HK1214958A1 - 凝血酶溶液及其使用方法 - Google Patents
凝血酶溶液及其使用方法Info
- Publication number
- HK1214958A1 HK1214958A1 HK16102967.7A HK16102967A HK1214958A1 HK 1214958 A1 HK1214958 A1 HK 1214958A1 HK 16102967 A HK16102967 A HK 16102967A HK 1214958 A1 HK1214958 A1 HK 1214958A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- thrombin solution
- thrombin
- solution
- Prior art date
Links
- 108090000190 Thrombin Proteins 0.000 title 1
- 229960004072 thrombin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Mechanical Engineering (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL22339612 | 2012-12-03 | ||
US201361753542P | 2013-01-17 | 2013-01-17 | |
PCT/IL2013/000088 WO2014087394A1 (en) | 2012-12-03 | 2013-11-28 | Thrombin solution and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1214958A1 true HK1214958A1 (zh) | 2016-08-12 |
Family
ID=50825810
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16102967.7A HK1214958A1 (zh) | 2012-12-03 | 2016-03-15 | 凝血酶溶液及其使用方法 |
Country Status (14)
Country | Link |
---|---|
US (4) | US9212357B2 (zh) |
EP (2) | EP3760221A1 (zh) |
JP (2) | JP6526565B2 (zh) |
KR (1) | KR102101611B1 (zh) |
CN (2) | CN110251468A (zh) |
AU (1) | AU2013353636B2 (zh) |
BR (2) | BR122022012099B1 (zh) |
CA (1) | CA2892083A1 (zh) |
HK (1) | HK1214958A1 (zh) |
IL (1) | IL239043B (zh) |
MX (1) | MX358132B (zh) |
PL (1) | PL2925347T3 (zh) |
RU (1) | RU2670956C9 (zh) |
WO (1) | WO2014087394A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9212357B2 (en) | 2012-12-03 | 2015-12-15 | Omrix Biopharmaceuticals Ltd. | Thrombin solution and methods of use thereof |
CN107249623A (zh) * | 2015-03-13 | 2017-10-13 | 大利纬众生物科技股份有限公司 | 稳定凝血酶的方法及其组合物 |
US10159720B2 (en) | 2015-12-08 | 2018-12-25 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, preparation and uses thereof |
IL242984A0 (en) * | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
US10420134B2 (en) | 2016-02-02 | 2019-09-17 | Cisco Technology, Inc. | System and method to facilitate subframe scheduling in a split medium access control radio access network environment |
CN109010906B (zh) * | 2018-08-16 | 2021-05-14 | 陈明远 | 一种促进术后伤口局部止血及促进术后创面上皮化的生物胶水及其工作方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63243032A (ja) * | 1987-03-27 | 1988-10-07 | Green Cross Corp:The | トロンビンの加熱処理方法 |
US5605884A (en) | 1987-10-29 | 1997-02-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Factor VIII formulations in high ionic strength media |
US4877608A (en) | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
JP2715104B2 (ja) * | 1988-08-18 | 1998-02-18 | 株式会社ミドリ十字 | トロンビン乾燥製剤 |
DE3843126C3 (de) | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
KR100303872B1 (ko) | 1992-10-02 | 2001-11-22 | 크리스터 발스트룀, 프레드릭 베르그, 하랄트 알름 | 응고인자ⅷ제형을포함하는조성물,이것의제조방법및안정화제로서의계면활성제의사용방법 |
CN1100655A (zh) * | 1992-11-19 | 1995-03-29 | 迟斌元 | 一种含有缓冲剂和凝血酶的药物组合物 |
JP3028274B2 (ja) * | 1994-09-30 | 2000-04-04 | 持田製薬株式会社 | トロンビン固形製剤の安定化方法 |
GB9503750D0 (en) | 1995-02-24 | 1995-04-12 | Common Services Agency | Thrombin preparation |
JPWO2004043503A1 (ja) * | 2002-11-14 | 2006-03-09 | 財団法人化学及血清療法研究所 | トロンビン固定化生体吸収性合成不織布 |
EP1927658B1 (en) | 2004-06-22 | 2012-10-10 | Zymogenetics, Inc. | Thrombin compositions |
DK1766003T3 (da) * | 2004-06-22 | 2008-12-08 | Zymogenetics Inc | Thrombinpræparater |
ES2226587B1 (es) * | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
CA2612937C (en) * | 2005-07-22 | 2014-05-06 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
CN101282908A (zh) * | 2005-09-05 | 2008-10-08 | 兰贝克赛实验室有限公司 | 制备冻干的碳酸氢钠的方法 |
JP5138699B2 (ja) | 2006-11-24 | 2013-02-06 | カディラ・ヘルスケア・リミテッド | Peg−インターフェロンアルファ接合体の配合物 |
EP2111239B1 (en) * | 2006-12-15 | 2013-03-06 | Lifebond Ltd. | Gelatin-transglutaminase hemostatic dressings and sealants |
CN101214374A (zh) * | 2007-01-05 | 2008-07-09 | 兆科药业(合肥)有限公司 | 具有促凝血与止血功能的制剂 |
CA2717571C (en) | 2008-03-03 | 2016-08-23 | Omrix Biopharmaceuticals Ltd. | A gelatin sponge comprising an active ingredient, its preparation and use |
EP2331158B1 (en) * | 2008-09-22 | 2013-09-11 | Omrix Biopharmaceuticals Ltd. | Implantable device comprising a substrate pre-coated with stabilized fibrin |
BRPI0921429B1 (pt) | 2008-11-07 | 2022-07-12 | Takeda Pharmaceutical Company Limited | Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável |
WO2011131720A1 (en) | 2010-04-20 | 2011-10-27 | Octapharma Ag | New stabilizing agent for pharmaceutical proteins |
BR112012030457B1 (pt) * | 2010-06-01 | 2021-03-09 | Baxter International Inc. | processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, método para prover uma composição hemostática pronta para uso, e, kit para administrar uma composição hemostática |
IL207586A0 (en) | 2010-08-12 | 2010-12-30 | Omrix Biopharmaceuticals Ltd | A fibrin based therapeutic preparation and use thereof |
US9212357B2 (en) | 2012-12-03 | 2015-12-15 | Omrix Biopharmaceuticals Ltd. | Thrombin solution and methods of use thereof |
-
2013
- 2013-03-04 US US13/783,592 patent/US9212357B2/en active Active
- 2013-11-28 EP EP20191369.6A patent/EP3760221A1/en active Pending
- 2013-11-28 BR BR122022012099-7A patent/BR122022012099B1/pt active IP Right Grant
- 2013-11-28 JP JP2015544613A patent/JP6526565B2/ja active Active
- 2013-11-28 CN CN201910179940.4A patent/CN110251468A/zh active Pending
- 2013-11-28 WO PCT/IL2013/000088 patent/WO2014087394A1/en active Application Filing
- 2013-11-28 KR KR1020157017715A patent/KR102101611B1/ko active Application Filing
- 2013-11-28 BR BR112015013071-2A patent/BR112015013071B1/pt active IP Right Grant
- 2013-11-28 RU RU2015126540A patent/RU2670956C9/ru active
- 2013-11-28 CN CN201380063192.4A patent/CN104822387A/zh active Pending
- 2013-11-28 CA CA2892083A patent/CA2892083A1/en not_active Abandoned
- 2013-11-28 EP EP13820993.7A patent/EP2925347B1/en active Active
- 2013-11-28 PL PL13820993T patent/PL2925347T3/pl unknown
- 2013-11-28 AU AU2013353636A patent/AU2013353636B2/en active Active
- 2013-11-28 MX MX2015006986A patent/MX358132B/es active IP Right Grant
-
2015
- 2015-05-27 IL IL239043A patent/IL239043B/en active IP Right Grant
- 2015-11-09 US US14/935,743 patent/US10479987B2/en active Active
-
2016
- 2016-03-15 HK HK16102967.7A patent/HK1214958A1/zh unknown
-
2018
- 2018-05-24 JP JP2018099435A patent/JP2018162254A/ja active Pending
-
2019
- 2019-10-08 US US16/595,999 patent/US11225652B2/en active Active
-
2021
- 2021-12-09 US US17/546,447 patent/US11993797B2/en active Active
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