MA56137B1 - Sels de dihydrochlorure de valbénazine et leurs polymorphes - Google Patents
Sels de dihydrochlorure de valbénazine et leurs polymorphesInfo
- Publication number
- MA56137B1 MA56137B1 MA56137A MA56137A MA56137B1 MA 56137 B1 MA56137 B1 MA 56137B1 MA 56137 A MA56137 A MA 56137A MA 56137 A MA56137 A MA 56137A MA 56137 B1 MA56137 B1 MA 56137B1
- Authority
- MA
- Morocco
- Prior art keywords
- polymorphs
- dihydrochloride salts
- diseases
- methods
- relates
- Prior art date
Links
- PMSGGBFTMLDQAW-TZYFFPFWSA-N [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate dihydrochloride Chemical class Cl.Cl.COc1cc2CCN3C[C@@H](CC(C)C)[C@@H](C[C@@H]3c2cc1OC)OC(=O)[C@@H](N)C(C)C PMSGGBFTMLDQAW-TZYFFPFWSA-N 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 208000000269 Hyperkinesis Diseases 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- -1 hexahydro-2h-pyrido[2,1-a]isoquinolin-2-yl Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des sels dichlorhydrates de l'acide (s)-2-amino-3-méthyl-butyrique (2r,3r,11br)-3-isobutyl-9,10-diméthoxy-1,3,4,6,7,11b-. L'invention concerne un ester d'hexahydro-2h-pyrido[2,1-a]isoquinoléin-2-yle sous formes amorphes et cristallines, ainsi que des procédés de préparation et des compositions pharmaceutiques associés. L'invention concerne également des procédés d'utilisation pour traiter, prévenir ou améliorer un ou plusieurs symptômes de troubles et de maladies neurologiques, notamment des troubles ou des maladies du mouvement hyperkinétique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562249074P | 2015-10-30 | 2015-10-30 | |
PCT/US2016/059306 WO2017075340A1 (fr) | 2015-10-30 | 2016-10-28 | Sels de valbénazine et polymorphes associés |
Publications (2)
Publication Number | Publication Date |
---|---|
MA56137A MA56137A (fr) | 2022-04-13 |
MA56137B1 true MA56137B1 (fr) | 2024-03-29 |
Family
ID=57281297
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA43116A MA43116B1 (fr) | 2015-10-30 | 2016-10-28 | Ditosylate de valbénazine et polymorphes associés |
MA56137A MA56137B1 (fr) | 2015-10-30 | 2016-10-28 | Sels de dihydrochlorure de valbénazine et leurs polymorphes |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA43116A MA43116B1 (fr) | 2015-10-30 | 2016-10-28 | Ditosylate de valbénazine et polymorphes associés |
Country Status (31)
Country | Link |
---|---|
US (4) | US10065952B2 (fr) |
EP (3) | EP3875459B1 (fr) |
JP (3) | JP7109360B2 (fr) |
KR (1) | KR20180075591A (fr) |
CN (3) | CN115304596A (fr) |
AU (1) | AU2016343633B2 (fr) |
BR (1) | BR112018008460A2 (fr) |
CA (1) | CA3002074A1 (fr) |
CL (1) | CL2018001089A1 (fr) |
CO (1) | CO2018004589A2 (fr) |
CY (1) | CY1124002T1 (fr) |
DK (2) | DK3368534T3 (fr) |
EA (1) | EA201890852A1 (fr) |
ES (2) | ES2972600T3 (fr) |
FI (1) | FI3875459T3 (fr) |
HR (2) | HRP20240304T1 (fr) |
HU (2) | HUE065406T2 (fr) |
IL (2) | IL284874B2 (fr) |
LT (2) | LT3368534T (fr) |
MA (2) | MA43116B1 (fr) |
MX (1) | MX2018005136A (fr) |
MY (1) | MY193767A (fr) |
PH (1) | PH12018500900A1 (fr) |
PL (2) | PL3368534T3 (fr) |
PT (2) | PT3875459T (fr) |
RS (2) | RS65154B1 (fr) |
SA (1) | SA518391477B1 (fr) |
SG (1) | SG11201803408PA (fr) |
SI (2) | SI3875459T1 (fr) |
TN (1) | TN2018000121A1 (fr) |
WO (1) | WO2017075340A1 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3875459B1 (fr) | 2015-10-30 | 2023-12-13 | Neurocrine Biosciences, Inc. | Sels de dihydrochlorure de valbénazine et leurs polymorphes |
US10160757B2 (en) | 2015-12-23 | 2018-12-25 | Neuroscrine Biosciences, Inc. | Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) |
EP3523300A1 (fr) | 2016-10-06 | 2019-08-14 | Assia Chemical Industries Ltd. | Formes à l'état solide de valbénazine |
TW201827051A (zh) * | 2016-12-02 | 2018-08-01 | 美商神經性分泌生物科學公司 | 戊苯那嗪(valbenazine)於治療精神分裂症或情感性精神分裂症之用途 |
WO2018130345A1 (fr) * | 2017-01-10 | 2018-07-19 | Sandoz Ag | Base libre de valbénazine cristalline |
EA201991780A1 (ru) * | 2017-01-27 | 2021-10-26 | Нейрокрин Байосайенсиз, Инк. | Способы введения некоторых vmat2-ингибиторов |
EP3585787A1 (fr) * | 2017-02-27 | 2020-01-01 | Sandoz AG | Formes cristallines de sels de valbénazine |
US20200179352A1 (en) * | 2017-04-26 | 2020-06-11 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
IL273300B2 (en) | 2017-09-21 | 2024-06-01 | Neurocrine Biosciences Inc | High dose valbenazine formulation and related preparations, methods and kits |
JP2021502959A (ja) * | 2017-10-10 | 2021-02-04 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 特定のvmat2インヒビターを投与するための方法 |
US10993941B2 (en) | 2017-10-10 | 2021-05-04 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
WO2019104141A1 (fr) | 2017-11-22 | 2019-05-31 | Teva Pharmaceuticals Usa, Inc. | Forme à l'état solide de valbénazine |
EP3733666B1 (fr) * | 2017-12-26 | 2022-09-21 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Forme cristalline de di-p-toluènesulfonate de valbénazine, procédé de préparation associé et utilisation correspondante |
CN110818705A (zh) * | 2018-08-14 | 2020-02-21 | 苏州鹏旭医药科技有限公司 | 缬苯那嗪的盐型和相应晶型与其制备方法 |
JP2021528481A (ja) * | 2018-08-15 | 2021-10-21 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 特定のvmat2阻害剤を投与するための方法 |
CA3065236A1 (fr) | 2018-12-27 | 2020-06-27 | Apotex Inc. | Nouvelle forme cristalline de dibesylate de valbenazine |
WO2020213014A1 (fr) | 2019-04-19 | 2020-10-22 | Mylan Laboratories Limited | Procédé amélioré pour la préparation de valbénazine et de ses sels |
US10689380B1 (en) * | 2019-07-30 | 2020-06-23 | Farmhispania S.A. | Crystalline forms of valbenazine ditosylate |
US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
TW202124377A (zh) | 2019-09-13 | 2021-07-01 | 美商紐羅克里生物科學有限公司 | 戊苯那嗪(valbenazine)之合成方法 |
AU2021341936A1 (en) * | 2020-09-09 | 2023-05-25 | Crinetics Pharmaceuticals, Inc. | Formulations of a somatostatin modulator |
CN112569465B (zh) * | 2020-12-29 | 2022-07-19 | 华东理工大学 | 一种微针贴片的制备方法 |
US20240239791A1 (en) | 2021-04-26 | 2024-07-18 | Neurocrine Biosciences, Inc. | Processes for the synthesis of valbenazine |
AU2022301324A1 (en) | 2021-06-30 | 2024-02-08 | Neurocrine Biosciences, Inc. | Valbenazine for use in the add-on treatment of schizophrenia |
KR20240027750A (ko) * | 2021-06-30 | 2024-03-04 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 뇌성 마비로 인한 이상운동증 치료용 발베나진 |
TW202322816A (zh) | 2021-08-20 | 2023-06-16 | 美商紐羅克里生物科學有限公司 | 篩選 vmat2 抑制劑之方法 |
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