SA518391477B1 - أملاح فالبينازين وصور متعددة الشكل البلوري منها - Google Patents
أملاح فالبينازين وصور متعددة الشكل البلوري منهاInfo
- Publication number
- SA518391477B1 SA518391477B1 SA518391477A SA518391477A SA518391477B1 SA 518391477 B1 SA518391477 B1 SA 518391477B1 SA 518391477 A SA518391477 A SA 518391477A SA 518391477 A SA518391477 A SA 518391477A SA 518391477 B1 SA518391477 B1 SA 518391477B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- polymorphs
- salts
- diseases
- valbenazine salts
- valbenazine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
يتعلق الاختراع الحالي بتوفير أملاح إستر (2R،3R،11bR) -3- أيزو بيوتيل -9، 10- داي ميثوكسي 1، 3، 4، 6، 7، 11b- هكسا هيدرو -2H- بيريدو [2، 1-a] أيزو كينولين -2- يل لحمض (S) -2- أمينو – ميثيل – بيوتيريك في صور غير متبلرة وبلورية ، وعمليات تحضيرها وتركيباتها الصيدلانية. كذلك يتم توفير طرق لاستخدامها في علاج، الوقاية من، أو تخفيف واحد أو أكثر من أعراض الاضطرابات والأمراض العصبية بما في ذلك اضطرابات أو أمراض فرط الحركة.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562249074P | 2015-10-30 | 2015-10-30 | |
PCT/US2016/059306 WO2017075340A1 (en) | 2015-10-30 | 2016-10-28 | Valbenazine salts and polymorphs thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SA518391477B1 true SA518391477B1 (ar) | 2022-03-20 |
Family
ID=57281297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA518391477A SA518391477B1 (ar) | 2015-10-30 | 2018-04-30 | أملاح فالبينازين وصور متعددة الشكل البلوري منها |
Country Status (31)
Country | Link |
---|---|
US (4) | US10065952B2 (ar) |
EP (3) | EP3368534B1 (ar) |
JP (2) | JP7109360B2 (ar) |
KR (1) | KR20180075591A (ar) |
CN (3) | CN108473489B (ar) |
AU (1) | AU2016343633B2 (ar) |
BR (1) | BR112018008460A2 (ar) |
CA (1) | CA3002074A1 (ar) |
CL (1) | CL2018001089A1 (ar) |
CO (1) | CO2018004589A2 (ar) |
CY (1) | CY1124002T1 (ar) |
DK (2) | DK3368534T3 (ar) |
EA (1) | EA201890852A1 (ar) |
ES (1) | ES2857085T3 (ar) |
FI (1) | FI3875459T3 (ar) |
HR (2) | HRP20240304T1 (ar) |
HU (1) | HUE053872T2 (ar) |
IL (2) | IL284874B2 (ar) |
LT (2) | LT3875459T (ar) |
MA (2) | MA43116B1 (ar) |
MX (1) | MX2018005136A (ar) |
MY (1) | MY193767A (ar) |
PH (1) | PH12018500900A1 (ar) |
PL (1) | PL3368534T3 (ar) |
PT (2) | PT3368534T (ar) |
RS (2) | RS65154B1 (ar) |
SA (1) | SA518391477B1 (ar) |
SG (1) | SG11201803408PA (ar) |
SI (1) | SI3368534T1 (ar) |
TN (1) | TN2018000121A1 (ar) |
WO (1) | WO2017075340A1 (ar) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112018008460A2 (pt) | 2015-10-30 | 2018-11-06 | Neurocrine Biosciences Inc | sais de valbenazina e seus polimorfos |
RS63170B1 (sr) * | 2015-12-23 | 2022-05-31 | Neurocrine Biosciences Inc | Sintetički postupak za pripremanje (s)-(2r,3r,11br)-3-izobutil-9,10-dimetoksi-2,3,4,6,7,11b-heksahidro-1h-pirido[2,1,-a]izohinolin-2-il 2-amino-3-metilbutanoat di(4-metilbenzensulfonata) |
KR20190062460A (ko) | 2016-10-06 | 2019-06-05 | 아시아 케미컬 인더스트리스 리미티드 | 발베나진의 고체상 형태 |
WO2018102673A1 (en) * | 2016-12-02 | 2018-06-07 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating schizophrenia or schizoaffective disorder |
EP3568394A1 (en) | 2017-01-10 | 2019-11-20 | Sandoz AG | Crystalline valbenazine free base |
MX2019008855A (es) | 2017-01-27 | 2019-09-11 | Neurocrine Biosciences Inc | Metodos para la administracion de ciertos inhibidores del transportador de monamina vesicular 2 (vmat2). |
WO2018153632A1 (en) * | 2017-02-27 | 2018-08-30 | Sandoz Ag | Crystalline forms of valbenazine salts |
WO2018200605A1 (en) * | 2017-04-26 | 2018-11-01 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
EP3684333A2 (en) | 2017-09-21 | 2020-07-29 | Neurocrine Biosciences, Inc. | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
MX2020003421A (es) | 2017-10-10 | 2020-07-20 | Neurocrine Biosciences Inc | Metodos para la administracion de ciertos inhibidores del transportador vesicular de monoamina 2 (vmat2). |
US10993941B2 (en) | 2017-10-10 | 2021-05-04 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
KR20200108828A (ko) | 2017-11-22 | 2020-09-21 | 아시아 케미컬 인더스트리스 리미티드 | 발베나진의 고상 형태 |
EP3733666B1 (en) * | 2017-12-26 | 2022-09-21 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of valbenazine di-p-toluenesulfonate, preparation method thereof and use thereof |
CN110818705A (zh) * | 2018-08-14 | 2020-02-21 | 苏州鹏旭医药科技有限公司 | 缬苯那嗪的盐型和相应晶型与其制备方法 |
BR112021000019A2 (pt) | 2018-08-15 | 2021-04-06 | Neurocrine Biosciences Inc. | Métodos para administração de certos inibidores de vmat2 |
CA3065236A1 (en) | 2018-12-27 | 2020-06-27 | Apotex Inc. | Novel crystalline form of valbenazine dibesylate |
WO2020213014A1 (en) | 2019-04-19 | 2020-10-22 | Mylan Laboratories Limited | An improved process for the preparation of valbenazine and its salts |
US10689380B1 (en) * | 2019-07-30 | 2020-06-23 | Farmhispania S.A. | Crystalline forms of valbenazine ditosylate |
US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
CN117736203A (zh) | 2019-09-13 | 2024-03-22 | 纽罗克里生物科学有限公司 | 用于合成缬苯那嗪的方法 |
MX2023002761A (es) | 2020-09-09 | 2023-04-03 | Crinetics Pharmaceuticals Inc | Formulaciones de un modulador de somatostatina. |
CA3215792A1 (en) | 2021-04-26 | 2022-11-03 | John Lloyd Tucker | Processes for the synthesis of valbenazine |
CA3220946A1 (en) | 2021-06-30 | 2023-01-05 | Angel S. Angelov | Valbenazine for use in the add-on treatment of schizophrenia |
CA3221728A1 (en) * | 2021-06-30 | 2023-01-05 | Grace S. LIANG | Valbenazine for use in the treatment of dyskinesia due to cerebral palsy |
TW202322816A (zh) | 2021-08-20 | 2023-06-16 | 美商紐羅克里生物科學有限公司 | 篩選 vmat2 抑制劑之方法 |
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