HRP20050737A2 - Arylcycloalkyl derivatives with branched side chains as ppar receptor modulators, method for their production and their use as medicaments - Google Patents
Arylcycloalkyl derivatives with branched side chains as ppar receptor modulators, method for their production and their use as medicamentsInfo
- Publication number
- HRP20050737A2 HRP20050737A2 HR20050737A HRP20050737A HRP20050737A2 HR P20050737 A2 HRP20050737 A2 HR P20050737A2 HR 20050737 A HR20050737 A HR 20050737A HR P20050737 A HRP20050737 A HR P20050737A HR P20050737 A2 HRP20050737 A2 HR P20050737A2
- Authority
- HR
- Croatia
- Prior art keywords
- production
- branched side
- medicaments
- side chains
- receptor modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Izum se odnosi na arilcikloalkilne derivate s razgranatim bočnim lancima, kao i na njihove fiziološki podnošljive soli i fiziološki funkcionalne derivate. Opisani su spojevi formule (I),u kojoj skupine imaju značenja definirana u opisu, te njihove fiziološki podnošljive soli i postupci za njihovu proizvodnju. Ovi spojevi su prikladni npr. za liječenje i/ili prevenciju poremećaja metabolizma masnekiseline i poremećaja trošenja glukoze, kao i poremećaja u kojima ulogu ima inzulinska rezistencija.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10308352A DE10308352A1 (de) | 2003-02-27 | 2003-02-27 | Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
PCT/EP2004/001583 WO2004076402A1 (de) | 2003-02-27 | 2004-02-19 | Arylcycloalkylderivate mit verzweigten seitenketten als ppar rezeptor modulatoren, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20050737A2 true HRP20050737A2 (en) | 2006-07-31 |
Family
ID=32841932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20050737A HRP20050737A2 (en) | 2003-02-27 | 2005-08-26 | Arylcycloalkyl derivatives with branched side chains as ppar receptor modulators, method for their production and their use as medicaments |
Country Status (22)
Country | Link |
---|---|
US (1) | US7220876B2 (hr) |
EP (1) | EP1601643B1 (hr) |
JP (1) | JP2006519196A (hr) |
KR (1) | KR20050113195A (hr) |
CN (1) | CN100417641C (hr) |
AR (1) | AR043429A1 (hr) |
AT (1) | ATE503740T1 (hr) |
AU (1) | AU2004215675B2 (hr) |
BR (1) | BRPI0407858A (hr) |
CA (1) | CA2516626A1 (hr) |
CO (1) | CO5690543A2 (hr) |
DE (2) | DE10308352A1 (hr) |
HR (1) | HRP20050737A2 (hr) |
MA (1) | MA27740A1 (hr) |
MX (1) | MXPA05009054A (hr) |
NO (1) | NO20054380L (hr) |
PE (1) | PE20040957A1 (hr) |
PL (1) | PL377736A1 (hr) |
RU (1) | RU2005130004A (hr) |
TW (1) | TW200505831A (hr) |
WO (1) | WO2004076402A1 (hr) |
ZA (1) | ZA200505762B (hr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7399777B2 (en) * | 2001-08-31 | 2008-07-15 | Sanofi-Aventis Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals |
BRPI0515015A (pt) | 2004-08-11 | 2008-07-01 | Kyorin Seiyaku Kk | derivado cìclico de ácido aminobenzóico; medicamento; agonista ppar(alpha); agonista duplo ppar(alpha), y; agonista duplo ppar(alpha), (delta); modulador ppar; agente lipìdeo; agente profilático ou terapêutico compreendendo pelo menos um dos derivados cìclicos de ácido aminobenzóico ou sal do mesmo farmacêuticamente aceitável |
CN101189231B (zh) * | 2005-03-23 | 2011-05-18 | 杏林制药株式会社 | 环状氨基苯基链烷酸衍生物 |
JP2009509988A (ja) | 2005-09-29 | 2009-03-12 | サノフィ−アベンティス | フェニル−及びピリジニル−1,2,4−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
US20140024790A1 (en) | 2011-02-18 | 2014-01-23 | Haif Al-Shammari | Multinuclear metallocene catalyst complexes for olefin polymerisation and copolymerisation and method of preparing thereof |
SG11201707219VA (en) * | 2015-03-09 | 2017-10-30 | Lubrizol Corp | Method of lubricating an internal combustion engine |
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-
2003
- 2003-02-27 DE DE10308352A patent/DE10308352A1/de not_active Withdrawn
-
2004
- 2004-02-19 AU AU2004215675A patent/AU2004215675B2/en not_active Ceased
- 2004-02-19 JP JP2006501889A patent/JP2006519196A/ja active Pending
- 2004-02-19 DE DE502004012351T patent/DE502004012351D1/de not_active Expired - Lifetime
- 2004-02-19 WO PCT/EP2004/001583 patent/WO2004076402A1/de active Application Filing
- 2004-02-19 BR BRPI0407858-6A patent/BRPI0407858A/pt not_active IP Right Cessation
- 2004-02-19 EP EP04712515A patent/EP1601643B1/de not_active Expired - Lifetime
- 2004-02-19 KR KR1020057015772A patent/KR20050113195A/ko not_active Application Discontinuation
- 2004-02-19 MX MXPA05009054A patent/MXPA05009054A/es active IP Right Grant
- 2004-02-19 AT AT04712515T patent/ATE503740T1/de active
- 2004-02-19 CA CA002516626A patent/CA2516626A1/en not_active Abandoned
- 2004-02-19 RU RU2005130004/04A patent/RU2005130004A/ru not_active Application Discontinuation
- 2004-02-19 PL PL377736A patent/PL377736A1/pl not_active Application Discontinuation
- 2004-02-19 CN CNB2004800054773A patent/CN100417641C/zh not_active Expired - Fee Related
- 2004-02-25 TW TW093104701A patent/TW200505831A/zh unknown
- 2004-02-27 US US10/789,323 patent/US7220876B2/en active Active
- 2004-02-27 PE PE2004000202A patent/PE20040957A1/es not_active Application Discontinuation
- 2004-02-27 AR ARP040100632A patent/AR043429A1/es not_active Application Discontinuation
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2005
- 2005-07-19 ZA ZA200505762A patent/ZA200505762B/en unknown
- 2005-08-26 MA MA28463A patent/MA27740A1/fr unknown
- 2005-08-26 HR HR20050737A patent/HRP20050737A2/xx not_active Application Discontinuation
- 2005-08-26 CO CO05085501A patent/CO5690543A2/es not_active Application Discontinuation
- 2005-09-21 NO NO20054380A patent/NO20054380L/no unknown
Also Published As
Publication number | Publication date |
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CN100417641C (zh) | 2008-09-10 |
AU2004215675B2 (en) | 2010-01-21 |
ATE503740T1 (de) | 2011-04-15 |
CO5690543A2 (es) | 2006-10-31 |
US20040209873A1 (en) | 2004-10-21 |
PL377736A1 (pl) | 2006-02-20 |
CN1753866A (zh) | 2006-03-29 |
EP1601643A1 (de) | 2005-12-07 |
CA2516626A1 (en) | 2004-09-10 |
AR043429A1 (es) | 2005-07-27 |
DE502004012351D1 (de) | 2011-05-12 |
RU2005130004A (ru) | 2006-01-27 |
TW200505831A (en) | 2005-02-16 |
AU2004215675A1 (en) | 2004-09-10 |
US7220876B2 (en) | 2007-05-22 |
PE20040957A1 (es) | 2005-01-31 |
ZA200505762B (en) | 2006-05-31 |
JP2006519196A (ja) | 2006-08-24 |
BRPI0407858A (pt) | 2006-03-01 |
MA27740A1 (fr) | 2006-02-01 |
DE10308352A1 (de) | 2004-09-09 |
MXPA05009054A (es) | 2005-10-19 |
EP1601643B1 (de) | 2011-03-30 |
WO2004076402A1 (de) | 2004-09-10 |
KR20050113195A (ko) | 2005-12-01 |
NO20054380L (no) | 2005-09-21 |
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