AU2002217227A1 - 2-butyl-3-(4-(3(dibutylamino)propoxy)benzoyl)-5-nitro- benzofuran hydrochloride and preparation thereof - Google Patents
2-butyl-3-(4-(3(dibutylamino)propoxy)benzoyl)-5-nitro- benzofuran hydrochloride and preparation thereofInfo
- Publication number
- AU2002217227A1 AU2002217227A1 AU2002217227A AU1722702A AU2002217227A1 AU 2002217227 A1 AU2002217227 A1 AU 2002217227A1 AU 2002217227 A AU2002217227 A AU 2002217227A AU 1722702 A AU1722702 A AU 1722702A AU 2002217227 A1 AU2002217227 A1 AU 2002217227A1
- Authority
- AU
- Australia
- Prior art keywords
- dibutylamino
- propoxy
- benzoyl
- nitro
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0016069 | 2000-12-11 | ||
FR0016069A FR2817865B1 (en) | 2000-12-11 | 2000-12-11 | AMINOALKOXYBENZOYLE DERIVATIVE IN SALT FORM, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF AS SYNTHESIS INTERMEDIATE |
PCT/FR2001/003900 WO2002048078A1 (en) | 2000-12-11 | 2001-12-10 | 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002217227A1 true AU2002217227A1 (en) | 2002-06-24 |
Family
ID=8857481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002217227A Abandoned AU2002217227A1 (en) | 2000-12-11 | 2001-12-10 | 2-butyl-3-(4-(3(dibutylamino)propoxy)benzoyl)-5-nitro- benzofuran hydrochloride and preparation thereof |
Country Status (21)
Country | Link |
---|---|
US (1) | US6846936B2 (en) |
EP (1) | EP1351907B1 (en) |
JP (2) | JP4437004B2 (en) |
CN (2) | CN1295200C (en) |
AR (1) | AR035663A1 (en) |
AT (1) | ATE345319T1 (en) |
AU (1) | AU2002217227A1 (en) |
BR (1) | BR0116065B1 (en) |
CA (1) | CA2429268C (en) |
CZ (1) | CZ303489B6 (en) |
DE (1) | DE60124587T2 (en) |
DK (1) | DK1351907T3 (en) |
ES (1) | ES2276741T3 (en) |
FR (1) | FR2817865B1 (en) |
HK (1) | HK1055944A1 (en) |
HR (1) | HRP20030471B1 (en) |
HU (1) | HUP0500981A3 (en) |
MX (1) | MXPA03005223A (en) |
PL (1) | PL206029B1 (en) |
SK (1) | SK287770B6 (en) |
WO (1) | WO2002048078A1 (en) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI356054B (en) | 2004-03-31 | 2012-01-11 | Activus Pharma Co Ltd | Quaternary ammonium compound, producing method the |
GB0719180D0 (en) * | 2007-10-02 | 2007-11-14 | Cambrex Karlskoga Ab | New process |
FR2930149B1 (en) * | 2008-04-17 | 2011-02-18 | Sanofi Aventis | ASSOCIATION OF DRONEDARONE WITH AT LEAST ONE DIURETIC, ITS THERAPEUTIC APPLICATION |
KR20100135909A (en) * | 2008-04-17 | 2010-12-27 | 사노피-아벤티스 | Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality |
EP2116239A1 (en) * | 2008-04-29 | 2009-11-11 | Sanofi-Aventis | Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment |
EP2246341A1 (en) | 2009-01-23 | 2010-11-03 | Lonza Ltd. | Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans |
JP5788381B2 (en) * | 2009-04-08 | 2015-09-30 | カンブレックス カルルスクーガ アクチ ボラケットCambrex Karlskoga Ab | A novel process for preparing hydroxylamine and drugs |
UY32656A (en) | 2009-05-27 | 2010-12-31 | Sanofi Aventis | PROCEDURE TO PRODUCE BENZOFURANS |
UY32657A (en) | 2009-05-27 | 2010-12-31 | Sanofi Aventis | PROCEDURE FOR THE MANUFACTURE OF DRONEDARONA INTERMEDIATE PRODUCTS |
CN101993427B (en) * | 2009-08-26 | 2012-10-10 | 成都伊诺达博医药科技有限公司 | New method for preparing Dronedarone |
HUP0900759A2 (en) | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
IT1398317B1 (en) * | 2010-02-23 | 2013-02-22 | Chimico Internaz Spa Lab | NEW PROCEDURE FOR DRONEDARONE PREPARATION. |
FR2957079B1 (en) | 2010-03-02 | 2012-07-27 | Sanofi Aventis | PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES |
EP2371824A1 (en) * | 2010-03-08 | 2011-10-05 | Ratiopharm GmbH | Crystalline dronedarone salts |
FR2958290B1 (en) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF SULFONAMIDO-BENZOFURAN DERIVATIVES |
FR2958291B1 (en) | 2010-04-01 | 2013-07-05 | Sanofi Aventis | PROCESS FOR PREPARING AMINO-BENZOFURAN DERIVATIVES |
HUP1000330A2 (en) * | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
US8602215B2 (en) | 2010-06-30 | 2013-12-10 | Sanofi | Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation |
WO2012004658A2 (en) | 2010-07-09 | 2012-01-12 | Frichem Private Limited | Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof |
WO2012007959A1 (en) * | 2010-07-16 | 2012-01-19 | Glenmark Generics Limited | Process for preparing dronedarone |
FR2962731B1 (en) | 2010-07-19 | 2012-08-17 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF AMINO-BENZOYL-BENZOFURAN DERIVATIVES |
FR2963006B1 (en) | 2010-07-21 | 2013-03-15 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF NITRO-BENZOFURAN DERIVATIVES |
HUP1000386A2 (en) | 2010-07-22 | 2012-05-29 | Sanofi Sa | Novel process for producing dronedarone |
WO2012032545A1 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Processes for preparing dronedarone and its intermediates |
EP2447256A1 (en) * | 2010-10-21 | 2012-05-02 | Laboratorios Lesvi, S.L. | Process for obtaining dronedarone |
CN102070579B (en) * | 2011-01-19 | 2016-03-09 | 上海医药工业研究院 | The preparation method of 2-normal-butyl-3-(4-replaces propoxy-benzoyl)-5-substituted-amino cumarone |
CN102070581B (en) * | 2011-01-19 | 2015-11-25 | 上海医药工业研究院 | The preparation of 2-normal-butyl-3-(4-(the amino propoxy-of 3-di-n-butyl) benzoyl)-5-aminobenzofur |
CN102070580B (en) * | 2011-01-19 | 2015-05-20 | 上海医药工业研究院 | Preparation of 2-n-butyl-3-(4-(3-di-n-butyl amino propoxyl) benzoyl)-5-substituted amino benzfuran |
CN102070578B (en) * | 2011-01-19 | 2015-10-14 | 上海医药工业研究院 | The preparation method of 2-normal-butyl-3-(4-(the amino propoxy-of 3-di-n-butyl) benzoyl)-5-oxoethyl |
WO2012120544A2 (en) | 2011-03-10 | 2012-09-13 | Sun Pharmaceutical Industries Ltd. | PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE |
CN102690249B (en) * | 2011-03-22 | 2014-09-17 | 江苏康缘药业股份有限公司 | Preparation method of dronedarone |
HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
HUP1100166A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Reductive amination process for preparation of dronedarone using amine intermediary compound |
HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
WO2013014480A1 (en) | 2011-07-26 | 2013-01-31 | Sanofi | Process for preparation of dronedarone using amide intermediary compound |
WO2013014478A1 (en) | 2011-07-26 | 2013-01-31 | Sanofi | Reductive amination process for preparation of dronedarone using carboxyl intermediary compound |
WO2013014479A1 (en) | 2011-07-26 | 2013-01-31 | Sanofi | Reductive animation process for preparation of dronedarone using aldehyde intermediary compound |
ITMI20111672A1 (en) * | 2011-09-16 | 2013-03-17 | Olon Spa | EFFICIENT METHOD FOR THE PREPARATION OF DRONEDARONE CHLORIDRATO |
FR2983198B1 (en) * | 2011-11-29 | 2013-11-15 | Sanofi Sa | PROCESS FOR THE PREPARATION OF 5-AMINO-BENZOYL-BENZOFURAN DERIVATIVES |
EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
WO2013121235A2 (en) | 2012-02-13 | 2013-08-22 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
WO2013121234A1 (en) | 2012-02-14 | 2013-08-22 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
US9382223B2 (en) | 2012-02-22 | 2016-07-05 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
US9238636B2 (en) | 2012-05-31 | 2016-01-19 | Sanofi | Process for preparation of dronedarone by Grignard reaction |
CN102675267B (en) * | 2012-06-07 | 2015-05-13 | 济南富创医药科技有限公司 | Preparation method of dronedarone hydrochloride and intermediate of dronedarone hydrochloride |
CN108164411B (en) * | 2017-12-29 | 2021-03-02 | 苏州汶颢微流控技术股份有限公司 | Method for preparing p-heptyloxybenzoic acid based on microreactor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4024273A (en) * | 1974-06-20 | 1977-05-17 | Smithkline Corporation | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity |
US3947470A (en) * | 1974-06-20 | 1976-03-30 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
FR2665444B1 (en) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | AMINO-BENZOFURAN, BENZOTHIOPHENE OR INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE COMPOSITIONS CONTAINING THEM. |
US5731436A (en) * | 1994-08-31 | 1998-03-24 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents |
US5631369A (en) * | 1994-08-31 | 1997-05-20 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents |
-
2000
- 2000-12-11 FR FR0016069A patent/FR2817865B1/en not_active Expired - Fee Related
-
2001
- 2001-12-10 CN CNB018203787A patent/CN1295200C/en not_active Expired - Fee Related
- 2001-12-10 DE DE60124587T patent/DE60124587T2/en not_active Expired - Lifetime
- 2001-12-10 MX MXPA03005223A patent/MXPA03005223A/en active IP Right Grant
- 2001-12-10 JP JP2002549615A patent/JP4437004B2/en not_active Expired - Fee Related
- 2001-12-10 AR ARP010105714A patent/AR035663A1/en not_active Application Discontinuation
- 2001-12-10 US US10/433,639 patent/US6846936B2/en not_active Expired - Lifetime
- 2001-12-10 ES ES01270513T patent/ES2276741T3/en not_active Expired - Lifetime
- 2001-12-10 AT AT01270513T patent/ATE345319T1/en active
- 2001-12-10 WO PCT/FR2001/003900 patent/WO2002048078A1/en active IP Right Grant
- 2001-12-10 BR BRPI0116065-6A patent/BR0116065B1/en not_active IP Right Cessation
- 2001-12-10 EP EP01270513A patent/EP1351907B1/en not_active Expired - Lifetime
- 2001-12-10 SK SK727-2003A patent/SK287770B6/en not_active IP Right Cessation
- 2001-12-10 CA CA2429268A patent/CA2429268C/en not_active Expired - Fee Related
- 2001-12-10 CN CNB200510108930XA patent/CN100371314C/en not_active Expired - Fee Related
- 2001-12-10 HU HU0500981A patent/HUP0500981A3/en unknown
- 2001-12-10 PL PL364774A patent/PL206029B1/en unknown
- 2001-12-10 AU AU2002217227A patent/AU2002217227A1/en not_active Abandoned
- 2001-12-10 DK DK01270513T patent/DK1351907T3/en active
- 2001-12-10 CZ CZ20031611A patent/CZ303489B6/en not_active IP Right Cessation
-
2003
- 2003-06-11 HR HR20030471A patent/HRP20030471B1/en not_active IP Right Cessation
- 2003-11-13 HK HK03108257A patent/HK1055944A1/en not_active IP Right Cessation
-
2008
- 2008-07-11 JP JP2008181486A patent/JP2009024007A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2002217227A1 (en) | 2-butyl-3-(4-(3(dibutylamino)propoxy)benzoyl)-5-nitro- benzofuran hydrochloride and preparation thereof | |
AU2001270057A1 (en) | Acoustical and thermal insulator | |
AU2002226486A1 (en) | Novel c-glycoside derivatives and use thereof | |
AU2705201A (en) | Ceramic structure | |
SI1252144T1 (en) | Substituted glutarimides and use thereof il-12 production inhibitors | |
HK1064601A1 (en) | Pharmaceutical compositions comprising amlodipene maleate | |
GB0104705D0 (en) | Insulator ceramic composition | |
NO20006460L (en) | 4, 5, 6 and 7-Indole and indoline derivatives, their preparation and use | |
HK1054031B (en) | Pharmaceutically active pyrrolidine derivatives | |
AU5203601A (en) | Platen construction and swing chair | |
HK1091806A1 (en) | Antihistaminic piperidine derivatives and intermediates for the preparation thereof | |
SG100745A1 (en) | Ceramic composition and ceramic capacitor | |
HUP0300399A3 (en) | Herbicidal 3-(4,5-dihydroisoxazole-5-yl)benzoylpyrazoles, preparation and use thereof | |
AU3022201A (en) | Novel use of (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)- chromane and its physiologically aceptable salts | |
HUP0103651A3 (en) | Paroxetine maleate and process for its preparation | |
AU2001234180A1 (en) | Benzamide derivative and use thereof | |
AU7053000A (en) | Flint compounds and formulations thereof | |
PL353243A1 (en) | An improved form of form i celiprolol hydrochloride | |
AU2001280460A1 (en) | Pulmonary administration of flint | |
AU4304700A (en) | Immunostimulatory pharmaceutical composition and its use protocol | |
AU2001241928A1 (en) | Transferase 32253 and use therefor | |
AU2001286888A1 (en) | Tyrosine hydroxylase 5' control elements and uses thereof | |
HK1045506B (en) | Oxathiepino 6,5- i b /i ]dihydropyridines, and related compositions and methods | |
AU2002352774A1 (en) | 55053, a novel human eukaryotic kinase and uses therefor | |
AU2002224105A1 (en) | Piperidine compounds and medicinal use thereof |