AR123548A1 - Anticuerpos biespecíficos cd47-cd38 - Google Patents
Anticuerpos biespecíficos cd47-cd38Info
- Publication number
- AR123548A1 AR123548A1 ARP210102596A ARP210102596A AR123548A1 AR 123548 A1 AR123548 A1 AR 123548A1 AR P210102596 A ARP210102596 A AR P210102596A AR P210102596 A ARP210102596 A AR P210102596A AR 123548 A1 AR123548 A1 AR 123548A1
- Authority
- AR
- Argentina
- Prior art keywords
- chain variable
- variable region
- antigen
- human
- bisecific
- Prior art date
Links
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- 229940072221 immunoglobulins Drugs 0.000 abstract 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 abstract 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 abstract 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000052645 human CD38 Human genes 0.000 abstract 1
- 102000044459 human CD47 Human genes 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se proporcionan inmunoglobulinas heterodiméricas biespecíficas nuevas que captan tanto un componente del antígeno CD47 humano como el antígeno CD38 humano y en particular aquellas comprendiendo una región variable de cadena pesada anti-CD38 y una región variable de cadena liviana y una región variable de cadena pesada anti-CD47 y una región variable de cadena liviana. El presente invento también se relaciona con el uso de esta clase nueva de inmunoglobulinas heterodiméricas biespecíficas para tratar enfermedades de autoinmunidad y proliferativas y en particular los tipos de cáncer tal como tumores malignos hematológicos y tumores sólidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20197033 | 2020-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123548A1 true AR123548A1 (es) | 2022-12-14 |
Family
ID=72603323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102596A AR123548A1 (es) | 2020-09-18 | 2021-09-17 | Anticuerpos biespecíficos cd47-cd38 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220089767A1 (es) |
| EP (1) | EP4214231A1 (es) |
| JP (1) | JP2023542907A (es) |
| KR (1) | KR20230088370A (es) |
| CN (1) | CN116648463A (es) |
| AR (1) | AR123548A1 (es) |
| AU (1) | AU2021344635A1 (es) |
| CA (1) | CA3192465A1 (es) |
| CL (1) | CL2023000786A1 (es) |
| CO (1) | CO2023004698A2 (es) |
| IL (1) | IL301330A (es) |
| MX (1) | MX2023003192A (es) |
| PE (1) | PE20231573A1 (es) |
| TW (1) | TW202227497A (es) |
| WO (1) | WO2022058539A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202400660A (zh) * | 2022-05-06 | 2024-01-01 | 瑞士商伊克諾斯科學公司 | Cd3/bcma/cd38 三特異性抗體 |
| WO2023220641A2 (en) * | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
| EP1068241B1 (en) | 1998-04-02 | 2007-10-10 | Genentech, Inc. | Antibody variants and fragments thereof |
| GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| AU2011219496B2 (en) | 2010-02-23 | 2017-04-06 | Sanofi | Anti-alpha2 integrin antibodies and their uses |
| BR112013023918A2 (pt) | 2011-03-25 | 2016-12-13 | Glenmark Pharmaceuticals Sa | imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para produzir uma imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para construir uma interface proteína-proteína de um domínio de uma proteína de múltiplos domínios e uso de um domínio doador de um primeiro e de um segundo membro de uma super-família de imunoglobulina de ocorrência natural |
| TWI588156B (zh) | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
| CA2874083C (en) * | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
| CN111303293B (zh) * | 2018-11-14 | 2022-08-30 | 杭州尚健生物技术有限公司 | 一种融合蛋白及其用途 |
-
2021
- 2021-09-17 EP EP21782659.3A patent/EP4214231A1/en active Pending
- 2021-09-17 PE PE2023001174A patent/PE20231573A1/es unknown
- 2021-09-17 CN CN202180076954.9A patent/CN116648463A/zh active Pending
- 2021-09-17 MX MX2023003192A patent/MX2023003192A/es unknown
- 2021-09-17 CA CA3192465A patent/CA3192465A1/en active Pending
- 2021-09-17 KR KR1020237013184A patent/KR20230088370A/ko active Search and Examination
- 2021-09-17 AU AU2021344635A patent/AU2021344635A1/en active Pending
- 2021-09-17 IL IL301330A patent/IL301330A/en unknown
- 2021-09-17 WO PCT/EP2021/075687 patent/WO2022058539A1/en active Application Filing
- 2021-09-17 JP JP2023517964A patent/JP2023542907A/ja active Pending
- 2021-09-17 US US17/478,706 patent/US20220089767A1/en active Pending
- 2021-09-17 AR ARP210102596A patent/AR123548A1/es unknown
- 2021-09-18 TW TW110135023A patent/TW202227497A/zh unknown
-
2023
- 2023-03-17 CL CL2023000786A patent/CL2023000786A1/es unknown
- 2023-04-17 CO CONC2023/0004698A patent/CO2023004698A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL301330A (en) | 2023-05-01 |
| CA3192465A1 (en) | 2022-03-24 |
| JP2023542907A (ja) | 2023-10-12 |
| WO2022058539A1 (en) | 2022-03-24 |
| CL2023000786A1 (es) | 2023-09-15 |
| KR20230088370A (ko) | 2023-06-19 |
| CN116648463A (zh) | 2023-08-25 |
| MX2023003192A (es) | 2023-06-09 |
| CO2023004698A2 (es) | 2023-07-21 |
| AU2021344635A1 (en) | 2023-04-27 |
| TW202227497A (zh) | 2022-07-16 |
| EP4214231A1 (en) | 2023-07-26 |
| PE20231573A1 (es) | 2023-10-04 |
| AU2021344635A9 (en) | 2024-02-08 |
| US20220089767A1 (en) | 2022-03-24 |
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