CN104262439B - 一种以4-雄烯二酮一步法合成睾酮的方法 - Google Patents
一种以4-雄烯二酮一步法合成睾酮的方法 Download PDFInfo
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- CN104262439B CN104262439B CN201410523485.2A CN201410523485A CN104262439B CN 104262439 B CN104262439 B CN 104262439B CN 201410523485 A CN201410523485 A CN 201410523485A CN 104262439 B CN104262439 B CN 104262439B
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- testosterone
- potassium borohydride
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- androstenedione
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610435718.2A CN106046091B (zh) | 2014-10-08 | 2014-10-08 | 适于提高睾酮选择性的合成睾酮方法 |
CN201610435623.0A CN106146592B (zh) | 2014-10-08 | 2014-10-08 | 一种合成睾酮方法 |
CN201610435766.1A CN106188203B (zh) | 2014-10-08 | 2014-10-08 | 一种可提高睾酮的收率及大幅减少杂质的合成睾酮方法 |
CN201610435716.3A CN106188202B (zh) | 2014-10-08 | 2014-10-08 | 副产3,17‑二醇物含量大幅降低的合成睾酮方法 |
CN201410523485.2A CN104262439B (zh) | 2014-10-08 | 2014-10-08 | 一种以4-雄烯二酮一步法合成睾酮的方法 |
CN201610435622.6A CN106188201B (zh) | 2014-10-08 | 2014-10-08 | 工艺简单、适于降低还原剂浓度的合成睾酮方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410523485.2A CN104262439B (zh) | 2014-10-08 | 2014-10-08 | 一种以4-雄烯二酮一步法合成睾酮的方法 |
Related Child Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610435716.3A Division CN106188202B (zh) | 2014-10-08 | 2014-10-08 | 副产3,17‑二醇物含量大幅降低的合成睾酮方法 |
CN201610435622.6A Division CN106188201B (zh) | 2014-10-08 | 2014-10-08 | 工艺简单、适于降低还原剂浓度的合成睾酮方法 |
CN201610435718.2A Division CN106046091B (zh) | 2014-10-08 | 2014-10-08 | 适于提高睾酮选择性的合成睾酮方法 |
CN201610435623.0A Division CN106146592B (zh) | 2014-10-08 | 2014-10-08 | 一种合成睾酮方法 |
CN201610435766.1A Division CN106188203B (zh) | 2014-10-08 | 2014-10-08 | 一种可提高睾酮的收率及大幅减少杂质的合成睾酮方法 |
Publications (2)
Publication Number | Publication Date |
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CN104262439A CN104262439A (zh) | 2015-01-07 |
CN104262439B true CN104262439B (zh) | 2016-06-08 |
Family
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Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610435718.2A Active CN106046091B (zh) | 2014-10-08 | 2014-10-08 | 适于提高睾酮选择性的合成睾酮方法 |
CN201610435716.3A Active CN106188202B (zh) | 2014-10-08 | 2014-10-08 | 副产3,17‑二醇物含量大幅降低的合成睾酮方法 |
CN201610435766.1A Active CN106188203B (zh) | 2014-10-08 | 2014-10-08 | 一种可提高睾酮的收率及大幅减少杂质的合成睾酮方法 |
CN201610435623.0A Active CN106146592B (zh) | 2014-10-08 | 2014-10-08 | 一种合成睾酮方法 |
CN201410523485.2A Active CN104262439B (zh) | 2014-10-08 | 2014-10-08 | 一种以4-雄烯二酮一步法合成睾酮的方法 |
CN201610435622.6A Active CN106188201B (zh) | 2014-10-08 | 2014-10-08 | 工艺简单、适于降低还原剂浓度的合成睾酮方法 |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610435718.2A Active CN106046091B (zh) | 2014-10-08 | 2014-10-08 | 适于提高睾酮选择性的合成睾酮方法 |
CN201610435716.3A Active CN106188202B (zh) | 2014-10-08 | 2014-10-08 | 副产3,17‑二醇物含量大幅降低的合成睾酮方法 |
CN201610435766.1A Active CN106188203B (zh) | 2014-10-08 | 2014-10-08 | 一种可提高睾酮的收率及大幅减少杂质的合成睾酮方法 |
CN201610435623.0A Active CN106146592B (zh) | 2014-10-08 | 2014-10-08 | 一种合成睾酮方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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CN201610435622.6A Active CN106188201B (zh) | 2014-10-08 | 2014-10-08 | 工艺简单、适于降低还原剂浓度的合成睾酮方法 |
Country Status (1)
Country | Link |
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CN (6) | CN106046091B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017093980A1 (en) * | 2015-12-05 | 2017-06-08 | Lupin Limited | Process for preparation of testosterone |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10104327A1 (de) * | 2001-01-24 | 2002-07-25 | Schering Ag | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
CN102558267A (zh) * | 2012-01-13 | 2012-07-11 | 宜城市共同药业有限公司 | 庚酸睾酮的制备方法 |
CN103012529A (zh) * | 2012-09-26 | 2013-04-03 | 宜城市共同药业有限公司 | 一种高收率诺龙的合成方法 |
-
2014
- 2014-10-08 CN CN201610435718.2A patent/CN106046091B/zh active Active
- 2014-10-08 CN CN201610435716.3A patent/CN106188202B/zh active Active
- 2014-10-08 CN CN201610435766.1A patent/CN106188203B/zh active Active
- 2014-10-08 CN CN201610435623.0A patent/CN106146592B/zh active Active
- 2014-10-08 CN CN201410523485.2A patent/CN104262439B/zh active Active
- 2014-10-08 CN CN201610435622.6A patent/CN106188201B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN106188201B (zh) | 2017-10-24 |
CN106188202A (zh) | 2016-12-07 |
CN106188202B (zh) | 2017-10-24 |
CN106188203A (zh) | 2016-12-07 |
CN106188203B (zh) | 2017-10-24 |
CN106146592A (zh) | 2016-11-23 |
CN106046091B (zh) | 2017-08-25 |
CN106188201A (zh) | 2016-12-07 |
CN106046091A (zh) | 2016-10-26 |
CN106146592B (zh) | 2017-10-24 |
CN104262439A (zh) | 2015-01-07 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170621 Address after: Zheng Lu sanhuangmiao village Tianning District 213111 Jiangsu city of Changzhou province Hu Village No. 302 Patentee after: JIANGSU JIAERKE PHARMACEUTICALS GROUP CORP., LTD. Address before: Gehu Lake Road Wujin District 213016 Jiangsu city of Changzhou province No. 1 Patentee before: Changzhou University |
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TR01 | Transfer of patent right | ||
CP01 | Change in the name or title of a patent holder |
Address after: 213111 Huzhuangtou 302, Sanhuangmiao Village Committee, Zhenglu Town, Tianning District, Changzhou City, Jiangsu Province Patentee after: Jiangsu Jiaerke Pharmaceutical Group Co., Ltd. Address before: 213111 Huzhuangtou 302, Sanhuangmiao Village Committee, Zhenglu Town, Tianning District, Changzhou City, Jiangsu Province Patentee before: JIANGSU JIAERKE PHARMACEUTICALS GROUP CORP., LTD. |
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CP01 | Change in the name or title of a patent holder |