HRP20120030T1 - [(1h-indol-5-il)-heteroariloksi]-(1-aza-biciklo[3.3.1] nonani kao kolinergički ligandi od n-achr za liječenje psihotičkih i neurodegenerativnih poremećaja - Google Patents
[(1h-indol-5-il)-heteroariloksi]-(1-aza-biciklo[3.3.1] nonani kao kolinergički ligandi od n-achr za liječenje psihotičkih i neurodegenerativnih poremećaja Download PDFInfo
- Publication number
- HRP20120030T1 HRP20120030T1 HR20120030T HRP20120030T HRP20120030T1 HR P20120030 T1 HRP20120030 T1 HR P20120030T1 HR 20120030 T HR20120030 T HR 20120030T HR P20120030 T HRP20120030 T HR P20120030T HR P20120030 T1 HRP20120030 T1 HR P20120030T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- aza
- indol
- formula
- bicyclo
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 title claims 3
- FMEHIMDNLRASDU-UHFFFAOYSA-N 1-azabicyclo[3.3.1]nonane Chemical class C1CCN2CCCC1C2 FMEHIMDNLRASDU-UHFFFAOYSA-N 0.000 title 1
- -1 1h- indol- 5 -yl Chemical group 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 31
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 239000002253 acid Substances 0.000 claims abstract 7
- 239000012458 free base Substances 0.000 claims abstract 7
- GGFORAABWCDWAK-KDOFPFPSSA-N 5-[6-[[(4s,5r)-1-azabicyclo[3.3.1]nonan-4-yl]oxy]pyridazin-3-yl]-1,3-dihydroindol-2-one Chemical compound C1=C2NC(=O)CC2=CC(C2=CC=C(N=N2)O[C@H]2CCN3CCC[C@@]2(C3)[H])=C1 GGFORAABWCDWAK-KDOFPFPSSA-N 0.000 claims abstract 3
- LEUQBJWNAXGICB-APWZRJJASA-N 5-[2-[[(4s,5r)-1-azabicyclo[3.3.1]nonan-4-yl]oxy]pyrimidin-5-yl]-1h-indole Chemical compound C1=C2NC=CC2=CC(C2=CN=C(N=C2)O[C@H]2CCN3CCC[C@@]2(C3)[H])=C1 LEUQBJWNAXGICB-APWZRJJASA-N 0.000 claims abstract 2
- HAHGPGNZEBCTCN-APWZRJJASA-N 5-[6-[[(4s,5r)-1-azabicyclo[3.3.1]nonan-4-yl]oxy]pyridazin-3-yl]-1h-indole Chemical compound C1=C2NC=CC2=CC(C2=CC=C(N=N2)O[C@H]2CCN3CCC[C@@]2(C3)[H])=C1 HAHGPGNZEBCTCN-APWZRJJASA-N 0.000 claims abstract 2
- LFDMNNLPIWWHBW-QUCCMNQESA-N 5-[6-[[(4s,5r)-1-azabicyclo[3.3.1]nonan-4-yl]oxy]pyridin-3-yl]-1h-indole Chemical compound C1=C2NC=CC2=CC(C2=CC=C(N=C2)O[C@H]2CCN3CCC[C@@]2(C3)[H])=C1 LFDMNNLPIWWHBW-QUCCMNQESA-N 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 claims 4
- HEDDSROUHOVUPD-KDOFPFPSSA-N 5-[2-[[(4s,5r)-1-azabicyclo[3.3.1]nonan-4-yl]oxy]pyrimidin-5-yl]-1,3-dihydroindol-2-one Chemical compound C1=C2NC(=O)CC2=CC(C2=CN=C(N=C2)O[C@H]2CCN3CCC[C@@]2(C3)[H])=C1 HEDDSROUHOVUPD-KDOFPFPSSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- MIMZWDOBVBBLPH-UTKZUKDTSA-N 5-[5-[[(4s,5r)-1-azabicyclo[3.3.1]nonan-4-yl]oxy]pyridin-2-yl]-1h-indole Chemical compound C1=C2NC=CC2=CC(C2=CC=C(C=N2)O[C@H]2CCN3CCC[C@@]2(C3)[H])=C1 MIMZWDOBVBBLPH-UTKZUKDTSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0525672.2A GB0525672D0 (en) | 2005-12-16 | 2005-12-16 | Organic compounds |
PCT/EP2006/012023 WO2007068476A1 (fr) | 2005-12-16 | 2006-12-14 | [ (1h- indol- 5 -yl) -heteroaryloxy] - (1-aza-bicyclo [3.3.1] nonanes utilises en tant que ligands cholinergiques de n-achr pour le traitement des troubles psychotiques et neurodegeneratifs. |
Publications (1)
Publication Number | Publication Date |
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HRP20120030T1 true HRP20120030T1 (hr) | 2012-02-29 |
Family
ID=35736290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120030T HRP20120030T1 (hr) | 2005-12-16 | 2012-01-10 | [(1h-indol-5-il)-heteroariloksi]-(1-aza-biciklo[3.3.1] nonani kao kolinergički ligandi od n-achr za liječenje psihotičkih i neurodegenerativnih poremećaja |
Country Status (35)
Country | Link |
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US (4) | US7713976B2 (fr) |
EP (2) | EP1966209B1 (fr) |
JP (1) | JP5230441B2 (fr) |
KR (2) | KR101174943B1 (fr) |
CN (1) | CN101331132B (fr) |
AR (1) | AR058348A1 (fr) |
AT (1) | ATE529427T1 (fr) |
AU (1) | AU2006326258B2 (fr) |
BR (1) | BRPI0619888A2 (fr) |
CA (1) | CA2631654C (fr) |
CR (1) | CR10056A (fr) |
CY (1) | CY1112708T1 (fr) |
DK (1) | DK1966209T3 (fr) |
EC (1) | ECSP088541A (fr) |
ES (1) | ES2375847T3 (fr) |
GB (1) | GB0525672D0 (fr) |
HK (1) | HK1121444A1 (fr) |
HR (1) | HRP20120030T1 (fr) |
IL (1) | IL191841A (fr) |
JO (1) | JO2734B1 (fr) |
MA (1) | MA30027B1 (fr) |
MY (1) | MY145627A (fr) |
NO (1) | NO20082937L (fr) |
NZ (1) | NZ569013A (fr) |
PE (1) | PE20070750A1 (fr) |
PL (1) | PL1966209T3 (fr) |
PT (1) | PT1966209E (fr) |
RU (1) | RU2471797C2 (fr) |
SA (1) | SA06270445B1 (fr) |
SI (1) | SI1966209T1 (fr) |
TN (1) | TNSN08260A1 (fr) |
TW (1) | TWI423965B (fr) |
UA (1) | UA94725C2 (fr) |
WO (1) | WO2007068476A1 (fr) |
ZA (1) | ZA200804628B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6262265A (ja) * | 1985-09-13 | 1987-03-18 | Hitachi Ltd | 復水器自動検査補修システム |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
GB0521508D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525672D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
TWI403320B (zh) * | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制bcl蛋白和結合夥伴間之交互作用的化合物及方法 |
CN102573842A (zh) * | 2009-07-23 | 2012-07-11 | 诺瓦提斯公司 | 氮杂双环烷基衍生物或吡咯烷-2-酮衍生物的用途 |
JO3250B1 (ar) * | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
MX2012007031A (es) * | 2009-12-17 | 2012-07-04 | Abbott Lab | Indoles e indolinas fusionadas al anillo amina de cabeza de puente utiles para tratar transtornos neurodegenerativos y neuropsiquiatricos. |
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