HRP20140611T1 - Inhibitori kinaze p70 s6 - Google Patents

Inhibitori kinaze p70 s6 Download PDF

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Publication number
HRP20140611T1
HRP20140611T1 HRP20140611AT HRP20140611T HRP20140611T1 HR P20140611 T1 HRP20140611 T1 HR P20140611T1 HR P20140611A T HRP20140611A T HR P20140611AT HR P20140611 T HRP20140611 T HR P20140611T HR P20140611 T1 HRP20140611 T1 HR P20140611T1
Authority
HR
Croatia
Prior art keywords
pharmaceutically acceptable
acceptable salt
compound according
intended
trifluoromethyl
Prior art date
Application number
HRP20140611AT
Other languages
English (en)
Croatian (hr)
Inventor
Robert Dean Dally
Jianping Huang
Sajan Joseph
Timothy Alan Shepherd
Christian L. Holst
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HRP20140611T1 publication Critical patent/HRP20140611T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HRP20140611AT 2007-05-11 2008-05-01 Inhibitori kinaze p70 s6 HRP20140611T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11
PCT/US2008/062143 WO2008140947A1 (en) 2007-05-11 2008-05-01 P70 s6 kinase inhibitors

Publications (1)

Publication Number Publication Date
HRP20140611T1 true HRP20140611T1 (hr) 2014-08-15

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20140611AT HRP20140611T1 (hr) 2007-05-11 2008-05-01 Inhibitori kinaze p70 s6

Country Status (33)

Country Link
US (2) US8093383B2 (OSRAM)
EP (1) EP2148880B1 (OSRAM)
JP (1) JP5503532B2 (OSRAM)
KR (1) KR101088219B1 (OSRAM)
CN (1) CN101679439B (OSRAM)
AR (1) AR066344A1 (OSRAM)
AU (1) AU2008251692B2 (OSRAM)
BR (1) BRPI0811212A2 (OSRAM)
CA (1) CA2687265C (OSRAM)
CL (1) CL2008001230A1 (OSRAM)
CO (1) CO6241109A2 (OSRAM)
CR (1) CR11106A (OSRAM)
DK (1) DK2148880T3 (OSRAM)
DO (1) DOP2009000257A (OSRAM)
EA (1) EA016445B1 (OSRAM)
EC (1) ECSP099721A (OSRAM)
ES (1) ES2483726T3 (OSRAM)
GT (1) GT200900292A (OSRAM)
HR (1) HRP20140611T1 (OSRAM)
IL (1) IL201564A (OSRAM)
MA (1) MA31433B1 (OSRAM)
MX (1) MX2009012075A (OSRAM)
MY (1) MY154898A (OSRAM)
NZ (1) NZ580423A (OSRAM)
PE (1) PE20090887A1 (OSRAM)
PL (1) PL2148880T3 (OSRAM)
PT (1) PT2148880E (OSRAM)
RS (1) RS53451B (OSRAM)
SI (1) SI2148880T1 (OSRAM)
TN (1) TN2009000446A1 (OSRAM)
TW (1) TWI423805B (OSRAM)
UA (1) UA99284C2 (OSRAM)
WO (1) WO2008140947A1 (OSRAM)

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ES2620119T3 (es) 2012-11-16 2017-06-27 Merck Patent Gmbh Derivados heterocíclicos novedosos como moduladores de la actividad de quinasa
JP6280130B2 (ja) * 2012-11-16 2018-02-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ キナーゼ活性のモジュレーターとしての新規イミダゾール−ピペリジニル誘導体
BR112015011974A8 (pt) 2012-11-29 2019-10-08 Merck Patent Gmbh derivados de azaquinazolina carboxamida, seus usos e processo para sua produção, medicamento e composição farmacêutica
MX370448B (es) * 2013-03-11 2019-12-13 Merck Patent Gmbh Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa.
CN105392499B (zh) 2013-04-17 2018-07-24 西格诺药品有限公司 用于治疗癌症的包含tor激酶抑制剂和胞苷类似物的组合疗法
WO2014172436A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
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Also Published As

Publication number Publication date
SI2148880T1 (sl) 2014-07-31
IL201564A0 (en) 2010-05-31
JP2010526814A (ja) 2010-08-05
DK2148880T3 (da) 2014-06-16
BRPI0811212A2 (pt) 2014-10-29
TN2009000446A1 (en) 2011-03-31
WO2008140947A1 (en) 2008-11-20
UA99284C2 (ru) 2012-08-10
PE20090887A1 (es) 2009-07-13
NZ580423A (en) 2012-02-24
AU2008251692A1 (en) 2008-11-20
MA31433B1 (fr) 2010-06-01
CA2687265C (en) 2012-12-04
MX2009012075A (es) 2009-11-19
CO6241109A2 (es) 2011-01-20
CN101679439A (zh) 2010-03-24
AR066344A1 (es) 2009-08-12
MY154898A (en) 2015-08-28
EA016445B1 (ru) 2012-05-30
ES2483726T3 (es) 2014-08-07
ECSP099721A (es) 2009-12-28
CL2008001230A1 (es) 2009-05-22
HK1140767A1 (en) 2010-10-22
CA2687265A1 (en) 2008-11-20
EA200971051A1 (ru) 2010-06-30
PL2148880T3 (pl) 2014-10-31
PT2148880E (pt) 2014-08-28
RS53451B (sr) 2014-12-31
EP2148880A1 (en) 2010-02-03
JP5503532B2 (ja) 2014-05-28
EP2148880B1 (en) 2014-05-28
DOP2009000257A (es) 2010-03-31
US20090163714A1 (en) 2009-06-25
US20120071490A1 (en) 2012-03-22
TWI423805B (zh) 2014-01-21
KR20100005710A (ko) 2010-01-15
GT200900292A (es) 2011-06-24
KR101088219B1 (ko) 2011-11-30
US8093383B2 (en) 2012-01-10
AU2008251692B2 (en) 2012-10-11
TW200848053A (en) 2008-12-16
CN101679439B (zh) 2013-09-11
CR11106A (es) 2010-04-12
IL201564A (en) 2014-08-31

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