MA43116B1 - Ditosylate de valbénazine et polymorphes associés - Google Patents

Ditosylate de valbénazine et polymorphes associés

Info

Publication number
MA43116B1
MA43116B1 MA43116A MA43116A MA43116B1 MA 43116 B1 MA43116 B1 MA 43116B1 MA 43116 A MA43116 A MA 43116A MA 43116 A MA43116 A MA 43116A MA 43116 B1 MA43116 B1 MA 43116B1
Authority
MA
Morocco
Prior art keywords
polymorphs
diseases
methods
valbenazine ditosylate
disorders
Prior art date
Application number
MA43116A
Other languages
English (en)
Other versions
MA43116A (fr
Inventor
Thierry Bonnaud
Kevin Mcgee
Scott ZOOK
Andrew Carr
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57281297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA43116(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of MA43116A publication Critical patent/MA43116A/fr
Publication of MA43116B1 publication Critical patent/MA43116B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La présente invention concerne des sels de l'ester (2r,3r,11br)-3-isobutyl-9,10-diméthoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,l-a]isoquinolin-2-ylique de l'acide (s)-2-amino-3-méthyl-butyrique sous formes amorphe et cristalline, ainsi que des procédés de préparation et des compositions pharmaceutiques de ceux-ci. L'invention concerne également des méthodes d'utilisation de celles-ci pour le traitement, la prévention, ou l'atténuation d'un ou de plusieurs symptômes de troubles et de maladies neurologiques, y compris des troubles ou des maladies hyperkinétiques.
MA43116A 2015-10-30 2016-10-28 Ditosylate de valbénazine et polymorphes associés MA43116B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562249074P 2015-10-30 2015-10-30
PCT/US2016/059306 WO2017075340A1 (fr) 2015-10-30 2016-10-28 Sels de valbénazine et polymorphes associés

Publications (2)

Publication Number Publication Date
MA43116A MA43116A (fr) 2018-09-05
MA43116B1 true MA43116B1 (fr) 2021-04-30

Family

ID=57281297

Family Applications (2)

Application Number Title Priority Date Filing Date
MA056137A MA56137A (fr) 2015-10-30 2016-10-28 Sels de valbénazine et leurs polymorphes
MA43116A MA43116B1 (fr) 2015-10-30 2016-10-28 Ditosylate de valbénazine et polymorphes associés

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA056137A MA56137A (fr) 2015-10-30 2016-10-28 Sels de valbénazine et leurs polymorphes

Country Status (31)

Country Link
US (4) US10065952B2 (fr)
EP (3) EP4344742A2 (fr)
JP (2) JP7109360B2 (fr)
KR (1) KR20180075591A (fr)
CN (3) CN115304596A (fr)
AU (1) AU2016343633B2 (fr)
BR (1) BR112018008460A2 (fr)
CA (1) CA3002074A1 (fr)
CL (1) CL2018001089A1 (fr)
CO (1) CO2018004589A2 (fr)
CY (1) CY1124002T1 (fr)
DK (2) DK3368534T3 (fr)
EA (1) EA201890852A1 (fr)
ES (1) ES2857085T3 (fr)
FI (1) FI3875459T3 (fr)
HR (2) HRP20240304T1 (fr)
HU (1) HUE053872T2 (fr)
IL (2) IL284874B2 (fr)
LT (2) LT3875459T (fr)
MA (2) MA56137A (fr)
MX (1) MX2018005136A (fr)
MY (1) MY193767A (fr)
PH (1) PH12018500900A1 (fr)
PL (1) PL3368534T3 (fr)
PT (2) PT3875459T (fr)
RS (2) RS61645B1 (fr)
SA (1) SA518391477B1 (fr)
SG (1) SG11201803408PA (fr)
SI (1) SI3368534T1 (fr)
TN (1) TN2018000121A1 (fr)
WO (1) WO2017075340A1 (fr)

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US10703750B2 (en) * 2017-01-10 2020-07-07 Sandoz Ag Crystalline valbenazine free base
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US10954235B2 (en) * 2017-02-27 2021-03-23 Sandoz Ag Crystalline forms of valbenazine salts
WO2018200605A1 (fr) * 2017-04-26 2018-11-01 Neurocrine Biosciences, Inc. Utilisation de valbénazine pour le traitement de la dyskinésie induite par la lévodopa
JP7250006B2 (ja) 2017-09-21 2023-03-31 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 高投与量バルベナジン製剤ならびにそれに関連する組成物、方法およびキット
KR20200066661A (ko) 2017-10-10 2020-06-10 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
US10993941B2 (en) 2017-10-10 2021-05-04 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
US11384077B2 (en) 2017-11-22 2022-07-12 Assia Chemical Industries Ltd. Solid state form of Valbenazine
JP7212958B2 (ja) * 2017-12-26 2023-01-26 ▲蘇▼州科睿思制▲葯▼有限公司 バルベナジントシル酸塩の結晶形及びその製造方法並びに用途
CN110818705A (zh) * 2018-08-14 2020-02-21 苏州鹏旭医药科技有限公司 缬苯那嗪的盐型和相应晶型与其制备方法
BR112021000019A2 (pt) 2018-08-15 2021-04-06 Neurocrine Biosciences Inc. Métodos para administração de certos inibidores de vmat2
CA3065236A1 (fr) * 2018-12-27 2020-06-27 Apotex Inc. Nouvelle forme cristalline de dibesylate de valbenazine
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US10689380B1 (en) * 2019-07-30 2020-06-23 Farmhispania S.A. Crystalline forms of valbenazine ditosylate
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
US20220363680A1 (en) 2019-09-13 2022-11-17 Neurocrine Biosciences, Inc. Processes for the synthesis of valbenazine
EP4210700A1 (fr) 2020-09-09 2023-07-19 Crinetics Pharmaceuticals, Inc. Formulations d'un modulateur de somatostatine
EP4330255A1 (fr) 2021-04-26 2024-03-06 Neurocrine Biosciences, Inc. Procédés de synthèse de valbénazine
WO2023278991A1 (fr) * 2021-06-30 2023-01-05 Neurocrine Biosciences, Inc. Valbénazine destinée à être utilisée dans le traitement de la dyskinésie due à une paralysie cérébrale
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