HRP20030471B1 - 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof - Google Patents

2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof

Info

Publication number
HRP20030471B1
HRP20030471B1 HR20030471A HRP20030471A HRP20030471B1 HR P20030471 B1 HRP20030471 B1 HR P20030471B1 HR 20030471 A HR20030471 A HR 20030471A HR P20030471 A HRP20030471 A HR P20030471A HR P20030471 B1 HRP20030471 B1 HR P20030471B1
Authority
HR
Croatia
Prior art keywords
dibutylamino
butyl
propoxy
preparation
benzoyl
Prior art date
Application number
HR20030471A
Other languages
English (en)
Croatian (hr)
Inventor
Biard Michel
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20030471A2 publication Critical patent/HRP20030471A2/hr
Publication of HRP20030471B1 publication Critical patent/HRP20030471B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HR20030471A 2000-12-11 2003-06-11 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof HRP20030471B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0016069A FR2817865B1 (fr) 2000-12-11 2000-12-11 Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
PCT/FR2001/003900 WO2002048078A1 (fr) 2000-12-11 2001-12-10 Chlorhydrate du 2-butyl-3-(4-'3-(dibutylamino)propoxy!benzoyl)-5-nitro-benzofurane et sa preparation

Publications (2)

Publication Number Publication Date
HRP20030471A2 HRP20030471A2 (en) 2004-08-31
HRP20030471B1 true HRP20030471B1 (en) 2011-07-31

Family

ID=8857481

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030471A HRP20030471B1 (en) 2000-12-11 2003-06-11 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof

Country Status (21)

Country Link
US (1) US6846936B2 (cs)
EP (1) EP1351907B1 (cs)
JP (2) JP4437004B2 (cs)
CN (2) CN1295200C (cs)
AR (1) AR035663A1 (cs)
AT (1) ATE345319T1 (cs)
AU (1) AU2002217227A1 (cs)
BR (1) BR0116065B1 (cs)
CA (1) CA2429268C (cs)
CZ (1) CZ303489B6 (cs)
DE (1) DE60124587T2 (cs)
DK (1) DK1351907T3 (cs)
ES (1) ES2276741T3 (cs)
FR (1) FR2817865B1 (cs)
HK (1) HK1055944A1 (cs)
HR (1) HRP20030471B1 (cs)
HU (1) HUP0500981A3 (cs)
MX (1) MXPA03005223A (cs)
PL (1) PL206029B1 (cs)
SK (1) SK287770B6 (cs)
WO (1) WO2002048078A1 (cs)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI356054B (en) * 2004-03-31 2012-01-11 Activus Pharma Co Ltd Quaternary ammonium compound, producing method the
GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
FR2930149B1 (fr) * 2008-04-17 2011-02-18 Sanofi Aventis Association de dronedarone avec au moins un diuretique, son application en therapeutique
EP2280701A2 (en) * 2008-04-17 2011-02-09 Sanofi-Aventis Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality
EP2116239A1 (en) * 2008-04-29 2009-11-11 Sanofi-Aventis Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment
EP2246341A1 (en) 2009-01-23 2010-11-03 Lonza Ltd. Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans
US20120122971A1 (en) * 2009-04-08 2012-05-17 Cambrex Karlskoga Ab New process for preparing hydroxylamines and medicaments
UY32656A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos
TW201111354A (en) 2009-05-27 2011-04-01 Sanofi Aventis Process for the production of Dronedarone intermediates
CN101993427B (zh) * 2009-08-26 2012-10-10 成都伊诺达博医药科技有限公司 一种制备决奈达隆的方法
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
IT1398317B1 (it) * 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
EP2371824A1 (en) * 2010-03-08 2011-10-05 Ratiopharm GmbH Crystalline dronedarone salts
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
WO2012004658A2 (en) * 2010-07-09 2012-01-12 Frichem Private Limited Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof
WO2012007959A1 (en) * 2010-07-16 2012-01-19 Glenmark Generics Limited Process for preparing dronedarone
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
WO2012032545A1 (en) 2010-09-08 2012-03-15 Cadila Healthcare Limited Processes for preparing dronedarone and its intermediates
EP2447256A1 (en) * 2010-10-21 2012-05-02 Laboratorios Lesvi, S.L. Process for obtaining dronedarone
CN102070579B (zh) * 2011-01-19 2016-03-09 上海医药工业研究院 2-正丁基-3-(4-取代丙氧基苯甲酰基)-5-取代氨基苯并呋喃的制备方法
CN102070581B (zh) * 2011-01-19 2015-11-25 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-氨基苯并呋喃的制备
CN102070578B (zh) * 2011-01-19 2015-10-14 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-烷酰基氨基苯并呋喃的制备方法
CN102070580B (zh) * 2011-01-19 2015-05-20 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-取代氨基苯并呋喃的制备
WO2012120544A2 (en) 2011-03-10 2012-09-13 Sun Pharmaceutical Industries Ltd. PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE
CN102690249B (zh) * 2011-03-22 2014-09-17 江苏康缘药业股份有限公司 一种决奈达隆的制备方法
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100166A2 (en) * 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
WO2013014478A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive amination process for preparation of dronedarone using carboxyl intermediary compound
WO2013014480A1 (en) 2011-07-26 2013-01-31 Sanofi Process for preparation of dronedarone using amide intermediary compound
WO2013014479A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive animation process for preparation of dronedarone using aldehyde intermediary compound
ITMI20111672A1 (it) * 2011-09-16 2013-03-17 Olon Spa Metodo efficiente per la preparazione di dronedarone cloridrato
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) * 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
CN102675267B (zh) * 2012-06-07 2015-05-13 济南富创医药科技有限公司 盐酸决奈达隆及其中间体的制备方法
CN108164411B (zh) * 2017-12-29 2021-03-02 苏州汶颢微流控技术股份有限公司 基于微反应器制备对庚氧基苯甲酸的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471609A1 (fr) * 1990-08-06 1992-02-19 Sanofi Dérivés de Benzofuranne, Benzothiophène, Indole ou Indolizine, leur procédé de préparation ainsi que les compositions les contenant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024273A (en) * 1974-06-20 1977-05-17 Smithkline Corporation Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5731436A (en) * 1994-08-31 1998-03-24 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471609A1 (fr) * 1990-08-06 1992-02-19 Sanofi Dérivés de Benzofuranne, Benzothiophène, Indole ou Indolizine, leur procédé de préparation ainsi que les compositions les contenant

Also Published As

Publication number Publication date
ATE345319T1 (de) 2006-12-15
SK287770B6 (sk) 2011-09-05
JP2009024007A (ja) 2009-02-05
PL364774A1 (en) 2004-12-13
CZ20031611A3 (cs) 2003-08-13
ES2276741T3 (es) 2007-07-01
CN1295200C (zh) 2007-01-17
EP1351907B1 (fr) 2006-11-15
US6846936B2 (en) 2005-01-25
SK7272003A3 (en) 2003-11-04
CZ303489B6 (cs) 2012-10-17
DK1351907T3 (da) 2007-03-26
BR0116065A (pt) 2003-10-28
HK1055944A1 (en) 2004-01-30
CA2429268C (fr) 2011-02-01
CN1769262A (zh) 2006-05-10
HUP0500981A2 (en) 2006-03-28
PL206029B1 (pl) 2010-06-30
HRP20030471A2 (en) 2004-08-31
JP2004515536A (ja) 2004-05-27
US20040010032A1 (en) 2004-01-15
DE60124587T2 (de) 2007-09-20
CA2429268A1 (fr) 2002-06-20
DE60124587D1 (de) 2006-12-28
FR2817865B1 (fr) 2005-02-18
FR2817865A1 (fr) 2002-06-14
MXPA03005223A (es) 2004-04-20
EP1351907A1 (fr) 2003-10-15
BR0116065B1 (pt) 2014-03-25
HUP0500981A3 (en) 2012-09-28
CN100371314C (zh) 2008-02-27
JP4437004B2 (ja) 2010-03-24
AU2002217227A1 (en) 2002-06-24
WO2002048078A1 (fr) 2002-06-20
CN1479706A (zh) 2004-03-03
AR035663A1 (es) 2004-06-23

Similar Documents

Publication Publication Date Title
HRP20030471B1 (en) 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof
SE9503214D0 (sv) Farmaceutisk produkt
NO20032861L (no) Heteroarylurea nevropeptid Y Y5-reseptorantagonister
LU92520I2 (fr) Bédaquiline, ou son sel d'addition d'acide ou de base pharmaceutiquement acceptable, y compris le fumarate de bédaquiline
IT1319645B1 (it) Base cristallina di citalopram.
TW200716520A (en) 3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
NO20042811L (no) Substituerte henzoksazoler og analoger som estrogene midler
Shin et al. Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2
MXPA04005784A (es) 2-fenilbenzofuranos sustituidos como agentes estrogenitos.
SE9903291D0 (sv) New process
NO20001514L (no) Vitronectin-reseptor-antagonist
BR0014808A (pt) Processos de preparação de um composto, e, compostos nitroaromáticos
IT1319240B1 (it) Procedimento per la oligomerizzazione selettiva dell'etilene.
SE0102440D0 (sv) New compound
HUP0300972A2 (hu) Gatifloxacin-pentahidrát
HUP0203635A2 (hu) Eljárás citalopram előállítására
DK0517221T3 (da) ((Arylalkylpiperidin-4-yl)-methyl)-2alfa,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-oner og beslægtede forbindelser, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
BR0115963A (pt) Derivados de benzofurano e benzotiofeno
HUP0301942A2 (hu) Eljárás citalopram elżállítására
NO20022620L (no) Fremgangsmåte for fremstilling av 5-(1-piperazinyl)- benzofuran-2-karboksamid ved hjelp av overgangsmetallkatalysertaminering
HUP0300295A2 (hu) Helyettesített benzamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
LV12733A (lv) A novel crystalline form of 6-hydroxy-3- (4-¬2-(piperidin-1-yl) ethoxy¾ phenoxy)-2-(4-methoxyphenyl) benzo ¬b¾ thiophene hydrochloryde
DE60107832D1 (en) Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
HUP0300180A2 (en) Method for the preparation of citalopram
NO20003794L (no) Fremgangsmåte for å fremstille sannsynlighetskart over treffpunktposisjon for en brönn

Legal Events

Date Code Title Description
A1OB Publication of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS, FR

ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20131112

Year of fee payment: 13

PBON Lapse due to non-payment of renewal fee

Effective date: 20141210