SI2403951T1 - Tumorsko selektivni mutanti adenovirusa e1a in e1b - Google Patents

Tumorsko selektivni mutanti adenovirusa e1a in e1b

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Publication number
SI2403951T1
SI2403951T1 SI201031077T SI201031077T SI2403951T1 SI 2403951 T1 SI2403951 T1 SI 2403951T1 SI 201031077 T SI201031077 T SI 201031077T SI 201031077 T SI201031077 T SI 201031077T SI 2403951 T1 SI2403951 T1 SI 2403951T1
Authority
SI
Slovenia
Prior art keywords
mutants
tumor
selective adenovirus
adenovirus
selective
Prior art date
Application number
SI201031077T
Other languages
English (en)
Slovenian (sl)
Inventor
Tony Reid
Farah Hedjran
Shantanu Kumar
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of SI2403951T1 publication Critical patent/SI2403951T1/sl

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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SI201031077T 2009-03-02 2010-03-02 Tumorsko selektivni mutanti adenovirusa e1a in e1b SI2403951T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15682209P 2009-03-02 2009-03-02
EP10749205.0A EP2403951B1 (en) 2009-03-02 2010-03-02 Tumor-selective adenovirus e1a and e1b mutants
PCT/US2010/025926 WO2010101921A2 (en) 2009-03-02 2010-03-02 Tumor-selective e1a and e1b mutants

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SI2403951T1 true SI2403951T1 (sl) 2016-04-29

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SI201031077T SI2403951T1 (sl) 2009-03-02 2010-03-02 Tumorsko selektivni mutanti adenovirusa e1a in e1b
SI201031944T SI3029144T1 (sl) 2009-03-02 2010-03-02 Tumorsko-selektivni adenovirus E1A in E1B mutanti

Family Applications After (1)

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SI201031944T SI3029144T1 (sl) 2009-03-02 2010-03-02 Tumorsko-selektivni adenovirus E1A in E1B mutanti

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US (6) US9073980B2 (enExample)
EP (4) EP2403951B1 (enExample)
JP (5) JP6072414B2 (enExample)
KR (4) KR101922539B1 (enExample)
CY (1) CY1122385T1 (enExample)
DK (2) DK3029144T3 (enExample)
ES (2) ES2557812T3 (enExample)
HR (2) HRP20151396T1 (enExample)
HU (2) HUE026386T2 (enExample)
LT (1) LT3029144T (enExample)
PL (2) PL3029144T3 (enExample)
PT (2) PT2403951E (enExample)
SI (2) SI2403951T1 (enExample)
SM (2) SMT201900565T1 (enExample)
WO (1) WO2010101921A2 (enExample)

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US20220403438A1 (en) 2019-10-08 2022-12-22 Trustees Of Boston College Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins
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EP3591059B1 (en) 2022-07-20
DK3029144T3 (da) 2019-10-21
US11618888B2 (en) 2023-04-04
JP2012519014A (ja) 2012-08-23
CY1122385T1 (el) 2021-01-27
EP4123030A1 (en) 2023-01-25
JP2016028035A (ja) 2016-02-25
KR20170077278A (ko) 2017-07-05
KR101922539B1 (ko) 2018-11-27
JP6072414B2 (ja) 2017-02-01
HUE026386T2 (en) 2016-06-28
EP3591059A1 (en) 2020-01-08
KR101752910B1 (ko) 2017-06-30
EP3029144B1 (en) 2019-07-10
PT2403951E (pt) 2016-01-29
US20210171917A1 (en) 2021-06-10
US20160017294A1 (en) 2016-01-21
JP2018113971A (ja) 2018-07-26
EP2403951B1 (en) 2015-09-30
PT3029144T (pt) 2019-10-28
SMT201500329B (it) 2016-02-25
US12195766B2 (en) 2025-01-14
US10876097B2 (en) 2020-12-29
DK2403951T3 (en) 2016-01-11
US20230272349A1 (en) 2023-08-31
KR20110122866A (ko) 2011-11-11
WO2010101921A2 (en) 2010-09-10
PL3029144T3 (pl) 2020-06-01
PL2403951T3 (pl) 2016-04-29
JP2022023074A (ja) 2022-02-07
EP2403951A4 (en) 2012-08-22
JP6375273B2 (ja) 2018-08-15
KR102150027B1 (ko) 2020-10-26
US9073980B2 (en) 2015-07-07
HRP20151396T1 (hr) 2016-03-25
HUE046565T2 (hu) 2020-03-30
HRP20191808T1 (hr) 2019-12-27
ES2750305T3 (es) 2020-03-25
JP7326396B2 (ja) 2023-08-15
US20110318311A1 (en) 2011-12-29
KR20180049188A (ko) 2018-05-10
SMT201900565T1 (it) 2019-11-13
JP6817979B2 (ja) 2021-01-20
JP2020078326A (ja) 2020-05-28
LT3029144T (lt) 2019-10-25
US20250327037A1 (en) 2025-10-23
WO2010101921A3 (en) 2011-01-06
EP2403951A2 (en) 2012-01-11
ES2557812T3 (es) 2016-01-28
EP3029144A1 (en) 2016-06-08
US20190136204A1 (en) 2019-05-09
SI3029144T1 (sl) 2019-11-29
KR20190104643A (ko) 2019-09-10
KR102020018B1 (ko) 2019-09-09

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