HRP20151396T1 - Mutanti adenovirusa e1a i e1b selektivni za tumore - Google Patents

Mutanti adenovirusa e1a i e1b selektivni za tumore Download PDF

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Publication number
HRP20151396T1
HRP20151396T1 HRP20151396T HRP20151396T HRP20151396T1 HR P20151396 T1 HRP20151396 T1 HR P20151396T1 HR P20151396 T HRP20151396 T HR P20151396T HR P20151396 T HRP20151396 T HR P20151396T HR P20151396 T1 HRP20151396 T1 HR P20151396T1
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Croatia
Prior art keywords
pea3
functional part
site
binding site
nucleotides
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HRP20151396T
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English (en)
Croatian (hr)
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Tony Reid
Farah Hedjran
Shantanu Kumar
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Univ California
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Publication of HRP20151396T1 publication Critical patent/HRP20151396T1/hr

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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HRP20151396T 2009-03-02 2010-03-02 Mutanti adenovirusa e1a i e1b selektivni za tumore HRP20151396T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15682209P 2009-03-02 2009-03-02
EP10749205.0A EP2403951B1 (en) 2009-03-02 2010-03-02 Tumor-selective adenovirus e1a and e1b mutants
PCT/US2010/025926 WO2010101921A2 (en) 2009-03-02 2010-03-02 Tumor-selective e1a and e1b mutants

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HRP20151396T1 true HRP20151396T1 (hr) 2016-03-25

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HRP20151396T HRP20151396T1 (hr) 2009-03-02 2010-03-02 Mutanti adenovirusa e1a i e1b selektivni za tumore
HRP20191808TT HRP20191808T1 (hr) 2009-03-02 2019-10-03 Mutanti tumorsko-selektivnih adenovirusa e1a i e1b

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HRP20191808TT HRP20191808T1 (hr) 2009-03-02 2019-10-03 Mutanti tumorsko-selektivnih adenovirusa e1a i e1b

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US (6) US9073980B2 (enExample)
EP (4) EP2403951B1 (enExample)
JP (5) JP6072414B2 (enExample)
KR (4) KR101922539B1 (enExample)
CY (1) CY1122385T1 (enExample)
DK (2) DK3029144T3 (enExample)
ES (2) ES2557812T3 (enExample)
HR (2) HRP20151396T1 (enExample)
HU (2) HUE026386T2 (enExample)
LT (1) LT3029144T (enExample)
PL (2) PL3029144T3 (enExample)
PT (2) PT2403951E (enExample)
SI (2) SI2403951T1 (enExample)
SM (2) SMT201900565T1 (enExample)
WO (1) WO2010101921A2 (enExample)

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EP3591059B1 (en) 2022-07-20
DK3029144T3 (da) 2019-10-21
US11618888B2 (en) 2023-04-04
JP2012519014A (ja) 2012-08-23
CY1122385T1 (el) 2021-01-27
EP4123030A1 (en) 2023-01-25
JP2016028035A (ja) 2016-02-25
KR20170077278A (ko) 2017-07-05
KR101922539B1 (ko) 2018-11-27
JP6072414B2 (ja) 2017-02-01
HUE026386T2 (en) 2016-06-28
EP3591059A1 (en) 2020-01-08
KR101752910B1 (ko) 2017-06-30
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DK2403951T3 (en) 2016-01-11
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US20110318311A1 (en) 2011-12-29
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