PT2235012E - Derivados de 4-aminopirimidina como antagonistas de receptor h4 de histamina - Google Patents
Derivados de 4-aminopirimidina como antagonistas de receptor h4 de histamina Download PDFInfo
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- PT2235012E PT2235012E PT88656038T PT08865603T PT2235012E PT 2235012 E PT2235012 E PT 2235012E PT 88656038 T PT88656038 T PT 88656038T PT 08865603 T PT08865603 T PT 08865603T PT 2235012 E PT2235012 E PT 2235012E
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- 150000005007 4-aminopyrimidines Chemical class 0.000 title description 3
- 229940119240 Histamine H4 receptor antagonist Drugs 0.000 title description 2
- 239000003396 histamine H4 receptor antagonist Substances 0.000 title description 2
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- 125000000217 alkyl group Chemical group 0.000 claims description 231
- 125000000623 heterocyclic group Chemical group 0.000 claims description 183
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 165
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 110
- 229910052736 halogen Inorganic materials 0.000 claims description 81
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- 238000000034 method Methods 0.000 claims description 69
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 59
- 125000003118 aryl group Chemical group 0.000 claims description 58
- 125000001424 substituent group Chemical group 0.000 claims description 58
- 125000005843 halogen group Chemical group 0.000 claims description 56
- 125000002619 bicyclic group Chemical group 0.000 claims description 54
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- 150000003839 salts Chemical class 0.000 claims description 47
- 229910052799 carbon Inorganic materials 0.000 claims description 45
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 42
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 41
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- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 claims description 30
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Landscapes
- Health & Medical Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07382006 | 2007-12-21 | ||
| US3153408P | 2008-02-26 | 2008-02-26 |
Publications (1)
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| PT2235012E true PT2235012E (pt) | 2013-08-28 |
Family
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| PT88656038T PT2235012E (pt) | 2007-12-21 | 2008-12-18 | Derivados de 4-aminopirimidina como antagonistas de receptor h4 de histamina |
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| PE (1) | PE20091330A1 (enExample) |
| PL (1) | PL2235012T3 (enExample) |
| PT (1) | PT2235012E (enExample) |
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| WO (1) | WO2009080721A2 (enExample) |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| MX2011006682A (es) | 2008-12-22 | 2011-07-13 | Merck Patent Gmbh | Nuevas formas polimorficas de dihidrogeno-fosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirim idin-2-il]-bencil}-2h-piridazin-3-ona y procesos para su preparacion. |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| AR078833A1 (es) | 2009-10-29 | 2011-12-07 | Palau Pharma Sa | Derivados de heteroarilos que contienen nitrogeno como inhibidores dela cinasa jak3 |
| AR079725A1 (es) * | 2009-12-23 | 2012-02-15 | Palau Pharma Sa | Derivados de aminoalquilpirimidina como antagonistas del receptor h4 |
| EP3378476A1 (en) | 2012-06-08 | 2018-09-26 | Sensorion | H4 receptor inhibitors for treating tinnitus |
| JP7274473B2 (ja) * | 2017-10-17 | 2023-05-16 | パラウ ファルマ，エス．エル．ユー． | ４－アミノピリミジン化合物の合成 |
| GB201817047D0 (en) | 2018-10-19 | 2018-12-05 | Heptares Therapeutics Ltd | H4 antagonist compounds |
Family Cites Families (7)
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| RU2361869C2 (ru) * | 2002-02-05 | 2009-07-20 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Новые арил- и гетероарилпиперазины |
| EP1505064A1 (en) * | 2003-08-05 | 2005-02-09 | Bayer HealthCare AG | 2-Aminopyrimidine derivatives |
| WO2005054239A1 (en) * | 2003-12-05 | 2005-06-16 | Bayer Healthcare Ag | 2-aminopyrimidine derivatives |
| US20080058356A1 (en) * | 2003-12-15 | 2008-03-06 | Neurocrine Biosciences, Inc. | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists |
| US20080275064A1 (en) * | 2005-04-11 | 2008-11-06 | Deborah Slee | Substituted Pyrimidines as Adenosine Receptor Antagonists |
| KR20080043840A (ko) * | 2005-09-13 | 2008-05-19 | 팔라우 파르마 에스에이 | 히스타민 ｈ4 수용체 활성의 조정자로서 2-아미노피리미딘유도체 |
| EP1976851A2 (en) * | 2006-01-17 | 2008-10-08 | Neurocrine Biosciences, Inc. | Phenoxy-substituted pyrimidines as adenosine receptor antagonists |
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2008
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- 2008-12-18 SI SI200831056T patent/SI2235012T1/sl unknown
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