HK8488A - Antifungal agents,processes for their preparation,and pharmaceutical compositions containing them - Google Patents

Antifungal agents,processes for their preparation,and pharmaceutical compositions containing them

Info

Publication number
HK8488A
HK8488A HK84/88A HK8488A HK8488A HK 8488 A HK8488 A HK 8488A HK 84/88 A HK84/88 A HK 84/88A HK 8488 A HK8488 A HK 8488A HK 8488 A HK8488 A HK 8488A
Authority
HK
Hong Kong
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
antifungal agents
Prior art date
Application number
HK84/88A
Other languages
English (en)
Inventor
Kenneth Richardson
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27261198&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK8488(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of HK8488A publication Critical patent/HK8488A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK84/88A 1981-06-06 1988-01-28 Antifungal agents,processes for their preparation,and pharmaceutical compositions containing them HK8488A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8117379 1981-06-06
GB8131370 1981-10-17
GB8206329 1982-03-04

Publications (1)

Publication Number Publication Date
HK8488A true HK8488A (en) 1988-02-05

Family

ID=27261198

Family Applications (1)

Application Number Title Priority Date Filing Date
HK84/88A HK8488A (en) 1981-06-06 1988-01-28 Antifungal agents,processes for their preparation,and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US4404216A (fr)
EP (1) EP0069442B1 (fr)
KR (1) KR850001132B1 (fr)
AU (1) AU529987B2 (fr)
CA (1) CA1181076A (fr)
DE (1) DE3262386D1 (fr)
DK (1) DK149849C (fr)
EG (1) EG17222A (fr)
ES (2) ES512882A0 (fr)
FI (1) FI71134C (fr)
GR (1) GR76491B (fr)
HK (1) HK8488A (fr)
HU (1) HU189143B (fr)
IE (1) IE53144B1 (fr)
IL (1) IL65963A (fr)
IN (1) IN158113B (fr)
LU (1) LU88329I2 (fr)
MX (1) MX7119E (fr)
MY (1) MY8800094A (fr)
NL (1) NL930061I2 (fr)
NO (2) NO156128C (fr)
NZ (1) NZ200864A (fr)
PH (1) PH18015A (fr)
PL (1) PL130909B1 (fr)
PT (1) PT75017B (fr)
SG (1) SG80887G (fr)
YU (1) YU42770B (fr)

Families Citing this family (76)

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US5466821A (en) * 1981-03-18 1995-11-14 Zeneca Limited Heterocyclic compounds
DE3218130A1 (de) * 1982-05-14 1983-11-17 Basf Ag, 6700 Ludwigshafen Azolylmethyloxirane, verfahren zu ihrer herstellung und diese enthaltende fungizide
US4510148A (en) * 1982-06-12 1985-04-09 Pfizer Inc. 2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents
US4466974A (en) * 1982-11-16 1984-08-21 Pfizer Inc. Bistriazole antifungal agents
GB8302500D0 (en) * 1983-01-29 1983-03-02 Pfizer Ltd Antifungal agents
GB8304282D0 (en) * 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
GB8305377D0 (en) * 1983-02-25 1983-03-30 Pfizer Ltd Antifungal agents
DE3307216A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Fungizide mittel
DE3307217A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte 1,3-diazolyl-2-propanole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
DE3307218A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
US4992454A (en) * 1983-03-16 1991-02-12 Pfizer Inc. Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof
DE3313073A1 (de) * 1983-04-12 1984-10-18 Bayer Ag, 5090 Leverkusen 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
GB8313235D0 (en) * 1983-05-13 1983-06-22 Pfizer Ltd Antifungal agents
US4482564A (en) * 1983-06-03 1984-11-13 Schering Corporation Triazolyl-substituted propane derivatives
DE3332415A1 (de) * 1983-09-08 1985-03-28 Messerschmitt-Bölkow-Blohm GmbH, 8012 Ottobrunn Steuerbares stroemungsumlenksystem
USH672H (en) 1986-12-31 1989-09-05 E. R. Squibb & Sons, Inc. Stable antifungal capsule formulation
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GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
DE4134125C2 (de) * 1991-10-15 1995-02-02 Mack Chem Pharm Triazol-Derivate enthaltende pharmazeutische Zusammensetzungen zur rektalen Applikation
TW212798B (fr) * 1991-11-25 1993-09-11 Takeda Pharm Industry Co Ltd
CA2102518A1 (fr) * 1992-03-04 1993-09-05 Vladimir Z. Gurevich Agents antifongiques
ES2040181B1 (es) * 1992-03-30 1994-05-16 Uriach & Cia Sa J Procedimiento para la obtencion de nuevas dihidropiridinas.
IL105200A (en) * 1993-03-29 1997-03-18 Teva Pharma Regiospecific processes for the preparation of 1, 3-bis (1, 2, 4-triazol-1-yl)-propan- 2-ol derivatives
CA2106032C (fr) * 1993-09-13 1995-11-07 Gamini Weeratunga Methodes pour la fabrication de la fluoconazole et de ses derives, composes intermediaires utiles pour leur fabrication, et combinaisons comportant de la fluoconazole
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
NZ270418A (en) 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
CA2139079C (fr) * 1994-12-23 1996-05-28 K.S. Keshava Murthy Procede commercial pour la fabrication de fluconazole et intermediaires utiles a cette fin
CN1054853C (zh) * 1995-01-11 2000-07-26 上海三维制药公司 氟康唑中间体1－[2－(2,4－二氟苯基)2,3－环氧丙基]－1h－1,2,4－三氮唑及其甲磺酸盐的制备方法
US6200992B1 (en) 1995-06-07 2001-03-13 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
US5665751A (en) * 1995-06-07 1997-09-09 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
US5770616A (en) * 1995-06-07 1998-06-23 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
NZ272586A (en) * 1995-07-17 1996-10-28 Apotex Inc Process for preparing fluconazole and triazolylepoxypropane precursors
US5908855A (en) * 1996-07-16 1999-06-01 The Procter & Gamble Company Compositions for treating viral infections
GB9605705D0 (en) 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
TW436484B (en) * 1996-04-24 2001-05-28 Dev Center Biotechnology 1,2,3,4-tetrahydroisoquinoline derivatives having a nitrogen-containing heterocyclic methyl substituent, the preparation process and pharmaceutical composition thereof
DE19617282A1 (de) * 1996-04-30 1997-11-06 Bayer Ag Triazolyl-mercaptide
DE19617461A1 (de) 1996-05-02 1997-11-06 Bayer Ag Acylmercapto-triazolyl-Derivate
DE19619544A1 (de) * 1996-05-15 1997-11-20 Bayer Ag Triazolyl-Disulfide
DE19620407A1 (de) * 1996-05-21 1997-11-27 Bayer Ag Thiocyano-triazolyl-Derivate
DE19620590A1 (de) * 1996-05-22 1997-11-27 Bayer Ag Sulfonyl-mercapto-triazolyl-Derivate
US5710280A (en) * 1996-07-09 1998-01-20 Development Center For Biotechnology Preparation of fluconazole and pharmaceutically acceptable salts thereof
NZ328607A (en) * 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
KR100194945B1 (ko) * 1997-01-29 1999-06-15 서치영 플루코나졸의 제조방법
GR980100028A (el) * 1998-01-15 1999-09-30 Drug Research Hellas ����� Φαρμακευτικα προιοντα για τοπικη χρηση που περιεχουν φλουκοναζολη σε συγκεντρωσεις μεταξυ 0,2% και 5%
CN1081189C (zh) * 1998-07-17 2002-03-20 国家医药管理局四川抗菌素工业研究所 唑醇类新衍生物及其制备方法和医药用途
IN191188B (fr) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
KR100423666B1 (ko) * 2001-02-07 2004-03-18 보령제약 주식회사 항진균 외용 제제
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
ATE309226T1 (de) * 2001-03-23 2005-11-15 Richter Gedeon Vegyeszet Verfahren zur herstellung von fluconazole und kristallmodifikationen davon
US6951654B2 (en) * 2001-03-27 2005-10-04 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
GB2400848B (en) * 2002-02-12 2005-06-22 Fdc Ltd Novel anti-fungal agents
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
US8404751B2 (en) * 2002-09-27 2013-03-26 Hallux, Inc. Subunguicide, and method for treating onychomycosis
US20050074494A1 (en) * 2003-10-06 2005-04-07 Xiu-Xiu Cheng Itraconazole immediate release formulation
GB0402491D0 (en) * 2004-02-04 2004-03-10 Pfizer Ltd Medicaments
US20050282878A1 (en) * 2004-04-13 2005-12-22 Batchu Chandrasekhar Process for the purification of fluconazole
US20060252940A1 (en) * 2005-05-05 2006-11-09 Sudhakar Valluri Crystalline 1-[2-(2,4-difluorophenyl)-oxiranyl methyl]-1h-1,2,4-triazole
KR100998816B1 (ko) * 2005-10-31 2010-12-06 주식회사 대웅제약 신규한 항진균성 트리아졸 유도체
TWI426918B (zh) * 2007-02-12 2014-02-21 Merck Sharp & Dohme Ｉｌ-２３拮抗劑於治療感染之用途
KR100909953B1 (ko) * 2007-06-15 2009-07-31 한국화학연구원 항진균 활성을 갖는 트라이아졸 유도체, 이의 제조방법 및이를 함유하는 약학 조성물
US20090062357A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched fluconazole
JP2009286756A (ja) * 2008-05-30 2009-12-10 Fujifilm Finechemicals Co Ltd トリアゾール誘導体またはその塩
KR100971371B1 (ko) 2010-02-04 2010-07-20 동국제약 주식회사 신규한 중간체를 이용한 보리코나졸의 제조방법
WO2011101862A1 (fr) 2010-02-17 2011-08-25 Fdc Limited Formulation stabilisée de la forme polymorphe iii du fluconazole
US9309273B2 (en) 2011-12-11 2016-04-12 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
CA2904703A1 (fr) 2013-03-14 2014-10-02 Hallux, Inc. Procede de traitement d'infections, maladies ou troubles d'unite d'ongle
BR102013027313B1 (pt) * 2013-10-23 2019-06-18 Iharabras S.A. Indústrias Químicas Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso
RU2538962C1 (ru) * 2013-11-19 2015-01-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Противогрибковые соединения на основе производных 3,5,8-триоксабицикло[5.1.0]октана
ES2821021T3 (es) 2015-09-18 2021-04-23 Nqp 1598 Ltd Procedimiento de compuestos antifúngicos
EA202190092A1 (ru) 2018-06-21 2021-05-18 Юманити Терапьютикс, Инк. Композиции и способы лечения и профилактики неврологических расстройств
CN111454227A (zh) * 2020-05-21 2020-07-28 湖南复瑞生物医药技术有限责任公司 一种西洛他唑中间体的制备方法
CN112137972A (zh) * 2020-09-16 2020-12-29 石家庄四药有限公司 一种氟康唑片剂组合物、片剂及制备方法
KR102434209B1 (ko) * 2022-01-28 2022-08-19 전기열 천연 오일을 함유한 발모촉진 및 탈모방지용 조성물

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
AU529987B2 (en) 1983-06-30
PL236740A1 (en) 1983-04-25
ES8404348A1 (es) 1984-05-01
MY8800094A (en) 1988-12-31
IE821285L (en) 1982-12-06
EP0069442A1 (fr) 1983-01-12
FI822005A0 (fi) 1982-06-04
AU8448482A (en) 1982-12-23
NO156128B (no) 1987-04-21
SG80887G (en) 1988-09-16
NL930061I1 (nl) 1993-09-01
NZ200864A (en) 1985-07-12
KR840000528A (ko) 1984-02-25
YU42770B (en) 1988-12-31
GR76491B (fr) 1984-08-10
PH18015A (en) 1985-02-28
NO156128C (no) 1987-07-29
FI822005L (fi) 1982-12-07
HU189143B (en) 1986-06-30
NO821886L (no) 1982-12-07
DE3262386D1 (en) 1985-03-28
YU119582A (en) 1984-12-31
IL65963A0 (en) 1982-09-30
NL930061I2 (nl) 1993-10-01
PL130909B1 (en) 1984-09-29
CA1181076A (fr) 1985-01-15
FI71134C (fi) 1986-11-24
LU88329I2 (fr) 1994-05-04
ES8307794A1 (es) 1983-08-01
EG17222A (en) 1991-03-30
KR850001132B1 (ko) 1985-08-09
DK252282A (da) 1982-12-07
DK149849C (da) 1987-04-27
US4404216A (en) 1983-09-13
NO1994019I1 (no) 1994-11-02
FI71134B (fi) 1986-08-14
EP0069442B1 (fr) 1985-02-20
PT75017A (en) 1982-07-01
IE53144B1 (en) 1988-07-20
PT75017B (en) 1985-01-07
MX7119E (es) 1987-06-29
ES520794A0 (es) 1984-05-01
DK149849B (da) 1986-10-13
ES512882A0 (es) 1983-08-01
IL65963A (en) 1985-02-28
IN158113B (fr) 1986-09-06

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