MA32230B1 - Formes cristallines et deux formes solvatées de lactates de 4-amino-5-fluoro -3-[5-(4-méthylpipérazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one - Google Patents

Formes cristallines et deux formes solvatées de lactates de 4-amino-5-fluoro -3-[5-(4-méthylpipérazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one

Info

Publication number
MA32230B1
MA32230B1 MA33250A MA33250A MA32230B1 MA 32230 B1 MA32230 B1 MA 32230B1 MA 33250 A MA33250 A MA 33250A MA 33250 A MA33250 A MA 33250A MA 32230 B1 MA32230 B1 MA 32230B1
Authority
MA
Morocco
Prior art keywords
forms
amino
methylpiperazine
benzimidazole
quinoline
Prior art date
Application number
MA33250A
Other languages
Arabic (ar)
English (en)
Inventor
Danielle Giron
Walter Hammerschmidt
Philippe Piechon
Johanne Polasek
Andreas Schreiner
Frank Stowasser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40622140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32230(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32230B1 publication Critical patent/MA32230B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des formes cristallines ou des polymorphes de lactates de 4-amino-5-fluoro-3-[5-(4-méthylpipérazin-1-yl)-1h-benzimidazol-2-yl] quinolin-2(1h)-one, ainsi que leurs procédés de préparation, des compositions pharmaceutiques les comprenant et des procédés de traitement les utilisant.
MA33250A 2008-03-19 2010-10-15 Formes cristallines et deux formes solvatées de lactates de 4-amino-5-fluoro -3-[5-(4-méthylpipérazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one MA32230B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3774608P 2008-03-19 2008-03-19
PCT/EP2009/053222 WO2009115562A2 (fr) 2008-03-19 2009-03-18 Formes cristallines et deux formes solvatées de lactates de 4-amino-5-fluoro -3-[5-(4-méthylpipérazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one

Publications (1)

Publication Number Publication Date
MA32230B1 true MA32230B1 (fr) 2011-04-01

Family

ID=40622140

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33250A MA32230B1 (fr) 2008-03-19 2010-10-15 Formes cristallines et deux formes solvatées de lactates de 4-amino-5-fluoro -3-[5-(4-méthylpipérazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one

Country Status (25)

Country Link
US (1) US8563556B2 (fr)
EP (1) EP2257544B1 (fr)
JP (1) JP2011515370A (fr)
KR (1) KR20100137517A (fr)
CN (1) CN101970425B (fr)
AR (1) AR070924A1 (fr)
AU (1) AU2009227003B2 (fr)
BR (1) BRPI0909762A2 (fr)
CA (1) CA2718076A1 (fr)
CL (1) CL2009000651A1 (fr)
CO (1) CO6321253A2 (fr)
EC (1) ECSP10010555A (fr)
HK (1) HK1147492A1 (fr)
IL (1) IL208020A0 (fr)
MA (1) MA32230B1 (fr)
MX (1) MX2010010152A (fr)
MY (1) MY150554A (fr)
NZ (2) NZ600887A (fr)
PE (1) PE20091628A1 (fr)
PH (2) PH12012502568A1 (fr)
RU (1) RU2497820C2 (fr)
SG (1) SG188919A1 (fr)
TW (1) TWI426072B (fr)
WO (1) WO2009115562A2 (fr)
ZA (1) ZA201006263B (fr)

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AR070924A1 (es) 2008-03-19 2010-05-12 Novartis Ag Formas cristalinas y dos formas solvatadas de sales del acido lactico de 4- amino -5- fluoro-3-(5-(4-metilpiperazin-1-il ) -1h- bencimidazol-2-il) quinolin -2-(1h) - ona
ES2707625T3 (es) 2010-04-16 2019-04-04 Novartis Ag Compuesto orgánico para su utilización en el tratamiento del cáncer de hígado
WO2011128405A1 (fr) 2010-04-16 2011-10-20 Novartis Ag Combinaison de composés organiques
AR081776A1 (es) 2010-06-30 2012-10-17 Novartis Ag Composiciones farmaceuticas que comprenden monohidrato de lactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, proceso para la produccion de la composicion
JP2014513930A (ja) 2011-03-17 2014-06-19 ノバルティス アーゲー Ｈｒ陽性対象における乳がんのバイオマーカーとしてのｆｇｆｒおよびそのリガンド
KR20140023358A (ko) 2011-05-19 2014-02-26 노파르티스 아게 선양 낭성 암종의 치료에 사용하기 위한 4-아미노-5-플루오로-3-[6-(4-메틸피페라진-1-일)-1h-벤즈이미다졸-2-일]-1h-퀴놀린-2-온
MX2014003182A (es) 2011-09-15 2014-09-22 Novartis Ag Uso de 4-amino-5-fluoro-3-[6-(4-metilpiperazin-1-il)-1h-bencimidaz ol-2-il]-1h-quinolin-2-ona en el tratamiento de cancer en pacientes con insuficiencia hepática moderada.
WO2013063003A1 (fr) 2011-10-28 2013-05-02 Novartis Ag Méthode de traitement des tumeurs stromales gastro-intestinales
IN2014DN05869A (fr) 2012-01-31 2015-05-22 Novartis Ag
US20150202203A1 (en) 2012-07-11 2015-07-23 Novartis Ag Method of Treating Gastrointestinal Stromal Tumors
WO2014058785A1 (fr) 2012-10-10 2014-04-17 Novartis Ag Polythérapie
EP2764866A1 (fr) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibiteurs de l'enzyme activant nedd8
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
WO2015138920A1 (fr) 2014-03-14 2015-09-17 Novartis Ag Molécules d'anticorps anti-lag-3 et leurs utilisations
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
EP4245376A3 (fr) 2014-10-14 2023-12-13 Novartis AG Molécules d'anticorps de pd-l1 et leurs utilisations
EP3233918A1 (fr) 2014-12-19 2017-10-25 Novartis AG Polythérapies
KR20170129802A (ko) 2015-03-10 2017-11-27 아두로 바이오테크, 인코포레이티드 ＂인터페론 유전자의 자극인자＂-의존적 신호전달을 활성화하는 조성물 및 방법
WO2017019897A1 (fr) 2015-07-29 2017-02-02 Novartis Ag Polythérapies comprenant des molécules d'anticorps contre tim -3
PT3317301T (pt) 2015-07-29 2021-07-09 Novartis Ag Terapias de associação compreendendo moléculas de anticorpo contra lag-3
EP3328418A1 (fr) 2015-07-29 2018-06-06 Novartis AG Traitements combinés comprenant des molécules d'anticorps qui se lient à pd-1
HRP20220436T1 (hr) 2015-11-03 2022-05-27 Janssen Biotech, Inc. Protutijela koja se specifično vežu na pd-1 i njihove uporabe
WO2017106656A1 (fr) 2015-12-17 2017-06-22 Novartis Ag Molécules d'anticorps anti-pd-1 et leurs utilisations
US11098077B2 (en) 2016-07-05 2021-08-24 Chinook Therapeutics, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1317442B1 (fr) 2000-09-11 2005-11-16 Chiron Corporation Derives de quinolinone comme inhibiteurs de tyrosine kinase
US20050256157A1 (en) 2002-08-23 2005-11-17 Chiron Corporation Combination therapy with CHK1 inhibitors
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
JP4613130B2 (ja) 2002-08-23 2011-01-12 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド ベンゾイミダゾールキノリノンおよびそれらの使用
CN100377709C (zh) * 2002-11-13 2008-04-02 希龙公司 受体酪氨酸激酶抑制剂的制药用途及相关检测方法
US7838527B2 (en) * 2002-11-13 2010-11-23 Novartis Vaccines And Diagnostics, Inc. Methods of treating cancer and related methods
CA2543820C (fr) * 2003-11-07 2012-07-10 Chiron Corporation Methodes de synthese de composes de quinolinone
US7875624B2 (en) * 2004-02-20 2011-01-25 Novartis Vaccines And Diagnostics, Inc. Modulating and measuring cellular adhesion
JP5371246B2 (ja) * 2005-01-27 2013-12-18 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 転移した腫瘍の治療
US20110178097A1 (en) * 2005-05-23 2011-07-21 Novartis Ag Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
PL1957074T3 (pl) 2005-11-29 2014-08-29 Novartis Ag Preparaty chinolinonów
AR070924A1 (es) 2008-03-19 2010-05-12 Novartis Ag Formas cristalinas y dos formas solvatadas de sales del acido lactico de 4- amino -5- fluoro-3-(5-(4-metilpiperazin-1-il ) -1h- bencimidazol-2-il) quinolin -2-(1h) - ona
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme

Also Published As

Publication number Publication date
ECSP10010555A (es) 2010-11-30
MX2010010152A (es) 2010-10-25
NZ587829A (en) 2012-08-31
AU2009227003A1 (en) 2009-09-24
CN101970425B (zh) 2014-04-16
EP2257544B1 (fr) 2014-12-03
CL2009000651A1 (es) 2010-07-19
SG188919A1 (en) 2013-04-30
EP2257544A2 (fr) 2010-12-08
RU2010142396A (ru) 2012-04-27
MY150554A (en) 2014-01-30
US20110021536A1 (en) 2011-01-27
HK1147492A1 (en) 2011-08-12
ZA201006263B (en) 2011-05-25
AU2009227003B2 (en) 2013-03-14
JP2011515370A (ja) 2011-05-19
CA2718076A1 (fr) 2009-09-24
PH12012502568A1 (en) 2014-10-27
US8563556B2 (en) 2013-10-22
PH12012502569A1 (en) 2015-09-21
TWI426072B (zh) 2014-02-11
CO6321253A2 (es) 2011-09-20
BRPI0909762A2 (pt) 2018-04-03
AR070924A1 (es) 2010-05-12
TW201000463A (en) 2010-01-01
PE20091628A1 (es) 2009-11-19
KR20100137517A (ko) 2010-12-30
RU2497820C2 (ru) 2013-11-10
NZ600887A (en) 2013-10-25
WO2009115562A2 (fr) 2009-09-24
IL208020A0 (en) 2010-12-30
WO2009115562A3 (fr) 2009-11-26
CN101970425A (zh) 2011-02-09

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