DK2235012T3 - 4-Aminpyrimidinderivater som histamin H4-receptorantagonister - Google Patents

4-Aminpyrimidinderivater som histamin H4-receptorantagonister

Info

Publication number
DK2235012T3
DK2235012T3 DK08865603.8T DK08865603T DK2235012T3 DK 2235012 T3 DK2235012 T3 DK 2235012T3 DK 08865603 T DK08865603 T DK 08865603T DK 2235012 T3 DK2235012 T3 DK 2235012T3
Authority
DK
Denmark
Prior art keywords
histamine
receptor antagonists
pyrimidine derivatives
amine pyrimidine
amine
Prior art date
Application number
DK08865603.8T
Other languages
Danish (da)
English (en)
Inventor
Soliva Robert Soliva
Gonza Lez Elena Carceller
Fuentes Eva Mara A Medina
Bernado Marina Virgili
Via Josep Marta
Original Assignee
Palau Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palau Pharma Sa filed Critical Palau Pharma Sa
Application granted granted Critical
Publication of DK2235012T3 publication Critical patent/DK2235012T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK08865603.8T 2007-12-21 2008-12-18 4-Aminpyrimidinderivater som histamin H4-receptorantagonister DK2235012T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07382006 2007-12-21
US3153408P 2008-02-26 2008-02-26
PCT/EP2008/067950 WO2009080721A2 (en) 2007-12-21 2008-12-18 4 -aminopyrimidine derivatives as histamine h4 receptor antagonists

Publications (1)

Publication Number Publication Date
DK2235012T3 true DK2235012T3 (da) 2013-10-07

Family

ID=39473347

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08865603.8T DK2235012T3 (da) 2007-12-21 2008-12-18 4-Aminpyrimidinderivater som histamin H4-receptorantagonister

Country Status (24)

Country Link
US (1) US8431580B2 (enExample)
EP (1) EP2235012B1 (enExample)
JP (1) JP5498396B2 (enExample)
KR (1) KR101639819B1 (enExample)
CN (1) CN101903385B (enExample)
AR (1) AR069814A1 (enExample)
AU (1) AU2008341678B2 (enExample)
BR (1) BRPI0820779B8 (enExample)
CA (1) CA2709650C (enExample)
CL (1) CL2008003811A1 (enExample)
CY (1) CY1114427T1 (enExample)
DK (1) DK2235012T3 (enExample)
ES (1) ES2430210T3 (enExample)
HR (1) HRP20130918T1 (enExample)
IL (1) IL206413A (enExample)
PE (1) PE20091330A1 (enExample)
PL (1) PL2235012T3 (enExample)
PT (1) PT2235012E (enExample)
RU (1) RU2489430C2 (enExample)
SI (1) SI2235012T1 (enExample)
TW (1) TWI429440B (enExample)
UA (1) UA101963C2 (enExample)
WO (1) WO2009080721A2 (enExample)
ZA (1) ZA201005179B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
EA019320B1 (ru) 2008-12-22 2014-02-28 Мерк Патент Гмбх Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
JP5759471B2 (ja) 2009-10-29 2015-08-05 ヴェクチュラ リミテッド Ｊａｋ３キナーゼ阻害剤としての窒素含有ヘテロアリール誘導体
JP5781537B2 (ja) * 2009-12-23 2015-09-24 メディシス ファーマシューティカル コーポレイション ヒスタミンｈ４受容体アンタゴニストとしてのアミノアルキルピリミジン誘導体
HUE039713T2 (hu) 2012-06-08 2019-02-28 Sensorion H4 receptor inhibitorok tinnitus kezelésére
ES2946551T3 (es) 2017-10-17 2023-07-20 Palau Pharma S L U Síntesis de compuestos de 4-aminopirimidina
GB201817047D0 (en) 2018-10-19 2018-12-05 Heptares Therapeutics Ltd H4 antagonist compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361869C2 (ru) * 2002-02-05 2009-07-20 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Новые арил- и гетероарилпиперазины
EP1505064A1 (en) * 2003-08-05 2005-02-09 Bayer HealthCare AG 2-Aminopyrimidine derivatives
WO2005054239A1 (en) * 2003-12-05 2005-06-16 Bayer Healthcare Ag 2-aminopyrimidine derivatives
CA2551944A1 (en) * 2003-12-15 2005-06-30 Almirall Prodesfarma Ag 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists
DE602006020864D1 (de) * 2005-04-11 2011-05-05 Almirall Sa 2, 6-di-(hetero-)aryl-4-amido-pyrimidine als adenosin-rezeptor-antagonisten
US20090306038A1 (en) * 2005-09-13 2009-12-10 Carceller Gonzalez Elena 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity
WO2007084914A2 (en) * 2006-01-17 2007-07-26 Neurocrine Biosciences, Inc. Phenoxy-substituted pyrimidines as adenosine receptor antagonists

Also Published As

Publication number Publication date
CN101903385B (zh) 2013-11-06
PE20091330A1 (es) 2009-09-07
IL206413A (en) 2015-06-30
WO2009080721A2 (en) 2009-07-02
JP2011506566A (ja) 2011-03-03
PT2235012E (pt) 2013-08-28
CL2008003811A1 (es) 2009-05-22
US8431580B2 (en) 2013-04-30
KR101639819B1 (ko) 2016-07-14
EP2235012B1 (en) 2013-07-17
ZA201005179B (en) 2012-03-28
BRPI0820779A2 (pt) 2015-06-16
AU2008341678A1 (en) 2009-07-02
CA2709650A1 (en) 2009-07-02
WO2009080721A3 (en) 2009-09-11
TW200938197A (en) 2009-09-16
JP5498396B2 (ja) 2014-05-21
UA101963C2 (en) 2013-05-27
TWI429440B (zh) 2014-03-11
SI2235012T1 (sl) 2013-11-29
PL2235012T3 (pl) 2013-12-31
KR20100096184A (ko) 2010-09-01
AU2008341678B2 (en) 2013-03-21
BRPI0820779B8 (pt) 2021-05-25
EP2235012A2 (en) 2010-10-06
CA2709650C (en) 2016-06-07
RU2010130418A (ru) 2012-01-27
CY1114427T1 (el) 2016-08-31
ES2430210T3 (es) 2013-11-19
HRP20130918T1 (hr) 2013-11-08
BRPI0820779B1 (pt) 2020-02-04
US20110039817A1 (en) 2011-02-17
RU2489430C2 (ru) 2013-08-10
HK1149003A1 (en) 2011-09-23
CN101903385A (zh) 2010-12-01
IL206413A0 (en) 2010-12-30
AR069814A1 (es) 2010-02-17

Similar Documents

Publication Publication Date Title
DK2007752T3 (da) Benzimidazol-2-yl-pyrimidiner og -pyraziner som modulatorer af histamin H4-receptoren
IL206413A0 (en) 4-aminopyrimidine derivatives as histamine h4 receptor antagonists
DK2094709T3 (da) Thiazol-pyrazolopyrimidiner som CRF1-receptorantagonister
IL205665A0 (en) Heteroaryl derivatives as orexin receptor antagonists
DK2089382T3 (da) Substituerede diazepan-forbindelser som orexin-receptor-antagonister
ZA200800320B (en) Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists
DK2004654T3 (da) Pyrazolopyrimidin derivater til anvendelse som kinase antagonister
DK2401270T3 (da) Pyrazolderivater anvendt som CCR4-receptorantagonister.
IL192310A0 (en) Substituted aniline derivatives useful as histamine h3 antagonists
DK2401269T3 (da) Indolderivater som crth2-receptorantagonister
DK1951660T3 (da) Histamin-3-receptorantagonister
IL201112A0 (en) Thiazolidine derivatives as orexin receptor antagonists
IL202657A0 (en) Imidazole derivatives as ccr2 receptor antagonists
BRPI0910118A2 (pt) antagonistas de receptores do glucagon
ES2465673T9 (es) Derivados de pirimidina
ZA200610416B (en) Indole derivatives as histamine receptor antagonists
IL208355A0 (en) Heterocyclic copmpounds as adenosine receptor antagonist
DK2170831T3 (da) Benzazepin-derivater egnede som vasopressin-antagonister
BRPI0920496A2 (pt) derivados substituídos de pirimidina etriazina
DK2398780T3 (da) Cyclopropylamidderivater, som er målrettet mod histamin H3-receptoren
IL192308A0 (en) Oxazoloisoquinoline derivatives as thrombin receptor antagonists
BRPI0720078A2 (pt) 2-aminoquinolinas como antagonistas de receptores de 5-ht(5a)
DK1943242T3 (da) Piperidin-4-yl-pyridazin-3-ylamin-derivater som hurtigt opløsende antagonister af dopamin-2-receptorer
DK2148873T3 (da) 4-alkoxypyridazinderivater som hurtigt dissocierende dopamin 2- receptorantagonister
EP2516420B8 (en) Aminoalkylpyrimidine derivatives as histamine h4 receptor antagonists