HRP20020485A2 - Methods and compositions for levovirin - Google Patents
Methods and compositions for levovirin Download PDFInfo
- Publication number
- HRP20020485A2 HRP20020485A2 HR20020485A HRP20020485A HRP20020485A2 HR P20020485 A2 HRP20020485 A2 HR P20020485A2 HR 20020485 A HR20020485 A HR 20020485A HR P20020485 A HRP20020485 A HR P20020485A HR P20020485 A2 HRP20020485 A2 HR P20020485A2
- Authority
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- Croatia
- Prior art keywords
- compound
- antiviral
- ribavirin
- drug
- virus
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 65
- IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 title claims description 7
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000001558 permutation test Methods 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000020978 protein processing Effects 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 229960004880 tolnaftate Drugs 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 230000005951 type IV hypersensitivity Effects 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000003242 unipolar neuron Anatomy 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17209799P | 1999-12-23 | 1999-12-23 | |
| US17344699P | 1999-12-29 | 1999-12-29 | |
| US17511100P | 2000-01-06 | 2000-01-06 | |
| US19075800P | 2000-03-20 | 2000-03-20 | |
| US22694700P | 2000-08-22 | 2000-08-22 | |
| US22687500P | 2000-08-22 | 2000-08-22 | |
| US23382300P | 2000-09-19 | 2000-09-19 | |
| US23382200P | 2000-09-19 | 2000-09-19 | |
| US23354800P | 2000-09-19 | 2000-09-19 | |
| US23382100P | 2000-09-19 | 2000-09-19 | |
| US23546500P | 2000-09-26 | 2000-09-26 | |
| PCT/US2000/034605 WO2001045509A1 (en) | 1999-12-23 | 2000-12-19 | Compositions and methods for l-nucleosides, l-nucleotides, and their analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20020485A2 true HRP20020485A2 (en) | 2005-10-31 |
Family
ID=27582702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020485A HRP20020485A2 (en) | 1999-12-23 | 2002-06-03 | Methods and compositions for levovirin |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1244356A4 (ja) |
| JP (1) | JP2003523957A (ja) |
| KR (1) | KR20030032908A (ja) |
| CN (1) | CN1420723A (ja) |
| AU (1) | AU2442201A (ja) |
| BR (1) | BR0016162A (ja) |
| CA (1) | CA2384326A1 (ja) |
| CZ (1) | CZ20022112A3 (ja) |
| HK (1) | HK1049944A1 (ja) |
| HR (1) | HRP20020485A2 (ja) |
| HU (1) | HUP0300219A3 (ja) |
| IL (1) | IL148514A0 (ja) |
| MX (1) | MXPA02006251A (ja) |
| NO (1) | NO20022969D0 (ja) |
| NZ (1) | NZ517634A (ja) |
| PL (1) | PL364927A1 (ja) |
| SI (1) | SI20976A (ja) |
| SK (1) | SK8612002A3 (ja) |
| WO (1) | WO2001045509A1 (ja) |
| YU (1) | YU47802A (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| CN1863812A (zh) | 2003-09-11 | 2006-11-15 | 弗·哈夫曼-拉罗切有限公司 | 多晶型核苷化合物 |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| CN101511185A (zh) * | 2006-09-11 | 2009-08-19 | 南方研究所 | 唑类核苷和作为rna和dna病毒聚合酶抑制剂的用途 |
| CN102952104A (zh) * | 2011-08-17 | 2013-03-06 | 黑龙江省松花江药业有限公司 | 一种呋喃类化合物 |
| CN106061984A (zh) | 2014-02-13 | 2016-10-26 | 配体药物公司 | 前药化合物及其用途 |
| EP3164136A4 (en) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
| CN104387431A (zh) * | 2014-10-24 | 2015-03-04 | 江南大学 | 一种高特异性的利巴韦林人工抗原的制备方法 |
| EP3156050A1 (en) * | 2015-10-16 | 2017-04-19 | Universitat Autònoma De Barcelona | New combination therapies for treating neurological damage |
| CA3087932A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
| CN109528638B (zh) * | 2018-12-20 | 2021-07-06 | 江西润泽药业有限公司 | 利巴韦林衍生物制剂及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3798209A (en) * | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
| EP0262125B1 (en) * | 1986-03-27 | 1996-03-27 | Gensia, Inc. | AICA riboside for the prophylactic treatment of diseases with restricted blood flow. |
| GB9019812D0 (en) * | 1990-09-11 | 1990-10-24 | Scotgen Ltd | Novel antibodies for treatment and prevention of infection in animals and man |
| US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| US5981507A (en) * | 1995-12-14 | 1999-11-09 | Advanced Magnetics, Inc. | Polymeric carriers linked to nucleotide analogues via a phosphoramide bond |
| PL187107B1 (pl) * | 1996-10-16 | 2004-05-31 | Icn Pharmaceuticals | L-nukleozydy monocykliczne, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie |
| ES2172288T3 (es) * | 1998-05-15 | 2002-09-16 | Schering Corp | Terapia de combinacion que comprende ribavirina e interferon alfa en pacientes que no han sido sometidos a tratamiento antiviral y que tienen infeccion cronica de hepatitis c. |
| US6277830B1 (en) * | 1998-10-16 | 2001-08-21 | Schering Corporation | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
| WO2000030656A1 (en) * | 1998-11-20 | 2000-06-02 | The Salk Institute For Biological Studies | Neuron stimulation by ribavirin, and analogs thereof |
-
2000
- 2000-12-19 CA CA002384326A patent/CA2384326A1/en not_active Abandoned
- 2000-12-19 PL PL00364927A patent/PL364927A1/xx not_active Application Discontinuation
- 2000-12-19 SI SI200020047A patent/SI20976A/sl not_active IP Right Cessation
- 2000-12-19 YU YU47802A patent/YU47802A/sh unknown
- 2000-12-19 AU AU24422/01A patent/AU2442201A/en not_active Abandoned
- 2000-12-19 HU HU0300219A patent/HUP0300219A3/hu unknown
- 2000-12-19 JP JP2001546256A patent/JP2003523957A/ja active Pending
- 2000-12-19 KR KR1020027008069A patent/KR20030032908A/ko not_active Application Discontinuation
- 2000-12-19 WO PCT/US2000/034605 patent/WO2001045509A1/en not_active Application Discontinuation
- 2000-12-19 SK SK861-2002A patent/SK8612002A3/sk not_active Application Discontinuation
- 2000-12-19 CZ CZ20022112A patent/CZ20022112A3/cs unknown
- 2000-12-19 NZ NZ517634A patent/NZ517634A/en not_active Application Discontinuation
- 2000-12-19 EP EP00988189A patent/EP1244356A4/en not_active Withdrawn
- 2000-12-19 MX MXPA02006251A patent/MXPA02006251A/es unknown
- 2000-12-19 BR BR0016162-4A patent/BR0016162A/pt not_active IP Right Cessation
- 2000-12-19 CN CN00817416A patent/CN1420723A/zh active Pending
- 2000-12-19 IL IL14851400A patent/IL148514A0/xx unknown
-
2002
- 2002-06-03 HR HR20020485A patent/HRP20020485A2/hr not_active Application Discontinuation
- 2002-06-20 NO NO20022969A patent/NO20022969D0/no not_active Application Discontinuation
-
2003
- 2003-03-28 HK HK03102255.3A patent/HK1049944A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ517634A (en) | 2004-06-25 |
| EP1244356A1 (en) | 2002-10-02 |
| CZ20022112A3 (cs) | 2003-05-14 |
| YU47802A (sh) | 2006-03-03 |
| CA2384326A1 (en) | 2001-06-28 |
| BR0016162A (pt) | 2002-08-13 |
| AU2442201A (en) | 2001-07-03 |
| EP1244356A4 (en) | 2003-03-19 |
| HUP0300219A2 (hu) | 2003-06-28 |
| WO2001045509A1 (en) | 2001-06-28 |
| JP2003523957A (ja) | 2003-08-12 |
| NO20022969L (no) | 2002-06-20 |
| PL364927A1 (en) | 2004-12-27 |
| CN1420723A (zh) | 2003-05-28 |
| NO20022969D0 (no) | 2002-06-20 |
| MXPA02006251A (es) | 2003-01-28 |
| HUP0300219A3 (en) | 2005-07-28 |
| SI20976A (sl) | 2003-02-28 |
| KR20030032908A (ko) | 2003-04-26 |
| HK1049944A1 (zh) | 2003-06-06 |
| SK8612002A3 (en) | 2003-03-04 |
| IL148514A0 (en) | 2002-09-12 |
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| A1OB | Publication of a patent application | ||
| OBST | Application withdrawn |