MX2008001211A - Derivados de bencilpiperazina y su uso medico. - Google Patents

Derivados de bencilpiperazina y su uso medico.

Info

Publication number
MX2008001211A
MX2008001211A MX2008001211A MX2008001211A MX2008001211A MX 2008001211 A MX2008001211 A MX 2008001211A MX 2008001211 A MX2008001211 A MX 2008001211A MX 2008001211 A MX2008001211 A MX 2008001211A MX 2008001211 A MX2008001211 A MX 2008001211A
Authority
MX
Mexico
Prior art keywords
benzylpiperazine
derivates
medical use
compounds
agonists
Prior art date
Application number
MX2008001211A
Other languages
English (en)
Inventor
Mervyn Thompson
Geoffrey Stemp
David Timothy Macpherson
Steven James Stanway
Christopher Norbert Johnson
Susan Marie Westaway
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0515381A external-priority patent/GB0515381D0/en
Priority claimed from GB0611469A external-priority patent/GB0611469D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX2008001211A publication Critical patent/MX2008001211A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invencion se refire a nuevos derivados de bencilpiperazina tal como los compuestos de formula (I), que tienen actividad como agonistas del receptor GPR38 (ver formula (I)) y al uso de dichos compuestos o sus composiciones farmaceuticas en el tratamiento de trastornos gastrointestinales.
MX2008001211A 2005-07-26 2006-07-24 Derivados de bencilpiperazina y su uso medico. MX2008001211A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0515381A GB0515381D0 (en) 2005-07-26 2005-07-26 Compounds
GB0611469A GB0611469D0 (en) 2006-06-09 2006-06-09 Compounds
PCT/EP2006/007390 WO2007012479A2 (en) 2005-07-26 2006-07-24 Benzylpiperazine derivates and their medical use

Publications (1)

Publication Number Publication Date
MX2008001211A true MX2008001211A (es) 2008-03-24

Family

ID=37560776

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008001211A MX2008001211A (es) 2005-07-26 2006-07-24 Derivados de bencilpiperazina y su uso medico.

Country Status (29)

Country Link
US (2) US8536182B2 (es)
EP (2) EP1907374B1 (es)
JP (1) JP4938777B2 (es)
KR (1) KR101281435B1 (es)
AR (1) AR054508A1 (es)
AU (1) AU2006274212B2 (es)
BR (1) BRPI0613987A2 (es)
CA (1) CA2616513C (es)
CR (1) CR9722A (es)
CY (1) CY1113257T1 (es)
DK (1) DK1907374T3 (es)
EA (1) EA014061B1 (es)
EG (1) EG26235A (es)
ES (1) ES2390812T3 (es)
HK (1) HK1116477A1 (es)
HR (1) HRP20120833T1 (es)
IL (1) IL188854A (es)
JO (1) JO2747B1 (es)
MA (1) MA29723B1 (es)
MX (1) MX2008001211A (es)
MY (1) MY150098A (es)
NO (1) NO340489B1 (es)
NZ (1) NZ565062A (es)
PE (1) PE20070180A1 (es)
PL (1) PL1907374T3 (es)
PT (1) PT1907374E (es)
SI (1) SI1907374T1 (es)
TW (1) TWI376375B (es)
WO (1) WO2007012479A2 (es)

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GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
PE20070180A1 (es) * 2005-07-26 2007-04-25 Glaxo Group Ltd Compuestos de bencilpiperazina como agonistas del receptor gpr38
GB0524814D0 (en) * 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
ES2355607T3 (es) 2006-01-27 2011-03-29 M's Science Corporation Derivados de piperidina y piperazina.
DE602007006019D1 (de) * 2006-06-28 2010-06-02 Glaxo Group Ltd Für die behandlung von durch den gpr38-rezeptor vermittelten krankheiten geeignete piperazinylderivate
GB0723317D0 (en) * 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds
MX2011008857A (es) 2009-02-27 2011-09-30 Raqualia Pharma Inc Derivados de oxiindol con actividad agonistica del receptor de motilina.
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
WO2011095450A1 (en) 2010-02-02 2011-08-11 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN113292485B (zh) * 2021-06-08 2023-10-27 河南大学 苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用

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Also Published As

Publication number Publication date
BRPI0613987A2 (pt) 2011-03-01
AR054508A1 (es) 2007-06-27
MA29723B1 (fr) 2008-09-01
JO2747B1 (en) 2014-03-15
SI1907374T1 (sl) 2012-11-30
US20130317041A1 (en) 2013-11-28
EP2441763A1 (en) 2012-04-18
TWI376375B (en) 2012-11-11
KR101281435B1 (ko) 2013-07-02
NZ565062A (en) 2011-02-25
NO20081014L (no) 2008-04-10
PT1907374E (pt) 2012-11-05
WO2007012479A2 (en) 2007-02-01
IL188854A (en) 2013-08-29
ES2390812T3 (es) 2012-11-16
PE20070180A1 (es) 2007-04-25
EG26235A (en) 2013-05-07
EA014061B1 (ru) 2010-08-30
CA2616513A1 (en) 2007-02-01
EA200800421A1 (ru) 2008-06-30
CA2616513C (en) 2013-02-19
WO2007012479A3 (en) 2007-04-26
MY150098A (en) 2013-11-29
AU2006274212A1 (en) 2007-02-01
US20090054456A1 (en) 2009-02-26
JP4938777B2 (ja) 2012-05-23
KR20080037663A (ko) 2008-04-30
EP1907374A2 (en) 2008-04-09
IL188854A0 (en) 2008-04-13
US8536182B2 (en) 2013-09-17
HK1116477A1 (en) 2008-12-24
DK1907374T3 (da) 2012-10-15
CY1113257T1 (el) 2016-04-13
TW200745081A (en) 2007-12-16
NO340489B1 (no) 2017-05-02
PL1907374T3 (pl) 2012-12-31
EP1907374B1 (en) 2012-08-22
CR9722A (es) 2008-04-10
AU2006274212B2 (en) 2011-06-09
JP2009502842A (ja) 2009-01-29
HRP20120833T1 (hr) 2012-11-30

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