DK1766003T3 - Thrombinpræparater - Google Patents

Thrombinpræparater

Info

Publication number
DK1766003T3
DK1766003T3 DK05766031T DK05766031T DK1766003T3 DK 1766003 T3 DK1766003 T3 DK 1766003T3 DK 05766031 T DK05766031 T DK 05766031T DK 05766031 T DK05766031 T DK 05766031T DK 1766003 T3 DK1766003 T3 DK 1766003T3
Authority
DK
Denmark
Prior art keywords
thrombin
thrombin preparations
cacl2
mannitol
nacl
Prior art date
Application number
DK05766031T
Other languages
English (en)
Inventor
Shan Jiang
Richard I Senderoff
Jeffrey D Meyer
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK1766003T3 publication Critical patent/DK1766003T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
DK05766031T 2004-06-22 2005-06-21 Thrombinpræparater DK1766003T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58182404P 2004-06-22 2004-06-22
PCT/US2005/021743 WO2006009989A1 (en) 2004-06-22 2005-06-21 Thrombin compositions

Publications (1)

Publication Number Publication Date
DK1766003T3 true DK1766003T3 (da) 2008-12-08

Family

ID=34981715

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05766031T DK1766003T3 (da) 2004-06-22 2005-06-21 Thrombinpræparater

Country Status (11)

Country Link
US (2) US7393674B2 (da)
EP (1) EP1766003B1 (da)
JP (1) JP4767253B2 (da)
AT (1) ATE405643T1 (da)
AU (2) AU2005265251B2 (da)
CA (1) CA2570478C (da)
DE (1) DE602005009191D1 (da)
DK (1) DK1766003T3 (da)
ES (2) ES2395466T3 (da)
IL (1) IL179852A0 (da)
WO (1) WO2006009989A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4767253B2 (ja) * 2004-06-22 2011-09-07 ザイモジェネティクス， インコーポレイテッド トロンビン組成物
US8233963B2 (en) 2007-02-19 2012-07-31 Medtronic Navigation, Inc. Automatic identification of tracked surgical devices using an electromagnetic localization system
CA2937487C (en) * 2007-06-15 2018-01-09 Zymogenetics, Inc. Stabilized thrombin compositions
KR20100134078A (ko) * 2008-04-16 2010-12-22 잇빤 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 트롬빈 고정화 생체 흡수성 시트 제제의 제조방법
EP2113564A1 (en) * 2008-05-01 2009-11-04 Arecor Limited Protein formulation
MX345479B (es) 2010-06-01 2017-02-01 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
JP6289096B2 (ja) 2010-06-01 2018-03-07 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 乾燥した安定な止血組成物を作製するためのプロセス
US8697118B2 (en) * 2011-10-18 2014-04-15 St. Teresa Medical, Inc. Stabilizers for hemostatic products
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
CA2874290C (en) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Dry haemostatic composition
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
US9212357B2 (en) 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CN104274827B (zh) 2013-07-01 2020-07-14 上海贺普药业股份有限公司 贺普拉肽的制剂
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CN106999621B (zh) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 用于止血和伤口愈合的干组合物
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US20160193381A1 (en) * 2015-01-06 2016-07-07 St. Teresa Medical, Inc. Hemostatic products
EP3316930B1 (en) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
JP6926101B2 (ja) 2015-11-06 2021-08-25 エシコン・インコーポレイテッドＥｔｈｉｃｏｎ， Ｉｎｃ． 圧密止血セルロース系凝集体
WO2017083050A1 (en) 2015-11-12 2017-05-18 St. Teresa Medical, Inc. A method of sealing a durotomy
US11413335B2 (en) 2018-02-13 2022-08-16 Guangzhou Bioseal Biotech Co. Ltd Hemostatic compositions and methods of making thereof
CN107754005B (zh) 2016-08-15 2021-06-15 广州倍绣生物技术有限公司 止血组合物及其制造方法
US10953128B2 (en) 2017-11-02 2021-03-23 St. Teresa Medical, Inc. Fibrin sealant products
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법
IL261190A (en) * 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4363319A (en) 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
US4696812A (en) 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
JPS63243032A (ja) 1987-03-27 1988-10-07 Green Cross Corp:The トロンビンの加熱処理方法
JPS6440433A (en) 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
EP0443724B1 (en) 1990-02-20 1999-03-17 Baxter International Inc. Viral-safe purified human thrombin
JPH0813750B2 (ja) 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
EP0505604B1 (en) 1991-03-28 1996-09-25 Warner-Lambert Company Highly purified thrombin preparation
DE69433939T2 (de) 1993-11-03 2005-08-11 Clarion Pharmaceuticals, Inc., Madison Hämostatisches pflaster
RU2136319C1 (ru) 1993-12-23 1999-09-10 Джонсон энд Джонсон Медикал, Инк. Биоабсорбируемое хирургическое гемостатическое средство и способ его получения (варианты)
WO1998057678A2 (en) 1997-06-18 1998-12-23 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen
US6310183B1 (en) * 1997-09-10 2001-10-30 Novo Nordisk A/S Coagulation factor VIIa composition
US5981254A (en) 1997-10-30 1999-11-09 Haemacure Corporation Process for producing thrombin from plasma
EP1221479B1 (en) 1999-09-27 2006-11-22 Sysmex Corporation Method for stabilizing thrombin
CA2384814A1 (en) * 1999-09-29 2001-04-05 The Trustees Of The University Of Pennsylvania Methods for rapid peg-modification of viral vectors, compositions for enhanced gene transduction, compositions with enhanced physical stability, and uses therefor
US20050232899A1 (en) 2002-05-31 2005-10-20 Aradigm Corporation Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b
JP4767253B2 (ja) 2004-06-22 2011-09-07 ザイモジェネティクス， インコーポレイテッド トロンビン組成物

Also Published As

Publication number Publication date
AU2005265251B2 (en) 2009-09-10
EP1766003A1 (en) 2007-03-28
EP1766003B1 (en) 2008-08-20
IL179852A0 (en) 2007-05-15
ATE405643T1 (de) 2008-09-15
JP2008503240A (ja) 2008-02-07
CA2570478A1 (en) 2006-01-26
AU2009238369B2 (en) 2012-05-24
CA2570478C (en) 2011-08-23
ES2313383T3 (es) 2009-03-01
AU2005265251A1 (en) 2006-01-26
DE602005009191D1 (de) 2008-10-02
WO2006009989A1 (en) 2006-01-26
US7393674B2 (en) 2008-07-01
US20060002918A1 (en) 2006-01-05
ES2395466T3 (es) 2013-02-12
US20070104705A1 (en) 2007-05-10
JP4767253B2 (ja) 2011-09-07
AU2009238369A1 (en) 2009-12-10
US7473543B2 (en) 2009-01-06

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