HRP20140114T1 - Inhibitori kinaze 1 koji reguliraju signal apoptoze - Google Patents
Inhibitori kinaze 1 koji reguliraju signal apoptoze Download PDFInfo
- Publication number
- HRP20140114T1 HRP20140114T1 HRP20140114AT HRP20140114T HRP20140114T1 HR P20140114 T1 HRP20140114 T1 HR P20140114T1 HR P20140114A T HRP20140114A T HR P20140114AT HR P20140114 T HRP20140114 T HR P20140114T HR P20140114 T1 HRP20140114 T1 HR P20140114T1
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- Croatia
- Prior art keywords
- alkyl
- pyrrolo
- pyridin
- benzamide
- cycloalkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30086910P | 2010-02-03 | 2010-02-03 | |
| PCT/US2011/022137 WO2011097079A1 (en) | 2010-02-03 | 2011-01-21 | Apoptosis signal-regulating kinase 1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140114T1 true HRP20140114T1 (hr) | 2014-03-14 |
Family
ID=43645892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140114AT HRP20140114T1 (hr) | 2010-02-03 | 2011-01-21 | Inhibitori kinaze 1 koji reguliraju signal apoptoze |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8802695B2 (https=) |
| EP (1) | EP2531501B1 (https=) |
| JP (1) | JP5711270B2 (https=) |
| CN (1) | CN102834393B (https=) |
| CA (1) | CA2787360C (https=) |
| DK (1) | DK2531501T3 (https=) |
| ES (1) | ES2445917T3 (https=) |
| HR (1) | HRP20140114T1 (https=) |
| PL (1) | PL2531501T3 (https=) |
| PT (1) | PT2531501E (https=) |
| RS (1) | RS53176B (https=) |
| SI (1) | SI2531501T1 (https=) |
| SM (1) | SMT201400012B (https=) |
| WO (1) | WO2011097079A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| PL2531501T3 (pl) | 2010-02-03 | 2014-05-30 | Takeda Pharmaceuticals Co | Inhibitory kinazy 1 regulującej sygnał apoptotyczny |
| SI2588475T1 (sl) | 2010-07-02 | 2015-12-31 | Gilead Sciences, Inc. | Kinazni inhibitorji za regulacijo apoptoznega signala |
| EP2651417B1 (en) | 2010-12-16 | 2016-11-30 | Calchan Limited | Ask1 inhibiting pyrrolopyrimidine derivatives |
| CA2857374A1 (en) | 2011-09-02 | 2013-03-07 | The Trustees Of Columbia University In The City Of New York | Camkii, ip3r, calcineurin, p38 and mk2/3 inhibitors to treat metabolic disturbances of obesity |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| AU2013259737A1 (en) * | 2012-05-08 | 2014-10-02 | Lycera Corporation | Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease |
| SI3077047T1 (sl) * | 2013-12-04 | 2019-09-30 | Galmed Research & Development Ltd. | Soli aramchola |
| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| TW201618781A (zh) | 2014-08-13 | 2016-06-01 | 吉李德科學股份有限公司 | 治療肺高血壓之方法 |
| EP3197448B1 (en) | 2014-09-24 | 2019-04-24 | Gilead Sciences, Inc. | Methods of treating liver disease |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| TWI685491B (zh) | 2014-12-23 | 2020-02-21 | 美商基利科學股份有限公司 | 製備５-（４-環丙基-１ｈ-咪唑-１-基）-ｎ-（６-（４-異丙基-４ｈ-１,２,４-三唑-３-基）吡啶-２-基）-２-氟-４-甲基苯甲醯胺之方法 |
| US10849911B2 (en) | 2015-06-10 | 2020-12-01 | Galmed Research And Development Ltd. | Low dose compositions of Aramachol salts |
| WO2017169503A1 (ja) * | 2016-04-01 | 2017-10-05 | 国立大学法人 千葉大学 | 含窒素芳香族アミドの製造方法、ピロール・イミダゾールポリアミドの製造方法、及び化合物 |
| EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| MA45918A (fr) | 2016-08-15 | 2019-06-19 | Bayer Ag | Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides |
| TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
| TWI752155B (zh) | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| JOP20190221A1 (ar) | 2017-04-05 | 2019-09-23 | Seal Rock Therapeutics Inc | مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها |
| CN110869017B (zh) | 2017-05-12 | 2023-05-05 | 英安塔制药有限公司 | 细胞凋亡信号调节激酶1抑制剂及其使用方法 |
| WO2018218044A2 (en) * | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals Inc | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2018218051A1 (en) * | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10253018B2 (en) | 2017-05-25 | 2019-04-09 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| CN110770233B (zh) * | 2017-06-19 | 2022-07-26 | 广东东阳光药业有限公司 | 稠合双环类化合物及其在药物中的应用 |
| WO2019046186A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF |
| CN111801314B (zh) | 2018-01-02 | 2023-10-31 | 西尔洛克治疗公司 | Ask1抑制剂化合物及其用途 |
| EP3787621B1 (en) | 2018-05-02 | 2024-12-18 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2019213239A1 (en) | 2018-05-02 | 2019-11-07 | Enanta Pharmaceuticals Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| JP2021529186A (ja) * | 2018-07-03 | 2021-10-28 | ノバルティス アーゲー | Ｎｌｒｐ調節剤 |
| MX2021001783A (es) * | 2018-08-14 | 2021-08-11 | Biogen Ma Inc | Agentes inhibidores de ask1. |
| US10968199B2 (en) | 2018-08-22 | 2021-04-06 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020106707A1 (en) | 2018-11-19 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11466033B2 (en) | 2019-03-25 | 2022-10-11 | Enanta Pharmaceuticals, Inc. | Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors |
| MX2021013657A (es) * | 2019-05-10 | 2022-02-21 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco. |
| CN111808079A (zh) * | 2020-08-05 | 2020-10-23 | 中国药科大学 | 吲哚类ask1小分子抑制剂及其制备方法和应用 |
| US20240124444A1 (en) * | 2020-12-28 | 2024-04-18 | Celgene Corporation | Heterocyclic Compounds and Their Use for Parasitic Diseases |
| WO2024054749A2 (en) * | 2022-09-08 | 2024-03-14 | Bridge Medicines | Inhibitors of enl/af9 yeats and flt3 |
| CN115368352B (zh) * | 2022-10-25 | 2023-08-15 | 南京盛德瑞尔医药科技有限公司 | 一种葡萄糖激酶激动剂及其制备方法和应用 |
| CN117122288B (zh) * | 2023-09-08 | 2024-10-18 | 太原理工大学 | 基于锚定卷积网络的癫痫脑电信号预警方法及装置 |
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-
2011
- 2011-01-21 PL PL11701347T patent/PL2531501T3/pl unknown
- 2011-01-21 JP JP2012551994A patent/JP5711270B2/ja not_active Expired - Fee Related
- 2011-01-21 DK DK11701347.4T patent/DK2531501T3/en active
- 2011-01-21 US US13/577,182 patent/US8802695B2/en not_active Expired - Fee Related
- 2011-01-21 CA CA2787360A patent/CA2787360C/en not_active Expired - Fee Related
- 2011-01-21 ES ES11701347.4T patent/ES2445917T3/es active Active
- 2011-01-21 WO PCT/US2011/022137 patent/WO2011097079A1/en not_active Ceased
- 2011-01-21 HR HRP20140114AT patent/HRP20140114T1/hr unknown
- 2011-01-21 SI SI201130115T patent/SI2531501T1/sl unknown
- 2011-01-21 PT PT117013474T patent/PT2531501E/pt unknown
- 2011-01-21 RS RS20140066A patent/RS53176B/sr unknown
- 2011-01-21 EP EP11701347.4A patent/EP2531501B1/en active Active
- 2011-01-21 CN CN201180016037.8A patent/CN102834393B/zh not_active Expired - Fee Related
-
2014
- 2014-01-27 SM SM201400012T patent/SMT201400012B/xx unknown
- 2014-07-21 US US14/336,871 patent/US9403819B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2531501B1 (en) | 2013-11-20 |
| JP5711270B2 (ja) | 2015-04-30 |
| US8802695B2 (en) | 2014-08-12 |
| CA2787360C (en) | 2019-03-05 |
| PL2531501T3 (pl) | 2014-05-30 |
| CN102834393A (zh) | 2012-12-19 |
| SMT201400012B (it) | 2014-03-07 |
| WO2011097079A1 (en) | 2011-08-11 |
| CA2787360A1 (en) | 2011-08-11 |
| US9403819B2 (en) | 2016-08-02 |
| PT2531501E (pt) | 2014-02-17 |
| US20120316194A1 (en) | 2012-12-13 |
| SI2531501T1 (sl) | 2014-04-30 |
| EP2531501A1 (en) | 2012-12-12 |
| DK2531501T3 (en) | 2014-02-24 |
| JP2013518881A (ja) | 2013-05-23 |
| US20140329850A1 (en) | 2014-11-06 |
| CN102834393B (zh) | 2015-07-22 |
| ES2445917T3 (es) | 2014-03-06 |
| RS53176B (sr) | 2014-06-30 |
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