DK3029144T3 - Tumorselektive adenovirus e1a- og e1b-mutanter - Google Patents

Tumorselektive adenovirus e1a- og e1b-mutanter

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Publication number
DK3029144T3
DK3029144T3 DK15182086.7T DK15182086T DK3029144T3 DK 3029144 T3 DK3029144 T3 DK 3029144T3 DK 15182086 T DK15182086 T DK 15182086T DK 3029144 T3 DK3029144 T3 DK 3029144T3
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Denmark
Prior art keywords
mutants
tumor selective
selective adenovirus
adenovirus
tumor
Prior art date
Application number
DK15182086.7T
Other languages
English (en)
Inventor
Tony Reid
Farah Hedjran
Shantanu Kumar
Original Assignee
Univ California
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Publication date
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Publication of DK3029144T3 publication Critical patent/DK3029144T3/da

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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DK15182086.7T 2009-03-02 2010-03-02 Tumorselektive adenovirus e1a- og e1b-mutanter DK3029144T3 (da)

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Application Number Priority Date Filing Date Title
US15682209P 2009-03-02 2009-03-02
EP10749205.0A EP2403951B1 (en) 2009-03-02 2010-03-02 Tumor-selective adenovirus e1a and e1b mutants

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DK3029144T3 true DK3029144T3 (da) 2019-10-21

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DK10749205.0T DK2403951T3 (da) 2009-03-02 2010-03-02 Tumorselektive e1a- og e1b-adenovirusmutanter
DK15182086.7T DK3029144T3 (da) 2009-03-02 2010-03-02 Tumorselektive adenovirus e1a- og e1b-mutanter

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US (5) US9073980B2 (da)
EP (4) EP3591059B1 (da)
JP (5) JP6072414B2 (da)
KR (4) KR102150027B1 (da)
CY (1) CY1122385T1 (da)
DK (2) DK2403951T3 (da)
ES (2) ES2557812T3 (da)
HR (2) HRP20151396T1 (da)
HU (2) HUE046565T2 (da)
LT (1) LT3029144T (da)
PL (2) PL2403951T3 (da)
PT (2) PT3029144T (da)
SI (2) SI2403951T1 (da)
SM (1) SMT201500329B (da)
WO (1) WO2010101921A2 (da)

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KR20110122866A (ko) 2011-11-11
SMT201500329B (it) 2016-02-25
KR101752910B1 (ko) 2017-06-30
JP6375273B2 (ja) 2018-08-15
US9073980B2 (en) 2015-07-07
KR101922539B1 (ko) 2018-11-27
PL2403951T3 (pl) 2016-04-29
HUE026386T2 (en) 2016-06-28
US20160017294A1 (en) 2016-01-21
US20190136204A1 (en) 2019-05-09
JP2020078326A (ja) 2020-05-28
SI2403951T1 (sl) 2016-04-29
KR102020018B1 (ko) 2019-09-09
US10876097B2 (en) 2020-12-29
US20110318311A1 (en) 2011-12-29
JP2012519014A (ja) 2012-08-23
LT3029144T (lt) 2019-10-25
JP2016028035A (ja) 2016-02-25
JP2022023074A (ja) 2022-02-07
JP6072414B2 (ja) 2017-02-01
EP3591059A1 (en) 2020-01-08
EP4123030A1 (en) 2023-01-25
PT3029144T (pt) 2019-10-28
PT2403951E (pt) 2016-01-29
KR20170077278A (ko) 2017-07-05
EP2403951B1 (en) 2015-09-30
JP7326396B2 (ja) 2023-08-15
KR102150027B1 (ko) 2020-10-26
JP6817979B2 (ja) 2021-01-20
KR20190104643A (ko) 2019-09-10
EP3591059B1 (en) 2022-07-20
CY1122385T1 (el) 2021-01-27
KR20180049188A (ko) 2018-05-10
WO2010101921A3 (en) 2011-01-06
DK2403951T3 (da) 2016-01-11
PL3029144T3 (pl) 2020-06-01
ES2557812T3 (es) 2016-01-28
EP2403951A4 (en) 2012-08-22
US20230272349A1 (en) 2023-08-31
ES2750305T3 (es) 2020-03-25
US20210171917A1 (en) 2021-06-10
WO2010101921A2 (en) 2010-09-10
HRP20151396T1 (hr) 2016-03-25
HUE046565T2 (hu) 2020-03-30
SI3029144T1 (sl) 2019-11-29
HRP20191808T1 (hr) 2019-12-27
US11618888B2 (en) 2023-04-04
EP3029144B1 (en) 2019-07-10
EP2403951A2 (en) 2012-01-11
JP2018113971A (ja) 2018-07-26
EP3029144A1 (en) 2016-06-08

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