ECSP12012065A - Derivados de pirazina y su uso en el tratamiento de trastornos neurológicos - Google Patents
Derivados de pirazina y su uso en el tratamiento de trastornos neurológicosInfo
- Publication number
- ECSP12012065A ECSP12012065A ECSP12012065A ECSP12012065A EC SP12012065 A ECSP12012065 A EC SP12012065A EC SP12012065 A ECSP12012065 A EC SP12012065A EC SP12012065 A ECSP12012065 A EC SP12012065A
- Authority
- EC
- Ecuador
- Prior art keywords
- pirazina
- derivatives
- treatment
- neurological disorders
- medicaments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La invención se refiere a novedosos compuestos heterocíclicos de la fórmula (I) en donde todas las variables son como se definen en la memoria descriptiva, en forma libre o en forma de sal, a su preparación, a su uso médico, y a medicamentos que los comprenden.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29172409P | 2009-12-31 | 2009-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP12012065A true ECSP12012065A (es) | 2012-08-31 |
Family
ID=43598456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP12012065 ECSP12012065A (es) | 2009-12-31 | 2012-07-25 | Derivados de pirazina y su uso en el tratamiento de trastornos neurológicos |
Country Status (27)
Country | Link |
---|---|
US (2) | US20120277244A1 (es) |
EP (1) | EP2519515B1 (es) |
JP (1) | JP5600754B2 (es) |
KR (1) | KR101419157B1 (es) |
CN (1) | CN102712621B (es) |
AU (1) | AU2010338365B2 (es) |
BR (1) | BR112012015916A2 (es) |
CA (1) | CA2785341A1 (es) |
CL (1) | CL2012001762A1 (es) |
CR (1) | CR20120332A (es) |
CU (1) | CU20120099A7 (es) |
EA (1) | EA201200952A1 (es) |
EC (1) | ECSP12012065A (es) |
ES (1) | ES2445536T3 (es) |
GT (1) | GT201200219A (es) |
HK (1) | HK1172023A1 (es) |
HN (1) | HN2012001413A (es) |
IL (1) | IL220268A0 (es) |
MX (1) | MX2012007754A (es) |
NZ (1) | NZ600136A (es) |
PE (1) | PE20121640A1 (es) |
PL (1) | PL2519515T3 (es) |
PT (1) | PT2519515E (es) |
SG (1) | SG181431A1 (es) |
TN (1) | TN2012000249A1 (es) |
WO (1) | WO2011080176A1 (es) |
ZA (1) | ZA201203614B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101052122B1 (ko) | 2005-10-25 | 2011-07-26 | 시오노기세야쿠 가부시키가이샤 | 아미노디히드로티아진 유도체 |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
AU2008245082B8 (en) | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
WO2010047372A1 (ja) | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Bace1阻害活性を有する2-アミノピリミジン-4-オンおよび2-アミノピリジン誘導体 |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
EP2511268B2 (en) | 2009-12-11 | 2021-02-17 | Shionogi & Co., Ltd. | Oxazine derivative |
KR101730937B1 (ko) | 2010-06-09 | 2017-04-27 | 얀센 파마슈티카 엔.브이. | 베타-세크레타아제(bace) 저해제로 유용한 5,6-디하이드로-2h-[1,4]옥사진-3-일-아민 유도체 |
MX2012014382A (es) * | 2010-06-09 | 2013-01-29 | Janssen Pharmaceutica Nv | Derivados de 5-amino-3, 6-dihidro-1h-pirazin-2-ona utiles como inhibidores de beta-secretasa (bace). |
BR112012033291A2 (pt) * | 2010-06-28 | 2016-11-22 | Janssen Pharmaceutica Nv | derivados de 3-amino-5,6-di-hidro-1h-piranzin-2-ona úteis para o tratamento de doença de alzheimer e outras formas de demência |
CN103261199A (zh) | 2010-10-29 | 2013-08-21 | 盐野义制药株式会社 | 萘啶衍生物 |
JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
EA022409B1 (ru) | 2010-12-22 | 2015-12-30 | Янссен Фармацевтика Нв | Производные 5,6-дигидроимидазо[1,2-а]пиразин-8-иламина, пригодные в качестве ингибиторов бета-секретазы (васе) |
US8524897B2 (en) | 2011-01-12 | 2013-09-03 | Novartis Ag | Crystalline oxazine derivative |
WO2012095521A1 (en) * | 2011-01-13 | 2012-07-19 | Novartis Ag | Bace-2 inhibitors for the treatment of metabolic disorders |
EP2663561B1 (en) | 2011-01-13 | 2016-03-16 | Novartis AG | Novel heterocyclic derivatives and their use in the treatment of neurological disorders |
HUE026338T2 (en) | 2011-03-01 | 2016-05-30 | Janssen Pharmaceutica Nv | Beta-secretase (BACE) inhibitors 6,7-dihydro-pyrazolo [1,5-a] pyrazin-4-ylamine derivatives |
AU2012224632B2 (en) | 2011-03-09 | 2016-06-16 | Janssen Pharmaceutica Nv | 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (BACE) |
WO2012138590A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
EP2694489B1 (en) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
MX2013011947A (es) | 2011-04-13 | 2014-01-16 | Merck Sharp & Dohme | Iminotiazinas 5-sustituidas y sus monoxidos y dioxidos como inhibidores de la enzima que encinde la proteina precursora amiloide en el sitio beta, composiciones y su uso. |
WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
AU2012298983A1 (en) | 2011-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as BACE inhibitors, compositions and their use |
US8338413B1 (en) | 2012-03-07 | 2012-12-25 | Novartis Ag | Oxazine derivatives and their use in the treatment of neurological disorders |
US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
CN104870000A (zh) | 2012-12-20 | 2015-08-26 | 默沙东公司 | 作为bace抑制剂的c5,c6氧杂环稠合的亚胺基噻嗪二氧化物化合物,组合物及其用途 |
KR102243133B1 (ko) | 2013-06-12 | 2021-04-22 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-6,7-디하이드로[1,2,3]트리아졸로[1,5-a]피라진 유도체 |
US9834559B2 (en) | 2013-06-12 | 2017-12-05 | Janssen Pharmaceutica Nv | 4-Amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2H)-one derivatives as inhibitors of beta-secretase (BACE) |
ES2697684T3 (es) | 2013-06-12 | 2019-01-25 | Janssen Pharmaceutica Nv | Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5 a]pirazina como inhibidores de beta-secretasa (BACE) |
KR20170095881A (ko) | 2014-12-18 | 2017-08-23 | 얀센 파마슈티카 엔.브이. | 베타―세크레타제의 2,3,4,5―테트라히드로피리딘―6―아민 및 3,4―디히드로―2h―피롤―5―아민 화합물 억제제 |
CN107011134B (zh) * | 2017-04-28 | 2021-02-05 | 浙江中欣氟材股份有限公司 | 一种2-氟-5-溴苯乙酮的合成方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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NL6911868A (es) | 1968-08-31 | 1970-03-03 | ||
AUPQ319899A0 (en) * | 1999-10-01 | 1999-10-28 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds |
CA2436487A1 (en) * | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd. | Methods of inhibiting kinases |
CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
US7728025B2 (en) | 2003-12-29 | 2010-06-01 | Banyu Pharmaceutical Co., Ltd. | 2-heteroaryl-substituted benzimidazole derivative |
US20050215884A1 (en) * | 2004-02-27 | 2005-09-29 | Greicius Michael D | Evaluation of Alzheimer's disease using an independent component analysis of an individual's resting-state functional MRI |
KR101052122B1 (ko) * | 2005-10-25 | 2011-07-26 | 시오노기세야쿠 가부시키가이샤 | 아미노디히드로티아진 유도체 |
HUE032640T2 (en) * | 2005-11-08 | 2017-10-30 | Vertex Pharma | Heterocyclic modulator of ATP-binding cassette transcripts |
WO2008079933A2 (en) * | 2006-12-22 | 2008-07-03 | Novartis Ag | Heteroaryl-heteroaryl compounds as cdk inhibitors for the treatment of cancer, inflammation and viral infections |
CN101910143B (zh) | 2008-01-18 | 2013-08-21 | 卫材R&D管理有限公司 | 稠合的氨基二氢噻嗪衍生物 |
WO2010047372A1 (ja) | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Bace1阻害活性を有する2-アミノピリミジン-4-オンおよび2-アミノピリジン誘導体 |
AR077328A1 (es) * | 2009-07-24 | 2011-08-17 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos |
MX2012014382A (es) * | 2010-06-09 | 2013-01-29 | Janssen Pharmaceutica Nv | Derivados de 5-amino-3, 6-dihidro-1h-pirazin-2-ona utiles como inhibidores de beta-secretasa (bace). |
BR112012033291A2 (pt) * | 2010-06-28 | 2016-11-22 | Janssen Pharmaceutica Nv | derivados de 3-amino-5,6-di-hidro-1h-piranzin-2-ona úteis para o tratamento de doença de alzheimer e outras formas de demência |
-
2010
- 2010-12-22 SG SG2012036935A patent/SG181431A1/en unknown
- 2010-12-22 CN CN201080060047.7A patent/CN102712621B/zh not_active Expired - Fee Related
- 2010-12-22 US US13/518,907 patent/US20120277244A1/en not_active Abandoned
- 2010-12-22 BR BR112012015916A patent/BR112012015916A2/pt not_active IP Right Cessation
- 2010-12-22 KR KR1020127019872A patent/KR101419157B1/ko not_active IP Right Cessation
- 2010-12-22 WO PCT/EP2010/070502 patent/WO2011080176A1/en active Application Filing
- 2010-12-22 EP EP20100796064 patent/EP2519515B1/en active Active
- 2010-12-22 PL PL10796064T patent/PL2519515T3/pl unknown
- 2010-12-22 ES ES10796064T patent/ES2445536T3/es active Active
- 2010-12-22 CA CA 2785341 patent/CA2785341A1/en not_active Abandoned
- 2010-12-22 AU AU2010338365A patent/AU2010338365B2/en not_active Ceased
- 2010-12-22 EA EA201200952A patent/EA201200952A1/ru unknown
- 2010-12-22 PT PT10796064T patent/PT2519515E/pt unknown
- 2010-12-22 MX MX2012007754A patent/MX2012007754A/es active IP Right Grant
- 2010-12-22 NZ NZ60013610A patent/NZ600136A/xx not_active IP Right Cessation
- 2010-12-22 PE PE2012000897A patent/PE20121640A1/es not_active Application Discontinuation
- 2010-12-22 JP JP2012546418A patent/JP5600754B2/ja not_active Expired - Fee Related
-
2012
- 2012-05-17 ZA ZA2012/03614A patent/ZA201203614B/en unknown
- 2012-05-22 TN TNP2012000249A patent/TN2012000249A1/en unknown
- 2012-06-07 IL IL220268A patent/IL220268A0/en unknown
- 2012-06-19 CR CR20120332A patent/CR20120332A/es unknown
- 2012-06-25 CU CU20120099A patent/CU20120099A7/es unknown
- 2012-06-27 CL CL2012001762A patent/CL2012001762A1/es unknown
- 2012-06-28 GT GT201200219A patent/GT201200219A/es unknown
- 2012-06-28 HN HN2012001413A patent/HN2012001413A/es unknown
- 2012-07-25 EC ECSP12012065 patent/ECSP12012065A/es unknown
- 2012-12-12 HK HK12112853A patent/HK1172023A1/xx not_active IP Right Cessation
-
2015
- 2015-07-21 US US14/805,446 patent/US20150322038A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2519515B1 (en) | 2013-11-06 |
CN102712621A (zh) | 2012-10-03 |
WO2011080176A1 (en) | 2011-07-07 |
KR101419157B1 (ko) | 2014-07-11 |
SG181431A1 (en) | 2012-07-30 |
NZ600136A (en) | 2013-09-27 |
CR20120332A (es) | 2012-07-12 |
CA2785341A1 (en) | 2011-07-07 |
MX2012007754A (es) | 2012-08-01 |
EP2519515A1 (en) | 2012-11-07 |
PT2519515E (pt) | 2014-02-17 |
ZA201203614B (en) | 2013-01-30 |
US20150322038A1 (en) | 2015-11-12 |
PL2519515T3 (pl) | 2014-04-30 |
PE20121640A1 (es) | 2012-12-17 |
AU2010338365B2 (en) | 2014-01-30 |
HK1172023A1 (en) | 2013-04-12 |
IL220268A0 (en) | 2012-07-31 |
CL2012001762A1 (es) | 2012-12-21 |
HN2012001413A (es) | 2015-03-23 |
TN2012000249A1 (en) | 2013-12-12 |
EA201200952A1 (ru) | 2013-02-28 |
ES2445536T3 (es) | 2014-03-03 |
JP5600754B2 (ja) | 2014-10-01 |
JP2013516395A (ja) | 2013-05-13 |
GT201200219A (es) | 2013-10-10 |
BR112012015916A2 (pt) | 2017-04-25 |
US20120277244A1 (en) | 2012-11-01 |
AU2010338365A1 (en) | 2012-06-07 |
CU20120099A7 (es) | 2012-07-31 |
KR20120102795A (ko) | 2012-09-18 |
CN102712621B (zh) | 2015-03-11 |
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