ES2750305T3 - Mutantes de E1A y E1B de adenovirus selectivos de tumor - Google Patents

Mutantes de E1A y E1B de adenovirus selectivos de tumor Download PDF

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Publication number
ES2750305T3
ES2750305T3 ES15182086T ES15182086T ES2750305T3 ES 2750305 T3 ES2750305 T3 ES 2750305T3 ES 15182086 T ES15182086 T ES 15182086T ES 15182086 T ES15182086 T ES 15182086T ES 2750305 T3 ES2750305 T3 ES 2750305T3
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expression
cells
pea3
site
gene
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Spanish (es)
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Tony Reid
Farah Hedjran
Shantanu Kumar
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University of California Berkeley
University of California, San Diego
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University of California Berkeley
University of California, San Diego
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A—HUMAN NECESSITIES
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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ES15182086T 2009-03-02 2010-03-02 Mutantes de E1A y E1B de adenovirus selectivos de tumor Active ES2750305T3 (es)

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US15682209P 2009-03-02 2009-03-02

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ES15182086T Active ES2750305T3 (es) 2009-03-02 2010-03-02 Mutantes de E1A y E1B de adenovirus selectivos de tumor
ES10749205.0T Active ES2557812T3 (es) 2009-03-02 2010-03-02 Mutantes de E1a y E1b de adenovirus selectivos de tumor

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US (6) US9073980B2 (enExample)
EP (4) EP4123030A1 (enExample)
JP (5) JP6072414B2 (enExample)
KR (4) KR102020018B1 (enExample)
CY (1) CY1122385T1 (enExample)
DK (2) DK2403951T3 (enExample)
ES (2) ES2750305T3 (enExample)
HR (2) HRP20151396T1 (enExample)
HU (2) HUE026386T2 (enExample)
LT (1) LT3029144T (enExample)
PL (2) PL2403951T3 (enExample)
PT (2) PT2403951E (enExample)
SI (2) SI3029144T1 (enExample)
SM (2) SMT201900565T1 (enExample)
WO (1) WO2010101921A2 (enExample)

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CN114262691A (zh) * 2020-09-16 2022-04-01 杭州康万达医药科技有限公司 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途
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KR102150027B1 (ko) 2020-10-26
US20250327037A1 (en) 2025-10-23
SI3029144T1 (sl) 2019-11-29
US11618888B2 (en) 2023-04-04
US20110318311A1 (en) 2011-12-29
US12195766B2 (en) 2025-01-14
JP6375273B2 (ja) 2018-08-15
JP6072414B2 (ja) 2017-02-01
HUE026386T2 (en) 2016-06-28
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