HRP20030661B1 - 11c-halogen steroids, their production and use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain 11c-halogen steroids - Google Patents
11c-halogen steroids, their production and use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain 11c-halogen steroidsInfo
- Publication number
- HRP20030661B1 HRP20030661B1 HR20030661A HRP20030661A HRP20030661B1 HR P20030661 B1 HRP20030661 B1 HR P20030661B1 HR 20030661 A HR20030661 A HR 20030661A HR P20030661 A HRP20030661 A HR P20030661A HR P20030661 B1 HRP20030661 B1 HR P20030661B1
- Authority
- HR
- Croatia
- Prior art keywords
- groups
- radical
- branched
- chain
- production
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 2
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 CH3 radical Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000005840 aryl radicals Chemical class 0.000 abstract 2
- LPXQRXLUHJKZIE-UHFFFAOYSA-N 8-azaguanine Chemical compound NC1=NC(O)=C2NN=NC2=N1 LPXQRXLUHJKZIE-UHFFFAOYSA-N 0.000 abstract 1
- NFGODEMQGQNUKK-UHFFFAOYSA-M [6-(diethylamino)-9-(2-octadecoxycarbonylphenyl)xanthen-3-ylidene]-diethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1C1=C2C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C21 NFGODEMQGQNUKK-UHFFFAOYSA-M 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0025—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10104327A DE10104327A1 (de) | 2001-01-24 | 2001-01-24 | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
| PCT/EP2002/000722 WO2002059139A1 (en) | 2001-01-24 | 2002-01-24 | Androgenic 7-substituted 11-halogen steroids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20030661A2 HRP20030661A2 (en) | 2005-06-30 |
| HRP20030661B1 true HRP20030661B1 (en) | 2011-10-31 |
Family
ID=7672351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030661A HRP20030661B1 (en) | 2001-01-24 | 2003-08-20 | 11c-halogen steroids, their production and use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain 11c-halogen steroids |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7361645B2 (sh) |
| EP (1) | EP1353938B1 (sh) |
| JP (1) | JP4339591B2 (sh) |
| KR (1) | KR100728088B1 (sh) |
| CN (1) | CN1234721C (sh) |
| AR (1) | AR053299A1 (sh) |
| AT (1) | ATE386045T1 (sh) |
| AU (1) | AU2002238516B2 (sh) |
| BG (1) | BG66133B1 (sh) |
| BR (1) | BR0206653A (sh) |
| CA (1) | CA2434187C (sh) |
| CY (1) | CY1110377T1 (sh) |
| CZ (1) | CZ303553B6 (sh) |
| DE (2) | DE10104327A1 (sh) |
| DK (1) | DK1353938T3 (sh) |
| EA (1) | EA006674B1 (sh) |
| EE (1) | EE05274B1 (sh) |
| ES (1) | ES2300431T3 (sh) |
| HK (1) | HK1064678A1 (sh) |
| HR (1) | HRP20030661B1 (sh) |
| HU (1) | HUP0303020A3 (sh) |
| IL (2) | IL156807A0 (sh) |
| MX (1) | MXPA03006578A (sh) |
| NO (1) | NO325754B1 (sh) |
| NZ (1) | NZ527041A (sh) |
| PE (1) | PE20020848A1 (sh) |
| PL (1) | PL207582B1 (sh) |
| PT (1) | PT1353938E (sh) |
| RS (1) | RS50740B (sh) |
| SK (1) | SK287444B6 (sh) |
| TW (1) | TWI333494B (sh) |
| UA (1) | UA75907C2 (sh) |
| UY (1) | UY27133A1 (sh) |
| WO (1) | WO2002059139A1 (sh) |
| ZA (1) | ZA200306537B (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10234525A1 (de) * | 2002-07-25 | 2004-02-05 | Schering Ag | Zusammensetzung, enthaltend ein androgenes 11ß-Halogensteroid und ein Gestagen sowie männliches Kontrazeptivum auf Basis dieser Zusammensetzung |
| DE10233723A1 (de) | 2002-07-24 | 2004-02-12 | Schering Ag | Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene |
| NZ549529A (en) | 2002-07-24 | 2008-04-30 | Schering Aktiengellschaft | Microbiological processes for the production of 7alpha-substituted 11alpha-hydroxy steroids |
| WO2004011008A1 (de) * | 2002-07-25 | 2004-02-05 | Schering Aktiengesellschaft | ZUSAMMENSETZUNG, ENTHALTEND EIN ANDROGENES 11β-HALOGENSTEROID UND EIN GESTAGEN SOWIE MÄNNLICHES KONTRAZEPTIVUM AUF BASIS DIESER ZUSAMMENSETZUNG |
| JO2492B1 (en) * | 2003-04-28 | 2009-10-05 | شيرينج ايه جي | A pharmaceutical formula in the form of aqueous gel for the skin use of its active ingredients |
| US7879357B2 (en) * | 2003-04-28 | 2011-02-01 | Bayer Schering Pharma Ag | Pharmaceutical composition in the form of a hydrogel for transdermal administration of active ingredients |
| CN104262439B (zh) * | 2014-10-08 | 2016-06-08 | 常州大学 | 一种以4-雄烯二酮一步法合成睾酮的方法 |
| TWI530504B (zh) * | 2014-12-01 | 2016-04-21 | 臺灣永光化學工業股份有限公司 | 烷基酸睾酮化合物之合成方法 |
| US20220411460A1 (en) * | 2021-06-29 | 2022-12-29 | Board Of Regents, The University Of Texas System | Modified glucocorticoids |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB863661A (en) * | 1958-06-06 | 1961-03-22 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
| FR1489519A (fr) * | 1965-08-16 | 1967-07-21 | Glaxo Lab Ltd | Procédé de préparation de nouveaux 19-nor-stéroïdes et produits obtenus |
| GB1260463A (en) * | 1968-01-29 | 1972-01-19 | Glaxo Lab Ltd | 11beta-BROMO-19-NOR-STEROIDS |
| US3665021A (en) * | 1966-07-29 | 1972-05-23 | Glaxo Lab Ltd | 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids |
| DE2410442A1 (de) * | 1974-03-01 | 1975-09-11 | Schering Ag | Verfahren zur herstellung von 11-fluorandrostenen |
| US3966713A (en) * | 1974-03-01 | 1976-06-29 | Schering Aktiengesellschaft | 11β-FLUOROANDROSTENES |
| US5952319A (en) * | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
| WO2000059920A2 (en) * | 1999-04-06 | 2000-10-12 | Akzo Nobel N.V. | Orally active 7.alpha.-alkyl androgens |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH380118A (de) * | 1959-06-17 | 1964-07-31 | Ciba Geigy | Neue Halogenandrostenverbindungen und Verfahren zu deren Herstellung |
| GB1159434A (en) * | 1965-08-16 | 1969-07-23 | Glaxo Lab Ltd | 11beta&;-Fluoro-19-nor-Steroids |
| DE3214690A1 (de) * | 1982-04-16 | 1983-10-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-chlor-(delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch)-steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| GB8721384D0 (en) * | 1987-09-11 | 1987-10-21 | Erba Farmitalia | 17-substituted andro-sta-1 4-dien-3-one derivatives |
| US5342834A (en) * | 1989-04-07 | 1994-08-30 | The Population Council, Inc. | Method for androgen supplementation |
| US20020012694A1 (en) * | 1997-09-17 | 2002-01-31 | Alfred J. Moo-Young | Transdermal administration of ment |
| US6767902B2 (en) * | 1997-09-17 | 2004-07-27 | The Population Council, Inc. | Androgen as a male contraceptive and non-contraceptive androgen replacement |
| US6881728B1 (en) * | 1999-03-08 | 2005-04-19 | Akzo Nobel N.V. | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens |
| DE19959696A1 (de) * | 1999-12-08 | 2001-06-21 | Jenapharm Gmbh | Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
-
2001
- 2001-01-24 DE DE10104327A patent/DE10104327A1/de not_active Ceased
-
2002
- 2002-01-24 EA EA200300756A patent/EA006674B1/ru not_active IP Right Cessation
- 2002-01-24 CZ CZ20032006A patent/CZ303553B6/cs not_active IP Right Cessation
- 2002-01-24 NZ NZ527041A patent/NZ527041A/en not_active IP Right Cessation
- 2002-01-24 UA UA2003087912A patent/UA75907C2/uk unknown
- 2002-01-24 RS YUP-594/03A patent/RS50740B/sr unknown
- 2002-01-24 BR BR0206653-0A patent/BR0206653A/pt not_active IP Right Cessation
- 2002-01-24 IL IL15680702A patent/IL156807A0/xx active IP Right Grant
- 2002-01-24 JP JP2002559441A patent/JP4339591B2/ja not_active Expired - Fee Related
- 2002-01-24 AR ARP020100238A patent/AR053299A1/es active IP Right Grant
- 2002-01-24 HU HU0303020A patent/HUP0303020A3/hu unknown
- 2002-01-24 CN CNB028040686A patent/CN1234721C/zh not_active Expired - Fee Related
- 2002-01-24 MX MXPA03006578A patent/MXPA03006578A/es active IP Right Grant
- 2002-01-24 DK DK02704667T patent/DK1353938T3/da active
- 2002-01-24 PT PT02704667T patent/PT1353938E/pt unknown
- 2002-01-24 SK SK954-2003A patent/SK287444B6/sk not_active IP Right Cessation
- 2002-01-24 UY UY27133A patent/UY27133A1/es not_active Application Discontinuation
- 2002-01-24 AT AT02704667T patent/ATE386045T1/de active
- 2002-01-24 DE DE60224982T patent/DE60224982T2/de not_active Expired - Lifetime
- 2002-01-24 EP EP02704667A patent/EP1353938B1/en not_active Expired - Lifetime
- 2002-01-24 US US10/467,352 patent/US7361645B2/en not_active Expired - Fee Related
- 2002-01-24 WO PCT/EP2002/000722 patent/WO2002059139A1/en active IP Right Grant
- 2002-01-24 TW TW091101142A patent/TWI333494B/zh not_active IP Right Cessation
- 2002-01-24 PE PE2002000053A patent/PE20020848A1/es not_active Application Discontinuation
- 2002-01-24 CA CA002434187A patent/CA2434187C/en not_active Expired - Fee Related
- 2002-01-24 ES ES02704667T patent/ES2300431T3/es not_active Expired - Lifetime
- 2002-01-24 EE EEP200300346A patent/EE05274B1/xx not_active IP Right Cessation
- 2002-01-24 AU AU2002238516A patent/AU2002238516B2/en not_active Ceased
- 2002-01-24 KR KR1020037009732A patent/KR100728088B1/ko not_active IP Right Cessation
- 2002-01-24 PL PL361730A patent/PL207582B1/pl not_active IP Right Cessation
-
2003
- 2003-07-07 IL IL156807A patent/IL156807A/en not_active IP Right Cessation
- 2003-07-23 NO NO20033321A patent/NO325754B1/no not_active IP Right Cessation
- 2003-07-23 BG BG108023A patent/BG66133B1/bg unknown
- 2003-08-20 HR HR20030661A patent/HRP20030661B1/xx not_active IP Right Cessation
- 2003-08-21 ZA ZA200306537A patent/ZA200306537B/en unknown
-
2004
- 2004-09-28 HK HK04107492A patent/HK1064678A1/xx not_active IP Right Cessation
-
2008
- 2008-05-13 CY CY20081100508T patent/CY1110377T1/el unknown
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB863661A (en) * | 1958-06-06 | 1961-03-22 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
| FR1489519A (fr) * | 1965-08-16 | 1967-07-21 | Glaxo Lab Ltd | Procédé de préparation de nouveaux 19-nor-stéroïdes et produits obtenus |
| US3665021A (en) * | 1966-07-29 | 1972-05-23 | Glaxo Lab Ltd | 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids |
| GB1260463A (en) * | 1968-01-29 | 1972-01-19 | Glaxo Lab Ltd | 11beta-BROMO-19-NOR-STEROIDS |
| DE2410442A1 (de) * | 1974-03-01 | 1975-09-11 | Schering Ag | Verfahren zur herstellung von 11-fluorandrostenen |
| US3966713A (en) * | 1974-03-01 | 1976-06-29 | Schering Aktiengesellschaft | 11β-FLUOROANDROSTENES |
| US5952319A (en) * | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
| WO2000059920A2 (en) * | 1999-04-06 | 2000-10-12 | Akzo Nobel N.V. | Orally active 7.alpha.-alkyl androgens |
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| PNAN | Change of the applicant name, address/residence |
Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, DE |
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Effective date: 20140124 |