HRP20130918T1 - Derivati 4-aminopirimidina kao receptori antagonista histamina h4 - Google Patents

Derivati 4-aminopirimidina kao receptori antagonista histamina h4 Download PDF

Info

Publication number
HRP20130918T1
HRP20130918T1 HRP20130918AT HRP20130918T HRP20130918T1 HR P20130918 T1 HRP20130918 T1 HR P20130918T1 HR P20130918A T HRP20130918A T HR P20130918AT HR P20130918 T HRP20130918 T HR P20130918T HR P20130918 T1 HRP20130918 T1 HR P20130918T1
Authority
HR
Croatia
Prior art keywords
alkyl
group
substituted
formula
cycloalkyl
Prior art date
Application number
HRP20130918AT
Other languages
English (en)
Croatian (hr)
Inventor
Elena CARCELLER GONZÁLEZ
Eva María MEDINA FUENTES
Robert Soliva Soliva
Marina VIRGILI BERNADÓ
Josep MARTÍ VIA
Original Assignee
Palau Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palau Pharma S.A. filed Critical Palau Pharma S.A.
Publication of HRP20130918T1 publication Critical patent/HRP20130918T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20130918AT 2007-12-21 2008-12-18 Derivati 4-aminopirimidina kao receptori antagonista histamina h4 HRP20130918T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07382006 2007-12-21
US3153408P 2008-02-26 2008-02-26
PCT/EP2008/067950 WO2009080721A2 (en) 2007-12-21 2008-12-18 4 -aminopyrimidine derivatives as histamine h4 receptor antagonists

Publications (1)

Publication Number Publication Date
HRP20130918T1 true HRP20130918T1 (hr) 2013-11-08

Family

ID=39473347

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20130918AT HRP20130918T1 (hr) 2007-12-21 2008-12-18 Derivati 4-aminopirimidina kao receptori antagonista histamina h4

Country Status (24)

Country Link
US (1) US8431580B2 (enExample)
EP (1) EP2235012B1 (enExample)
JP (1) JP5498396B2 (enExample)
KR (1) KR101639819B1 (enExample)
CN (1) CN101903385B (enExample)
AR (1) AR069814A1 (enExample)
AU (1) AU2008341678B2 (enExample)
BR (1) BRPI0820779B8 (enExample)
CA (1) CA2709650C (enExample)
CL (1) CL2008003811A1 (enExample)
CY (1) CY1114427T1 (enExample)
DK (1) DK2235012T3 (enExample)
ES (1) ES2430210T3 (enExample)
HR (1) HRP20130918T1 (enExample)
IL (1) IL206413A (enExample)
PE (1) PE20091330A1 (enExample)
PL (1) PL2235012T3 (enExample)
PT (1) PT2235012E (enExample)
RU (1) RU2489430C2 (enExample)
SI (1) SI2235012T1 (enExample)
TW (1) TWI429440B (enExample)
UA (1) UA101963C2 (enExample)
WO (1) WO2009080721A2 (enExample)
ZA (1) ZA201005179B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
MY160526A (en) 2008-12-22 2017-03-15 Merck Patent Gmbh Novel polymorphic forms of 6-(1-methyl-1h-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2h-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
AU2010311378B2 (en) 2009-10-29 2014-04-24 Vectura Limited N-containing heteroaryl derivatives as JAK3 kinase inhibitors
PE20121505A1 (es) * 2009-12-23 2012-11-05 Medicis Pharmaceutical Corp Derivados de aminoalquilpirimidina como antagonistas del receptor h4 de histamina
US9688989B2 (en) 2012-06-08 2017-06-27 Sensorion H4 receptor inhibitors for treating tinnitus
ES2946551T3 (es) * 2017-10-17 2023-07-20 Palau Pharma S L U Síntesis de compuestos de 4-aminopirimidina
GB201817047D0 (en) 2018-10-19 2018-12-05 Heptares Therapeutics Ltd H4 antagonist compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361869C2 (ru) * 2002-02-05 2009-07-20 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Новые арил- и гетероарилпиперазины
EP1505064A1 (en) * 2003-08-05 2005-02-09 Bayer HealthCare AG 2-Aminopyrimidine derivatives
WO2005054239A1 (en) * 2003-12-05 2005-06-16 Bayer Healthcare Ag 2-aminopyrimidine derivatives
SMP200600024B (it) * 2003-12-15 2006-07-19 Almirall Prodesfarma Ag 2,6-Biseteroaril-4-amminopirimidine come antagonisti del recettore dell'adenosina
EP1888565B1 (en) * 2005-04-11 2011-03-23 Almirall, S.A. 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists
AU2006290715A1 (en) * 2005-09-13 2007-03-22 Palau Pharma, S.A. 2-aminopyrimidine derivatives as modulators of the histamine H4 receptor activity
WO2007084914A2 (en) * 2006-01-17 2007-07-26 Neurocrine Biosciences, Inc. Phenoxy-substituted pyrimidines as adenosine receptor antagonists

Also Published As

Publication number Publication date
CA2709650C (en) 2016-06-07
PL2235012T3 (pl) 2013-12-31
WO2009080721A3 (en) 2009-09-11
CY1114427T1 (el) 2016-08-31
JP5498396B2 (ja) 2014-05-21
DK2235012T3 (da) 2013-10-07
UA101963C2 (en) 2013-05-27
BRPI0820779A2 (pt) 2015-06-16
PT2235012E (pt) 2013-08-28
ZA201005179B (en) 2012-03-28
US20110039817A1 (en) 2011-02-17
EP2235012A2 (en) 2010-10-06
IL206413A (en) 2015-06-30
SI2235012T1 (sl) 2013-11-29
CN101903385B (zh) 2013-11-06
TWI429440B (zh) 2014-03-11
RU2010130418A (ru) 2012-01-27
TW200938197A (en) 2009-09-16
KR101639819B1 (ko) 2016-07-14
BRPI0820779B1 (pt) 2020-02-04
PE20091330A1 (es) 2009-09-07
WO2009080721A2 (en) 2009-07-02
AU2008341678B2 (en) 2013-03-21
CA2709650A1 (en) 2009-07-02
BRPI0820779B8 (pt) 2021-05-25
CN101903385A (zh) 2010-12-01
JP2011506566A (ja) 2011-03-03
KR20100096184A (ko) 2010-09-01
US8431580B2 (en) 2013-04-30
ES2430210T3 (es) 2013-11-19
HK1149003A1 (en) 2011-09-23
CL2008003811A1 (es) 2009-05-22
RU2489430C2 (ru) 2013-08-10
IL206413A0 (en) 2010-12-30
AR069814A1 (es) 2010-02-17
EP2235012B1 (en) 2013-07-17
AU2008341678A1 (en) 2009-07-02

Similar Documents

Publication Publication Date Title
HRP20130918T1 (hr) Derivati 4-aminopirimidina kao receptori antagonista histamina h4
CA2628131A1 (en) Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods
ES2549087T3 (es) Derivados de aminodihidrotiazina como inhibidores de BACE para el tratamiento de la enfermedad de Alzheimer
RU2011140064A (ru) Ингибиторы тирозинкиназы брутона
AR068057A1 (es) Esteres de 1-fenil-2-(3,5-dicloro)-piridina, metodo de preparacion de los mismos, composiciones farmaceuticas que los contienen y usos de los mismos para el tratamiento de enfermedades del tracto respiratorio.
JP2008222557A (ja) ピロロ［３，２−ｄ］ピリミジン誘導体及びこれを有効成分とする医薬組成物
HRP20230090T1 (hr) Heterociklički spojevi kao imunomodulatori
RU2010117156A (ru) Гетероциклические соединения в качестве антагонистов crth2 рецептора
RU2014141579A (ru) Гетероциклические соединения в качестве ингибиторов бета-лактамаз
RU2009123930A (ru) Химические соединения 637: пиридопиримидиндионы в качестве ингибиторов pde4
HRP20090673T1 (hr) Derivati kvinolina i njihova uporaba kao mikobakterijskih inhibitora
RU2014123434A (ru) Фармацевтические соединения
RU2010148570A (ru) Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
WO2001085730A1 (en) Pyrido' 1,2-alpha pyrazine and piperidine derivatives as ligands for the neuropeptide y y5 receptor
RU2012110246A (ru) Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
AR045955A1 (es) Compuestos benzoimidazolicos
RU2009102535A (ru) Производные карбамидов тропана, их получение и их применение в терапии
RU2015108898A (ru) 3-ЦИКЛОГЕКСЕНИЛ И ЦИКЛОГЕКСИЛ ЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ И ИНДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RORгаммаТ И ИХ ПРИМЕНЕНИЯ
RU2007108861A (ru) Трифтометилзамещенные бензамиды в качестве ингибиторов киназ
MX2010004819A (es) Derivados de [1h-pirazolo[3,4-b]piridin-4-il]-fenilo o piridin-2-ilo como proteina cinasa c-theta.
ATE550337T1 (de) Modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kappa-b-aktivität und deren verwendung
JP2015514063A5 (enExample)
JP2009538910A5 (enExample)
EA023824B1 (ru) ПРОИЗВОДНЫЕ 3,4-ДИГИДРОПИРРОЛО[1,2-a]ПИРАЗИН-1-ИЛАМИНА, ПРИГОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE)
JP2009534358A5 (enExample)