HRP20020298B1 - Pharmaceutical solutions of levosimendan - Google Patents

Pharmaceutical solutions of levosimendan

Info

Publication number
HRP20020298B1
HRP20020298B1 HR20020298A HRP20020298A HRP20020298B1 HR P20020298 B1 HRP20020298 B1 HR P20020298B1 HR 20020298 A HR20020298 A HR 20020298A HR P20020298 A HRP20020298 A HR P20020298A HR P20020298 B1 HRP20020298 B1 HR P20020298B1
Authority
HR
Croatia
Prior art keywords
levosimendan
pharmaceutical solutions
less
solution
infusion
Prior art date
Application number
HR20020298A
Other languages
English (en)
Croatian (hr)
Inventor
Baeckstroem Reijo
Granvik Paivi
Haikala Ritva
Pelttari Sirpa
Saukko Eva
Yrjoelae Reija
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8555263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20020298(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of HRP20020298A2 publication Critical patent/HRP20020298A2/hr
Publication of HRP20020298B1 publication Critical patent/HRP20020298B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HR20020298A 1999-09-10 2002-04-08 Pharmaceutical solutions of levosimendan HRP20020298B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991925A FI109659B (fi) 1999-09-10 1999-09-10 Levosimendaanin farmaseuttisia liuoksia
PCT/FI2000/000761 WO2001019334A2 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan

Publications (2)

Publication Number Publication Date
HRP20020298A2 HRP20020298A2 (en) 2003-06-30
HRP20020298B1 true HRP20020298B1 (en) 2007-02-28

Family

ID=8555263

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020298A HRP20020298B1 (en) 1999-09-10 2002-04-08 Pharmaceutical solutions of levosimendan

Country Status (39)

Country Link
US (2) US6730673B1 (xx)
EP (1) EP1210085B1 (xx)
JP (1) JP4708648B2 (xx)
KR (1) KR100869752B1 (xx)
CN (1) CN1203855C (xx)
AR (1) AR025449A1 (xx)
AT (1) ATE315937T1 (xx)
AU (1) AU771027B2 (xx)
BG (1) BG65827B1 (xx)
BR (1) BRPI0013924B8 (xx)
CA (1) CA2382013C (xx)
CO (1) CO5180582A1 (xx)
CZ (1) CZ303095B6 (xx)
DE (1) DE60025627T2 (xx)
DK (1) DK1210085T3 (xx)
EA (1) EA005067B1 (xx)
EE (1) EE05375B1 (xx)
ES (1) ES2256034T3 (xx)
FI (1) FI109659B (xx)
HK (1) HK1049282B (xx)
HR (1) HRP20020298B1 (xx)
HU (1) HU228340B1 (xx)
IL (2) IL148379A0 (xx)
IS (1) IS2244B (xx)
ME (1) ME00523B (xx)
MX (1) MXPA02002423A (xx)
MY (1) MY125984A (xx)
NO (1) NO331989B1 (xx)
NZ (1) NZ517605A (xx)
PL (1) PL202356B1 (xx)
PT (1) PT1210085E (xx)
RS (1) RS50445B (xx)
SI (1) SI1210085T1 (xx)
SK (1) SK287154B6 (xx)
TR (1) TR200200620T2 (xx)
TW (1) TWI242434B (xx)
UA (1) UA73954C2 (xx)
WO (1) WO2001019334A2 (xx)
ZA (1) ZA200201828B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
CN100367964C (zh) * 2004-04-29 2008-02-13 王思清 左西孟旦-β环糊精包含物制剂
JP2008530186A (ja) * 2005-02-18 2008-08-07 オリオン コーポレーション 心不全治療法
JP2010514778A (ja) * 2006-12-28 2010-05-06 オリオン コーポレーション 非経口投与のためのレボシメンダン製剤
WO2012093404A2 (en) 2011-01-03 2012-07-12 Gufic Biosciences Limited Parenteral formulations of levosimendan
US9597425B2 (en) * 2011-10-18 2017-03-21 St. Teresa Medical, Inc. Method of forming a hemostatic product
US9808529B2 (en) * 2012-05-18 2017-11-07 Luoda Pharma Pty Ltd Liquid formulation
CN105106113B (zh) * 2015-09-30 2019-07-26 济南康和医药科技有限公司 一种左西孟旦注射液及其制备方法
EA034565B1 (ru) * 2015-11-06 2020-02-20 Каринофарм Гмбх Композиции левосимендана для внутривенного введения в виде инфузии или инъекции и концентрата для инфузии
WO2017083050A1 (en) 2015-11-12 2017-05-18 St. Teresa Medical, Inc. A method of sealing a durotomy
CN108261398A (zh) * 2016-12-30 2018-07-10 齐鲁制药有限公司 一种含有左西孟旦的供注射用药物制剂及其制备方法
US10953128B2 (en) 2017-11-02 2021-03-23 St. Teresa Medical, Inc. Fibrin sealant products
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
WO2021126884A1 (en) 2019-12-16 2021-06-24 Tenax Therapeutics, Inc. LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-pEF)
CN111514147B (zh) * 2020-05-12 2021-09-17 成都欣捷高新技术开发股份有限公司 用于急性失代偿心力衰竭症状的左西孟旦钠药用组合物及制备方法
US11760730B2 (en) * 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan
WO2023027670A2 (en) * 2021-08-23 2023-03-02 Tum Ekip Ilac Anonim Sirketi Lyophilized levosimendan compositions
CN115518037A (zh) * 2022-10-14 2022-12-27 上药东英（江苏）药业有限公司 一种安全质量稳定的左西孟旦注射剂组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2251615B (en) 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
FI980902A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia

Also Published As

Publication number Publication date
PL202356B1 (pl) 2009-06-30
FI19991925A (fi) 2001-03-10
WO2001019334A2 (en) 2001-03-22
SI1210085T1 (sl) 2006-04-30
DK1210085T3 (da) 2006-05-08
HRP20020298A2 (en) 2003-06-30
CZ303095B6 (cs) 2012-03-28
SK287154B6 (sk) 2010-01-07
PL354028A1 (en) 2003-12-15
FI109659B (fi) 2002-09-30
BR0013924B1 (pt) 2013-09-24
NZ517605A (en) 2003-08-29
IS2244B (is) 2007-05-15
EP1210085A2 (en) 2002-06-05
ZA200201828B (en) 2003-08-27
TWI242434B (en) 2005-11-01
ME00523B (me) 2011-10-10
HK1049282B (zh) 2005-12-30
NO20021090D0 (no) 2002-03-05
CO5180582A1 (es) 2002-07-30
BG65827B1 (bg) 2010-02-26
CA2382013A1 (en) 2001-03-22
HK1049282A1 (en) 2003-05-09
MY125984A (en) 2006-09-29
BR0013924A (pt) 2002-05-21
JP2003509351A (ja) 2003-03-11
DE60025627T2 (de) 2006-11-16
HUP0202749A2 (hu) 2003-02-28
IS6296A (is) 2002-03-06
ATE315937T1 (de) 2006-02-15
IL148379A (en) 2006-12-10
JP4708648B2 (ja) 2011-06-22
UA73954C2 (uk) 2005-10-17
TR200200620T2 (tr) 2002-09-23
NO331989B1 (no) 2012-05-21
AU7004400A (en) 2001-04-17
EA200200348A1 (ru) 2002-08-29
RS50445B (sr) 2010-03-02
BG106589A (bg) 2002-11-29
EP1210085B1 (en) 2006-01-18
NO20021090L (no) 2002-03-05
CA2382013C (en) 2009-08-11
WO2001019334A3 (en) 2001-11-15
KR100869752B1 (ko) 2008-11-21
CN1203855C (zh) 2005-06-01
DE60025627D1 (de) 2006-04-06
BRPI0013924B8 (pt) 2021-05-25
YU16902A (sh) 2004-09-03
ES2256034T3 (es) 2006-07-16
AU771027B2 (en) 2004-03-11
HUP0202749A3 (en) 2003-03-28
SK3272002A3 (en) 2002-12-03
CZ2002788A3 (cs) 2002-11-13
EE200200129A (et) 2003-04-15
EE05375B1 (et) 2011-02-15
IL148379A0 (en) 2002-09-12
US6730673B1 (en) 2004-05-04
MXPA02002423A (es) 2002-08-12
EA005067B1 (ru) 2004-10-28
PT1210085E (pt) 2006-05-31
HU228340B1 (en) 2013-03-28
US6943164B2 (en) 2005-09-13
US20040106617A1 (en) 2004-06-03
AR025449A1 (es) 2002-11-27
KR20020048400A (ko) 2002-06-22
CN1373665A (zh) 2002-10-09

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Payment date: 20190828

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Effective date: 20200908