CR10056A - [(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos - Google Patents

[(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos

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Publication number
CR10056A
CR10056A CR10056A CR10056A CR10056A CR 10056 A CR10056 A CR 10056A CR 10056 A CR10056 A CR 10056A CR 10056 A CR10056 A CR 10056A CR 10056 A CR10056 A CR 10056A
Authority
CR
Costa Rica
Prior art keywords
aza
treatment
neurodegenerative disorders
piscotic
heteroariloxi
Prior art date
Application number
CR10056A
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English (en)
Inventor
Feuerbach Dominik
Frederiksen Mathias
Hurth Konstanze
Lucien Roy Bernard
Wagner Bratrix
Original Assignee
Novartis Ag
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35736290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR10056(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR10056A publication Critical patent/CR10056A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

La presente invención se refiere a derivados de 1-aza-biciclo-alquilo de la Fórmula (I): en donde los sustituyentes son como se definen en la memoria descriptiva, y a los proceso para su producción, a composiciones farmacéuticas que los comprenden y a su uso en la fabricación de un medicamento para el tratamiento y/o demora del progreso de trastornos piscóticos y neurodegenerativos.
CR10056A 2005-12-16 2008-06-09 [(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos CR10056A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0525672.2A GB0525672D0 (en) 2005-12-16 2005-12-16 Organic compounds

Publications (1)

Publication Number Publication Date
CR10056A true CR10056A (es) 2008-08-27

Family

ID=35736290

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10056A CR10056A (es) 2005-12-16 2008-06-09 [(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos

Country Status (35)

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US (4) US7713976B2 (es)
EP (2) EP1966209B1 (es)
JP (1) JP5230441B2 (es)
KR (2) KR20120018383A (es)
CN (1) CN101331132B (es)
AR (1) AR058348A1 (es)
AT (1) ATE529427T1 (es)
AU (1) AU2006326258B2 (es)
BR (1) BRPI0619888A2 (es)
CA (1) CA2631654C (es)
CR (1) CR10056A (es)
CY (1) CY1112708T1 (es)
DK (1) DK1966209T3 (es)
EC (1) ECSP088541A (es)
ES (1) ES2375847T3 (es)
GB (1) GB0525672D0 (es)
HK (1) HK1121444A1 (es)
HR (1) HRP20120030T1 (es)
IL (1) IL191841A (es)
JO (1) JO2734B1 (es)
MA (1) MA30027B1 (es)
MY (1) MY145627A (es)
NO (1) NO20082937L (es)
NZ (1) NZ569013A (es)
PE (1) PE20070750A1 (es)
PL (1) PL1966209T3 (es)
PT (1) PT1966209E (es)
RU (1) RU2471797C2 (es)
SA (1) SA06270445B1 (es)
SI (1) SI1966209T1 (es)
TN (1) TNSN08260A1 (es)
TW (1) TWI423965B (es)
UA (1) UA94725C2 (es)
WO (1) WO2007068476A1 (es)
ZA (1) ZA200804628B (es)

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GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
TWI403320B (zh) 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
US20120157464A1 (en) 2009-07-23 2012-06-21 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
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JP2014503568A (ja) 2011-01-27 2014-02-13 ノバルティス アーゲー ニコチン酸アセチルコリン受容体α７活性化因子の使用
CA2830458A1 (en) * 2011-03-18 2012-09-27 Novartis Ag Combinations of alpha 7 nicotinic acetylcholine receptor activators and mglur5 antagonists for use in dopamine induced dyskinesia in parkinson's disease
EP2768507B1 (en) 2011-10-20 2019-12-11 Novartis AG Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
KR102043309B1 (ko) 2012-12-11 2019-11-11 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 활성화제 치료에 대한 반응성의 예측 바이오마커
BR112015016995B8 (pt) 2013-01-15 2022-07-26 Novartis Ag Uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
WO2014111751A1 (en) 2013-01-15 2014-07-24 Novartis Ag Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy
BR112015016992A8 (pt) 2013-01-15 2018-01-23 Novartis Ag uso de agonistas do receptor alfa 7 nicotínico de acetilcolina

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