (2) | LT3368534T (hr) |
MA (2) | MA43116B1 (hr) |
MX (1) | MX2018005136A (hr) |
MY (1) | MY193767A (hr) |
PH (1) | PH12018500900A1 (hr) |
PL (1) | PL3368534T3 (hr) |
PT (2) | PT3368534T (hr) |
RS (2) | RS61645B1 (hr) |
SA (1) | SA518391477B1 (hr) |
SG (1) | SG11201803408PA (hr) |
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