HRP20110007T1 - Smanjivanje potencijalnih jatrogenskih rizika povezanih s cjepivima protiv gripe - Google Patents
Smanjivanje potencijalnih jatrogenskih rizika povezanih s cjepivima protiv gripe Download PDFInfo
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- HRP20110007T1 HRP20110007T1 HR20110007T HRP20110007T HRP20110007T1 HR P20110007 T1 HRP20110007 T1 HR P20110007T1 HR 20110007 T HR20110007 T HR 20110007T HR P20110007 T HRP20110007 T HR P20110007T HR P20110007 T1 HRP20110007 T1 HR P20110007T1
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- 229960003971 influenza vaccine Drugs 0.000 title claims 2
- 230000003247 decreasing effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 13
- 229960005486 vaccine Drugs 0.000 claims abstract 12
- 244000052769 pathogen Species 0.000 claims abstract 5
- 238000012360 testing method Methods 0.000 claims abstract 3
- 241000700605 Viruses Species 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 239000012678 infectious agent Substances 0.000 claims 3
- 241000711904 Pneumoviridae Species 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 241001466953 Echovirus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 241000712045 Morbillivirus Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000711902 Pneumovirus Species 0.000 claims 1
- 241000702247 Reoviridae Species 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000710799 Rubella virus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 230000000984 immunochemical effect Effects 0.000 claims 1
- 229940031551 inactivated vaccine Drugs 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 229940124590 live attenuated vaccine Drugs 0.000 claims 1
- 229940023012 live-attenuated vaccine Drugs 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229940031346 monovalent vaccine Drugs 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 238000000751 protein extraction Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 229940031626 subunit vaccine Drugs 0.000 claims 1
- 229960000172 trivalent influenza vaccine Drugs 0.000 claims 1
- 229940031418 trivalent vaccine Drugs 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 210000003501 vero cell Anatomy 0.000 abstract 1
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Abstract
Postupak za pripremanje cjepiva protiv gripe iz virusa gripe izraslog u kulturi MDCK stanične linije, koji sadrži stupanj u kojem se uzgojeni virus i/ili cjepivo i/ili kultura testira na prisutnost infekcijskog agensa koji može rasti u navedenoj staničnoj liniji, ali koji ne raste u embriju kokošjih jaja, naznačen time, da je navedeni infekcijski agens jedan ili više od sljedećih patogena: Reoviridae kod sisavaca; Pneumoviridae; Pneumovirusi od Pneumoviridae; Morbillivirusi iz familije Paramyxoviridae; Echovirusi od Enterovirusa iz familije Picornaviridae ; ili Rotavirus. Patent sadrži još 11 patentnih zahtjeva.
Claims (12)
1. Postupak za pripremanje cjepiva protiv gripe iz virusa gripe izraslog u kulturi MDCK stanične linije, koji sadrži stupanj u kojem se uzgojeni virus i/ili cjepivo i/ili kultura testira na prisutnost infekcijskog agensa koji može rasti u navedenoj staničnoj liniji, ali koji ne raste u embriju kokošjih jaja, naznačen time, da je navedeni infekcijski agens jedan ili više od sljedećih patogena: Reoviridae kod sisavaca; Pneumoviridae; Pneumovirusi od Pneumoviridae; Morbillivirusi iz familije Paramyxoviridae; Echovirusi od Enterovirusa iz familije Picornaviridae ; ili Rotavirus.
2. Postupak prema patentnom zahtjevu 1, naznačen time, da infekcijski agens jest jedan ili više od sljedećih patogena: respiratorni sincicijski virus (RSV); virus rubeole.
3. Postupak prema patentnom zahtjevu 1, naznačen time, da nadalje sadrži jedan ili više od sljedećih stupnjeva: stupanj inaktivacije; stupanj miješanja tri virusna soja da se napravi trovalentno cjepivo; stupanj formuliranja cjepiva za injektiranje; stupanj združivanja cjepiva s adjuvansom; stupanj mjerenja sadržaja HA; stupanj podešavanja sadržaja HA, na pr. razrjeđivanjem; stupanj dodavanja konzervansa; stupanj odstranjivanja rezidualnih nukleinskih kiselina koje pripadaju stanici domaćina.
4. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da se kultura testira imunokemijskom detekcijom; testovima inokulacije stanične kulture i/ili detekcijom nukleinske kiseline.
5. Postupak prema patentnom zahtjevu 4, naznačen time, da se detekcija provodi metodom ELISA i/ili PCR.
6. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da se testiranje provodi kod jednog od sljedećih stupnjeva: virusna infekcija, stadiji rasta, prikupljanje virusa, procesuiranje virusa, razdvajanje, ekstrakcija membranskih proteina, formuliranje cjepiva, pakiranje cjepiva.
7. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da cjepivo jest živo atenuirano cjepivo.
8. Postupak prema bilo kojem od patentnih zahtjeva 1-6, naznačen time, da cjepivo jest inaktivirano cjepivo.
9. Postupak prema patentnom zahtjevu 8, naznačen time, da cjepivo jest cjelostanično, fragmentirano ili subjunitno cjepivo.
10. Postupak prema bilo kojem od patentnih zahtjeva 1 do 9, naznačen time, da cjepivo jest trovalentno cjepivo protiv gripe.
11. Postupak prema bilo kojem od patentnih zahtjeva 1 do 9, naznačen time, da cjepivo jest monovalentno cjepivo protiv pandemijske gripe.
12. Postupak prema patentnom zahtjevu 11, naznačen time, da cjepivo uključuje soj H5 ili H7 virusa gripe.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04255471 | 2004-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110007T1 true HRP20110007T1 (hr) | 2011-04-30 |
Family
ID=35520177
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100673T HRP20100673T1 (hr) | 2004-09-09 | 2010-12-06 | Smanjivanje potencijalnih jatrogenskih rizika povezanih s cjepivima protiv gripe |
| HR20110007T HRP20110007T1 (hr) | 2004-09-09 | 2011-01-05 | Smanjivanje potencijalnih jatrogenskih rizika povezanih s cjepivima protiv gripe |
| HRP20120640TT HRP20120640T1 (hr) | 2004-09-09 | 2012-08-07 | Smanjenje potencijalnih jatrogenih rizika vezanih uz cjepiva protiv gripe |
| HRP20130962TT HRP20130962T1 (hr) | 2004-09-09 | 2013-10-10 | Smanjenje potencijalnih iatrogenih rizika povezanih sa antigenima cjepiva |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100673T HRP20100673T1 (hr) | 2004-09-09 | 2010-12-06 | Smanjivanje potencijalnih jatrogenskih rizika povezanih s cjepivima protiv gripe |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120640TT HRP20120640T1 (hr) | 2004-09-09 | 2012-08-07 | Smanjenje potencijalnih jatrogenih rizika vezanih uz cjepiva protiv gripe |
| HRP20130962TT HRP20130962T1 (hr) | 2004-09-09 | 2013-10-10 | Smanjenje potencijalnih iatrogenih rizika povezanih sa antigenima cjepiva |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US8119337B2 (hr) |
| EP (5) | EP2179744B1 (hr) |
| JP (7) | JP2008512443A (hr) |
| AT (2) | ATE489965T1 (hr) |
| CA (2) | CA2890962A1 (hr) |
| CY (3) | CY1111180T1 (hr) |
| DE (3) | DE602005025170D1 (hr) |
| DK (4) | DK2236155T3 (hr) |
| ES (4) | ES2386272T3 (hr) |
| HK (2) | HK1105364A1 (hr) |
| HR (4) | HRP20100673T1 (hr) |
| PL (4) | PL2179744T3 (hr) |
| PT (4) | PT2179744E (hr) |
| RS (3) | RS51721B (hr) |
| SI (4) | SI2179744T1 (hr) |
| WO (1) | WO2006027698A1 (hr) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2179744T3 (pl) | 2004-09-09 | 2011-09-30 | Novartis Ag | Zmniejszanie potencjału zagrożeń działaniami jatrogennymi związanymi ze szczepionkami przeciwko grypie |
| ES2310062B1 (es) | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| WO2007052163A2 (en) * | 2005-11-01 | 2007-05-10 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment |
| BRPI0618254A2 (pt) | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
| NZ567978A (en) | 2005-11-04 | 2011-09-30 | Novartis Vaccines & Diagnostic | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| US10842867B2 (en) | 2005-11-04 | 2020-11-24 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| AU2006310337B9 (en) | 2005-11-04 | 2013-11-28 | Novartis Ag | Adjuvanted influenza vaccines including cytokine-inducing agents |
| ATE539765T1 (de) | 2005-11-04 | 2012-01-15 | Novartis Vaccines & Diagnostic | Grippeimpfstoffe mit kombinationen aus teilchenförmigen adjuvantien und immunverstärkern |
| EP1976559B3 (en) | 2006-01-27 | 2020-02-19 | Seqirus UK Limited | Influenza vaccines containing hemagglutinin and matrix proteins |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| CN101472941B (zh) | 2006-03-31 | 2017-08-08 | 沃弗-威斯康星校友研究基金会 | 用于疫苗的高滴度重组流感病毒 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| CA3016948A1 (en) * | 2006-09-11 | 2008-03-20 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| WO2008059018A2 (en) * | 2006-11-15 | 2008-05-22 | Intervet International B.V. | Vaccine for vaccinating felines and canines against influenza virus |
| EA200900784A1 (ru) | 2006-12-06 | 2009-12-30 | Новартис Аг | Вакцины, включающие антиген из четырех штаммов вируса гриппа |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| EP2185191B1 (en) | 2007-06-27 | 2012-09-12 | Novartis AG | Low-additive influenza vaccines |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| EP2889042A3 (en) | 2008-03-18 | 2015-10-14 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
| US20110217330A1 (en) | 2008-11-05 | 2011-09-08 | Bruno Rene Andre | Novel method |
| WO2010092477A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
| ES2608841T3 (es) | 2009-02-10 | 2017-04-17 | Seqirus UK Limited | Vacunas contra la gripe con cantidades reducidas de escualeno |
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