MX395142B - Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores. - Google Patents

Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores.

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Publication number
MX395142B
MX395142B MX2018013952A MX2018013952A MX395142B MX 395142 B MX395142 B MX 395142B MX 2018013952 A MX2018013952 A MX 2018013952A MX 2018013952 A MX2018013952 A MX 2018013952A MX 395142 B MX395142 B MX 395142B
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Mexico
Prior art keywords
tumor
cells
markers
infiltrating regulatory
marker
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MX2018013952A
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English (en)
Other versions
MX2018013952A (es
Inventor
Massimiliano Pagani
Sergio Abrignani
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Checkmab S R L
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Publication date
Application filed by Checkmab S R L filed Critical Checkmab S R L
Publication of MX2018013952A publication Critical patent/MX2018013952A/es
Publication of MX395142B publication Critical patent/MX395142B/es

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
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Abstract

La presente invención se refiere a un método in vitro para determinar el pronóstico de un individuo que tiene un tumor sólido seleccionado del grupo que consiste en: cáncer de pulmón de células no pequeñas, cáncer colorrectal, cáncer de mama, cáncer gástrico o una metástasis derivada de los mismo, dicho método comprende los pasos de: a) obtener una muestra biológica aislada que contiene células T reguladoras infiltrantes de tumores del individuo; b) detectar LAYN en la muestra; c) comparar el LAYN detectado con un control seleccionado de i) un patrón conocido de un individuo normal o de una población normal, o ii) de células T diferentes de células T reguladoras; y d) basada en la comparación determinar un pronóstico, una LAYN más alta en la muestra del individuo indica un mal pronóstico.
MX2018013952A 2016-05-16 2017-05-15 Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores. MX395142B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16169791 2016-05-16
EP16198724 2016-11-14
PCT/EP2017/061642 WO2017198631A1 (en) 2016-05-16 2017-05-15 Markers selectively deregulated in tumor-infiltrating regulatory t cells

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MX2018013952A MX2018013952A (es) 2019-06-24
MX395142B true MX395142B (es) 2025-03-25

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MX2022010703A MX2022010703A (es) 2016-05-16 2018-11-14 Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores.

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US (3) US20190391152A1 (es)
EP (2) EP4092045A1 (es)
JP (3) JP7358047B2 (es)
KR (1) KR102623927B1 (es)
CN (1) CN109715653A (es)
AU (1) AU2017266686B2 (es)
CA (1) CA3023980A1 (es)
ES (1) ES2922525T3 (es)
MX (2) MX395142B (es)
WO (1) WO2017198631A1 (es)

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EP3458473B1 (en) 2022-04-13
EP4092045A1 (en) 2022-11-23
JP2025172069A (ja) 2025-11-20
ES2922525T3 (es) 2022-09-16
US12247982B2 (en) 2025-03-11
BR112018073414A2 (pt) 2019-08-27
US20250251401A1 (en) 2025-08-07
US20190391152A1 (en) 2019-12-26
AU2017266686A1 (en) 2019-01-03
JP2019518452A (ja) 2019-07-04
JP7358047B2 (ja) 2023-10-10
WO2017198631A1 (en) 2017-11-23
JP2023113918A (ja) 2023-08-16
EP3458473A1 (en) 2019-03-27
MX2022010703A (es) 2022-09-27
MX2018013952A (es) 2019-06-24
KR102623927B1 (ko) 2024-01-12
KR20190006009A (ko) 2019-01-16
EP3458473B8 (en) 2022-08-17
AU2017266686B2 (en) 2023-03-09
US20230375555A1 (en) 2023-11-23
CA3023980A1 (en) 2017-11-23
US20260056201A9 (en) 2026-02-26
CN109715653A (zh) 2019-05-03

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