HRP20040043A2 - Dolastatin 10 derivatives - Google Patents

Info

Publication number

HRP20040043A2

HRP20040043A2 HR20040043A HRP20040043A HRP20040043A2 HR P20040043 A2 HRP20040043 A2 HR P20040043A2 HR 20040043 A HR20040043 A HR 20040043A HR P20040043 A HRP20040043 A HR P20040043A HR P20040043 A2 HRP20040043 A2 HR P20040043A2

Authority

HR

Croatia

Prior art keywords

methyl

butyl

propyl

methoxy

carbamoyl

Prior art date

2001-07-19

Links

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• OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical class CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 title description 5
• 150000001875 compounds Chemical class 0.000 claims description 218
• -1 carbamoyloxy Chemical group 0.000 claims description 203
• 125000000217 alkyl group Chemical group 0.000 claims description 55
• 125000001424 substituent group Chemical group 0.000 claims description 53
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 44
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 42
• 229910052736 halogen Chemical group 0.000 claims description 39
• 150000002367 halogens Chemical group 0.000 claims description 39
• 125000003545 alkoxy group Chemical group 0.000 claims description 37
• 125000000623 heterocyclic group Chemical group 0.000 claims description 36
• 206010028980 Neoplasm Diseases 0.000 claims description 34
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 34
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 32
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 31
• 229910052739 hydrogen Inorganic materials 0.000 claims description 30
• 239000001257 hydrogen Substances 0.000 claims description 29
• 238000002360 preparation method Methods 0.000 claims description 26
• 125000004414 alkyl thio group Chemical group 0.000 claims description 23
• 125000003118 aryl group Chemical group 0.000 claims description 22
• 238000011282 treatment Methods 0.000 claims description 22
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 21
• 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 21
• 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 19
• 201000011510 cancer Diseases 0.000 claims description 19
• 150000003839 salts Chemical class 0.000 claims description 18
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 17
• 238000000034 method Methods 0.000 claims description 17
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 16
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 16
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 16
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 15
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 13
• 125000004442 acylamino group Chemical group 0.000 claims description 11
• 125000006239 protecting group Chemical group 0.000 claims description 11
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 10
• 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
• 239000002253 acid Substances 0.000 claims description 9
• ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 9
• 239000003814 drug Substances 0.000 claims description 9
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
• 239000003795 chemical substances by application Substances 0.000 claims description 8
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 8
• 239000000825 pharmaceutical preparation Substances 0.000 claims description 8
• 125000001691 aryl alkyl amino group Chemical group 0.000 claims description 7
• 229940079593 drug Drugs 0.000 claims description 7
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 6
• UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical group C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims description 6
• 206010006187 Breast cancer Diseases 0.000 claims description 6
• UJJMBYCPDLMLTD-UHFFFAOYSA-N N-[1-[[3-methoxy-5-methyl-1-[2-[3-[(1-methylsulfanyl-2-phenylethyl)amino]-3-oxopropyl]pyrrolidin-1-yl]-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)SC)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C UJJMBYCPDLMLTD-UHFFFAOYSA-N 0.000 claims description 6
• 125000003342 alkenyl group Chemical group 0.000 claims description 6
• 125000000304 alkynyl group Chemical group 0.000 claims description 6
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 6
• 239000003937 drug carrier Substances 0.000 claims description 6
• 150000002148 esters Chemical class 0.000 claims description 6
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 5
• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 5
• XRLOGWLEHBAMOF-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N-[1-[2-[3-[[1-(2-hydroxyethylsulfanyl)-2-phenylethyl]amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)SCCO)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C XRLOGWLEHBAMOF-UHFFFAOYSA-N 0.000 claims description 5
• KKZIZHSDEBJQFG-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[1-[2-[1-ethylsulfanyl-3-[2-(3-hydroxyphenyl)ethylamino]-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound C1CCN(C(=O)CC(OC)C(C(C)CC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C)C1C(SCC)C(C)C(=O)NCCC1=CC=CC(O)=C1 KKZIZHSDEBJQFG-UHFFFAOYSA-N 0.000 claims description 5
• MXERUZYPBDNRSK-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[1-[2-[3-[2-(3-hydroxyphenyl)ethylamino]-2-methyl-1-methylsulfanyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC)C(C)C(=O)NCCC1=CC=CC(O)=C1 MXERUZYPBDNRSK-UHFFFAOYSA-N 0.000 claims description 5
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 5
• 208000026310 Breast neoplasm Diseases 0.000 claims description 5
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 5
• ZODZAMGATMBGTR-UHFFFAOYSA-N N-[1-[[1-[2-[3-[(1-ethylsulfanyl-2-phenylethyl)amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide Chemical compound CCSC(CC1=CC=CC=C1)NC(=O)CCC1CCCN1C(=O)CC(OC)C(C(C)CC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C ZODZAMGATMBGTR-UHFFFAOYSA-N 0.000 claims description 5
• 125000001769 aryl amino group Chemical group 0.000 claims description 5
• 208000035269 cancer or benign tumor Diseases 0.000 claims description 5
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
• 238000009833 condensation Methods 0.000 claims description 5
• 230000005494 condensation Effects 0.000 claims description 5
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 5
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
• 208000020816 lung neoplasm Diseases 0.000 claims description 5
• KHUUDBXXZJCVTL-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[1-[2-[3-[2-(2-hydroxyphenyl)ethylamino]-1-methylsulfanyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC)CC(=O)NCCC1=CC=CC=C1O KHUUDBXXZJCVTL-UHFFFAOYSA-N 0.000 claims description 4
• TWYMOCZMECAMCV-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[3-methoxy-5-methyl-1-[2-[1-methylsulfanyl-3-oxo-3-(2-pyridin-3-ylethylamino)propyl]pyrrolidin-1-yl]-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC)CC(=O)NCCC1=CC=CN=C1 TWYMOCZMECAMCV-UHFFFAOYSA-N 0.000 claims description 4
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 4
• YOPKFWATQGUYGD-UHFFFAOYSA-N 3-[1-[4-[[2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methylsulfanylpropanoic acid Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(CC(O)=O)SC YOPKFWATQGUYGD-UHFFFAOYSA-N 0.000 claims description 4
• 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims description 4
• 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
• 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
• 206010009944 Colon cancer Diseases 0.000 claims description 4
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
• NIRXJUYBAYTMIZ-CWQSAYAXSA-N N-[1-[2-[3-[[(1R)-1-tert-butylsulfanyl-2-phenylethyl]amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N,3-dimethylbutanamide Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)N[C@@H](CC1=CC=CC=C1)SC(C)(C)C)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C NIRXJUYBAYTMIZ-CWQSAYAXSA-N 0.000 claims description 4
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 4
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
• 201000010881 cervical cancer Diseases 0.000 claims description 4
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
• KWBIXTIBYFUAGV-UHFFFAOYSA-N ethylcarbamic acid Chemical compound CCNC(O)=O KWBIXTIBYFUAGV-UHFFFAOYSA-N 0.000 claims description 4
• 201000005202 lung cancer Diseases 0.000 claims description 4
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
• 125000003395 phenylethylamino group Chemical group [H]N(*)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
• IYUPHNXLARLFHK-GNXDQWMXSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N-[1-[2-[3-[[(1S)-1-(4-hydroxyphenyl)sulfanyl-2-phenylethyl]amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide Chemical compound C(C)(CC)C(C(CC(=O)N1C(CCC1)CCC(N[C@H](CC1=CC=CC=C1)SC1=CC=C(C=C1)O)=O)OC)N(C(=O)C(C(C)C)NC(C(C(C)C)N(C)C)=O)C IYUPHNXLARLFHK-GNXDQWMXSA-N 0.000 claims description 3
• GEHZHCFDPWGZNJ-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N-[1-[2-[3-[[1-(3-hydroxyphenyl)sulfanyl-2-phenylethyl]amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide Chemical compound C(C)(CC)C(C(CC(=O)N1C(CCC1)CCC(NC(CC1=CC=CC=C1)SC1=CC(=CC=C1)O)=O)OC)N(C(=O)C(C(C)C)NC(C(C(C)C)N(C)C)=O)C GEHZHCFDPWGZNJ-UHFFFAOYSA-N 0.000 claims description 3
• ZXESHIUVGWQOGO-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N-[1-[2-[3-[[1-(furan-2-ylmethylsulfanyl)-2-phenylethyl]amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)SCC1=CC=CO1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C ZXESHIUVGWQOGO-UHFFFAOYSA-N 0.000 claims description 3
• BGDDJBIDUBFBPL-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N-[3-methoxy-5-methyl-1-oxo-1-[2-[3-oxo-3-(2-phenylethylamino)-2-(1-phenylethylsulfanyl)propyl]pyrrolidin-1-yl]heptan-4-yl]-N,3-dimethylbutanamide Chemical compound C(C)(CC)C(C(CC(N1C(CCC1)CC(SC(C)C1=CC=CC=C1)C(NCCC1=CC=CC=C1)=O)=O)OC)N(C(=O)C(C(C)C)NC(C(C(C)C)N(C)C)=O)C BGDDJBIDUBFBPL-UHFFFAOYSA-N 0.000 claims description 3
• OOXJHBGWHMQRNQ-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N-[3-methoxy-5-methyl-1-oxo-1-[2-[3-oxo-3-[(1-pentylsulfanyl-2-phenylethyl)amino]propyl]pyrrolidin-1-yl]heptan-4-yl]-N,3-dimethylbutanamide Chemical compound CCCCCSC(CC1=CC=CC=C1)NC(=O)CCC1CCCN1C(=O)CC(OC)C(C(C)CC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C OOXJHBGWHMQRNQ-UHFFFAOYSA-N 0.000 claims description 3
• ZWDUDEYRRNPVQF-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[1-[2-[3-[2-(3-hydroxyphenyl)ethylamino]-1-methylsulfanyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC)CC(=O)NCCC1=CC=CC(O)=C1 ZWDUDEYRRNPVQF-UHFFFAOYSA-N 0.000 claims description 3
• GPFGIXVDYZCJBN-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[3-methoxy-5-methyl-1-[2-[1-methylsulfanyl-3-oxo-3-(2-thiophen-2-ylethylamino)propyl]pyrrolidin-1-yl]-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC)CC(=O)NCCC1=CC=CS1 GPFGIXVDYZCJBN-UHFFFAOYSA-N 0.000 claims description 3
• XICREFSYSCYVRC-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[3-methoxy-5-methyl-1-[2-[1-methylsulfanyl-3-oxo-3-(pyridin-4-ylmethylamino)propyl]pyrrolidin-1-yl]-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC)CC(=O)NCC1=CC=NC=C1 XICREFSYSCYVRC-UHFFFAOYSA-N 0.000 claims description 3
• PWJLIMNTXNTEIB-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[3-methoxy-5-methyl-1-[2-[3-[methyl(2-phenylethyl)amino]-1-methylsulfanyl-3-oxopropyl]pyrrolidin-1-yl]-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC)CC(=O)N(C)CCC1=CC=CC=C1 PWJLIMNTXNTEIB-UHFFFAOYSA-N 0.000 claims description 3
• JCMHQJKNNNDDAM-UHFFFAOYSA-N 2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-n-[3-methoxy-5-methyl-1-oxo-1-[2-[3-oxo-3-(2-phenylethylamino)-1-phenylsulfanylpropyl]pyrrolidin-1-yl]heptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(SC=1C=CC=CC=1)CC(=O)NCCC1=CC=CC=C1 JCMHQJKNNNDDAM-UHFFFAOYSA-N 0.000 claims description 3
• 206010005003 Bladder cancer Diseases 0.000 claims description 3
• MRFMGAGBQFQZGP-UHFFFAOYSA-N CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)SC1=CC=C(F)C=C1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)SC1=CC=C(F)C=C1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C MRFMGAGBQFQZGP-UHFFFAOYSA-N 0.000 claims description 3
• NCAFAMLMPHBKOE-UHFFFAOYSA-N CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)SCC1=CC=C(F)C=C1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)SCC1=CC=C(F)C=C1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C NCAFAMLMPHBKOE-UHFFFAOYSA-N 0.000 claims description 3
• MYUYMGQXTHIJCT-UHFFFAOYSA-N CN(C(C(=O)NC(C(=O)N(C(C(CC(=O)N1C(CCC1)C(CC1=CC=CC=C1)NC(=O)CCSCCNC(O)=O)OC)C(CC)C)C)C(C)C)C(C)C)C Chemical compound CN(C(C(=O)NC(C(=O)N(C(C(CC(=O)N1C(CCC1)C(CC1=CC=CC=C1)NC(=O)CCSCCNC(O)=O)OC)C(CC)C)C)C(C)C)C(C)C)C MYUYMGQXTHIJCT-UHFFFAOYSA-N 0.000 claims description 3
• NIRXJUYBAYTMIZ-UHFFFAOYSA-N N-[1-[2-[3-[(1-tert-butylsulfanyl-2-phenylethyl)amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N,3-dimethylbutanamide Chemical compound C(C)(CC)C(C(CC(=O)N1C(CCC1)CCC(NC(CC1=CC=CC=C1)SC(C)(C)C)=O)OC)N(C(=O)C(C(C)C)NC(C(C(C)C)N(C)C)=O)C NIRXJUYBAYTMIZ-UHFFFAOYSA-N 0.000 claims description 3
• VJSGUGPEPUAPQQ-UHFFFAOYSA-N N-[1-[2-[3-[[1-(4-tert-butylphenyl)sulfanyl-2-phenylethyl]amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-N,3-dimethylbutanamide Chemical compound C(C)(CC)C(C(CC(=O)N1C(CCC1)CCC(NC(CC1=CC=CC=C1)SC1=CC=C(C=C1)C(C)(C)C)=O)OC)N(C(=O)C(C(C)C)NC(C(C(C)C)N(C)C)=O)C VJSGUGPEPUAPQQ-UHFFFAOYSA-N 0.000 claims description 3
• XGMNNVWMRODHHX-UHFFFAOYSA-N N-[1-[[1-[2-[3-[(1-ethylsulfonyl-2-phenylethyl)amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)S(=O)(=O)CC)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C XGMNNVWMRODHHX-UHFFFAOYSA-N 0.000 claims description 3
• DDIRASQDPWJJTM-UHFFFAOYSA-N N-[1-[[1-[2-[3-[[1-(benzenesulfonyl)-2-phenylethyl]amino]-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide Chemical compound CCC(C)C(C(CC(=O)N1CCCC1CCC(=O)NC(CC1=CC=CC=C1)S(=O)(=O)C1=CC=CC=C1)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C DDIRASQDPWJJTM-UHFFFAOYSA-N 0.000 claims description 3
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