SG11201906973TA - Multiple transgene recombinant adenovirus - Google Patents
Multiple transgene recombinant adenovirusInfo
- Publication number
- SG11201906973TA SG11201906973TA SG11201906973TA SG11201906973TA SG11201906973TA SG 11201906973T A SG11201906973T A SG 11201906973TA SG 11201906973T A SG11201906973T A SG 11201906973TA SG 11201906973T A SG11201906973T A SG 11201906973TA SG 11201906973T A SG11201906973T A SG 11201906973TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- san diego
- recombinant adenovirus
- english
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIPO I PCT (51) International Patent Classification: Cl 2N 7/01 (2006.01) A61K 35/761 (2015.01) Cl 2N 15/861 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/016032 (22) International Filing Date: 30 January 2018 (30.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/452,342 30 January 2017 (30.01.2017) US 62/520,945 16 June 2017 (16.06.2017) US (71) Applicant: EPICENTRX, INC. [US/US]; 4445 Eastgate Mall, Suite 200, San Diego, CA 92121 (US). (72) Inventors: REID, Tony R.; 5517 Carriage Court, San Diego, CA 92130 (US). ORONSKY, Bryan T.; 28540 Matadero Creek Lane, Los Altos Hills, CA 94022 (US). LARSON, Christopher; 3815 Lebon Dr. Apt. 335, San Diego, CA 92122 (US). (74) Agent: DAVENPORT, Andrew M. et al.; Goodwin Proc- ter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1 O \" (57) : The invention provides a recombinant adenovirus comprising two (or more) therapeutic transgenes, e.g., CD80 and 0 CD137L. The transgenes are preferably inserted into an Elb-19K insertion site and/or an E3 insertion site. omit VIII °nolo 010 Holimo Ill ono mil (10) International Publication Number WO 2018/140973 Al (54) Title: MULTIPLE TRANSGENE RECOMBINANT ADENOVIRUS
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762452342P | 2017-01-30 | 2017-01-30 | |
US201762520945P | 2017-06-16 | 2017-06-16 | |
PCT/US2018/016032 WO2018140973A1 (en) | 2017-01-30 | 2018-01-30 | Multiple transgene recombinant adenovirus |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201906973TA true SG11201906973TA (en) | 2019-08-27 |
Family
ID=62978741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201906973TA SG11201906973TA (en) | 2017-01-30 | 2018-01-30 | Multiple transgene recombinant adenovirus |
Country Status (12)
Country | Link |
---|---|
US (1) | US20190352616A1 (en) |
EP (1) | EP3574090A4 (en) |
JP (1) | JP2020505049A (en) |
KR (1) | KR20190128634A (en) |
CN (1) | CN110741080A (en) |
AU (1) | AU2018213417A1 (en) |
BR (1) | BR112019015600A2 (en) |
CA (1) | CA3052090A1 (en) |
IL (1) | IL268291A (en) |
MX (1) | MX2019008921A (en) |
SG (1) | SG11201906973TA (en) |
WO (1) | WO2018140973A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2014236207B2 (en) | 2013-03-14 | 2019-05-23 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
JP7054527B2 (en) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | High-throughput assay to measure adenovirus replication kinetics |
KR20220163505A (en) | 2016-02-23 | 2022-12-09 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
EP3532082A4 (en) | 2016-12-12 | 2020-08-26 | Salk Institute for Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
US20200155625A1 (en) * | 2017-05-24 | 2020-05-21 | Epicentrx, Inc. | Anti-angiogenic adenovirus |
WO2022007800A1 (en) * | 2020-07-06 | 2022-01-13 | 嘉兴安宇生物科技有限公司 | Recombinant adenovirus vaccine for african swine fever and method for constructing same |
EP4349975A1 (en) * | 2021-05-25 | 2024-04-10 | Voncolytic Therapeutics Co., Ltd. | Chimeric broad-spectrum oncolytic adenovirus with multiple mechanisms synergizing with and enhancing efficacy of immunotherapy, and application thereof in tumor treatment |
CN113249342B (en) * | 2021-05-25 | 2023-12-01 | 江苏万戎生物医药科技有限公司 | Chimeric broad-spectrum oncolytic adenovirus with multiple mechanism synergistic and synergistic immunotherapy and application thereof in tumor treatment |
WO2024015876A1 (en) | 2022-07-13 | 2024-01-18 | Epicentrx, Inc. | Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100896483B1 (en) * | 2007-07-13 | 2009-05-08 | 연세대학교 산학협력단 | Anti-Tumor Pharmaceutical Composition Comprising Dendritic Cell and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL |
US9073980B2 (en) * | 2009-03-02 | 2015-07-07 | The Regents Of The University Of California | Tumor selective E1a and E1b mutants |
KR20180108886A (en) * | 2010-03-23 | 2018-10-04 | 인트렉손 코포레이션 | Vectors Conditionally Expressing Therapeutic Proteins, Host Cells Comprising the Vectors, and Uses Thereof |
RU2013118723A (en) * | 2010-09-24 | 2014-10-27 | Онкос Терапьютикс Ой | ONCOLITIC Adenovirus VECTORS CODING MONOCLONAL ANTIBODIES AGAINST CTLA-4 |
ES2759785T3 (en) * | 2012-02-02 | 2020-05-12 | Univ Texas | Adenoviruses expressing heterologous oncogenic antigens |
WO2014170389A1 (en) * | 2013-04-18 | 2014-10-23 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
CN103614416B (en) * | 2013-09-30 | 2016-09-07 | 中国人民解放军第二军医大学东方肝胆外科医院 | A kind of recombination oncolytic adenovirus of carrier's cell-penetrating peptide p53 and GM-CSF gene and application thereof |
PL3198009T3 (en) * | 2014-09-24 | 2022-01-24 | Salk Institute For Biological Studies | Oncolytic tumor viruses and methods of use |
US10232053B2 (en) * | 2016-12-30 | 2019-03-19 | Trieza Therapeutics, Inc. | Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer |
-
2018
- 2018-01-30 KR KR1020197025498A patent/KR20190128634A/en not_active Application Discontinuation
- 2018-01-30 MX MX2019008921A patent/MX2019008921A/en unknown
- 2018-01-30 US US16/482,055 patent/US20190352616A1/en not_active Abandoned
- 2018-01-30 AU AU2018213417A patent/AU2018213417A1/en active Pending
- 2018-01-30 JP JP2019541188A patent/JP2020505049A/en active Pending
- 2018-01-30 SG SG11201906973TA patent/SG11201906973TA/en unknown
- 2018-01-30 WO PCT/US2018/016032 patent/WO2018140973A1/en unknown
- 2018-01-30 EP EP18743942.7A patent/EP3574090A4/en active Pending
- 2018-01-30 BR BR112019015600-3A patent/BR112019015600A2/en unknown
- 2018-01-30 CA CA3052090A patent/CA3052090A1/en active Pending
- 2018-01-30 CN CN201880021787.6A patent/CN110741080A/en active Pending
-
2019
- 2019-07-28 IL IL268291A patent/IL268291A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2018213417A1 (en) | 2019-08-15 |
EP3574090A4 (en) | 2021-01-06 |
KR20190128634A (en) | 2019-11-18 |
MX2019008921A (en) | 2019-11-08 |
WO2018140973A1 (en) | 2018-08-02 |
BR112019015600A2 (en) | 2020-03-17 |
US20190352616A1 (en) | 2019-11-21 |
CA3052090A1 (en) | 2018-08-02 |
JP2020505049A (en) | 2020-02-20 |
EP3574090A1 (en) | 2019-12-04 |
CN110741080A (en) | 2020-01-31 |
IL268291A (en) | 2019-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201906973TA (en) | Multiple transgene recombinant adenovirus | |
SG11201908719QA (en) | Biomarkers and car t cell therapies with enhanced efficacy | |
SG11201907848YA (en) | Antibodies binding to vista at acidic ph | |
SG11201807279QA (en) | Binding proteins and methods of use thereof | |
SG11201805709RA (en) | Anti-pro/latent myostatin antibodies and methods of use thereof | |
SG11201407370QA (en) | Humanized il-7 rodents | |
SG11201407486PA (en) | Compositions and methods for modulating utrn expression | |
SG11201805157TA (en) | Targeted disruption of the mhc cell receptor | |
SG11201807025SA (en) | Crispr/cas systems for c-1 fixing bacteria | |
SG11201407483YA (en) | Compositions and methods for modulating smn gene family expression | |
SG11201804662PA (en) | Image projection system | |
SG11201804375WA (en) | Compositions and methods for internalizing enzymes | |
SG11201407561UA (en) | ANTI-Ly6E ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE | |
SG11201803958WA (en) | Nucleic acids encoding repetitive amino acid sequences rich in proline and alanine residues that have low repetitive nucleotide sequences | |
SG11201804673WA (en) | Novel anti-claudin antibodies and methods of use | |
SG11201809374VA (en) | Cd40l-fc fusion polypeptides and methods of use thereof | |
SG11201810757YA (en) | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase | |
SG11201907889YA (en) | Glycan-interacting compounds and methods of use | |
SG11201906319XA (en) | Compositions and methods for the depletion of cd137+ cells | |
SG11201908456VA (en) | Linker units and molecular constructs comprising same | |
SG11201909520VA (en) | Rna for treatment of autoimmune diseases | |
SG11201906976YA (en) | Tumor selective tata-box and caat-box mutants | |
SG11201907434RA (en) | Compositions and methods for immunooncology | |
SG11201900238UA (en) | Compounds and methods for modulation of smn2 | |
SG11201901063SA (en) | Therapeutic agents for neurodegenerative diseases |