ATE405643T1 - Thrombinzusammensetzungen - Google Patents

Thrombinzusammensetzungen

Info

Publication number
ATE405643T1
ATE405643T1 AT05766031T AT05766031T ATE405643T1 AT E405643 T1 ATE405643 T1 AT E405643T1 AT 05766031 T AT05766031 T AT 05766031T AT 05766031 T AT05766031 T AT 05766031T AT E405643 T1 ATE405643 T1 AT E405643T1
Authority
AT
Austria
Prior art keywords
compositions
thrombine
thrombin
cacl2
mannitol
Prior art date
Application number
AT05766031T
Other languages
English (en)
Inventor
Shan Jiang
Richard Senderoff
Jeffrey Meyer
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE405643T1 publication Critical patent/ATE405643T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
AT05766031T 2004-06-22 2005-06-21 Thrombinzusammensetzungen ATE405643T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58182404P 2004-06-22 2004-06-22

Publications (1)

Publication Number Publication Date
ATE405643T1 true ATE405643T1 (de) 2008-09-15

Family

ID=34981715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05766031T ATE405643T1 (de) 2004-06-22 2005-06-21 Thrombinzusammensetzungen

Country Status (11)

Country Link
US (2) US7393674B2 (de)
EP (1) EP1766003B1 (de)
JP (1) JP4767253B2 (de)
AT (1) ATE405643T1 (de)
AU (2) AU2005265251B2 (de)
CA (1) CA2570478C (de)
DE (1) DE602005009191D1 (de)
DK (1) DK1766003T3 (de)
ES (2) ES2313383T3 (de)
IL (1) IL179852A0 (de)
WO (1) WO2006009989A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005265251B2 (en) * 2004-06-22 2009-09-10 Baxter International Inc. Thrombin compositions
US8233963B2 (en) 2007-02-19 2012-07-31 Medtronic Navigation, Inc. Automatic identification of tracked surgical devices using an electromagnetic localization system
JP5253501B2 (ja) * 2007-06-15 2013-07-31 ザイモジェネティクス， インコーポレイテッド 安定化トロンビン組成物
WO2009128474A1 (ja) * 2008-04-16 2009-10-22 財団法人化学及血清療法研究所 トロンビン固定化生体吸収性シート製剤の製造方法
EP2113564A1 (de) * 2008-05-01 2009-11-04 Arecor Limited Proteinformulierung
MX345479B (es) 2010-06-01 2017-02-01 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
ES2682302T3 (es) * 2010-06-01 2018-09-19 Baxter International Inc Proceso para la producción de composiciones hemostáticas secas y estables
US8697118B2 (en) * 2011-10-18 2014-04-15 St. Teresa Medical, Inc. Stabilizers for hemostatic products
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
US9212357B2 (en) 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CN104274827B (zh) * 2013-07-01 2020-07-14 上海贺普药业股份有限公司 贺普拉肽的制剂
RU2678592C1 (ru) 2013-12-11 2019-01-30 Ферросан Медикал Дивайсиз А/С Сухая композиция, содержащая компонент, улучшающий экструзию
WO2016058612A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
WO2016112026A1 (en) * 2015-01-06 2016-07-14 St. Teresa Medical, Inc. Hemostatic products
EP3316930B1 (de) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Spritze zum mischen zweier komponenten und zum aufrechterhalten eines vakuums im lagerzustand
CA3004272C (en) 2015-11-06 2023-11-07 Ethicon, Inc. Compacted hemostatic cellulosic aggregates
CA3004734A1 (en) 2015-11-12 2017-06-18 St. Teresa Medical, Inc. A method of sealing a durotomy
US11413335B2 (en) 2018-02-13 2022-08-16 Guangzhou Bioseal Biotech Co. Ltd Hemostatic compositions and methods of making thereof
CN107754005B (zh) * 2016-08-15 2021-06-15 广州倍绣生物技术有限公司 止血组合物及其制造方法
WO2019089717A1 (en) 2017-11-02 2019-05-09 St. Teresa Medical, Inc. Fibrin sealant products
BR112020021998A2 (pt) 2018-05-09 2021-01-26 Ferrosan Medical Devices A/S métodos para preparar uma composição hemostática e para reconstituir uma composição de trombina seca, composição hemostática, e, estojo.
IL261190A (en) * 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4363319A (en) 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
US4696812A (en) 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
JPS63243032A (ja) 1987-03-27 1988-10-07 Green Cross Corp:The トロンビンの加熱処理方法
JPS6440433A (en) 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
ES2131504T3 (es) 1990-02-20 1999-08-01 Baxter Int Trombina humana purificada viricamente segura.
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
DE69122376D1 (de) 1991-03-28 1996-10-31 Warner Lambert Co Hochreine Thrombinzubereitung
CA2175203A1 (en) 1993-11-03 1995-05-11 Thaddeus P. Pruss Hemostatic patch
RU2136319C1 (ru) 1993-12-23 1999-09-10 Джонсон энд Джонсон Медикал, Инк. Биоабсорбируемое хирургическое гемостатическое средство и способ его получения (варианты)
EP0993311B1 (de) 1997-06-18 2012-11-14 Angiotech Pharmaceuticals (US), Inc. Thrombin und mikrofibrillares collagen enthaltene zusammensetzung sowie herstellungsmethoden und dessen gebrauch
US6310183B1 (en) * 1997-09-10 2001-10-30 Novo Nordisk A/S Coagulation factor VIIa composition
US5981254A (en) 1997-10-30 1999-11-09 Haemacure Corporation Process for producing thrombin from plasma
AU7320300A (en) 1999-09-27 2001-04-30 International Reagents Corporation Means of stabilizing thrombin and compositions
WO2001023001A2 (en) * 1999-09-29 2001-04-05 The Trustees Of The University Of Pennsylvania Rapid peg-modification
US20050232899A1 (en) 2002-05-31 2005-10-20 Aradigm Corporation Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b
AU2005265251B2 (en) * 2004-06-22 2009-09-10 Baxter International Inc. Thrombin compositions

Also Published As

Publication number Publication date
US7393674B2 (en) 2008-07-01
AU2009238369B2 (en) 2012-05-24
DE602005009191D1 (de) 2008-10-02
IL179852A0 (en) 2007-05-15
CA2570478A1 (en) 2006-01-26
ES2395466T3 (es) 2013-02-12
ES2313383T3 (es) 2009-03-01
DK1766003T3 (da) 2008-12-08
AU2005265251B2 (en) 2009-09-10
EP1766003A1 (de) 2007-03-28
JP4767253B2 (ja) 2011-09-07
US20060002918A1 (en) 2006-01-05
US20070104705A1 (en) 2007-05-10
US7473543B2 (en) 2009-01-06
JP2008503240A (ja) 2008-02-07
WO2006009989A1 (en) 2006-01-26
CA2570478C (en) 2011-08-23
AU2009238369A1 (en) 2009-12-10
AU2005265251A1 (en) 2006-01-26
EP1766003B1 (de) 2008-08-20

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