FI19991925A - Levosimendaanin farmaseuttisia liuoksia - Google Patents

Levosimendaanin farmaseuttisia liuoksia

Info

Publication number
FI19991925A
FI19991925A FI991925A FI19991925A FI19991925A FI 19991925 A FI19991925 A FI 19991925A FI 991925 A FI991925 A FI 991925A FI 19991925 A FI19991925 A FI 19991925A FI 19991925 A FI19991925 A FI 19991925A
Authority
FI
Finland
Prior art keywords
levosimendan
pharmaceutical solutions
pharmaceutical
solutions
Prior art date
Application number
FI991925A
Other languages
English (en)
Swedish (sv)
Other versions
FI109659B (fi
Inventor
Reijo Baeckstroem
Paeivi Granvik
Ritva Haikala
Sirpa Pelttari
Eva Saukko
Reija Yrjoelae
Original Assignee
Orion Yhtymae Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8555263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI19991925(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Yhtymae Oyj filed Critical Orion Yhtymae Oyj
Priority to FI991925A priority Critical patent/FI109659B/fi
Priority to UA2002042873A priority patent/UA73954C2/uk
Priority to MYPI20003682A priority patent/MY125984A/en
Priority to TW089117581A priority patent/TWI242434B/zh
Priority to ARP000104525A priority patent/AR025449A1/es
Priority to CO00067212A priority patent/CO5180582A1/es
Priority to US10/070,689 priority patent/US6730673B1/en
Priority to CZ20020788A priority patent/CZ303095B6/cs
Priority to CNB008126453A priority patent/CN1203855C/zh
Priority to PL354028A priority patent/PL202356B1/pl
Priority to MXPA02002423A priority patent/MXPA02002423A/es
Priority to AU70044/00A priority patent/AU771027B2/en
Priority to PCT/FI2000/000761 priority patent/WO2001019334A2/en
Priority to DE60025627T priority patent/DE60025627T2/de
Priority to ES00958562T priority patent/ES2256034T3/es
Priority to CA002382013A priority patent/CA2382013C/en
Priority to IL14837900A priority patent/IL148379A0/xx
Priority to YUP-169/02A priority patent/RS50445B/sr
Priority to EP00958562A priority patent/EP1210085B1/en
Priority to MEP-2008-866A priority patent/ME00523B/me
Priority to BRPI0013924A priority patent/BRPI0013924B8/pt
Priority to PT00958562T priority patent/PT1210085E/pt
Priority to TR2002/00620T priority patent/TR200200620T2/xx
Priority to JP2001522969A priority patent/JP4708648B2/ja
Priority to DK00958562T priority patent/DK1210085T3/da
Priority to AT00958562T priority patent/ATE315937T1/de
Priority to EA200200348A priority patent/EA005067B1/ru
Priority to HU0202749A priority patent/HU228340B1/hu
Priority to NZ517605A priority patent/NZ517605A/en
Priority to KR20027002923A priority patent/KR100869752B1/ko
Priority to SI200030801T priority patent/SI1210085T1/sl
Priority to SK327-2002A priority patent/SK287154B6/sk
Priority to EEP200200129A priority patent/EE05375B1/xx
Publication of FI19991925A publication Critical patent/FI19991925A/fi
Priority to IL148379A priority patent/IL148379A/en
Priority to NO20021090A priority patent/NO331989B1/no
Priority to ZA200201828A priority patent/ZA200201828B/xx
Priority to IS6296A priority patent/IS2244B/is
Priority to BG106589A priority patent/BG65827B1/bg
Priority to HR20020298A priority patent/HRP20020298B1/xx
Publication of FI109659B publication Critical patent/FI109659B/fi
Application granted granted Critical
Priority to HK03101189.6A priority patent/HK1049282B/zh
Priority to US10/703,565 priority patent/US6943164B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FI991925A 1999-09-10 1999-09-10 Levosimendaanin farmaseuttisia liuoksia FI109659B (fi)

Priority Applications (41)

Application Number Priority Date Filing Date Title
FI991925A FI109659B (fi) 1999-09-10 1999-09-10 Levosimendaanin farmaseuttisia liuoksia
UA2002042873A UA73954C2 (uk) 1999-09-10 2000-08-09 Водний розчин для внутрішньовенного введення та фармацевтичний розчин, що містять левосимендан
MYPI20003682A MY125984A (en) 1999-09-10 2000-08-11 Pharmaceutical solutions of levosimendan.
TW089117581A TWI242434B (en) 1999-09-10 2000-08-30 Pharmaceutical solutions of levosimendan
ARP000104525A AR025449A1 (es) 1999-09-10 2000-08-30 Soluciones farmaceuticas de levosimendan
CO00067212A CO5180582A1 (es) 1999-09-10 2000-09-06 Soluciones farmaceuticas de levosimendan
BRPI0013924A BRPI0013924B8 (pt) 1999-09-10 2000-09-08 soluções farmacêuticas de levosimendano
AT00958562T ATE315937T1 (de) 1999-09-10 2000-09-08 Pharmazeutische lösung von levosimendan
CNB008126453A CN1203855C (zh) 1999-09-10 2000-09-08 左西孟旦的药物溶液
PL354028A PL202356B1 (pl) 1999-09-10 2000-09-08 Wodny roztwór do infuzji dożylnej i kompozycja farmaceutyczna w postaci roztworu
MXPA02002423A MXPA02002423A (es) 1999-09-10 2000-09-08 Soluciones farmaceuticas de levosimendan.
AU70044/00A AU771027B2 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan
PCT/FI2000/000761 WO2001019334A2 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan
DE60025627T DE60025627T2 (de) 1999-09-10 2000-09-08 Pharmazeutische lösung von levosimendan
ES00958562T ES2256034T3 (es) 1999-09-10 2000-09-08 Soluciones farmaceuticas de levosimendano.
CA002382013A CA2382013C (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan
IL14837900A IL148379A0 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan
YUP-169/02A RS50445B (sr) 1999-09-10 2000-09-08 Farmaceutski rastvori levosimendana
EP00958562A EP1210085B1 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan
MEP-2008-866A ME00523B (me) 1999-09-10 2000-09-08 Farmaceutski rastvori levosimendana
US10/070,689 US6730673B1 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan
PT00958562T PT1210085E (pt) 1999-09-10 2000-09-08 Solucoes farmaceuticas de levosimendano
TR2002/00620T TR200200620T2 (tr) 1999-09-10 2000-09-08 Levosimendan farmasötik solüsyonları
JP2001522969A JP4708648B2 (ja) 1999-09-10 2000-09-08 レボシメンダンの医薬溶液
DK00958562T DK1210085T3 (da) 1999-09-10 2000-09-08 Farmaceutiske oplösninger af levosimendan
CZ20020788A CZ303095B6 (cs) 1999-09-10 2000-09-08 Vodný intravenosní infusní roztok nebo farmaceutický roztok obsahující levosimendan
EA200200348A EA005067B1 (ru) 1999-09-10 2000-09-08 Фармацевтические растворы левосимендана
HU0202749A HU228340B1 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan
NZ517605A NZ517605A (en) 1999-09-10 2000-09-08 Levosimendan solutions at a pH less than 5 particularly for intravenous administration
KR20027002923A KR100869752B1 (ko) 1999-09-10 2000-09-08 레보시멘단의 약학적 액제
SI200030801T SI1210085T1 (sl) 1999-09-10 2000-09-08 Farmacevtske raztopine levosimendana
SK327-2002A SK287154B6 (sk) 1999-09-10 2000-09-08 Vodný intravenózny infúzny roztok alebo farmaceutický roztok obsahujúci levosimendan
EEP200200129A EE05375B1 (et) 1999-09-10 2000-09-08 LevosimendaniÁfarmatseutilineÁlahus
IL148379A IL148379A (en) 1999-09-10 2002-02-26 Pharmacist solutions of Livsimanden
NO20021090A NO331989B1 (no) 1999-09-10 2002-03-05 Vandig intravenos infusjonsopplosning og intravenost infusjonskonsentrat omfattende levosimendan.
ZA200201828A ZA200201828B (en) 1999-09-10 2002-03-05 Pharmaceutical solutions of levosimendan.
IS6296A IS2244B (is) 1999-09-10 2002-03-06 Lyfjalausnir af levósímendani
BG106589A BG65827B1 (bg) 1999-09-10 2002-04-05 Фармацевтични разтвори от левосимендан
HR20020298A HRP20020298B1 (en) 1999-09-10 2002-04-08 Pharmaceutical solutions of levosimendan
HK03101189.6A HK1049282B (zh) 1999-09-10 2003-02-18 左西孟旦的藥物溶液
US10/703,565 US6943164B2 (en) 1999-09-10 2003-11-10 Pharmaceutical solutions of levosimendan

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991925 1999-09-10
FI991925A FI109659B (fi) 1999-09-10 1999-09-10 Levosimendaanin farmaseuttisia liuoksia

Publications (2)

Publication Number Publication Date
FI19991925A true FI19991925A (fi) 2001-03-10
FI109659B FI109659B (fi) 2002-09-30

Family

ID=8555263

Family Applications (1)

Application Number Title Priority Date Filing Date
FI991925A FI109659B (fi) 1999-09-10 1999-09-10 Levosimendaanin farmaseuttisia liuoksia

Country Status (39)

Country Link
US (2) US6730673B1 (fi)
EP (1) EP1210085B1 (fi)
JP (1) JP4708648B2 (fi)
KR (1) KR100869752B1 (fi)
CN (1) CN1203855C (fi)
AR (1) AR025449A1 (fi)
AT (1) ATE315937T1 (fi)
AU (1) AU771027B2 (fi)
BG (1) BG65827B1 (fi)
BR (1) BRPI0013924B8 (fi)
CA (1) CA2382013C (fi)
CO (1) CO5180582A1 (fi)
CZ (1) CZ303095B6 (fi)
DE (1) DE60025627T2 (fi)
DK (1) DK1210085T3 (fi)
EA (1) EA005067B1 (fi)
EE (1) EE05375B1 (fi)
ES (1) ES2256034T3 (fi)
FI (1) FI109659B (fi)
HK (1) HK1049282B (fi)
HR (1) HRP20020298B1 (fi)
HU (1) HU228340B1 (fi)
IL (2) IL148379A0 (fi)
IS (1) IS2244B (fi)
ME (1) ME00523B (fi)
MX (1) MXPA02002423A (fi)
MY (1) MY125984A (fi)
NO (1) NO331989B1 (fi)
NZ (1) NZ517605A (fi)
PL (1) PL202356B1 (fi)
PT (1) PT1210085E (fi)
RS (1) RS50445B (fi)
SI (1) SI1210085T1 (fi)
SK (1) SK287154B6 (fi)
TR (1) TR200200620T2 (fi)
TW (1) TWI242434B (fi)
UA (1) UA73954C2 (fi)
WO (1) WO2001019334A2 (fi)
ZA (1) ZA200201828B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
CN100367964C (zh) * 2004-04-29 2008-02-13 王思清 左西孟旦-β环糊精包含物制剂
WO2006087420A2 (en) * 2005-02-18 2006-08-24 Orion Corporation A method for treating heart failure
JP2010514778A (ja) * 2006-12-28 2010-05-06 オリオン コーポレーション 非経口投与のためのレボシメンダン製剤
WO2012093404A2 (en) * 2011-01-03 2012-07-12 Gufic Biosciences Limited Parenteral formulations of levosimendan
US20130096479A1 (en) * 2011-10-18 2013-04-18 St. Teresa Medical, Inc. Method of forming hemostatic products
JP2015516441A (ja) * 2012-05-18 2015-06-11 ルオダ ファーマ ピーティーワイ リミテッド 液体配合剤
CN105106113B (zh) * 2015-09-30 2019-07-26 济南康和医药科技有限公司 一种左西孟旦注射液及其制备方法
ME03761B (me) 2015-11-06 2021-01-20 Carinopharm Gmbh Poboljšane formulacije levosimendana za intravensku primjenu u vidu infuzije ili injekcije i koncentrata za infuziju
EP3373853A4 (en) 2015-11-12 2019-07-10 St. Teresa Medical, Inc. METHOD FOR SEALING A DUROTOMY
CN108261398A (zh) * 2016-12-30 2018-07-10 齐鲁制药有限公司 一种含有左西孟旦的供注射用药物制剂及其制备方法
US10953128B2 (en) 2017-11-02 2021-03-23 St. Teresa Medical, Inc. Fibrin sealant products
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
CA3161960A1 (en) 2019-12-16 2021-06-24 Tenax Therapeutics, Inc. Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (ph-hfpef)
CN111514147B (zh) * 2020-05-12 2021-09-17 成都欣捷高新技术开发股份有限公司 用于急性失代偿心力衰竭症状的左西孟旦钠药用组合物及制备方法
US11760730B2 (en) 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan
WO2023027670A2 (en) * 2021-08-23 2023-03-02 Tum Ekip Ilac Anonim Sirketi Lyophilized levosimendan compositions
CN115518037A (zh) * 2022-10-14 2022-12-27 上药东英（江苏）药业有限公司 一种安全质量稳定的左西孟旦注射剂组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2251615B (en) 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
FI980902A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia

Also Published As

Publication number Publication date
HU228340B1 (en) 2013-03-28
IS6296A (is) 2002-03-06
EP1210085A2 (en) 2002-06-05
TR200200620T2 (tr) 2002-09-23
AU7004400A (en) 2001-04-17
BG106589A (bg) 2002-11-29
CO5180582A1 (es) 2002-07-30
HUP0202749A3 (en) 2003-03-28
NZ517605A (en) 2003-08-29
ES2256034T3 (es) 2006-07-16
WO2001019334A2 (en) 2001-03-22
PL354028A1 (en) 2003-12-15
UA73954C2 (uk) 2005-10-17
BG65827B1 (bg) 2010-02-26
MY125984A (en) 2006-09-29
PL202356B1 (pl) 2009-06-30
DE60025627T2 (de) 2006-11-16
HK1049282B (zh) 2005-12-30
US6943164B2 (en) 2005-09-13
BR0013924B1 (pt) 2013-09-24
FI109659B (fi) 2002-09-30
EE200200129A (et) 2003-04-15
DK1210085T3 (da) 2006-05-08
YU16902A (sh) 2004-09-03
JP4708648B2 (ja) 2011-06-22
CZ303095B6 (cs) 2012-03-28
US6730673B1 (en) 2004-05-04
JP2003509351A (ja) 2003-03-11
HUP0202749A2 (hu) 2003-02-28
KR100869752B1 (ko) 2008-11-21
HK1049282A1 (en) 2003-05-09
SI1210085T1 (sl) 2006-04-30
NO20021090D0 (no) 2002-03-05
ZA200201828B (en) 2003-08-27
TWI242434B (en) 2005-11-01
EE05375B1 (et) 2011-02-15
CN1373665A (zh) 2002-10-09
CA2382013A1 (en) 2001-03-22
BR0013924A (pt) 2002-05-21
RS50445B (sr) 2010-03-02
ATE315937T1 (de) 2006-02-15
EP1210085B1 (en) 2006-01-18
KR20020048400A (ko) 2002-06-22
NO331989B1 (no) 2012-05-21
CA2382013C (en) 2009-08-11
IL148379A0 (en) 2002-09-12
CN1203855C (zh) 2005-06-01
US20040106617A1 (en) 2004-06-03
SK287154B6 (sk) 2010-01-07
DE60025627D1 (de) 2006-04-06
HRP20020298B1 (en) 2007-02-28
WO2001019334A3 (en) 2001-11-15
IS2244B (is) 2007-05-15
IL148379A (en) 2006-12-10
MXPA02002423A (es) 2002-08-12
PT1210085E (pt) 2006-05-31
HRP20020298A2 (en) 2003-06-30
ME00523B (me) 2011-10-10
CZ2002788A3 (cs) 2002-11-13
SK3272002A3 (en) 2002-12-03
EA200200348A1 (ru) 2002-08-29
AU771027B2 (en) 2004-03-11
NO20021090L (no) 2002-03-05
EA005067B1 (ru) 2004-10-28
AR025449A1 (es) 2002-11-27
BRPI0013924B8 (pt) 2021-05-25

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