KR20030032908A - Ｌ-누클레오시드, ｌ-누클레오티드 및 이들의 유사체에대한 조성물 및 방법 - Google Patents

Ｌ-누클레오시드, ｌ-누클레오티드 및 이들의 유사체에대한 조성물 및 방법 Download PDF

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Publication number
KR20030032908A
KR20030032908A KR1020027008069A KR20027008069A KR20030032908A KR 20030032908 A KR20030032908 A KR 20030032908A KR 1020027008069 A KR1020027008069 A KR 1020027008069A KR 20027008069 A KR20027008069 A KR 20027008069A KR 20030032908 A KR20030032908 A KR 20030032908A
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KR
South Korea
Prior art keywords
compound
ribavirin
type
antiviral
compounds
Prior art date
Application number
KR1020027008069A
Other languages
English (en)
Korean (ko)
Inventor
존슨 라우
쯔이 홍
로버트 탐
칸다 라마사미
친-충 린
푸선 제이틴
류비사 라킥
Original Assignee
아이씨엔 파마슈티컬스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아이씨엔 파마슈티컬스, 인코포레이티드 filed Critical 아이씨엔 파마슈티컬스, 인코포레이티드
Publication of KR20030032908A publication Critical patent/KR20030032908A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
KR1020027008069A 1999-12-23 2000-12-19 Ｌ-누클레오시드, ｌ-누클레오티드 및 이들의 유사체에대한 조성물 및 방법 KR20030032908A (ko)

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
US17209799P 1999-12-23 1999-12-23
US60/172,097 1999-12-23
US17344699P 1999-12-29 1999-12-29
US60/173,446 1999-12-29
US17511100P 2000-01-06 2000-01-06
US60/175,111 2000-01-06
US19075800P 2000-03-20 2000-03-20
US60/190,758 2000-03-20
US22687500P 2000-08-22 2000-08-22
US22694700P 2000-08-22 2000-08-22
US60/226,947 2000-08-22
US60/226,875 2000-08-22
US23382300P 2000-09-19 2000-09-19
US23382100P 2000-09-19 2000-09-19
US23382200P 2000-09-19 2000-09-19
US23354800P 2000-09-19 2000-09-19
US60/233,823 2000-09-19
US60/233,822 2000-09-19
US60/233,821 2000-09-19
US60/233,548 2000-09-19
US23546500P 2000-09-26 2000-09-26
US60/235,465 2000-09-26

Publications (1)

Publication Number Publication Date
KR20030032908A true KR20030032908A (ko) 2003-04-26

Family

ID=27582702

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027008069A KR20030032908A (ko) 1999-12-23 2000-12-19 Ｌ-누클레오시드, ｌ-누클레오티드 및 이들의 유사체에대한 조성물 및 방법

Country Status (20)

Country Link
EP (1) EP1244356A4 (ja)
JP (1) JP2003523957A (ja)
KR (1) KR20030032908A (ja)
CN (1) CN1420723A (ja)
AU (1) AU2442201A (ja)
BR (1) BR0016162A (ja)
CA (1) CA2384326A1 (ja)
CZ (1) CZ20022112A3 (ja)
HK (1) HK1049944A1 (ja)
HR (1) HRP20020485A2 (ja)
HU (1) HUP0300219A3 (ja)
IL (1) IL148514A0 (ja)
MX (1) MXPA02006251A (ja)
NO (1) NO20022969D0 (ja)
NZ (1) NZ517634A (ja)
PL (1) PL364927A1 (ja)
SI (1) SI20976A (ja)
SK (1) SK8612002A3 (ja)
WO (1) WO2001045509A1 (ja)
YU (1) YU47802A (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
US6930093B2 (en) * 2003-07-10 2005-08-16 Valeant Research & Development Use of ribofuranose derivatives against inflammatory bowel diseases
CN1863812A (zh) 2003-09-11 2006-11-15 弗·哈夫曼-拉罗切有限公司 多晶型核苷化合物
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
CN101511185A (zh) * 2006-09-11 2009-08-19 南方研究所 唑类核苷和作为rna和dna病毒聚合酶抑制剂的用途
CN102952104A (zh) * 2011-08-17 2013-03-06 黑龙江省松花江药业有限公司 一种呋喃类化合物
CN106061984A (zh) 2014-02-13 2016-10-26 配体药物公司 前药化合物及其用途
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
CN104387431A (zh) * 2014-10-24 2015-03-04 江南大学 一种高特异性的利巴韦林人工抗原的制备方法
EP3156050A1 (en) * 2015-10-16 2017-04-19 Universitat Autònoma De Barcelona New combination therapies for treating neurological damage
CA3087932A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
CN109528638B (zh) * 2018-12-20 2021-07-06 江西润泽药业有限公司 利巴韦林衍生物制剂及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
EP0262125B1 (en) * 1986-03-27 1996-03-27 Gensia, Inc. AICA riboside for the prophylactic treatment of diseases with restricted blood flow.
GB9019812D0 (en) * 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
US6387365B1 (en) * 1995-05-19 2002-05-14 Schering Corporation Combination therapy for chronic hepatitis C infection
US5981507A (en) * 1995-12-14 1999-11-09 Advanced Magnetics, Inc. Polymeric carriers linked to nucleotide analogues via a phosphoramide bond
PL187107B1 (pl) * 1996-10-16 2004-05-31 Icn Pharmaceuticals L-nukleozydy monocykliczne, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie
ES2172288T3 (es) * 1998-05-15 2002-09-16 Schering Corp Terapia de combinacion que comprende ribavirina e interferon alfa en pacientes que no han sido sometidos a tratamiento antiviral y que tienen infeccion cronica de hepatitis c.
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
WO2000030656A1 (en) * 1998-11-20 2000-06-02 The Salk Institute For Biological Studies Neuron stimulation by ribavirin, and analogs thereof

Also Published As

Publication number Publication date
NZ517634A (en) 2004-06-25
EP1244356A1 (en) 2002-10-02
CZ20022112A3 (cs) 2003-05-14
YU47802A (sh) 2006-03-03
CA2384326A1 (en) 2001-06-28
BR0016162A (pt) 2002-08-13
AU2442201A (en) 2001-07-03
EP1244356A4 (en) 2003-03-19
HUP0300219A2 (hu) 2003-06-28
WO2001045509A1 (en) 2001-06-28
JP2003523957A (ja) 2003-08-12
NO20022969L (no) 2002-06-20
PL364927A1 (en) 2004-12-27
HRP20020485A2 (en) 2005-10-31
CN1420723A (zh) 2003-05-28
NO20022969D0 (no) 2002-06-20
MXPA02006251A (es) 2003-01-28
HUP0300219A3 (en) 2005-07-28
SI20976A (sl) 2003-02-28
HK1049944A1 (zh) 2003-06-06
SK8612002A3 (en) 2003-03-04
IL148514A0 (en) 2002-09-12

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