HRP20090488T1 - Postupak za pripravu (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-il(1s,23)-3-[[(4-aminofenil)sulfonil](izobutil)amino]-1-benzil-2-hidroksipropilkarbamata - Google Patents

Postupak za pripravu (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-il(1s,23)-3-[[(4-aminofenil)sulfonil](izobutil)amino]-1-benzil-2-hidroksipropilkarbamata

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Publication number
HRP20090488T1
HRP20090488T1 HR20090488T HRP20090488T HRP20090488T1 HR P20090488 T1 HRP20090488 T1 HR P20090488T1 HR 20090488 T HR20090488 T HR 20090488T HR P20090488 T HRP20090488 T HR P20090488T HR P20090488 T1 HRP20090488 T1 HR P20090488T1
Authority
HR
Croatia
Prior art keywords
amino
isobutyl
hydroxypropylcarbamate
hexahydrofuro
aminophenyl
Prior art date
Application number
HR20090488T
Other languages
English (en)
Inventor
Martha Felix Goyvaerts Nicolaas
Tom Bert Paul Wigerinck Piet
Burghard Zinser Hartmut
M. Ebert Birgit
Original Assignee
Tibotec Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34740665&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20090488(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharmaceuticals Ltd. filed Critical Tibotec Pharmaceuticals Ltd.
Publication of HRP20090488T1 publication Critical patent/HRP20090488T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Postupak za pripravu spoja formule (6) te njegovih adicijskih soli, polimorfnih i/ili pseudopolimorfnih oblika, naznačen time da spomenuti postupak sadrži korake: (i) uvođenje izobutilamino skupine u spoju formule (1'); kako bi se dobio spoj formule (2'); (ii) uvođenje p-nitrofenilsulfonil skupine u spoj formule (2') kako bi se dobio spoj formule (3'); (iii) reduciranje nitro dijela spoja formule (3') kako bi se dobio spoj formule (4'); (iv) micanje zaštite sa spoja formule (4') kako bi se dobio spoj formule (5) sparivanje spoja formule (5) sa (3R, 3aS, 6aR)-heksahidrofuro[2,3-b]furan-3-il derivatom dobivenim aktivacijom (3R, 3aS, 6aR)-heksahidrofuro[2, 3-b] furan-3-ol ili njegovih prethodnika karbamolacijom sa sparujućim agensom kako bi se dobio spoj formule (6) gdje je spomenuti prethodnik (3R, 3aS, 6aR)-heksahidrofuro[2, 3-b] furan-3-ola sadrži spojeve u kojima je kisik alkoholne funkcionalne skupine zaštićen zaštitnim skupinama kisika, izabranim iz t-butil etera, acetata, benzil skupina, benzil etera, alila, silil zaštitnih skupina, alkoksialkil skupina tetrahidropiranil. Patent sadrži još 13 patentnih zahtjeva.
HR20090488T 2003-12-23 2009-09-15 Postupak za pripravu (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-il(1s,23)-3-[[(4-aminofenil)sulfonil](izobutil)amino]-1-benzil-2-hidroksipropilkarbamata HRP20090488T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03104949 2003-12-23
US56818304P 2004-05-04 2004-05-04
PCT/EP2004/053692 WO2005063770A1 (en) 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate

Publications (1)

Publication Number Publication Date
HRP20090488T1 true HRP20090488T1 (hr) 2009-10-31

Family

ID=34740665

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090488T HRP20090488T1 (hr) 2003-12-23 2009-09-15 Postupak za pripravu (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-il(1s,23)-3-[[(4-aminofenil)sulfonil](izobutil)amino]-1-benzil-2-hidroksipropilkarbamata

Country Status (21)

Country Link
EP (1) EP1725566B1 (hr)
KR (1) KR101192859B1 (hr)
CN (1) CN1898248B (hr)
AT (1) ATE433982T1 (hr)
AU (1) AU2004309122B2 (hr)
BR (1) BRPI0417272B8 (hr)
CA (1) CA2549460C (hr)
CY (1) CY1109379T1 (hr)
DE (1) DE602004021640D1 (hr)
DK (1) DK1725566T3 (hr)
ES (1) ES2328701T3 (hr)
HR (1) HRP20090488T1 (hr)
IL (1) IL174960A (hr)
MX (1) MXPA06007211A (hr)
NO (1) NO337636B1 (hr)
PL (1) PL1725566T3 (hr)
PT (1) PT1725566E (hr)
RU (1) RU2376308C2 (hr)
SI (1) SI1725566T1 (hr)
WO (1) WO2005063770A1 (hr)
ZA (1) ZA200605163B (hr)

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* Cited by examiner, † Cited by third party
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TWI432438B (zh) 2005-11-28 2014-04-01 Tibotec Pharm Ltd 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物及衍生物
ME01232B (me) * 2006-11-09 2013-06-20 Tibotec Pharm Ltd Etode za dobivanje heksahidrofuro[2,3-b]furan-3-ola
RU2009143867A (ru) 2007-04-27 2011-06-10 Тиботек Фармасьютикалз Лтд. (Ie) Способы получения производных n-изобутил-n-(2-гидрокси-3-амино-4-фенилбутил)-пара-нитробензолсульфониламида
EP2217548A1 (en) * 2007-10-26 2010-08-18 Concert Pharmaceuticals Inc. Deuterated darunavir
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
TWI482775B (zh) * 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
EP2426124B1 (en) * 2009-05-13 2013-08-07 Meiji Seika Pharma Co., Ltd. Process for producing pyripyropene derivative
SI2477992T1 (sl) 2009-09-17 2017-05-31 Mylan Laboratories Limited Postopki za pripravo darunavirja in njega amorfne oblike
WO2011083287A2 (en) 2010-01-05 2011-07-14 Cipla Limited Darunavir polymorph and process for preparation thereof
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
CN102584844B (zh) * 2011-01-11 2016-04-13 浙江九洲药业股份有限公司 一种达芦那韦晶型及其制备方法
EP2877474B1 (en) 2012-07-24 2020-11-04 Laurus Labs Limited A process for preparation of darunavir
CN103893178B (zh) * 2014-03-19 2016-06-01 中山大学 苯-磺酰胺类化合物在制备抗hiv-1病毒药物中的应用
US20160075643A1 (en) * 2014-09-16 2016-03-17 Zcl Chemicals Limited Novel process to prepare intermediates of hiv-protease inhibitors thereof
US10633390B2 (en) * 2015-06-25 2020-04-28 Msn Laboratories Private Limited Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
EP3532478B1 (en) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
KR102506813B1 (ko) 2016-11-17 2023-03-06 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 간소화된 다루나비르 제조 절차
CN117142989A (zh) * 2020-12-30 2023-12-01 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体a的生长方法和所得晶体
CN113896658A (zh) * 2021-09-24 2022-01-07 上药康丽（常州）药业有限公司 一种利用微通道反应器合成地瑞那韦中间体的方法

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WO1996022287A1 (en) 1995-01-20 1996-07-25 G.D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
KR100411856B1 (ko) 1995-02-03 2004-05-20 카네카 코포레이션 α-할로케톤,α-할로히드린및에폭사이드의제조법
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
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EA009590B1 (ru) 2001-05-11 2008-02-28 Тиботек Фармасьютикалз Лтд. 2-аминобензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра
EP1466896A4 (en) * 2001-12-28 2005-01-26 Ajinomoto Kk PROCESS FOR PRODUCING A CRYSTAL OF A BENZENESULFONAMIDE DERIVATIVE, AND A NEW CRYSTAL OF AN INTERMEDIATE PRODUCT OF SAID DERIVATIVE AND METHOD FOR PRODUCING THE SAME

Also Published As

Publication number Publication date
CA2549460C (en) 2014-08-05
DE602004021640D1 (de) 2009-07-30
ATE433982T1 (de) 2009-07-15
RU2376308C2 (ru) 2009-12-20
EP1725566A1 (en) 2006-11-29
CY1109379T1 (el) 2014-07-02
BRPI0417272B8 (pt) 2021-05-25
PL1725566T3 (pl) 2009-11-30
CN1898248B (zh) 2011-08-17
AU2004309122A1 (en) 2005-07-14
MXPA06007211A (es) 2006-08-18
BRPI0417272A (pt) 2007-03-27
NO337636B1 (no) 2016-05-23
ES2328701T3 (es) 2009-11-17
AU2004309122B2 (en) 2011-07-21
RU2006126670A (ru) 2008-01-27
EP1725566B1 (en) 2009-06-17
NO20063401L (no) 2006-07-21
ZA200605163B (en) 2007-12-27
BRPI0417272B1 (pt) 2020-08-18
WO2005063770A1 (en) 2005-07-14
PT1725566E (pt) 2009-09-16
KR20060123740A (ko) 2006-12-04
DK1725566T3 (da) 2009-10-05
CN1898248A (zh) 2007-01-17
IL174960A (en) 2011-06-30
IL174960A0 (en) 2006-08-20
KR101192859B1 (ko) 2012-10-19
SI1725566T1 (sl) 2009-12-31
CA2549460A1 (en) 2005-07-14

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