HRP20030781A2 - Method for the production of 4,6-diaminopyrimido[5,4-d]pyrimidines - Google Patents

Method for the production of 4,6-diaminopyrimido[5,4-d]pyrimidines Download PDF

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Publication number
HRP20030781A2
HRP20030781A2 HR20030781A HRP20030781A HRP20030781A2 HR P20030781 A2 HRP20030781 A2 HR P20030781A2 HR 20030781 A HR20030781 A HR 20030781A HR P20030781 A HRP20030781 A HR P20030781A HR P20030781 A2 HRP20030781 A2 HR P20030781A2
Authority
HR
Croatia
Prior art keywords
formula
compound
image
pyrimidine
group
Prior art date
Application number
HR20030781A
Other languages
English (en)
Croatian (hr)
Inventor
Rall Werner
Lock Ralf
Belzer Werner
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Publication of HRP20030781A2 publication Critical patent/HRP20030781A2/hr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20030781A 2001-03-30 2002-03-26 Method for the production of 4,6-diaminopyrimido[5,4-d]pyrimidines HRP20030781A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10115921A DE10115921A1 (de) 2001-03-30 2001-03-30 Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
PCT/EP2002/003353 WO2002079202A1 (de) 2001-03-30 2002-03-26 Verfahren zur herstellung von 4,6-diaminopyrimido[5,4-d]pyrimidinen

Publications (1)

Publication Number Publication Date
HRP20030781A2 true HRP20030781A2 (en) 2005-06-30

Family

ID=7679773

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030781A HRP20030781A2 (en) 2001-03-30 2002-03-26 Method for the production of 4,6-diaminopyrimido[5,4-d]pyrimidines

Country Status (21)

Country Link
US (2) US6680384B2 (cs)
EP (1) EP1383770B1 (cs)
JP (1) JP4451066B2 (cs)
KR (1) KR20030086338A (cs)
CN (1) CN1252072C (cs)
AT (1) ATE277052T1 (cs)
BR (1) BR0208534A (cs)
CA (1) CA2442061C (cs)
CZ (1) CZ296237B6 (cs)
DE (2) DE10115921A1 (cs)
DK (1) DK1383770T3 (cs)
ES (1) ES2224073T3 (cs)
HR (1) HRP20030781A2 (cs)
HU (1) HUP0303590A3 (cs)
MX (1) MXPA03008811A (cs)
PL (1) PL362922A1 (cs)
PT (1) PT1383770E (cs)
SI (1) SI1383770T1 (cs)
SK (1) SK11982003A3 (cs)
TR (1) TR200402474T4 (cs)
WO (1) WO2002079202A1 (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2518465A1 (en) 2003-03-25 2004-10-14 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2004103993A1 (en) 2003-05-14 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
DE602004010206T2 (de) 2003-08-13 2008-10-09 Takeda Pharmaceutical Co. Ltd. Dipeptidyl Peptidase Inhibitoren.
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7790734B2 (en) 2003-09-08 2010-09-07 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
UA85871C2 (uk) 2004-03-15 2009-03-10 Такеда Фармасьютікал Компані Лімітед Інгібітори дипептидилпептидази
EP1753730A1 (en) 2004-06-04 2007-02-21 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2006068978A2 (en) 2004-12-21 2006-06-29 Takeda Pharmaceutial Company Limited Dipeptidyl peptidase inhibitors
CN101374523B (zh) 2005-09-14 2012-04-11 武田药品工业株式会社 用于治疗糖尿病的二肽基肽酶抑制剂
US20070060529A1 (en) * 2005-09-14 2007-03-15 Christopher Ronald J Administration of dipeptidyl peptidase inhibitors
CA2622642C (en) 2005-09-16 2013-12-31 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
HRP20110800T1 (hr) * 2006-09-13 2011-12-31 Takeda Pharmaceutical Company Limited UPORABA 2-6-(3-AMINO-PIPERIDIN-1-IL)-3-METIL-2,4-DIOKSO-3,4-DIHIDRO-2H-PIRIMIDIN-1-ILMETIL-4-FLUORO-BENZONITRILA ZA LIJEČENJE DIJABETESA, RAKA, AUTOIMUNIH POREMEĆAJA I ZARAZE HIV-om
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
CA3213079A1 (en) 2021-04-13 2022-10-20 Kristin Lynne ANDREWS Amino-substituted heterocycles for treating cancers with egfr mutations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW414798B (en) 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608588A1 (de) 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
CZ296237B6 (cs) 2006-02-15
SI1383770T1 (sl) 2005-02-28
MXPA03008811A (es) 2004-02-18
PL362922A1 (en) 2004-11-02
HUP0303590A2 (hu) 2004-03-01
JP4451066B2 (ja) 2010-04-14
EP1383770B1 (de) 2004-09-22
EP1383770A1 (de) 2004-01-28
CA2442061A1 (en) 2002-10-10
CZ20032654A3 (cs) 2004-02-18
ATE277052T1 (de) 2004-10-15
US6680384B2 (en) 2004-01-20
DE10115921A1 (de) 2002-10-02
BR0208534A (pt) 2004-03-23
CA2442061C (en) 2010-06-29
US6849734B2 (en) 2005-02-01
DE50201120D1 (de) 2004-10-28
DK1383770T3 (da) 2004-12-20
CN1252072C (zh) 2006-04-19
JP2004525944A (ja) 2004-08-26
HK1064091A1 (en) 2005-01-21
HUP0303590A3 (en) 2004-11-29
CN1500091A (zh) 2004-05-26
KR20030086338A (ko) 2003-11-07
WO2002079202A1 (de) 2002-10-10
US20040059114A1 (en) 2004-03-25
US20020198380A1 (en) 2002-12-26
PT1383770E (pt) 2004-11-30
ES2224073T3 (es) 2005-03-01
SK11982003A3 (sk) 2004-02-03
TR200402474T4 (tr) 2004-12-21

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