HRP20150553T1 - Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju - Google Patents
Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju Download PDFInfo
- Publication number
- HRP20150553T1 HRP20150553T1 HRP20150553TT HRP20150553T HRP20150553T1 HR P20150553 T1 HRP20150553 T1 HR P20150553T1 HR P20150553T T HRP20150553T T HR P20150553TT HR P20150553 T HRP20150553 T HR P20150553T HR P20150553 T1 HRP20150553 T1 HR P20150553T1
- Authority
- HR
- Croatia
- Prior art keywords
- use according
- substance
- myeloma
- leukemia
- polypeptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17855309P | 2009-05-15 | 2009-05-15 | |
| EP10774475.7A EP2429574B1 (en) | 2009-05-15 | 2010-05-14 | Compositions and methods for treating hematologic cancers targeting the sirp - cd47 interaction |
| PCT/CA2010/000743 WO2010130053A1 (en) | 2009-05-15 | 2010-05-14 | COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRPα - CD47 INTERACTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150553T1 true HRP20150553T1 (hr) | 2015-08-28 |
Family
ID=43084582
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150553TT HRP20150553T1 (hr) | 2009-05-15 | 2010-05-14 | Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju |
| HRP20240362TT HRP20240362T1 (hr) | 2009-05-15 | 2010-05-14 | Pripravci i postupci namijenjeni liječenju hematološkog raka, koji ciljaju na međudjelovanje između sirp-alfa i cd47 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240362TT HRP20240362T1 (hr) | 2009-05-15 | 2010-05-14 | Pripravci i postupci namijenjeni liječenju hematološkog raka, koji ciljaju na međudjelovanje između sirp-alfa i cd47 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10907209B2 (https=) |
| EP (3) | EP4311863A3 (https=) |
| JP (6) | JP6091891B2 (https=) |
| CN (2) | CN107252476A (https=) |
| AU (1) | AU2010246872B2 (https=) |
| CA (2) | CA2761438C (https=) |
| DK (2) | DK2429574T3 (https=) |
| ES (2) | ES2539141T3 (https=) |
| FI (1) | FI2995315T3 (https=) |
| HR (2) | HRP20150553T1 (https=) |
| HU (1) | HUE065432T2 (https=) |
| PL (2) | PL2995315T3 (https=) |
| PT (2) | PT2429574E (https=) |
| SI (2) | SI2995315T1 (https=) |
| WO (1) | WO2010130053A1 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009205665B2 (en) | 2008-01-15 | 2013-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
| PL2995315T3 (pl) * | 2009-05-15 | 2024-04-22 | University Health Network | Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie sirp alfa-cd47 |
| SI2804617T1 (sl) * | 2012-01-17 | 2020-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Visokoafinitetni SIRP-alfa reagenti |
| DK2806883T3 (da) | 2012-01-25 | 2019-07-22 | Dnatrix Inc | Biomarkører og kombinationsterapier under anvendelse af onkolytisk virus og immunomodulation |
| CN102643347A (zh) * | 2012-03-29 | 2012-08-22 | 中国人民解放军第四军医大学 | 一种白血病干细胞靶向可溶性蛋白TrxHis-hSIRPα |
| CN103804495A (zh) * | 2012-11-07 | 2014-05-21 | 深圳大学 | 抗肿瘤基因工程二价类抗体及其制备方法及抗肿瘤基因工程药物 |
| ES2914814T3 (es) * | 2012-12-17 | 2022-06-16 | Pf Argentum Ip Holdings Llc | Tratamiento de células enfermas CD47+ con fusiones SIRP Alfa-Fc |
| US9873747B2 (en) | 2013-01-31 | 2018-01-23 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
| CA2900256C (en) | 2013-02-05 | 2023-03-21 | Kim J. HASENKRUG | Cd47 targeted therapies for the treatment of infectious disease |
| CN103665165B (zh) * | 2013-08-28 | 2016-02-24 | 江苏匡亚生物医药科技有限公司 | 一种靶向人CD47-SIRPα信号通路的双特异性抗体及其制备方法和用途 |
| KR102314088B1 (ko) * | 2014-03-24 | 2021-10-15 | 이뮨원코 바이오파마슈티컬즈 (상하이) 컴퍼니 리미티드 | 새로운 이중 기능성의 재조합 융합 단백질, 이의 제조 방법 및 용도 |
| TWI759810B (zh) * | 2014-08-08 | 2022-04-01 | 美商Ａｌｘ腫瘤技術股份有限公司 | 信號調節蛋白α(signal-regulatory proteinα, SIRP-α)變體構築物及其用途 |
| HUE046661T2 (hu) | 2014-08-15 | 2020-03-30 | Merck Patent Gmbh | SIRP-alfa immunglobulin fúziós proteinek |
| EP3012271A1 (en) | 2014-10-24 | 2016-04-27 | Effimune | Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases |
| CN106146670B (zh) * | 2015-04-24 | 2019-01-15 | 宜明昂科生物医药技术（上海）有限公司 | 一种新的重组双功能融合蛋白及其制备和应用 |
| WO2017027422A1 (en) | 2015-08-07 | 2017-02-16 | Alexo Therapeutics Inc. | Constructs having a sirp-alpha domain or variant thereof |
| NZ741324A (en) | 2015-09-21 | 2021-09-24 | Erasmus Univ Medical Center | Anti-cd47 antibodies and methods of use |
| JP7078533B2 (ja) | 2015-10-21 | 2022-05-31 | オーエスイー イムノセラピューティクス | 炎症促進性細胞へのマクロファージ分極を改変して癌を治療するための抗ＳＩＲＰａ化合物 |
| CN107149682B (zh) * | 2016-03-04 | 2022-01-04 | 复旦大学 | 一种靶向cd47的免疫检查点抑制剂药物组合物及其制备方法 |
| RS66062B1 (sr) | 2016-04-14 | 2024-11-29 | Ose Immunotherapeutics | Nova anti-sirpa antitela i njihove terapijske primene |
| AU2017250029C1 (en) * | 2016-04-15 | 2022-03-24 | Pfizer Inc. | Macrophage stimulation in CD47 blockade therapy |
| US20190135921A1 (en) * | 2016-05-19 | 2019-05-09 | Adaerata, Limited Partnership | Methods of preventing or treating slamf7 positive and slamf7 negative cancers |
| JP7241677B2 (ja) | 2016-07-19 | 2023-03-17 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗ｃｄ４７併用療法 |
| CA3042581A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Enhancement of cd47 blockade therapy by proteasome inhibitors |
| WO2018081898A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by hdac inhibitors |
| CN118027200A (zh) | 2016-12-09 | 2024-05-14 | 艾利妥 | 抗SIRPα抗体及其使用方法 |
| US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
| LT3565579T (lt) | 2017-01-05 | 2023-09-11 | Kahr Medical Ltd. | Pd1-41bbl sulietas baltymas ir jo panaudojimo būdai |
| PT3565828T (pt) | 2017-01-05 | 2022-02-08 | Kahr Medical Ltd | Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização |
| WO2018127918A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirp alpha-cd70 fusion protein and methods of use thereof |
| WO2019023347A1 (en) | 2017-07-26 | 2019-01-31 | Forty Seven, Inc. | ANTI-SIRP-ALPHA ANTIBODIES AND ASSOCIATED METHODS |
| JP7262440B2 (ja) | 2017-08-02 | 2023-04-21 | フェインズ セラピューティクス，インコーポレーテッド | 抗ｃｄ４７抗体及びその使用 |
| JP7395471B2 (ja) | 2017-10-13 | 2023-12-11 | オーセ イミュノセラピューティクス | 改変抗ＳＩＲＰａ抗体及びその使用 |
| US11771764B2 (en) | 2017-11-06 | 2023-10-03 | Pfizer Inc. | CD47 blockade with radiation therapy |
| CN108484774B (zh) * | 2018-03-09 | 2021-11-05 | 上海高菲生物科技有限公司 | 一种SIRPα融合蛋白及其制备方法和用途 |
| AU2019233577A1 (en) | 2018-03-13 | 2020-09-03 | Ose Immunotherapeutics | Use of anti-human SIRPa v1 antibodies and method for producing anti-SIRPa v1 antibodies |
| CN110386984B (zh) * | 2018-04-17 | 2022-04-22 | 杭州尚健生物技术有限公司 | 结合cd47蛋白的融合蛋白及其应用 |
| EP3802602A1 (en) | 2018-05-25 | 2021-04-14 | Alector LLC | Anti-sirpa antibodies and methods of use thereof |
| CN108872569A (zh) * | 2018-06-19 | 2018-11-23 | 浠思（上海）生物技术有限公司 | 利用HTRF一步法筛选CD47/SIRP alpha阻断剂的方法 |
| KR20250079073A (ko) | 2018-07-10 | 2025-06-04 | 고쿠리츠다이가쿠호진 고베다이가쿠 | 항 SIRPα 항체 |
| US12134638B2 (en) | 2018-07-11 | 2024-11-05 | Kahr Medical Ltd. | SIRPalpha-4-1BBL variant fusion protein and methods of use thereof |
| KR20210044221A (ko) | 2018-07-11 | 2021-04-22 | 카 메디컬 리미티드 | Pd1-4-1bbl 변이체 융합 단백질 및 이의 사용 방법 |
| WO2020047326A2 (en) * | 2018-08-31 | 2020-03-05 | ALX Oncology Inc. | Decoy polypeptides |
| US20220289821A1 (en) * | 2018-11-29 | 2022-09-15 | Trillium Therapeutics Inc | Biomarkers for cd47 blockade therapy |
| BR112021024003A2 (pt) | 2019-05-31 | 2022-04-19 | Alx Oncology Inc | Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico |
| AU2020394204A1 (en) | 2019-11-27 | 2022-06-02 | ALX Oncology Inc. | Combination therapies for treating cancer |
| WO2022034946A1 (ko) * | 2020-08-14 | 2022-02-17 | 한국과학기술연구원 | 항암활성을 갖는 면역조절 단백질-siRNA 복합체 |
| KR102398032B1 (ko) * | 2020-09-22 | 2022-05-19 | 비피진 주식회사 | 암 치료를 위한 5''-뉴클레오티다아제 변이체 |
| KR102557016B1 (ko) * | 2020-09-22 | 2023-07-20 | 비피진 주식회사 | 암 치료를 위한 cd47 바인더 및 리포좀 복합체 |
| WO2022130016A1 (en) | 2020-12-18 | 2022-06-23 | Instil Bio (Uk) Limited | Tumor infiltrating lymphocytes and anti-cd47 therapeutics |
| WO2022229818A1 (en) | 2021-04-27 | 2022-11-03 | Pf Argentum Ip Holdings Llc | Enhancement of cd47 blockade therapy with dhfr inhibitors |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
| BR112023025194A2 (pt) | 2021-06-04 | 2024-02-27 | Boehringer Ingelheim Int | Anticorpos anti-sirp-alfa |
| WO2023278778A1 (en) * | 2021-06-30 | 2023-01-05 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd47-sirpα therapeutic agent |
| AU2022322029A1 (en) * | 2021-08-05 | 2024-02-15 | Immunos Therapeutics Ag | Combination medicaments comprising hla fusion proteins |
| WO2023073580A1 (en) | 2021-10-29 | 2023-05-04 | Pfizer Inc. | Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy |
| US20250367255A1 (en) | 2021-11-08 | 2025-12-04 | Pfizer Inc. | Enhancement Of CD47 Blockade Therapy With Anti-VEGF Agents |
| JP2025518578A (ja) | 2022-05-25 | 2025-06-17 | ファイザー・インク | がんの処置のためのｓｉｒｐアルファ融合タンパク質の投薬レジメン |
| WO2024040151A1 (en) | 2022-08-18 | 2024-02-22 | Pfizer Inc. | Sirp alpha fusion protein and anti-cd38 antibody combination therapies |
| CN120390653A (zh) | 2022-12-09 | 2025-07-29 | 辉瑞大药厂 | Cd47阻断剂及抗bcma/抗cd3双特异性抗体的组合疗法 |
| WO2024124107A2 (en) | 2022-12-09 | 2024-06-13 | Pfizer Inc. | Cd47 blocking agent and anti-cd20 / anti-cd3 bispecific antibody combination therapy |
| EP4633652A2 (en) * | 2022-12-15 | 2025-10-22 | KaliVir Immunotherapeutics, Inc. | Compositions of cd47/sirp-alpha immune checkpoint inhibitors and uses thereof |
| CN116879560A (zh) * | 2023-05-23 | 2023-10-13 | 中山大学 | SIRPα抑制剂及SIRPα-Fc融合蛋白在制备治疗肿瘤的药物中的用途 |
| WO2026062544A1 (en) | 2024-09-23 | 2026-03-26 | Pfizer Inc. | Sirp alpha fusion protein formulation |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US6641809B1 (en) | 1990-03-26 | 2003-11-04 | Bristol-Myers Squibb Company | Method of regulating cellular processes mediated by B7 and CD28 |
| US5844095A (en) | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| EP0914452A2 (en) | 1996-06-17 | 1999-05-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel ptp20, pcp-2, bdp1, clk and sirp proteins and related products and methods |
| US6541615B1 (en) | 1996-11-15 | 2003-04-01 | Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. | SIRP proteins and uses thereof |
| CA2226962A1 (en) * | 1998-02-16 | 1999-08-16 | Marie Sarfati | Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| AU1701001A (en) | 1999-11-30 | 2001-06-12 | Eberhard-Karls-Universitat Tubingen Universitatsklinikum | Antibodies against signal regulator proteins |
| GB9930706D0 (en) | 1999-12-24 | 2000-02-16 | Medical Res Council | Composition for inhibiting macrophage activity |
| AU2002315052A1 (en) | 2001-05-15 | 2002-11-25 | Emory University | Polynucleotides and polypeptides relating to the modulation of sirp alpha-cd47 |
| EP1369128A1 (en) | 2002-06-07 | 2003-12-10 | Procorde GmbH | Inhibitors of glycoprotein VI and their therapeutic use |
| US20040213792A1 (en) | 2003-04-24 | 2004-10-28 | Clemmons David R. | Method for inhibiting cellular activation by insulin-like growth factor-1 |
| JP3936673B2 (ja) | 2003-06-02 | 2007-06-27 | 国立大学法人群馬大学 | Ｃｄ４７部分ペプチドと抗ｓｈｐｓ−１モノクロナール抗体 |
| JP4637749B2 (ja) * | 2003-11-11 | 2011-02-23 | 中外製薬株式会社 | ヒト化抗ｃｄ４７抗体 |
| JP2007008895A (ja) * | 2005-07-04 | 2007-01-18 | Chugai Pharmaceut Co Ltd | 抗ｃｄ４７抗体とインテグリンリガンドとの併用 |
| EP1910542B1 (en) * | 2005-07-22 | 2009-12-02 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
| US7514229B2 (en) | 2005-09-29 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and evaluating treatment of blood disorders |
| AU2007213709A1 (en) | 2006-02-08 | 2007-08-16 | Targeted Molecular Diagnostics, Llc | Bivalent ErbB ligand binding molecules and methods for their preparation and use |
| US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| US20100239578A1 (en) * | 2007-10-11 | 2010-09-23 | University Health Network | Modulation of sirp-alpha - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor |
| DE102007056623B3 (de) | 2007-11-23 | 2009-05-20 | Mtu Friedrichshafen Gmbh | Verfahren zur Regelung eines stationären Gasmotors |
| AU2009205665B2 (en) | 2008-01-15 | 2013-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
| CA2965198C (en) * | 2008-01-15 | 2021-02-16 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| US20110237498A1 (en) | 2008-12-19 | 2011-09-29 | Novartis Ag | Soluble polypeptides for use in treating autoimmune and inflammatory disorders |
| PL2995315T3 (pl) * | 2009-05-15 | 2024-04-22 | University Health Network | Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie sirp alfa-cd47 |
| HRP20221260T1 (hr) | 2010-05-14 | 2023-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Humanizirana i kimerna monoklonska protutijela za cd47 |
| KR102338833B1 (ko) | 2012-02-06 | 2021-12-13 | 인히브릭스, 인크. | Cd47 항체 및 그 사용 방법 |
| ES2914814T3 (es) | 2012-12-17 | 2022-06-16 | Pf Argentum Ip Holdings Llc | Tratamiento de células enfermas CD47+ con fusiones SIRP Alfa-Fc |
-
2010
- 2010-05-14 PL PL15160169.7T patent/PL2995315T3/pl unknown
- 2010-05-14 DK DK10774475.7T patent/DK2429574T3/da active
- 2010-05-14 JP JP2012510083A patent/JP6091891B2/ja active Active
- 2010-05-14 HR HRP20150553TT patent/HRP20150553T1/hr unknown
- 2010-05-14 FI FIEP15160169.7T patent/FI2995315T3/fi active
- 2010-05-14 WO PCT/CA2010/000743 patent/WO2010130053A1/en not_active Ceased
- 2010-05-14 HU HUE15160169A patent/HUE065432T2/hu unknown
- 2010-05-14 CN CN201710476053.4A patent/CN107252476A/zh active Pending
- 2010-05-14 CA CA2761438A patent/CA2761438C/en active Active
- 2010-05-14 CA CA2983972A patent/CA2983972C/en active Active
- 2010-05-14 EP EP23214532.6A patent/EP4311863A3/en active Pending
- 2010-05-14 PL PL10774475T patent/PL2429574T3/pl unknown
- 2010-05-14 AU AU2010246872A patent/AU2010246872B2/en active Active
- 2010-05-14 EP EP10774475.7A patent/EP2429574B1/en active Active
- 2010-05-14 DK DK15160169.7T patent/DK2995315T3/da active
- 2010-05-14 SI SI201032142T patent/SI2995315T1/sl unknown
- 2010-05-14 EP EP15160169.7A patent/EP2995315B1/en active Active
- 2010-05-14 CN CN2010800213987A patent/CN102596233A/zh active Pending
- 2010-05-14 PT PT107744757T patent/PT2429574E/pt unknown
- 2010-05-14 ES ES10774475.7T patent/ES2539141T3/es active Active
- 2010-05-14 ES ES15160169T patent/ES2973099T3/es active Active
- 2010-05-14 PT PT151601697T patent/PT2995315T/pt unknown
- 2010-05-14 HR HRP20240362TT patent/HRP20240362T1/hr unknown
- 2010-05-14 US US13/320,629 patent/US10907209B2/en active Active
- 2010-05-14 SI SI201030950T patent/SI2429574T1/sl unknown
-
2015
- 2015-08-17 JP JP2015160462A patent/JP6254124B2/ja active Active
-
2017
- 2017-11-14 JP JP2017218996A patent/JP6410911B2/ja active Active
-
2018
- 2018-08-30 US US16/118,038 patent/US20190093174A1/en not_active Abandoned
- 2018-09-25 JP JP2018178322A patent/JP2019011347A/ja active Pending
-
2020
- 2020-06-01 JP JP2020095230A patent/JP2020143146A/ja active Pending
-
2022
- 2022-09-20 JP JP2022148798A patent/JP2022180495A/ja active Pending
-
2023
- 2023-11-22 US US18/518,353 patent/US20240084399A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20150553T1 (hr) | Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju | |
| RU2755728C2 (ru) | Новый конъюгат аманитина | |
| US20220048972A1 (en) | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer | |
| EA200970515A1 (ru) | МОДИФИЦИРОВАННЫЕ РАСТВОРИМЫЕ СЛИТЫЕ КОНСТРУКЦИИ РЕЦЕПТОРА FGF И Fc С УЛУЧШЕННОЙ БИОЛОГИЧЕСКОЙ АКТИВНОСТЬЮ | |
| US9833500B2 (en) | Immunotherapy with binding agents | |
| FI2691417T4 (fi) | Vasta-aineen Fc-variantteja | |
| HRP20171301T1 (hr) | Antitumorske kombinacije koje sadrže citarabin i protutijela koja specifično prepoznaju cd38 | |
| BR112014029099A2 (pt) | anticorpos anti-egfr e seu uso para inibir ou atenuar crescimento de tumor, bem como composição farmacêutica que o compreende | |
| CL2013003634A1 (es) | Complejo que comprende una proteina de fusion que comprende, un peptido viral, peptido conector, microglobulina beta 2 , peptido conector, dominios extracelulares alfa 1, 2 y 3 de mhc de clase i y un tercer peptido conector; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso | |
| BR112013017002A2 (pt) | "proteínas mic não naturais, seu uso no tratamento de malignalidade ou infecção viral, bem como composição compreendendo as referidas proteínas" | |
| JP2012526729A5 (https=) | ||
| FI3389699T3 (fi) | Kimeerisiä ja humanisoituja humaaneja monoklonaalisia ctla4-vasta-aineita ja niiden käyttötapoja | |
| HRP20220214T1 (hr) | Imunomodulacijska sredstva | |
| CY1118979T1 (el) | Αντισωματα που κατευθυνονται εναντι her-3 και χρησεις αυτων | |
| RU2014147741A (ru) | Модифицированные области антител и их применение | |
| NZ737844A (en) | Vista regulatory t cell mediator protein, vista binding agents and use thereof | |
| MX2010002053A (es) | Composiciones de proteinas de fusion de notch humanizadas y metodos de tratamiento. | |
| HRP20130314T2 (hr) | Optimizirana antitijela usmjerena na cd19 | |
| UA117216C2 (uk) | Пухлиноасоційований пептид та його застосування | |
| HRP20170720T1 (hr) | Konjugat inzulina s fragmentom imunoglobulina | |
| ATE459653T1 (de) | Monoklonale anti-cd71-antikörper und deren verwendung zur behandlung maligner tumorzellen | |
| BR112014007382A2 (pt) | anticorpos anti-erbb3 e seus usos | |
| RU2015143057A (ru) | Гипергликозилированные связывающие полипептиды | |
| AU2013362789A8 (en) | Treatment of CD47+ disease cells with SIRP Alpha-Fc fusions | |
| DK2073842T3 (da) | Anvendelse af humane celler af myeloid leukæmioprindelse til ekspression af antistoffer. |