HRP20030460A2 - Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders - Google Patents
Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders Download PDFInfo
- Publication number
- HRP20030460A2 HRP20030460A2 HR20030460A HRP20030460A HRP20030460A2 HR P20030460 A2 HRP20030460 A2 HR P20030460A2 HR 20030460 A HR20030460 A HR 20030460A HR P20030460 A HRP20030460 A HR P20030460A HR P20030460 A2 HRP20030460 A2 HR P20030460A2
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- pentamidine
- chlorpromazine
- neoplasm
- patient
- Prior art date
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- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 title claims description 65
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 title claims description 63
- 229960001076 chlorpromazine Drugs 0.000 title claims description 59
- 229960004448 pentamidine Drugs 0.000 title claims description 58
- 229940079593 drug Drugs 0.000 title description 27
- 239000003814 drug Substances 0.000 title description 27
- 238000011282 treatment Methods 0.000 title description 14
- 230000001613 neoplastic effect Effects 0.000 title description 2
- 239000000126 substance Substances 0.000 claims description 94
- 239000000203 mixture Substances 0.000 claims description 58
- 206010028980 Neoplasm Diseases 0.000 claims description 55
- 238000000034 method Methods 0.000 claims description 29
- 201000011510 cancer Diseases 0.000 claims description 28
- -1 putaperazine Chemical compound 0.000 claims description 27
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 21
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 201000005202 lung cancer Diseases 0.000 claims description 10
- 208000020816 lung neoplasm Diseases 0.000 claims description 10
- 239000003937 drug carrier Substances 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- 238000007918 intramuscular administration Methods 0.000 claims description 7
- IDBIFFKSXLYUOT-UHFFFAOYSA-N netropsin Chemical compound C1=C(C(=O)NCCC(N)=N)N(C)C=C1NC(=O)C1=CC(NC(=O)CN=C(N)N)=CN1C IDBIFFKSXLYUOT-UHFFFAOYSA-N 0.000 claims description 6
- DMABBVCVVXMJDH-UHFFFAOYSA-N phenamidine Chemical compound C1=CC(C(=N)N)=CC=C1OC1=CC=C(C(N)=N)C=C1 DMABBVCVVXMJDH-UHFFFAOYSA-N 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 238000001990 intravenous administration Methods 0.000 claims description 5
- MMURVNDSFNJHAM-OWOJBTEDSA-N 4-[(e)-2-(4-carbamimidoylphenyl)ethenyl]benzenecarboximidamide Chemical compound C1=CC(C(=N)N)=CC=C1\C=C\C1=CC=C(C(N)=N)C=C1 MMURVNDSFNJHAM-OWOJBTEDSA-N 0.000 claims description 4
- TUESWZZJYCLFNL-DAFODLJHSA-N chembl1301 Chemical compound C1=CC(C(=N)N)=CC=C1\C=C\C1=CC=C(C(N)=N)C=C1O TUESWZZJYCLFNL-DAFODLJHSA-N 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 208000003849 large cell carcinoma Diseases 0.000 claims description 4
- KRUVSRGJKCHYMY-UHFFFAOYSA-N 1,3-bis(3-carbamimidoylphenyl)urea Chemical compound NC(=N)C1=CC=CC(NC(=O)NC=2C=C(C=CC=2)C(N)=N)=C1 KRUVSRGJKCHYMY-UHFFFAOYSA-N 0.000 claims description 3
- YBEQGLWWCCCCRA-UHFFFAOYSA-N 4-[3-(4-carbamimidoyl-2-methoxyphenoxy)propoxy]-3-methoxybenzenecarboximidamide Chemical compound COC1=CC(C(N)=N)=CC=C1OCCCOC1=CC=C(C(N)=N)C=C1OC YBEQGLWWCCCCRA-UHFFFAOYSA-N 0.000 claims description 3
- KXHZWUUTWSKONE-UHFFFAOYSA-N 4-[4-(4-carbamimidoylphenoxy)butoxy]benzenecarboximidamide Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCOC1=CC=C(C(N)=N)C=C1 KXHZWUUTWSKONE-UHFFFAOYSA-N 0.000 claims description 3
- IUJKKCRARYRWFG-UHFFFAOYSA-N 4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCCOC1=CC=C(C(N)=N)C=C1 IUJKKCRARYRWFG-UHFFFAOYSA-N 0.000 claims description 3
- CFQYOTZLYKJVKS-UHFFFAOYSA-N 4-[9-(4-carbamimidoylphenoxy)nonoxy]benzenecarboximidamide Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCCCCOC1=CC=C(C(N)=N)C=C1 CFQYOTZLYKJVKS-UHFFFAOYSA-N 0.000 claims description 3
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- RGCVKNLCSQQDEP-UHFFFAOYSA-N Perphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 RGCVKNLCSQQDEP-UHFFFAOYSA-N 0.000 claims description 3
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- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 claims description 3
- HWURPQUPKQFGJI-UHFFFAOYSA-N [amino-[4-[5-[4-[amino(azaniumylidene)methyl]phenoxy]pentoxy]phenyl]methylidene]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(C(=[NH2+])N)=CC=C1OCCCCCOC1=CC=C(C(N)=[NH2+])C=C1 HWURPQUPKQFGJI-UHFFFAOYSA-N 0.000 claims description 3
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- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical compound CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 claims description 3
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- WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 claims description 3
- WTFXJFJYEJZMFO-UHFFFAOYSA-N propamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCOC1=CC=C(C(N)=N)C=C1 WTFXJFJYEJZMFO-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US09/706,929 US6569853B1 (en) | 2000-11-06 | 2000-11-06 | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| PCT/US2001/047959 WO2002058684A2 (en) | 2000-11-06 | 2001-10-30 | Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders |
Publications (1)
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| HRP20030460A2 true HRP20030460A2 (en) | 2005-04-30 |
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| HR20030460A HRP20030460A2 (en) | 2000-11-06 | 2003-06-06 | Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders |
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| EP (1) | EP1339399B1 (xx) |
| JP (1) | JP2004517915A (xx) |
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| CN (1) | CN1484525A (xx) |
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| AT (1) | ATE318590T1 (xx) |
| AU (1) | AU2002246636B8 (xx) |
| BG (1) | BG107831A (xx) |
| BR (1) | BR0115166A (xx) |
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| WO2001035935A2 (en) * | 1999-11-16 | 2001-05-25 | Oncozyme Pharma Inc. | Inhibitors of endo-exonuclease activity such as pentamidine for the treatment of cancer |
| DE10015818A1 (de) * | 2000-03-30 | 2001-10-18 | Infineon Technologies Ag | Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor |
| US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| US20030049320A1 (en) * | 2000-12-18 | 2003-03-13 | Wockhardt Limited | Novel in-situ forming controlled release microcarrier delivery system |
| US6992082B2 (en) * | 2001-01-19 | 2006-01-31 | Cytokinetics, Inc. | Phenothiazine kinesin inhibitors |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| WO2002069949A2 (en) * | 2001-03-06 | 2002-09-12 | Prendergast Patrick T | Combination therapy for reduction of toxycity of chemotherapeutic agents |
| WO2002096412A1 (en) * | 2001-05-31 | 2002-12-05 | The Cleveland Clinic Foundation | Ptpase inhibitors and method of using same |
| FR2825279B1 (fr) * | 2001-06-01 | 2005-04-08 | Molecular Engines Lab | Medicament utile dans le traitement du cancer |
| US20040010045A1 (en) * | 2001-09-07 | 2004-01-15 | Taolin Yi | Therapeutic compositions comprised of pentamidine and methods of using same to treat cancer |
| US20050215629A1 (en) * | 2001-09-07 | 2005-09-29 | Taolin Yi | PTPase inhibitors and methods of using the same |
| US7416723B2 (en) | 2001-09-07 | 2008-08-26 | The Cleveland Clinic Foundation | Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases |
| US7544681B2 (en) * | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| AU2004201240B2 (en) * | 2001-09-27 | 2008-08-07 | Bar Ilan University | Conjugated Psychotropic Drugs and Uses Thereof |
| US8053477B2 (en) * | 2002-03-29 | 2011-11-08 | University Of Maryland, Baltimore | Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same |
| AU2003241346A1 (en) * | 2002-05-01 | 2003-11-17 | The Cleveland Clinic Foundation | Therapeutic compositions comprised of pentamidine and methods of using same to treat cancer |
| MXPA05000485A (es) * | 2002-07-11 | 2005-04-19 | Combinatorx Inc | Combinacion de farmacos para el tratamiento de neoplasmas. |
| ES2343411T3 (es) * | 2003-03-26 | 2010-07-30 | Synergy Biosystems Ltd. | Procedimientos para identificar agentes biologicamente activos y combinaciones sinergicas. |
| EP2377528B1 (en) * | 2003-06-12 | 2014-02-19 | The Board of Regents of the University of Colorado | Fatty acid metabolism inhibitors for use in the treatment of cancer |
| US20050054708A1 (en) * | 2003-07-28 | 2005-03-10 | Nichols Matthew James | Combinations of drugs for the treatment of neoplasms |
| US20050080075A1 (en) * | 2003-08-25 | 2005-04-14 | Nichols M. James | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms |
| CN1878556A (zh) * | 2003-09-18 | 2006-12-13 | 康宾纳特克斯公司 | 治疗肿瘤的联合药物 |
| US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
| US20050100508A1 (en) * | 2003-11-12 | 2005-05-12 | Nichols M. J. | Methods for identifying drug combinations for the treatment of proliferative diseases |
| TW200526777A (en) * | 2003-11-12 | 2005-08-16 | Combinatorx Inc | Combinations for the treatment of proliferative diseases |
| WO2005046694A1 (en) * | 2003-11-13 | 2005-05-26 | Københavns Universitet | Thioridazine and derivatives thereof for reversing anti-microbial drug-resistance |
| WO2005070126A2 (en) | 2004-01-08 | 2005-08-04 | The Regents Of The University Of Colorado | Methods and compositions for treating human diseases and wounds with ucp and fas inhibitors |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| EP2574341B1 (en) * | 2004-03-29 | 2017-03-29 | University Of South Florida | Effective treatment of tumors and cancer with triciribine phosphate |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
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| EP1856247B1 (en) * | 2005-01-19 | 2016-05-04 | The Trustees of The University of Pennsylvania | Regulation of autophagy and cell survival |
| TW200719903A (en) * | 2005-04-19 | 2007-06-01 | Combinatorx Inc | Compositions for the treatment of neoplasms |
| US20100184710A1 (en) * | 2005-04-28 | 2010-07-22 | The Regents Of The University Of Colorado | Therapeutic Bifunctional Compounds |
| AU2006242667A1 (en) * | 2005-05-02 | 2006-11-09 | The Regents Of The University Of Colorado | Systems and methods for treating human inflammatory and proliferative diseases, with a combination of compounds, or a bifunctional compound,that provides fatty acid metabolism and glycolysis inhibition |
| JP5700909B2 (ja) | 2005-05-04 | 2015-04-15 | メディゲーネ アクチエンゲゼルシャフトＭｅｄｉＧｅｎｅ ＡＧ | パクリタキセルを含む陽イオン性リポソーム製剤を投与する方法 |
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| US20090298814A1 (en) * | 2005-06-07 | 2009-12-03 | Ramot At Tel Aviv Univeristy Ltd | Novel salts of conjugated psychotropic drugs and processes of preparing same |
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