HRP20161030T1 - Protutijelu slični vezivni proteini s dvostrukom promjenjivom regijom koji imaju prijelaznu orjentaciju vezivne regije - Google Patents
Protutijelu slični vezivni proteini s dvostrukom promjenjivom regijom koji imaju prijelaznu orjentaciju vezivne regije Download PDFInfo
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- HRP20161030T1 HRP20161030T1 HRP20161030TT HRP20161030T HRP20161030T1 HR P20161030 T1 HRP20161030 T1 HR P20161030T1 HR P20161030T T HRP20161030T T HR P20161030TT HR P20161030 T HRP20161030 T HR P20161030T HR P20161030 T1 HRP20161030 T1 HR P20161030T1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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Claims (16)
1. Protutijelu sličan vezivni protein koji sadrži četiri polipeptidna lanca koji tvore četiri mjesta vezanja antigena, pri čemu dva polipeptidna lanca imaju strukturu predstavljenu s formulom:
[image]
i dva polipeptidna lanca imaju strukturu predstavljenu s formulom:
[image]
pri čemu:
VL1 je varijabilna domena prvog lakog imunoglobulinskog lanca;
VL2 je varijabilna domena drugog lakog imunoglobulinskog lanca;
VH1 je varijabilna domena prvog teškog imunoglobulinskog lanca;
VH2 je varijabilna domena drugog teškog imunoglobulinskog lanca;
CL je konstantna domena lakog imunoglobulinskog lanca;
CH1 je imunoglobulinska CH1 konstantna domena teškog lanca;
Fc je imunoglobulinska zglobna regija i CH2, CH3 imunoglobulinska konstantna domena teških lanaca; i
L1, L2, L3, i L4 su amino kiselinske poveznice;
pri čemu:
L1 je duljine 3 do 12 ostataka amino kiseline;
L2 je duljine 3 do 14 ostataka amino kiseline;
L3 je duljine 1 do 8 ostataka amino kiseline; i
L4 je duljine 1 do 3 ostataka amino kiseline;
i pri čemu polipeptidi s formulom I i polipeptidi s formulom II tvore prijelazni par laki lanac-teški lanac.
2. Protutijelu sličan vezivni protein koji sadrži dva polipeptidna lanca koji tvore dva mjesta vezivanja antigena, pri čemu prvi polipeptidni lanac ima strukturu predstavljenu s formulom:
[image]
i drugi polipeptidni lanac ima strukturu predstavljenu s formulom:
[image]
pri čemu:
VL1 je varijabilna domena prvog lakog imunoglobulinskog lanca;
VL2 je varijabilna domena drugog lakog imunoglobulinskog lanca;
VH1 je varijabilna domena prvog teškog imunoglobulinskog lanca;
VH2 je varijabilna domena drugog teškog imunoglobulinskog lanca;
CL je konstantna domena lakog imunoglobulinskog lanca;
CH1 je imunoglobulinska CH1 konstantna domena teškog lanca; i
L1, L2, L3, i L4 su amino kiselinske poveznice;
pri čemu:
L1 je duljine 3 do 12 ostataka amino kiseline;
L2 je duljine 3 do 14 ostataka amino kiseline;
L3 je duljine 1 do 8 ostataka amino kiseline; i
L4 je duljine 1 do 3 ostatka amino kiseline;
i pri čemu prvi i drugi polipeptidi tvore prijelazni par laki lanac-teški lanac.
3. Protutijelu sličan vezivni protein prema bilo kojem zahtjevu 1 ili 2, pri čemu:
L1 je duljine 5 do 10 ostataka amino kiseline;
L2 je duljine 5 do 8 ostataka amino kiseline;
L3 je duljine 1 do 5 ostataka amino kiseline; i
L4 je duljine 1 do 2 ostatka amino kiseline.
4. Protutijelu sličan vezivni protein prema bilo kojem zahtjevu 1 ili 2, pri čemu:
L1 je duljine 7 ostataka amino kiseline;
L2 je duljine 5 ostataka amino kiseline;
L3 je duljine 1 ostatak amino kiseline; i
L4 je duljine 2 ostatka amino kiseline.
5. Protutijelu sličan vezivni protein koji sadrži četiri polipeptidna lanca koji tvore četiri mjesta vezanja antigena, pri čemu dva polipeptidna lanca imaju strukturu predstavljenu s formulom:
[image]
i dva polipeptidna lanca imaju strukturu predstavljenu s formulom:
[image]
pri čemu:
VL1 je varijabilna domena prvog lakog imunoglobulinskog lanca;
VL2 je varijabilna domena drugog lakog imunoglobulinskog lanca;
VH1 je varijabilna domena prvog teškog imunoglobulinskog lanca;
VH2 je varijabilna domena drugog teškog imunoglobulinskog lanca;
CL je konstantna domena lakog imunoglobulinskog lanca;
CH1 je imunoglobulinska CH1 konstantna domena teškog lanca;
Fc je imunoglobulinska zglobna regija i CH2, CH3 imunoglobulinska konstantna domena teških lanaca; i
L1, L2, L3, i L4 su amino kiselinske poveznice;
pri čemu:
L1 je duljine 1 do 3 ostatka amino kiseline;
L2 je duljine 1 do 4 ostatka amino kiseline;
L3 je duljine 2 do 15 ostataka amino kiseline; i
L4 je duljine 2 do 15 ostataka amino kiseline;
i pri čemu polipeptidi s formulom I i polipeptidi s formulom II tvore prijelazni par laki lanac-teški lanac.
6. Protutijelu sličan vezivni protein koji sadrži dva polipeptidna lanca koji tvore dva mjesta vezivanja antigena, pri čemu prvi polipeptidni lanac ima strukturu predstavljenu s formulom:
[image]
i drugi polipeptidni lanac ima strukturu predstavljenu s formulom:
[image]
pri čemu:
VL1 je varijabilna domena prvog lakog imunoglobulinskog lanca;
VL2 je varijabilna domena drugog lakog imunoglobulinskog lanca;
VH1 je varijabilna domena prvog teškog imunoglobulinskog lanca;
VH2 je varijabilna domena drugog teškog imunoglobulinskog lanca;
CL je konstantna domena lakog imunoglobulinskog lanca;
CH1 je imunoglobulinska CH1 konstantna domena teškog lanca; i
L1, L2, L3, i L4 su amino kiselinske poveznice;
pri čemu:
L1 je duljine 1 do 3 ostatka amino kiseline;
L2 je duljine 1 do 4 ostatka amino kiseline;
L3 je duljine 2 do 15 ostataka amino kiseline; i
L4 je duljine 2 do 15 ostataka amino kiseline;
i pri čemu prvi i drugi polipeptidi tvore prijelazni par laki lanac-teški lanac.
7. Protutijelu sličan vezivni protein prema bilo kojem zahtjevu 5 ili 6, naznačen time da:
L1 je duljine 1 do 2 ostatka amino kiseline;
L2 je duljine 1 do 2 ostatka amino kiseline;
L3 je duljine 4 do 12 ostataka amino kiseline; i
L4 je duljine 2 do 12 ostataka amino kiseline.
8. Protutijelu sličan vezivni protein prema bilo kojem zahtjevu 5 ili 6, naznačen time da:
L1 je duljine 1 ostatak amino kiseline;
L2 je duljine 2 ostatka amino kiseline;
L3 je duljine 7 ostataka amino kiseline; i
L4 je duljine 5 ostataka amino kiseline.
9. Protutijelu sličan vezivni protein prema bilo kojem od zahtjeva 1, 2, 5 ili 6, naznačen time da vezivni peptid može specifično vezati jedan ili više antigenskih ciljeva, pri čemu, poželjno, jedan ili više antigenskih ciljeva se bira iz skupine koju čine B7.1, B7.2, BAFF, BlyS, C3, C5, CCL11 (eotaksin), CCL15 (MIP-ld), CCL17 (TARC), CCL19 (MIP-3b), CCL2 (MCP-1), CCL20 (MIP-3a), CCL21 (MIP-2), SLC, CCL24 (MPIF-2/eotaxin-2), CCL25 (TECK), CCL26 (eotaxin-3), CCL3 (MIP-la), CCL4 (MIP-lb), CCL5 (RANTES), CCL7 (MCP-3), CCL8 (mcp-2), CD3, CD19, CD20, CD24, CD40, CD40L, CD80, CD86, CDH1 (E-kadherin), Kitinaza, CSF1 (M-CSF), CSF2 (GM-CSF), CSF3 (GCSF), CTLA4, CX3CL1 (SCYD1), CXCL12 (SDF1), CXCL13, EGFR, FCER1A, FCER2, HER2, IGF1R, IL-1, IL-12, IL13, IL15, IL17, IL18, IL1A, IL1B, IL1F10, IL1β, IL2, IL4, IL6, IL7, IL8, IL9, IL12/23, IL22, IL23, IL25, IL27, IL35, ITGB4 (b 4 integrin), LEP (leptin), MHC razred II, TLR2, TLR4, TLR5, TNF, TNFα, TNFSF4 (OX40 ligand), TNFSF5 (CD40 ligand), Toll-slični receptori, TREM1, TSLP, TWEAK, XCR1 (GPR5/CCXCR1), DNGR-1(CLEC91), i HMGB1.
10. Protutijelu sličan vezivni protein prema bilo kojem od zahtjeva 1, 2, 5 ili 6, naznačen time da vezivni peptid je bispecifičan i može vezati dva različita antigenska cilja, pri čemu, poželjno, dva različita antigenska cilja se biraju iz skupine koju čine IL4 i IL13, IGF1R i HER2, IGF1R i EGFR, EGFR i HER2, BK i IL13, PDL-1 i CTLA-4, CTLA4 i MHC razred II, IL-12 i IL-18, IL-1α i IL-1β, TNFα i IL12/23, TNFα i IL-12p40, TNFα i IL1β, TNFα i IL-23, i IL17 i IL23.
11. Protutijelu sličan vezivni protein prema bilo kojem od zahtjeva 1, 2, 5 ili 6, naznačen time da vezivni peptid može inhibirati funkciju jednog ili više antigenskih ciljeva.
12. Protutijelu sličan vezivni protein prema bilo kojem od zahtjeva 1, 2, 5 ili 6, naznačen time da barem jedna od poveznica odabrana iz skupine koju čine L1, L2, L3, i L4 sadrži barem jedan cisteinski ostatak.
13. Izolirana molekula nukleinske kiseline naznačena time da sadrži nukleotidnu sekvencu koja kodira protutijelu sličan vezivni peptid prema bilo kojem od zahtjeva 1, 2, 5 ili 6.
14. Ekspresijski vektor naznačen time da sadrži molekulu nukleinske kiseline prema zahtjevu13.
15. Izolirana stanica domaćin naznačena time da sadrži molekulu nukleinske kiseline prema zahtjevu 13 ili ekspresijski vektor prema zahtjevu 14, pri čemu, poželjno, stanica domaćin je stanica sisavca ili stanica insekta.
16. Farmaceutski pripravak naznačen time da sadrži farmaceutski prihvatljiv nosač i terapeutski učinkovitu količinu protutijelu sličnog vezivnog peptida prema bilo kojem od zahtjeva 1, 2, 5 ili 6.
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